BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 1579887 Cn1ncc2c1COCCOc1ccccc1/C=C/c1n[nH]c3ccc-2cc13 789780 (11E)-1-methyl-1,18,19,21-tetrahydro- 8H-10,7,4- (ethan[1]yl[1,2]diylidene)pyrazolo[3,4- f][1,4,12,13]benzodioxadiazacyclooctadecine::US20250353864, Example 1 Epidermal growth factor receptor [L858R] Homo sapiens 848 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789780 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789780&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579888 Cn1ncc2c1COCCOc1ccccc1/C=C/c1n[nH]c3ccc-2cc13 789780 (11E)-1-methyl-1,18,19,21-tetrahydro- 8H-10,7,4- (ethan[1]yl[1,2]diylidene)pyrazolo[3,4- f][1,4,12,13]benzodioxadiazacyclooctadecine::US20250353864, Example 1 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 251 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789780 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789780&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579889 Cn1ncc2c1COCCOc1ccccc1/C=C/c1n[nH]c3ccc-2cc13 789780 (11E)-1-methyl-1,18,19,21-tetrahydro- 8H-10,7,4- (ethan[1]yl[1,2]diylidene)pyrazolo[3,4- f][1,4,12,13]benzodioxadiazacyclooctadecine::US20250353864, Example 1 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 259 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789780 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789780&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579890 Cn1ncc2c1COCCOc1ccccc1/C=C/c1n[nH]c3ccc-2cc13 789780 (11E)-1-methyl-1,18,19,21-tetrahydro- 8H-10,7,4- (ethan[1]yl[1,2]diylidene)pyrazolo[3,4- f][1,4,12,13]benzodioxadiazacyclooctadecine::US20250353864, Example 1 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 68.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789780 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789780&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579891 Cn1ncc2c1COCCOc1ccccc1/C=C/c1n[nH]c3ccc-2cc13 789780 (11E)-1-methyl-1,18,19,21-tetrahydro- 8H-10,7,4- (ethan[1]yl[1,2]diylidene)pyrazolo[3,4- f][1,4,12,13]benzodioxadiazacyclooctadecine::US20250353864, Example 1 Epidermal growth factor receptor [1-745,751-1210,C797S] 177 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789780 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789780&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579892 Cn1ncc2c1COCCOc1ccccc1/C=C/c1n[nH]c3ccc-2cc13 789780 (11E)-1-methyl-1,18,19,21-tetrahydro- 8H-10,7,4- (ethan[1]yl[1,2]diylidene)pyrazolo[3,4- f][1,4,12,13]benzodioxadiazacyclooctadecine::US20250353864, Example 1 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789780 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789780&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579893 Cn1ncc2c1COCCOc1ccccc1/C=C/c1n[nH]c3ccc-2cc13 789780 (11E)-1-methyl-1,18,19,21-tetrahydro- 8H-10,7,4- (ethan[1]yl[1,2]diylidene)pyrazolo[3,4- f][1,4,12,13]benzodioxadiazacyclooctadecine::US20250353864, Example 1 Epidermal growth factor receptor Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789780 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789780&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579894 CC(C)NC(=O)c1cnc2c(c1)/C=C/c1n[nH]c3cnc(cc13)-c1cnn(C)c1COCCO2 789916 (18E)-8-methyl-N-(propan-2-yl)- 8,9,11,12-tetrahydro-2H-3,5- ethenodipyrazolo[3',4':9,10;4$#8243;,3$#8243;:13,14] [1,4]dioxacyclopentadecino[5,6- b]pyridine-16-carboxamide::US20250353864, Example 2 Epidermal growth factor receptor [L858R] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789916 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789916&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579895 CC(C)NC(=O)c1cnc2c(c1)/C=C/c1n[nH]c3cnc(cc13)-c1cnn(C)c1COCCO2 789916 (18E)-8-methyl-N-(propan-2-yl)- 8,9,11,12-tetrahydro-2H-3,5- ethenodipyrazolo[3',4':9,10;4$#8243;,3$#8243;:13,14] [1,4]dioxacyclopentadecino[5,6- b]pyridine-16-carboxamide::US20250353864, Example 2 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789916 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789916&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579896 CC(C)NC(=O)c1cnc2c(c1)/C=C/c1n[nH]c3cnc(cc13)-c1cnn(C)c1COCCO2 789916 (18E)-8-methyl-N-(propan-2-yl)- 8,9,11,12-tetrahydro-2H-3,5- ethenodipyrazolo[3',4':9,10;4$#8243;,3$#8243;:13,14] [1,4]dioxacyclopentadecino[5,6- b]pyridine-16-carboxamide::US20250353864, Example 2 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789916 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789916&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579897 CC(C)NC(=O)c1cnc2c(c1)/C=C/c1n[nH]c3cnc(cc13)-c1cnn(C)c1COCCO2 789916 (18E)-8-methyl-N-(propan-2-yl)- 8,9,11,12-tetrahydro-2H-3,5- ethenodipyrazolo[3',4':9,10;4$#8243;,3$#8243;:13,14] [1,4]dioxacyclopentadecino[5,6- b]pyridine-16-carboxamide::US20250353864, Example 2 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789916 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789916&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579898 CC(C)NC(=O)c1cnc2c(c1)/C=C/c1n[nH]c3cnc(cc13)-c1cnn(C)c1COCCO2 789916 (18E)-8-methyl-N-(propan-2-yl)- 8,9,11,12-tetrahydro-2H-3,5- ethenodipyrazolo[3',4':9,10;4$#8243;,3$#8243;:13,14] [1,4]dioxacyclopentadecino[5,6- b]pyridine-16-carboxamide::US20250353864, Example 2 Epidermal growth factor receptor Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789916 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789916&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579899 CNC(=O)c1cnc2c(c1)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1COCCO2 789920 (18E)-N,8-dimethyl-8,9,11,12-tetrahydro- 2H-3,5- ethenodipyrazolo[3',4':9,10;4$#8243;,3$#8243;:13,14] [1,4]dioxacyclopentadecino[5,6- b]pyridine-16-carboxamide::US20250353864, Example 3 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 863 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789920 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789920&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579900 Cc1c2c(nn1C)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789922 (17E)-8,15,16-trimethyl-2,8,9,11,12,15- hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 7 Epidermal growth factor receptor [L858R] Homo sapiens 687 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789922 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789922&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579901 Cc1c2c(nn1C)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789922 (17E)-8,15,16-trimethyl-2,8,9,11,12,15- hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 7 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 202 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789922 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789922&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579902 Cc1c2c(nn1C)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789922 (17E)-8,15,16-trimethyl-2,8,9,11,12,15- hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 7 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 898 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789922 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789922&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579903 Cc1c2c(nn1C)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789922 (17E)-8,15,16-trimethyl-2,8,9,11,12,15- hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 7 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 2117 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789922 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789922&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579904 Cc1c2c(nn1C)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789922 (17E)-8,15,16-trimethyl-2,8,9,11,12,15- hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 7 Epidermal growth factor receptor Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789922 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789922&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579905 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789926 (17E)-8,14,16-trimethyl-2,11,12,14- tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 8 Epidermal growth factor receptor [L858R] Homo sapiens 104 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789926 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789926&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579906 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789926 (17E)-8,14,16-trimethyl-2,11,12,14- tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 8 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 24.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789926 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789926&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579907 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789926 (17E)-8,14,16-trimethyl-2,11,12,14- tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 8 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 44.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789926 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789926&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579908 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789926 (17E)-8,14,16-trimethyl-2,11,12,14- tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 8 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 377 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789926 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789926&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579909 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789926 (17E)-8,14,16-trimethyl-2,11,12,14- tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 8 Epidermal growth factor receptor Homo sapiens 884 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789926 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789926&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579910 Cc1c2c(nn1C)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789941 (17E)-8,15,16-trimethyl-2,11,12,15- tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 9 Epidermal growth factor receptor [L858R] Homo sapiens 349 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789941 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789941&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579911 Cc1c2c(nn1C)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789941 (17E)-8,15,16-trimethyl-2,11,12,15- tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 9 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 27.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789941 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789941&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579912 Cc1c2c(nn1C)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789941 (17E)-8,15,16-trimethyl-2,11,12,15- tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 9 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 284 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789941 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789941&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579913 Cc1c2c(nn1C)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789941 (17E)-8,15,16-trimethyl-2,11,12,15- tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 9 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 945 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789941 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789941&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579914 Cc1c2c(nn1C)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789941 (17E)-8,15,16-trimethyl-2,11,12,15- tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 9 Epidermal growth factor receptor Homo sapiens 1167 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789941 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789941&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579915 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789942 (17E)-16-ethyl-8,14-dimethyl- 2,11,12,14-tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 10 Epidermal growth factor receptor [L858R] Homo sapiens 181 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789942 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789942&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579916 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789942 (17E)-16-ethyl-8,14-dimethyl- 2,11,12,14-tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 10 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 42.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789942 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789942&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579917 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789942 (17E)-16-ethyl-8,14-dimethyl- 2,11,12,14-tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 10 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 74.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789942 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789942&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579918 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789942 (17E)-16-ethyl-8,14-dimethyl- 2,11,12,14-tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 10 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 713 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789942 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789942&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579919 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789942 (17E)-16-ethyl-8,14-dimethyl- 2,11,12,14-tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 10 Epidermal growth factor receptor Homo sapiens 973 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789942 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789942&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579920 COCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789943 (17E)-16-(methoxymethyl)-8,14- dimethyl-2,11,12,14-tetrahydro-8H,10H- 3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 11 Epidermal growth factor receptor [L858R] Homo sapiens 1585 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789943 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789943&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579921 COCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789943 (17E)-16-(methoxymethyl)-8,14- dimethyl-2,11,12,14-tetrahydro-8H,10H- 3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 11 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 153 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789943 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789943&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579922 COCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789943 (17E)-16-(methoxymethyl)-8,14- dimethyl-2,11,12,14-tetrahydro-8H,10H- 3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 11 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 218 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789943 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789943&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579923 COCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789943 (17E)-16-(methoxymethyl)-8,14- dimethyl-2,11,12,14-tetrahydro-8H,10H- 3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 11 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 850 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789943 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789943&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579924 COCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789943 (17E)-16-(methoxymethyl)-8,14- dimethyl-2,11,12,14-tetrahydro-8H,10H- 3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 11 Epidermal growth factor receptor [1-745,751-1210,C797S] 798 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789943 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789943&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579925 COCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789943 (17E)-16-(methoxymethyl)-8,14- dimethyl-2,11,12,14-tetrahydro-8H,10H- 3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 11 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789943 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789943&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579926 COCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789943 (17E)-16-(methoxymethyl)-8,14- dimethyl-2,11,12,14-tetrahydro-8H,10H- 3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 11 Epidermal growth factor receptor Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789943 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789943&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579927 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCC[C@H](C)O2 789944 (12S,17E)-16-ethyl-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 14 Epidermal growth factor receptor [L858R] Homo sapiens 63.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789944 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789944&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579928 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCC[C@H](C)O2 789944 (12S,17E)-16-ethyl-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 14 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 19.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789944 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789944&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579929 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCC[C@H](C)O2 789944 (12S,17E)-16-ethyl-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 14 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 124 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789944 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789944&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579930 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCC[C@H](C)O2 789944 (12S,17E)-16-ethyl-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 14 Epidermal growth factor receptor [1-745,751-1210,C797S] 34.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789944 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789944&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579931 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCC[C@H](C)O2 789944 (12S,17E)-16-ethyl-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 14 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 312 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789944 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789944&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579932 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCC[C@H](C)O2 789944 (12S,17E)-16-ethyl-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 14 Epidermal growth factor receptor Homo sapiens 339 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789944 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789944&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579933 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCC[C@@H](C)O2 789945 (12R,17E)-16-ethyl-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 15 Epidermal growth factor receptor [L858R] Homo sapiens 105 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789945 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789945&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579934 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCC[C@@H](C)O2 789945 (12R,17E)-16-ethyl-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 15 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 26.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789945 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789945&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579935 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCC[C@@H](C)O2 789945 (12R,17E)-16-ethyl-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 15 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 139 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789945 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789945&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579936 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCC[C@@H](C)O2 789945 (12R,17E)-16-ethyl-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 15 Epidermal growth factor receptor [1-745,751-1210,C797S] 27.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789945 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789945&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579937 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCC[C@@H](C)O2 789945 (12R,17E)-16-ethyl-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 15 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 286 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789945 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789945&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579938 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCC[C@@H](C)O2 789945 (12R,17E)-16-ethyl-8,12,14-trimethyl- 2,11,12,14-tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 15 Epidermal growth factor receptor Homo sapiens 419 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789945 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789945&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579939 Cn1ncc2c1OCCCCOc1ccccc1/C=C/c1n[nH]c3ccc-2cc13 789946 (11E)-1-methyl-18,19,20,21-tetrahydro- 1H,8H-10,7,4- (ethan[1]yl[1,2]diylidene)pyrazolo[3,4- g][1,6,13,14]benzodioxadiazacyclononad ecine::US20250353864, Example 16 Epidermal growth factor receptor [L858R] Homo sapiens 49.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789946 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789946&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579940 Cn1ncc2c1OCCCCOc1ccccc1/C=C/c1n[nH]c3ccc-2cc13 789946 (11E)-1-methyl-18,19,20,21-tetrahydro- 1H,8H-10,7,4- (ethan[1]yl[1,2]diylidene)pyrazolo[3,4- g][1,6,13,14]benzodioxadiazacyclononad ecine::US20250353864, Example 16 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 48.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789946 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789946&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579941 Cn1ncc2c1OCCCCOc1ccccc1/C=C/c1n[nH]c3ccc-2cc13 789946 (11E)-1-methyl-18,19,20,21-tetrahydro- 1H,8H-10,7,4- (ethan[1]yl[1,2]diylidene)pyrazolo[3,4- g][1,6,13,14]benzodioxadiazacyclononad ecine::US20250353864, Example 16 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 132 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789946 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789946&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579942 Cn1ncc2c1OCCCCOc1ccccc1/C=C/c1n[nH]c3ccc-2cc13 789946 (11E)-1-methyl-18,19,20,21-tetrahydro- 1H,8H-10,7,4- (ethan[1]yl[1,2]diylidene)pyrazolo[3,4- g][1,6,13,14]benzodioxadiazacyclononad ecine::US20250353864, Example 16 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 521 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789946 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789946&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579943 Cn1ncc2c1OCCCCOc1ccccc1/C=C/c1n[nH]c3ccc-2cc13 789946 (11E)-1-methyl-18,19,20,21-tetrahydro- 1H,8H-10,7,4- (ethan[1]yl[1,2]diylidene)pyrazolo[3,4- g][1,6,13,14]benzodioxadiazacyclononad ecine::US20250353864, Example 16 Epidermal growth factor receptor Homo sapiens 523 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789946 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789946&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579944 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789947 2-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5-etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]ethan- 1-ol::US20250353864, Example 22 Epidermal growth factor receptor [L858R] Homo sapiens 4.49 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789947 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789947&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579945 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789947 2-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5-etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]ethan- 1-ol::US20250353864, Example 22 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 1.87 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789947 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789947&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579946 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789947 2-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5-etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]ethan- 1-ol::US20250353864, Example 22 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.540 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789947 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789947&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579947 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789947 2-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5-etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]ethan- 1-ol::US20250353864, Example 22 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 3.84 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789947 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789947&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579948 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789947 2-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5-etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]ethan- 1-ol::US20250353864, Example 22 Epidermal growth factor receptor [1-745,751-1210,C797S] 5.10 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789947 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789947&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579949 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789947 2-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5-etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]ethan- 1-ol::US20250353864, Example 22 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 94.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789947 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789947&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579950 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789947 2-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5-etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]ethan- 1-ol::US20250353864, Example 22 Epidermal growth factor receptor Homo sapiens 158 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789947 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789947&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579951 CCc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789948 2-[(17E)-16-ethyl-8-methyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]ethan- 1-ol::US20250353864, Example 23 Epidermal growth factor receptor [L858R] Homo sapiens 96.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789948 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789948&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579952 CCc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789948 2-[(17E)-16-ethyl-8-methyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]ethan- 1-ol::US20250353864, Example 23 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 13.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789948 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789948&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579953 CCc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789948 2-[(17E)-16-ethyl-8-methyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]ethan- 1-ol::US20250353864, Example 23 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 22.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789948 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789948&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579954 CCc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789948 2-[(17E)-16-ethyl-8-methyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]ethan- 1-ol::US20250353864, Example 23 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 29.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789948 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789948&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579955 CCc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789948 2-[(17E)-16-ethyl-8-methyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]ethan- 1-ol::US20250353864, Example 23 Epidermal growth factor receptor [1-745,751-1210,C797S] 44.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789948 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789948&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579956 CCc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789948 2-[(17E)-16-ethyl-8-methyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]ethan- 1-ol::US20250353864, Example 23 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 362 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789948 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789948&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579957 CCc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789948 2-[(17E)-16-ethyl-8-methyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]ethan- 1-ol::US20250353864, Example 23 Epidermal growth factor receptor Homo sapiens 290 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789948 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789948&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579958 Cc1c2c(nn1CCO)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789949 2-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15-yl]ethan- 1-ol::US20250353864, Example 24 Epidermal growth factor receptor [L858R] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789949 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789949&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579959 Cc1c2c(nn1CCO)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789949 2-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15-yl]ethan- 1-ol::US20250353864, Example 24 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 315 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789949 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789949&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579960 Cc1c2c(nn1CCO)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789949 2-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15-yl]ethan- 1-ol::US20250353864, Example 24 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 755 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789949 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789949&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579961 Cc1c2c(nn1CCO)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789949 2-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15-yl]ethan- 1-ol::US20250353864, Example 24 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 1772 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789949 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789949&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579962 Cc1c2c(nn1CCO)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789949 2-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15-yl]ethan- 1-ol::US20250353864, Example 24 Epidermal growth factor receptor Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789949 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789949&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579963 Cc1c2c(nn1CC(C)(C)O)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789950 1-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15-yl]-2- methylpropan-2-ol::US20250353864, Example 28 Epidermal growth factor receptor [L858R] Homo sapiens 1001 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789950 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789950&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579964 Cc1c2c(nn1CC(C)(C)O)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789950 1-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15-yl]-2- methylpropan-2-ol::US20250353864, Example 28 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 578 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789950 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789950&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579965 Cc1c2c(nn1CC(C)(C)O)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789950 1-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15-yl]-2- methylpropan-2-ol::US20250353864, Example 28 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 819 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789950 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789950&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579966 Cc1c2c(nn1CC(C)(C)O)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789950 1-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15-yl]-2- methylpropan-2-ol::US20250353864, Example 28 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789950 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789950&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579967 Cc1c2c(nn1CC(C)(C)O)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789950 1-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15-yl]-2- methylpropan-2-ol::US20250353864, Example 28 Epidermal growth factor receptor Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789950 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789950&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579968 Cc1nn(CC(C)(C)O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789951 1-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]-2- methylpropan-2-ol::US20250353864, Example 30 Epidermal growth factor receptor [L858R] Homo sapiens 268 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789951 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789951&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579969 Cc1nn(CC(C)(C)O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789951 1-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]-2- methylpropan-2-ol::US20250353864, Example 30 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 36.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789951 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789951&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579970 Cc1nn(CC(C)(C)O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789951 1-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]-2- methylpropan-2-ol::US20250353864, Example 30 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 216 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789951 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789951&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579971 Cc1nn(CC(C)(C)O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789951 1-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]-2- methylpropan-2-ol::US20250353864, Example 30 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 983 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789951 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789951&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579972 Cc1nn(CC(C)(C)O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789951 1-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]-2- methylpropan-2-ol::US20250353864, Example 30 Epidermal growth factor receptor Homo sapiens 1304 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789951 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789951&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579973 CC(=N)C1=C(\NCC(C)=O)OCCCOc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 789952 1-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]propan- 2-one::US20250353864, Example 31 Epidermal growth factor receptor [L858R] Homo sapiens 67.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789952 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789952&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579974 CC(=N)C1=C(\NCC(C)=O)OCCCOc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 789952 1-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]propan- 2-one::US20250353864, Example 31 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 4.93 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789952 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789952&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579975 CC(=N)C1=C(\NCC(C)=O)OCCCOc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 789952 1-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]propan- 2-one::US20250353864, Example 31 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 58.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789952 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789952&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579976 CC(=N)C1=C(\NCC(C)=O)OCCCOc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 789952 1-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]propan- 2-one::US20250353864, Example 31 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 732 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789952 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789952&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579977 CC(=N)C1=C(\NCC(C)=O)OCCCOc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 789952 1-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]propan- 2-one::US20250353864, Example 31 Epidermal growth factor receptor Homo sapiens 927 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789952 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789952&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579978 Cc1nn(CCN2CCCC2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789953 (17E)-8,16-dimethyl-14-[2-(pyrrolidin-1- yl)ethyl]-2,11,12,14-tetrahydro-8H,10H- 3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 32 Epidermal growth factor receptor [L858R] Homo sapiens 242 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789953 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789953&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579979 Cc1nn(CCN2CCCC2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789953 (17E)-8,16-dimethyl-14-[2-(pyrrolidin-1- yl)ethyl]-2,11,12,14-tetrahydro-8H,10H- 3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 32 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 37.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789953 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789953&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579980 Cc1nn(CCN2CCCC2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789953 (17E)-8,16-dimethyl-14-[2-(pyrrolidin-1- yl)ethyl]-2,11,12,14-tetrahydro-8H,10H- 3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 32 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 155 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789953 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789953&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579981 Cc1nn(CCN2CCCC2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789953 (17E)-8,16-dimethyl-14-[2-(pyrrolidin-1- yl)ethyl]-2,11,12,14-tetrahydro-8H,10H- 3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 32 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 457 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789953 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789953&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579982 Cc1nn(CCN2CCCC2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789953 (17E)-8,16-dimethyl-14-[2-(pyrrolidin-1- yl)ethyl]-2,11,12,14-tetrahydro-8H,10H- 3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 32 Epidermal growth factor receptor Homo sapiens 1262 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789953 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789953&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579983 Cc1nn(CCN2CC[C@H](O)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789954 (3S)-1-{2-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]ethyl}pyrrolidin-3-ol::US20250353864, Example 33 Epidermal growth factor receptor [L858R] Homo sapiens 121 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789954 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789954&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579984 Cc1nn(CCN2CC[C@H](O)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789954 (3S)-1-{2-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]ethyl}pyrrolidin-3-ol::US20250353864, Example 33 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 14.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789954 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789954&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579985 Cc1nn(CCN2CC[C@H](O)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789954 (3S)-1-{2-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]ethyl}pyrrolidin-3-ol::US20250353864, Example 33 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 25.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789954 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789954&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579986 Cc1nn(CCN2CC[C@H](O)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789954 (3S)-1-{2-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]ethyl}pyrrolidin-3-ol::US20250353864, Example 33 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 93.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789954 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789954&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579987 Cc1nn(CCN2CC[C@H](O)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789954 (3S)-1-{2-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]ethyl}pyrrolidin-3-ol::US20250353864, Example 33 Epidermal growth factor receptor [1-745,751-1210,C797S] 92.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789954 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789954&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579988 Cc1nn(CCN2CC[C@H](O)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789954 (3S)-1-{2-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]ethyl}pyrrolidin-3-ol::US20250353864, Example 33 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 306 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789954 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789954&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579989 Cc1nn(CCN2CC[C@H](O)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789954 (3S)-1-{2-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]ethyl}pyrrolidin-3-ol::US20250353864, Example 33 Epidermal growth factor receptor Homo sapiens 405 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789954 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789954&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579990 Cc1c2c(nn1CCN1CCCC1)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789955 (17E)-8,16-dimethyl-15-[2-(pyrrolidin-1- yl)ethyl]-2,11,12,15-tetrahydro-8H,10H- 3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 34 Epidermal growth factor receptor [L858R] Homo sapiens 114 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789955 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789955&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579991 Cc1c2c(nn1CCN1CCCC1)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789955 (17E)-8,16-dimethyl-15-[2-(pyrrolidin-1- yl)ethyl]-2,11,12,15-tetrahydro-8H,10H- 3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 34 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 40.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789955 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789955&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579992 Cc1c2c(nn1CCN1CCCC1)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789955 (17E)-8,16-dimethyl-15-[2-(pyrrolidin-1- yl)ethyl]-2,11,12,15-tetrahydro-8H,10H- 3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 34 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 154 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789955 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789955&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579993 Cc1c2c(nn1CCN1CCCC1)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789955 (17E)-8,16-dimethyl-15-[2-(pyrrolidin-1- yl)ethyl]-2,11,12,15-tetrahydro-8H,10H- 3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 34 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 190 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789955 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789955&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579994 Cc1c2c(nn1CCN1CCCC1)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789955 (17E)-8,16-dimethyl-15-[2-(pyrrolidin-1- yl)ethyl]-2,11,12,15-tetrahydro-8H,10H- 3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 34 Epidermal growth factor receptor Homo sapiens 326 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789955 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789955&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579995 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CCO2 789956 (10S,17E)-8,10,14,16-tetramethyl- 2,11,12,14-tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 35 Epidermal growth factor receptor [L858R] Homo sapiens 135 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789956 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789956&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579996 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CCO2 789956 (10S,17E)-8,10,14,16-tetramethyl- 2,11,12,14-tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 35 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 30.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789956 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789956&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579997 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CCO2 789956 (10S,17E)-8,10,14,16-tetramethyl- 2,11,12,14-tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 35 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 101 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789956 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789956&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579998 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CCO2 789956 (10S,17E)-8,10,14,16-tetramethyl- 2,11,12,14-tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 35 Epidermal growth factor receptor [1-745,751-1210,C797S] 99.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789956 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789956&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1579999 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CCO2 789956 (10S,17E)-8,10,14,16-tetramethyl- 2,11,12,14-tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 35 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 1041 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789956 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789956&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580000 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CCO2 789956 (10S,17E)-8,10,14,16-tetramethyl- 2,11,12,14-tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 35 Epidermal growth factor receptor Homo sapiens 584 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789956 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789956&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580001 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CCO2 789957 (10S,17E)-16-ethyl-8,10,14-trimethyl- 2,11,12,14-tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 37 Epidermal growth factor receptor [L858R] Homo sapiens 41.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789957 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789957&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580002 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CCO2 789957 (10S,17E)-16-ethyl-8,10,14-trimethyl- 2,11,12,14-tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 37 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 17.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789957 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789957&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580003 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CCO2 789957 (10S,17E)-16-ethyl-8,10,14-trimethyl- 2,11,12,14-tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 37 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 64.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789957 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789957&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580004 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CCO2 789957 (10S,17E)-16-ethyl-8,10,14-trimethyl- 2,11,12,14-tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 37 Epidermal growth factor receptor [1-745,751-1210,C797S] 49.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789957 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789957&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580005 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CCO2 789957 (10S,17E)-16-ethyl-8,10,14-trimethyl- 2,11,12,14-tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 37 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 212 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789957 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789957&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580006 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CCO2 789957 (10S,17E)-16-ethyl-8,10,14-trimethyl- 2,11,12,14-tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 37 Epidermal growth factor receptor Homo sapiens 157 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789957 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789957&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580007 Cc1ccc2c(n1)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CCO2 789958 (10S,18E)-8,10,16-trimethyl-2,8,11,12- tetrahydro-10H-3,5- ethenodipyrazolo[3',4':10,11;4$#8243;,3$#8243;:14,15] [1,5]dioxacyclopentadecino[7,6- b]pyridine::US20250353864, Example 39 Epidermal growth factor receptor [L858R] Homo sapiens 222 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789958 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789958&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580008 Cc1ccc2c(n1)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CCO2 789958 (10S,18E)-8,10,16-trimethyl-2,8,11,12- tetrahydro-10H-3,5- ethenodipyrazolo[3',4':10,11;4$#8243;,3$#8243;:14,15] [1,5]dioxacyclopentadecino[7,6- b]pyridine::US20250353864, Example 39 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 35.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789958 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789958&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580009 Cc1ccc2c(n1)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CCO2 789958 (10S,18E)-8,10,16-trimethyl-2,8,11,12- tetrahydro-10H-3,5- ethenodipyrazolo[3',4':10,11;4$#8243;,3$#8243;:14,15] [1,5]dioxacyclopentadecino[7,6- b]pyridine::US20250353864, Example 39 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 176 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789958 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789958&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580010 Cc1ccc2c(n1)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CCO2 789958 (10S,18E)-8,10,16-trimethyl-2,8,11,12- tetrahydro-10H-3,5- ethenodipyrazolo[3',4':10,11;4$#8243;,3$#8243;:14,15] [1,5]dioxacyclopentadecino[7,6- b]pyridine::US20250353864, Example 39 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 1442 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789958 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789958&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580011 Cc1ccc2c(n1)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CCO2 789958 (10S,18E)-8,10,16-trimethyl-2,8,11,12- tetrahydro-10H-3,5- ethenodipyrazolo[3',4':10,11;4$#8243;,3$#8243;:14,15] [1,5]dioxacyclopentadecino[7,6- b]pyridine::US20250353864, Example 39 Epidermal growth factor receptor Homo sapiens 1073 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789958 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789958&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580012 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2 789959 (17E)-8,12,14,16-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 43 Epidermal growth factor receptor [L858R] Homo sapiens 144 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789959 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789959&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580013 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2 789959 (17E)-8,12,14,16-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 43 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 13.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789959 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789959&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580014 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2 789959 (17E)-8,12,14,16-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 43 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 34.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789959 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789959&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580015 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2 789959 (17E)-8,12,14,16-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 43 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 74.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789959 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789959&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580016 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2 789959 (17E)-8,12,14,16-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 43 Epidermal growth factor receptor [1-745,751-1210,C797S] 133 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789959 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789959&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580017 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2 789959 (17E)-8,12,14,16-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 43 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 541 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789959 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789959&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580018 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2 789959 (17E)-8,12,14,16-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 43 Epidermal growth factor receptor Homo sapiens 543 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789959 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789959&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580019 Cc1c2c(nn1C)CN(C)CCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789960 (17E)-8,12,15,16-tetramethyl- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 44 Epidermal growth factor receptor [L858R] Homo sapiens 285 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789960 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789960&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580020 Cc1c2c(nn1C)CN(C)CCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789960 (17E)-8,12,15,16-tetramethyl- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 44 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 27.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789960 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789960&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580021 Cc1c2c(nn1C)CN(C)CCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789960 (17E)-8,12,15,16-tetramethyl- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 44 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 112 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789960 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789960&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580022 Cc1c2c(nn1C)CN(C)CCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789960 (17E)-8,12,15,16-tetramethyl- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 44 Epidermal growth factor receptor [1-745,751-1210,C797S] 130 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789960 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789960&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580023 Cc1c2c(nn1C)CN(C)CCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789960 (17E)-8,12,15,16-tetramethyl- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 44 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789960 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789960&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580024 Cc1c2c(nn1C)CN(C)CCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789960 (17E)-8,12,15,16-tetramethyl- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 44 Epidermal growth factor receptor Homo sapiens 1465 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789960 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789960&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580025 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1c(C)nn(C)c1OCCN(C)C2 789961 (17E)-6,8,12,14,16-pentamethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 47 Epidermal growth factor receptor [L858R] Homo sapiens 822 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789961&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580026 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1c(C)nn(C)c1OCCN(C)C2 789961 (17E)-6,8,12,14,16-pentamethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 47 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 79.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789961&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580027 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1c(C)nn(C)c1OCCN(C)C2 789961 (17E)-6,8,12,14,16-pentamethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 47 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 170 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789961&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580028 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1c(C)nn(C)c1OCCN(C)C2 789961 (17E)-6,8,12,14,16-pentamethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 47 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 488 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789961&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580029 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1c(C)nn(C)c1OCCN(C)C2 789961 (17E)-6,8,12,14,16-pentamethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 47 Epidermal growth factor receptor [1-745,751-1210,C797S] 944 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789961&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580030 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1c(C)nn(C)c1OCCN(C)C2 789961 (17E)-6,8,12,14,16-pentamethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 47 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789961&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580031 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1c(C)nn(C)c1OCCN(C)C2 789961 (17E)-6,8,12,14,16-pentamethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 47 Epidermal growth factor receptor Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789961&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580032 Cc1c2c(nn1CCO)CNC[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789962 yl]ethan-1-ol 2-[(10S,17E)-8,10,16-trimethyl-2,8,10,11,12,13-hexahydro-15H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-15-::US20250353864, Example 49 Epidermal growth factor receptor [L858R] Homo sapiens 862 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789962 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789962&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580033 Cc1c2c(nn1CCO)CNC[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789962 yl]ethan-1-ol 2-[(10S,17E)-8,10,16-trimethyl-2,8,10,11,12,13-hexahydro-15H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-15-::US20250353864, Example 49 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 126 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789962 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789962&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580034 Cc1c2c(nn1CCO)CNC[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789962 yl]ethan-1-ol 2-[(10S,17E)-8,10,16-trimethyl-2,8,10,11,12,13-hexahydro-15H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-15-::US20250353864, Example 49 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 84.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789962 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789962&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580035 Cc1c2c(nn1CCO)CNC[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789962 yl]ethan-1-ol 2-[(10S,17E)-8,10,16-trimethyl-2,8,10,11,12,13-hexahydro-15H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-15-::US20250353864, Example 49 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 617 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789962 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789962&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580036 Cc1c2c(nn1CCO)CNC[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789962 yl]ethan-1-ol 2-[(10S,17E)-8,10,16-trimethyl-2,8,10,11,12,13-hexahydro-15H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-15-::US20250353864, Example 49 Epidermal growth factor receptor [1-745,751-1210,C797S] 1040 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789962 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789962&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580037 Cc1c2c(nn1CCO)CNC[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789962 yl]ethan-1-ol 2-[(10S,17E)-8,10,16-trimethyl-2,8,10,11,12,13-hexahydro-15H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-15-::US20250353864, Example 49 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789962 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789962&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580038 Cc1c2c(nn1CCO)CNC[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789962 yl]ethan-1-ol 2-[(10S,17E)-8,10,16-trimethyl-2,8,10,11,12,13-hexahydro-15H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-15-::US20250353864, Example 49 Epidermal growth factor receptor Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789962 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789962&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580039 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 789963 (17E)-8,10,14,16-tetramethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 55 Epidermal growth factor receptor [L858R] Homo sapiens 35.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789963 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789963&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580040 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 789963 (17E)-8,10,14,16-tetramethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 55 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 4.10 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789963 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789963&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580041 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 789963 (17E)-8,10,14,16-tetramethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 55 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 33.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789963 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789963&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580042 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 789963 (17E)-8,10,14,16-tetramethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 55 Epidermal growth factor receptor [1-745,751-1210,C797S] 8.93 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789963 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789963&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580043 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 789963 (17E)-8,10,14,16-tetramethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 55 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 78.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789963 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789963&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580044 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 789963 (17E)-8,10,14,16-tetramethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 55 Epidermal growth factor receptor Homo sapiens 101 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789963 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789963&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580045 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 789964 2-[(17E)-8,10,16-trimethyl- 2,8,9,10,11,12-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 56 Epidermal growth factor receptor [L858R] Homo sapiens 22.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789964 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789964&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580046 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 789964 2-[(17E)-8,10,16-trimethyl- 2,8,9,10,11,12-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 56 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 1.22 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789964 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789964&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580047 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 789964 2-[(17E)-8,10,16-trimethyl- 2,8,9,10,11,12-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 56 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 1.12 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789964 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789964&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580048 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 789964 2-[(17E)-8,10,16-trimethyl- 2,8,9,10,11,12-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 56 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 15.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789964 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789964&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580049 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 789964 2-[(17E)-8,10,16-trimethyl- 2,8,9,10,11,12-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 56 Epidermal growth factor receptor [1-745,751-1210,C797S] 8.48 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789964 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789964&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580050 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 789964 2-[(17E)-8,10,16-trimethyl- 2,8,9,10,11,12-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 56 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 50.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789964 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789964&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580051 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 789964 2-[(17E)-8,10,16-trimethyl- 2,8,9,10,11,12-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 56 Epidermal growth factor receptor Homo sapiens 42.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789964 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789964&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580052 Cc1c2c(nn1C)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789965 (10S,17E)-8,10,12,15,16-pentamethyl- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 58 Epidermal growth factor receptor [L858R] Homo sapiens 9.29 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789965 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789965&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580053 Cc1c2c(nn1C)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789965 (10S,17E)-8,10,12,15,16-pentamethyl- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 58 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 1.57 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789965 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789965&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580054 Cc1c2c(nn1C)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789965 (10S,17E)-8,10,12,15,16-pentamethyl- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 58 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 11.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789965 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789965&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580055 Cc1c2c(nn1C)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789965 (10S,17E)-8,10,12,15,16-pentamethyl- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 58 Epidermal growth factor receptor [1-745,751-1210,C797S] 7.29 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789965 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789965&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580056 Cc1c2c(nn1C)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789965 (10S,17E)-8,10,12,15,16-pentamethyl- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 58 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 222 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789965 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789965&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580057 Cc1c2c(nn1C)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789965 (10S,17E)-8,10,12,15,16-pentamethyl- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 58 Epidermal growth factor receptor Homo sapiens 49.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789965 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789965&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580058 CCN1Cc2nn(C)c(C)c2/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 789966 (10S,17E)-12-ethyl-8,10,15,16- tetramethyl-2,10,11,12,13,15-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 59 Epidermal growth factor receptor [L858R] Homo sapiens 7.63 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789966 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789966&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580059 CCN1Cc2nn(C)c(C)c2/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 789966 (10S,17E)-12-ethyl-8,10,15,16- tetramethyl-2,10,11,12,13,15-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 59 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.700 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789966 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789966&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580060 CCN1Cc2nn(C)c(C)c2/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 789966 (10S,17E)-12-ethyl-8,10,15,16- tetramethyl-2,10,11,12,13,15-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 59 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 1.02 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789966 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789966&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580061 CCN1Cc2nn(C)c(C)c2/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 789966 (10S,17E)-12-ethyl-8,10,15,16- tetramethyl-2,10,11,12,13,15-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 59 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 18.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789966 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789966&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580062 CCN1Cc2nn(C)c(C)c2/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 789966 (10S,17E)-12-ethyl-8,10,15,16- tetramethyl-2,10,11,12,13,15-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 59 Epidermal growth factor receptor [1-745,751-1210,C797S] 2.42 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789966 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789966&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580063 CCN1Cc2nn(C)c(C)c2/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 789966 (10S,17E)-12-ethyl-8,10,15,16- tetramethyl-2,10,11,12,13,15-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 59 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 127 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789966 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789966&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580064 CCN1Cc2nn(C)c(C)c2/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 789966 (10S,17E)-12-ethyl-8,10,15,16- tetramethyl-2,10,11,12,13,15-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 59 Epidermal growth factor receptor Homo sapiens 44.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789966 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789966&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580065 Cc1c2c(nn1CCO)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789967 2-[(10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-15H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-15- yl]ethan-1-ol::US20250353864, Example 60 Epidermal growth factor receptor [L858R] Homo sapiens 101 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789967 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789967&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580066 Cc1c2c(nn1CCO)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789967 2-[(10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-15H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-15- yl]ethan-1-ol::US20250353864, Example 60 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 6.86 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789967 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789967&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580067 Cc1c2c(nn1CCO)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789967 2-[(10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-15H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-15- yl]ethan-1-ol::US20250353864, Example 60 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 3.27 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789967 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789967&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580068 Cc1c2c(nn1CCO)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789967 2-[(10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-15H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-15- yl]ethan-1-ol::US20250353864, Example 60 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 89.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789967 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789967&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580069 Cc1c2c(nn1CCO)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789967 2-[(10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-15H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-15- yl]ethan-1-ol::US20250353864, Example 60 Epidermal growth factor receptor [1-745,751-1210,C797S] 89.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789967 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789967&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580070 Cc1c2c(nn1CCO)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789967 2-[(10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-15H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-15- yl]ethan-1-ol::US20250353864, Example 60 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 678 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789967 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789967&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580071 Cc1c2c(nn1CCO)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789967 2-[(10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-15H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-15- yl]ethan-1-ol::US20250353864, Example 60 Epidermal growth factor receptor Homo sapiens 581 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789967 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789967&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580072 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 789968 2-[(10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 61 Epidermal growth factor receptor [L858R] Homo sapiens 1.23 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789968 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789968&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580073 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 789968 2-[(10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 61 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.290 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789968 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789968&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580074 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 789968 2-[(10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 61 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.170 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789968 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789968&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580075 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 789968 2-[(10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 61 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 1.08 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789968 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789968&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580076 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 789968 2-[(10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 61 Epidermal growth factor receptor [1-745,751-1210,C797S] 1.96 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789968 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789968&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580077 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 789968 2-[(10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 61 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 9.21 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789968 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789968&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580078 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 789968 2-[(10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 61 Epidermal growth factor receptor Homo sapiens 6.19 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789968 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789968&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580079 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C(=O)CO2 789969 (19E)-8,12,16,18-tetramethyl-2,11,12,16- tetrahydro-8H,10H-3,5- ethenotripyrazolo[3,4-h:3',4'-l:4$#8243;,3$#8243;- p][1,7,4]dioxazacycloheptadecin- 13(14H)-one::US20250353864, Example 63 Epidermal growth factor receptor [L858R] Homo sapiens 828 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789969 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789969&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580080 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C(=O)CO2 789969 (19E)-8,12,16,18-tetramethyl-2,11,12,16- tetrahydro-8H,10H-3,5- ethenotripyrazolo[3,4-h:3',4'-l:4$#8243;,3$#8243;- p][1,7,4]dioxazacycloheptadecin- 13(14H)-one::US20250353864, Example 63 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 43.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789969 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789969&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580081 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C(=O)CO2 789969 (19E)-8,12,16,18-tetramethyl-2,11,12,16- tetrahydro-8H,10H-3,5- ethenotripyrazolo[3,4-h:3',4'-l:4$#8243;,3$#8243;- p][1,7,4]dioxazacycloheptadecin- 13(14H)-one::US20250353864, Example 63 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 33.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789969 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789969&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580082 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C(=O)CO2 789969 (19E)-8,12,16,18-tetramethyl-2,11,12,16- tetrahydro-8H,10H-3,5- ethenotripyrazolo[3,4-h:3',4'-l:4$#8243;,3$#8243;- p][1,7,4]dioxazacycloheptadecin- 13(14H)-one::US20250353864, Example 63 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 296 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789969 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789969&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580083 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C(=O)CO2 789969 (19E)-8,12,16,18-tetramethyl-2,11,12,16- tetrahydro-8H,10H-3,5- ethenotripyrazolo[3,4-h:3',4'-l:4$#8243;,3$#8243;- p][1,7,4]dioxazacycloheptadecin- 13(14H)-one::US20250353864, Example 63 Epidermal growth factor receptor [1-745,751-1210,C797S] 228 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789969 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789969&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580084 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C(=O)CO2 789969 (19E)-8,12,16,18-tetramethyl-2,11,12,16- tetrahydro-8H,10H-3,5- ethenotripyrazolo[3,4-h:3',4'-l:4$#8243;,3$#8243;- p][1,7,4]dioxazacycloheptadecin- 13(14H)-one::US20250353864, Example 63 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789969 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789969&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580085 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C(=O)CO2 789969 (19E)-8,12,16,18-tetramethyl-2,11,12,16- tetrahydro-8H,10H-3,5- ethenotripyrazolo[3,4-h:3',4'-l:4$#8243;,3$#8243;- p][1,7,4]dioxazacycloheptadecin- 13(14H)-one::US20250353864, Example 63 Epidermal growth factor receptor Homo sapiens 782 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789969 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789969&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580086 CCc1nn(CCN2CC[C@H](O)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789970 (3S)-1-{2-[(17E)-16-ethyl-8-methyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]ethyl}pyrrolidin-3-ol::US20250353864, Example 69 Epidermal growth factor receptor [L858R] Homo sapiens 121 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789970 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789970&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580087 CCc1nn(CCN2CC[C@H](O)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789970 (3S)-1-{2-[(17E)-16-ethyl-8-methyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]ethyl}pyrrolidin-3-ol::US20250353864, Example 69 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 14.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789970 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789970&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580088 CCc1nn(CCN2CC[C@H](O)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789970 (3S)-1-{2-[(17E)-16-ethyl-8-methyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]ethyl}pyrrolidin-3-ol::US20250353864, Example 69 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 25.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789970 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789970&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580089 CCc1nn(CCN2CC[C@H](O)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789970 (3S)-1-{2-[(17E)-16-ethyl-8-methyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]ethyl}pyrrolidin-3-ol::US20250353864, Example 69 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 93.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789970 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789970&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580090 CCc1nn(CCN2CC[C@H](O)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789970 (3S)-1-{2-[(17E)-16-ethyl-8-methyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]ethyl}pyrrolidin-3-ol::US20250353864, Example 69 Epidermal growth factor receptor [1-745,751-1210,C797S] 92.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789970 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789970&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580091 CCc1nn(CCN2CC[C@H](O)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789970 (3S)-1-{2-[(17E)-16-ethyl-8-methyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]ethyl}pyrrolidin-3-ol::US20250353864, Example 69 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 306 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789970 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789970&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580092 CCc1nn(CCN2CC[C@H](O)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789970 (3S)-1-{2-[(17E)-16-ethyl-8-methyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]ethyl}pyrrolidin-3-ol::US20250353864, Example 69 Epidermal growth factor receptor Homo sapiens 405 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789970 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789970&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580093 Cn1ncc2c1OCCN1CC[C@@H](Oc3ccccc3/C=C/c3n[nH]c4ccc-2cc34)C1=O 789971 (10R,16E)-3-methyl-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 70 Epidermal growth factor receptor [L858R] Homo sapiens 70.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789971 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789971&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580094 Cn1ncc2c1OCCN1CC[C@@H](Oc3ccccc3/C=C/c3n[nH]c4ccc-2cc34)C1=O 789971 (10R,16E)-3-methyl-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 70 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 3.81 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789971 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789971&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580095 Cn1ncc2c1OCCN1CC[C@@H](Oc3ccccc3/C=C/c3n[nH]c4ccc-2cc34)C1=O 789971 (10R,16E)-3-methyl-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 70 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 3.68 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789971 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789971&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580096 Cn1ncc2c1OCCN1CC[C@@H](Oc3ccccc3/C=C/c3n[nH]c4ccc-2cc34)C1=O 789971 (10R,16E)-3-methyl-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 70 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 32.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789971 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789971&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580097 Cn1ncc2c1OCCN1CC[C@@H](Oc3ccccc3/C=C/c3n[nH]c4ccc-2cc34)C1=O 789971 (10R,16E)-3-methyl-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 70 Epidermal growth factor receptor [1-745,751-1210,C797S] 27.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789971 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789971&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580098 Cn1ncc2c1OCCN1CC[C@@H](Oc3ccccc3/C=C/c3n[nH]c4ccc-2cc34)C1=O 789971 (10R,16E)-3-methyl-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 70 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 73.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789971 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789971&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580099 Cn1ncc2c1OCCN1CC[C@@H](Oc3ccccc3/C=C/c3n[nH]c4ccc-2cc34)C1=O 789971 (10R,16E)-3-methyl-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 70 Epidermal growth factor receptor Homo sapiens 98.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789971 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789971&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580100 Cc1nn([C@H]2CNC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789972 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]pyrrolidin-3-ol::US20250353864, Example 74 Epidermal growth factor receptor [L858R] Homo sapiens 36.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789972 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789972&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580101 Cc1nn([C@H]2CNC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789972 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]pyrrolidin-3-ol::US20250353864, Example 74 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 12.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789972 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789972&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580102 Cc1nn([C@H]2CNC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789972 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]pyrrolidin-3-ol::US20250353864, Example 74 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 15.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789972 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789972&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580103 Cc1nn([C@H]2CNC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789972 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]pyrrolidin-3-ol::US20250353864, Example 74 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 74.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789972 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789972&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580104 Cc1nn([C@H]2CNC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789972 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]pyrrolidin-3-ol::US20250353864, Example 74 Epidermal growth factor receptor [1-745,751-1210,C797S] 39.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789972 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789972&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580105 Cc1nn([C@H]2CNC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789972 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]pyrrolidin-3-ol::US20250353864, Example 74 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 109 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789972 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789972&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580106 Cc1nn([C@H]2CNC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789972 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]pyrrolidin-3-ol::US20250353864, Example 74 Epidermal growth factor receptor Homo sapiens 86.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789972 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789972&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580107 Cc1nn([C@H]2CN(C)C[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789973 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]-1- methylpyrrolidin-3-ol::US20250353864, Example 75 Epidermal growth factor receptor [L858R] Homo sapiens 55.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789973 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789973&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580108 Cc1nn([C@H]2CN(C)C[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789973 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]-1- methylpyrrolidin-3-ol::US20250353864, Example 75 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 17.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789973 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789973&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580109 Cc1nn([C@H]2CN(C)C[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789973 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]-1- methylpyrrolidin-3-ol::US20250353864, Example 75 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 21.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789973 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789973&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580110 Cc1nn([C@H]2CN(C)C[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789973 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]-1- methylpyrrolidin-3-ol::US20250353864, Example 75 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 59.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789973 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789973&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580111 Cc1nn([C@H]2CN(C)C[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789973 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]-1- methylpyrrolidin-3-ol::US20250353864, Example 75 Epidermal growth factor receptor [1-745,751-1210,C797S] 28.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789973 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789973&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580112 Cc1nn([C@H]2CN(C)C[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789973 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]-1- methylpyrrolidin-3-ol::US20250353864, Example 75 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 84.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789973 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789973&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580113 Cc1nn([C@H]2CN(C)C[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789973 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]-1- methylpyrrolidin-3-ol::US20250353864, Example 75 Epidermal growth factor receptor Homo sapiens 295 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789973 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789973&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580114 Cc1nn([C@H]2COC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789974 (3R,4S)-4-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]oxolan- 3-ol::US20250353864, Example 76 Epidermal growth factor receptor [L858R] Homo sapiens 156 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789974 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789974&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580115 Cc1nn([C@H]2COC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789974 (3R,4S)-4-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]oxolan- 3-ol::US20250353864, Example 76 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 42.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789974 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789974&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580116 Cc1nn([C@H]2COC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789974 (3R,4S)-4-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]oxolan- 3-ol::US20250353864, Example 76 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 63.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789974 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789974&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580117 Cc1nn([C@H]2COC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789974 (3R,4S)-4-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]oxolan- 3-ol::US20250353864, Example 76 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 147 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789974 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789974&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580118 Cc1nn([C@H]2COC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789974 (3R,4S)-4-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]oxolan- 3-ol::US20250353864, Example 76 Epidermal growth factor receptor [1-745,751-1210,C797S] 90.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789974 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789974&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580119 Cc1nn([C@H]2COC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789974 (3R,4S)-4-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]oxolan- 3-ol::US20250353864, Example 76 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 233 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789974 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789974&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580120 Cc1nn([C@H]2COC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789974 (3R,4S)-4-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]oxolan- 3-ol::US20250353864, Example 76 Epidermal growth factor receptor Homo sapiens 538 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789974 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789974&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580121 Cc1nn([C@@H]2COC[C@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789975 (3S,4R)-4-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]oxolan- 3-ol::US20250353864, Example 77 Epidermal growth factor receptor [L858R] Homo sapiens 2084 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789975 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789975&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580122 Cc1nn([C@@H]2COC[C@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789975 (3S,4R)-4-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]oxolan- 3-ol::US20250353864, Example 77 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 427 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789975 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789975&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580123 Cc1nn([C@@H]2COC[C@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789975 (3S,4R)-4-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]oxolan- 3-ol::US20250353864, Example 77 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 453 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789975 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789975&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580124 Cc1nn([C@@H]2COC[C@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789975 (3S,4R)-4-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]oxolan- 3-ol::US20250353864, Example 77 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 749 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789975 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789975&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580125 Cc1nn([C@@H]2COC[C@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789975 (3S,4R)-4-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]oxolan- 3-ol::US20250353864, Example 77 Epidermal growth factor receptor [1-745,751-1210,C797S] 803 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789975 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789975&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580126 Cc1nn([C@@H]2COC[C@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789975 (3S,4R)-4-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]oxolan- 3-ol::US20250353864, Example 77 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 1882 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789975 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789975&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580127 Cc1nn([C@@H]2COC[C@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789975 (3S,4R)-4-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]oxolan- 3-ol::US20250353864, Example 77 Epidermal growth factor receptor Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789975 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789975&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580128 Cc1nn([C@H]2CC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789976 (rac)-2-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]cyclobutan-1-ol::US20250353864, Example 78 Epidermal growth factor receptor [L858R] Homo sapiens 688 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789976 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789976&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580129 Cc1nn([C@H]2CC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789976 (rac)-2-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]cyclobutan-1-ol::US20250353864, Example 78 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 206 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789976 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789976&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580130 Cc1nn([C@H]2CC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789976 (rac)-2-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]cyclobutan-1-ol::US20250353864, Example 78 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 296 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789976 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789976&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580131 Cc1nn([C@H]2CC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789976 (rac)-2-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]cyclobutan-1-ol::US20250353864, Example 78 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 212 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789976 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789976&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580132 Cc1nn([C@H]2CC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789976 (rac)-2-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]cyclobutan-1-ol::US20250353864, Example 78 Epidermal growth factor receptor [1-745,751-1210,C797S] 775 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789976 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789976&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580133 Cc1nn([C@H]2CC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789976 (rac)-2-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]cyclobutan-1-ol::US20250353864, Example 78 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 910 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789976 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789976&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580134 Cc1nn([C@H]2CC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789976 (rac)-2-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]cyclobutan-1-ol::US20250353864, Example 78 Epidermal growth factor receptor Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789976 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789976&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580135 Cc1c2c(nn1CCO)OCCOC(C)c1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789977 2-[(17E)-8,9,16-trimethyl-8,9,11,12- tetrahydro-3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazol-15(2H)- yl]ethan-1-ol::US20250353864, Example 79 Epidermal growth factor receptor [L858R] Homo sapiens 526 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789977 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789977&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580136 Cc1c2c(nn1CCO)OCCOC(C)c1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789977 2-[(17E)-8,9,16-trimethyl-8,9,11,12- tetrahydro-3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazol-15(2H)- yl]ethan-1-ol::US20250353864, Example 79 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 57.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789977 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789977&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580137 Cc1c2c(nn1CCO)OCCOC(C)c1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789977 2-[(17E)-8,9,16-trimethyl-8,9,11,12- tetrahydro-3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazol-15(2H)- yl]ethan-1-ol::US20250353864, Example 79 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 67.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789977 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789977&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580138 Cc1c2c(nn1CCO)OCCOC(C)c1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789977 2-[(17E)-8,9,16-trimethyl-8,9,11,12- tetrahydro-3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazol-15(2H)- yl]ethan-1-ol::US20250353864, Example 79 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 596 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789977 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789977&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580139 Cc1c2c(nn1CCO)OCCOC(C)c1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789977 2-[(17E)-8,9,16-trimethyl-8,9,11,12- tetrahydro-3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazol-15(2H)- yl]ethan-1-ol::US20250353864, Example 79 Epidermal growth factor receptor [1-745,751-1210,C797S] 284 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789977 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789977&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580140 Cc1c2c(nn1CCO)OCCOC(C)c1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789977 2-[(17E)-8,9,16-trimethyl-8,9,11,12- tetrahydro-3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazol-15(2H)- yl]ethan-1-ol::US20250353864, Example 79 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 951 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789977 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789977&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580141 Cc1c2c(nn1CCO)OCCOC(C)c1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789977 2-[(17E)-8,9,16-trimethyl-8,9,11,12- tetrahydro-3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazol-15(2H)- yl]ethan-1-ol::US20250353864, Example 79 Epidermal growth factor receptor Homo sapiens 1908 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789977 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789977&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580142 Cc1nn([C@H]2CCNC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789978 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]piperidin-3-ol::US20250353864, Example 80 Epidermal growth factor receptor [L858R] Homo sapiens 24.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789978 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789978&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580143 Cc1nn([C@H]2CCNC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789978 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]piperidin-3-ol::US20250353864, Example 80 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 4.37 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789978 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789978&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580144 Cc1nn([C@H]2CCNC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789978 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]piperidin-3-ol::US20250353864, Example 80 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 11.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789978 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789978&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580145 Cc1nn([C@H]2CCNC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789978 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]piperidin-3-ol::US20250353864, Example 80 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 38.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789978 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789978&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580146 Cc1nn([C@H]2CCNC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789978 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]piperidin-3-ol::US20250353864, Example 80 Epidermal growth factor receptor [1-745,751-1210,C797S] 39.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789978 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789978&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580147 Cc1nn([C@H]2CCNC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789978 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]piperidin-3-ol::US20250353864, Example 80 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 59.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789978 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789978&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580148 Cc1nn([C@H]2CCNC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789978 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]piperidin-3-ol::US20250353864, Example 80 Epidermal growth factor receptor Homo sapiens 50.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789978 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789978&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580149 Cc1c2c(nn1[C@H]1CCNC[C@@H]1O)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789979 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15- yl]piperidin-3-ol::US20250353864, Example 81 Epidermal growth factor receptor [L858R] Homo sapiens 16.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789979 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789979&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580150 Cc1c2c(nn1[C@H]1CCNC[C@@H]1O)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789979 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15- yl]piperidin-3-ol::US20250353864, Example 81 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 1.70 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789979 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789979&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580151 Cc1c2c(nn1[C@H]1CCNC[C@@H]1O)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789979 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15- yl]piperidin-3-ol::US20250353864, Example 81 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 7.42 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789979 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789979&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580152 Cc1c2c(nn1[C@H]1CCNC[C@@H]1O)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789979 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15- yl]piperidin-3-ol::US20250353864, Example 81 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 29.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789979 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789979&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580153 Cc1c2c(nn1[C@H]1CCNC[C@@H]1O)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789979 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15- yl]piperidin-3-ol::US20250353864, Example 81 Epidermal growth factor receptor [1-745,751-1210,C797S] 33.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789979 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789979&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580154 Cc1c2c(nn1[C@H]1CCNC[C@@H]1O)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789979 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15- yl]piperidin-3-ol::US20250353864, Example 81 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 40.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789979 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789979&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580155 Cc1c2c(nn1[C@H]1CCNC[C@@H]1O)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789979 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15- yl]piperidin-3-ol::US20250353864, Example 81 Epidermal growth factor receptor Homo sapiens 43.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789979 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789979&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580156 Cc1nn([C@H]2CCN(C)C[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789980 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]-1- methylpiperidin-3-ol::US20250353864, Example 82 Epidermal growth factor receptor [L858R] Homo sapiens 15.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789980 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789980&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580157 Cc1nn([C@H]2CCN(C)C[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789980 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]-1- methylpiperidin-3-ol::US20250353864, Example 82 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 1.24 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789980 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789980&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580158 Cc1nn([C@H]2CCN(C)C[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789980 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]-1- methylpiperidin-3-ol::US20250353864, Example 82 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 5.77 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789980 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789980&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580159 Cc1nn([C@H]2CCN(C)C[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789980 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]-1- methylpiperidin-3-ol::US20250353864, Example 82 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 27.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789980 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789980&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580160 Cc1nn([C@H]2CCN(C)C[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789980 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]-1- methylpiperidin-3-ol::US20250353864, Example 82 Epidermal growth factor receptor [1-745,751-1210,C797S] 29.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789980 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789980&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580161 Cc1nn([C@H]2CCN(C)C[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789980 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]-1- methylpiperidin-3-ol::US20250353864, Example 82 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 56.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789980 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789980&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580162 Cc1nn([C@H]2CCN(C)C[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789980 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]-1- methylpiperidin-3-ol::US20250353864, Example 82 Epidermal growth factor receptor Homo sapiens 67.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789980 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789980&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580163 Cc1c2c(nn1[C@H]1CCN(C)C[C@@H]1O)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789981 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15-yl]-1- methylpiperidin-3-ol::US20250353864, Example 83 Epidermal growth factor receptor [L858R] Homo sapiens 19.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789981 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789981&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580164 Cc1c2c(nn1[C@H]1CCN(C)C[C@@H]1O)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789981 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15-yl]-1- methylpiperidin-3-ol::US20250353864, Example 83 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 1.48 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789981 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789981&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580165 Cc1c2c(nn1[C@H]1CCN(C)C[C@@H]1O)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789981 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15-yl]-1- methylpiperidin-3-ol::US20250353864, Example 83 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 5.29 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789981 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789981&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580166 Cc1c2c(nn1[C@H]1CCN(C)C[C@@H]1O)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789981 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15-yl]-1- methylpiperidin-3-ol::US20250353864, Example 83 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 34.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789981 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789981&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580167 Cc1c2c(nn1[C@H]1CCN(C)C[C@@H]1O)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789981 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15-yl]-1- methylpiperidin-3-ol::US20250353864, Example 83 Epidermal growth factor receptor [1-745,751-1210,C797S] 31.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789981 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789981&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580168 Cc1c2c(nn1[C@H]1CCN(C)C[C@@H]1O)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789981 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15-yl]-1- methylpiperidin-3-ol::US20250353864, Example 83 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 55.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789981 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789981&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580169 Cc1c2c(nn1[C@H]1CCN(C)C[C@@H]1O)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789981 (rac)-4-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15-yl]-1- methylpiperidin-3-ol::US20250353864, Example 83 Epidermal growth factor receptor Homo sapiens 61.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789981 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789981&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580170 Cc1c2c(nn1CCN1CCCC1)OCCOC(C)c1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789982 (17E)-8,9,16-trimethyl-15-[2-(pyrrolidin- 1-yl)ethyl]-2,8,9,11,12,15-hexahydro- 3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 84 Epidermal growth factor receptor [L858R] Homo sapiens 285 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789982 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789982&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580171 Cc1c2c(nn1CCN1CCCC1)OCCOC(C)c1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789982 (17E)-8,9,16-trimethyl-15-[2-(pyrrolidin- 1-yl)ethyl]-2,8,9,11,12,15-hexahydro- 3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 84 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 30.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789982 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789982&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580172 Cc1c2c(nn1CCN1CCCC1)OCCOC(C)c1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789982 (17E)-8,9,16-trimethyl-15-[2-(pyrrolidin- 1-yl)ethyl]-2,8,9,11,12,15-hexahydro- 3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 84 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 28.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789982 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789982&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580173 Cc1c2c(nn1CCN1CCCC1)OCCOC(C)c1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789982 (17E)-8,9,16-trimethyl-15-[2-(pyrrolidin- 1-yl)ethyl]-2,8,9,11,12,15-hexahydro- 3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 84 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 381 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789982 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789982&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580174 Cc1c2c(nn1CCN1CCCC1)OCCOC(C)c1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789982 (17E)-8,9,16-trimethyl-15-[2-(pyrrolidin- 1-yl)ethyl]-2,8,9,11,12,15-hexahydro- 3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 84 Epidermal growth factor receptor [1-745,751-1210,C797S] 130 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789982 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789982&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580175 Cc1c2c(nn1CCN1CCCC1)OCCOC(C)c1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789982 (17E)-8,9,16-trimethyl-15-[2-(pyrrolidin- 1-yl)ethyl]-2,8,9,11,12,15-hexahydro- 3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 84 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 551 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789982 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789982&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580176 Cc1c2c(nn1CCN1CCCC1)OCCOC(C)c1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789982 (17E)-8,9,16-trimethyl-15-[2-(pyrrolidin- 1-yl)ethyl]-2,8,9,11,12,15-hexahydro- 3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 84 Epidermal growth factor receptor Homo sapiens 1076 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789982 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789982&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580177 Cc1nn([C@H]2CCOC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789983 (rac)-1,5-anhydr-30-2,3-dideoxy-3- [(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]-L- threo-pentitol::US20250353864, Example 85 Epidermal growth factor receptor [L858R] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789983 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789983&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580178 Cc1nn([C@H]2CCOC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789983 (rac)-1,5-anhydr-30-2,3-dideoxy-3- [(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]-L- threo-pentitol::US20250353864, Example 85 Epidermal growth factor receptor [T790M,L858R] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789983 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789983&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580179 Cc1nn([C@H]2CCOC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789983 (rac)-1,5-anhydr-30-2,3-dideoxy-3- [(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]-L- threo-pentitol::US20250353864, Example 85 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789983 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789983&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580180 Cc1nn([C@H]2CCOC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789983 (rac)-1,5-anhydr-30-2,3-dideoxy-3- [(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]-L- threo-pentitol::US20250353864, Example 85 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789983 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789983&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580181 Cc1nn([C@H]2CCOC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789983 (rac)-1,5-anhydr-30-2,3-dideoxy-3- [(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]-L- threo-pentitol::US20250353864, Example 85 Epidermal growth factor receptor [1-745,751-1210,C797S] >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789983 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789983&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580182 Cc1nn([C@H]2CCOC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789983 (rac)-1,5-anhydr-30-2,3-dideoxy-3- [(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]-L- threo-pentitol::US20250353864, Example 85 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789983 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789983&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580183 Cc1nn([C@H]2CCOC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789983 (rac)-1,5-anhydr-30-2,3-dideoxy-3- [(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]-L- threo-pentitol::US20250353864, Example 85 Epidermal growth factor receptor Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789983 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789983&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580184 Cc1nn([C@H]2COCC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789984 (rac)-1,5-anhydro-2,4-dideoxy-2-[(17E)- 8,16-dimethyl-2,8,11,12-tetrahydro- 10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]-L- threo-pentitol::US20250353864, Example 86 Epidermal growth factor receptor [L858R] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789984 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789984&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580185 Cc1nn([C@H]2COCC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789984 (rac)-1,5-anhydro-2,4-dideoxy-2-[(17E)- 8,16-dimethyl-2,8,11,12-tetrahydro- 10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]-L- threo-pentitol::US20250353864, Example 86 Epidermal growth factor receptor [T790M,L858R] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789984 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789984&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580186 Cc1nn([C@H]2COCC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789984 (rac)-1,5-anhydro-2,4-dideoxy-2-[(17E)- 8,16-dimethyl-2,8,11,12-tetrahydro- 10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]-L- threo-pentitol::US20250353864, Example 86 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789984 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789984&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580187 Cc1nn([C@H]2COCC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789984 (rac)-1,5-anhydro-2,4-dideoxy-2-[(17E)- 8,16-dimethyl-2,8,11,12-tetrahydro- 10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]-L- threo-pentitol::US20250353864, Example 86 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789984 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789984&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580188 Cc1nn([C@H]2COCC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789984 (rac)-1,5-anhydro-2,4-dideoxy-2-[(17E)- 8,16-dimethyl-2,8,11,12-tetrahydro- 10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]-L- threo-pentitol::US20250353864, Example 86 Epidermal growth factor receptor [1-745,751-1210,C797S] >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789984 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789984&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580189 Cc1nn([C@H]2COCC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789984 (rac)-1,5-anhydro-2,4-dideoxy-2-[(17E)- 8,16-dimethyl-2,8,11,12-tetrahydro- 10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]-L- threo-pentitol::US20250353864, Example 86 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789984 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789984&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580190 Cc1nn([C@H]2COCC[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789984 (rac)-1,5-anhydro-2,4-dideoxy-2-[(17E)- 8,16-dimethyl-2,8,11,12-tetrahydro- 10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]-L- threo-pentitol::US20250353864, Example 86 Epidermal growth factor receptor Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789984 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789984&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580191 Cc1c2c(nn1[C@H]1CCOC[C@@H]1O)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789985 (rac)-1,5-anhydro-2,3-dideoxy-3-[(17E)- 8,16-dimethyl-2,8,11,12-tetrahydro- 10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15-yl]-L- threo-pentitol::US20250353864, Example 87 Epidermal growth factor receptor [L858R] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789985 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789985&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580192 Cc1c2c(nn1[C@H]1CCOC[C@@H]1O)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789985 (rac)-1,5-anhydro-2,3-dideoxy-3-[(17E)- 8,16-dimethyl-2,8,11,12-tetrahydro- 10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15-yl]-L- threo-pentitol::US20250353864, Example 87 Epidermal growth factor receptor [T790M,L858R] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789985 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789985&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580193 Cc1c2c(nn1[C@H]1CCOC[C@@H]1O)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789985 (rac)-1,5-anhydro-2,3-dideoxy-3-[(17E)- 8,16-dimethyl-2,8,11,12-tetrahydro- 10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15-yl]-L- threo-pentitol::US20250353864, Example 87 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789985 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789985&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580194 Cc1c2c(nn1[C@H]1CCOC[C@@H]1O)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789985 (rac)-1,5-anhydro-2,3-dideoxy-3-[(17E)- 8,16-dimethyl-2,8,11,12-tetrahydro- 10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15-yl]-L- threo-pentitol::US20250353864, Example 87 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789985 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789985&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580195 Cc1c2c(nn1[C@H]1CCOC[C@@H]1O)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789985 (rac)-1,5-anhydro-2,3-dideoxy-3-[(17E)- 8,16-dimethyl-2,8,11,12-tetrahydro- 10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15-yl]-L- threo-pentitol::US20250353864, Example 87 Epidermal growth factor receptor [1-745,751-1210,C797S] >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789985 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789985&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580196 Cc1c2c(nn1[C@H]1CCOC[C@@H]1O)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789985 (rac)-1,5-anhydro-2,3-dideoxy-3-[(17E)- 8,16-dimethyl-2,8,11,12-tetrahydro- 10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15-yl]-L- threo-pentitol::US20250353864, Example 87 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789985 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789985&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580197 Cc1c2c(nn1[C@H]1CCOC[C@@H]1O)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789985 (rac)-1,5-anhydro-2,3-dideoxy-3-[(17E)- 8,16-dimethyl-2,8,11,12-tetrahydro- 10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15-yl]-L- threo-pentitol::US20250353864, Example 87 Epidermal growth factor receptor Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789985 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789985&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580198 Cc1c2c(nn1CCN1CCCC1)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789986 (10S,17E)-8,10,12,16-tetramethyl-15-[2- (pyrrolidin-1-yl)ethyl]-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 89 Epidermal growth factor receptor [L858R] Homo sapiens 4.66 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789986 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789986&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580199 Cc1c2c(nn1CCN1CCCC1)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789986 (10S,17E)-8,10,12,16-tetramethyl-15-[2- (pyrrolidin-1-yl)ethyl]-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 89 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.060 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789986 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789986&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580200 Cc1c2c(nn1CCN1CCCC1)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789986 (10S,17E)-8,10,12,16-tetramethyl-15-[2- (pyrrolidin-1-yl)ethyl]-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 89 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.450 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789986 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789986&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580201 Cc1c2c(nn1CCN1CCCC1)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789986 (10S,17E)-8,10,12,16-tetramethyl-15-[2- (pyrrolidin-1-yl)ethyl]-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 89 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 19.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789986 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789986&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580202 Cc1c2c(nn1CCN1CCCC1)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789986 (10S,17E)-8,10,12,16-tetramethyl-15-[2- (pyrrolidin-1-yl)ethyl]-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 89 Epidermal growth factor receptor [1-745,751-1210,C797S] 6.67 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789986 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789986&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580203 Cc1c2c(nn1CCN1CCCC1)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789986 (10S,17E)-8,10,12,16-tetramethyl-15-[2- (pyrrolidin-1-yl)ethyl]-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 89 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 191 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789986 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789986&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580204 Cc1c2c(nn1CCN1CCCC1)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789986 (10S,17E)-8,10,12,16-tetramethyl-15-[2- (pyrrolidin-1-yl)ethyl]-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 89 Epidermal growth factor receptor Homo sapiens 64.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789986 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789986&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580205 Cc1c2c(nn1CCN1CCN(C)CC1)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789987 (10S,17E)-8,10,12,16-tetramethyl-15-[2- (4-methylpiperazin-1-yl)ethyl]- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 90 Epidermal growth factor receptor [L858R] Homo sapiens 1.02 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789987 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789987&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580206 Cc1c2c(nn1CCN1CCN(C)CC1)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789987 (10S,17E)-8,10,12,16-tetramethyl-15-[2- (4-methylpiperazin-1-yl)ethyl]- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 90 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.060 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789987 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789987&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580207 Cc1c2c(nn1CCN1CCN(C)CC1)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789987 (10S,17E)-8,10,12,16-tetramethyl-15-[2- (4-methylpiperazin-1-yl)ethyl]- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 90 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.810 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789987 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789987&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580208 Cc1c2c(nn1CCN1CCN(C)CC1)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789987 (10S,17E)-8,10,12,16-tetramethyl-15-[2- (4-methylpiperazin-1-yl)ethyl]- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 90 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 11.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789987 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789987&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580209 Cc1c2c(nn1CCN1CCN(C)CC1)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789987 (10S,17E)-8,10,12,16-tetramethyl-15-[2- (4-methylpiperazin-1-yl)ethyl]- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 90 Epidermal growth factor receptor [1-745,751-1210,C797S] 4.65 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789987 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789987&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580210 Cc1c2c(nn1CCN1CCN(C)CC1)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789987 (10S,17E)-8,10,12,16-tetramethyl-15-[2- (4-methylpiperazin-1-yl)ethyl]- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 90 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 81.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789987 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789987&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580211 Cc1c2c(nn1CCN1CCN(C)CC1)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789987 (10S,17E)-8,10,12,16-tetramethyl-15-[2- (4-methylpiperazin-1-yl)ethyl]- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 90 Epidermal growth factor receptor Homo sapiens 17.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789987 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789987&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580212 Cn1ncc2c1OCCCOc1nn3ccn(C)c(=O)c3c1/C=C/c1n[nH]c3ccc-2cc13 789988 (20E)-8,18-dimethyl-2,8,11,12- tetrahydro-10H-3,5- ethenodipyrazolo[3$#8243;,4$#8243;:10',11';4$#8243;,3':14', 15'][1,5]dioxacyclopentadecino[6',7':3,4] pyrazolo[1,5-a]pyrazin-19(18H)-one::US20250353864, Example 91 Epidermal growth factor receptor [L858R] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789988 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789988&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580213 Cn1ncc2c1OCCCOc1nn3ccn(C)c(=O)c3c1/C=C/c1n[nH]c3ccc-2cc13 789988 (20E)-8,18-dimethyl-2,8,11,12- tetrahydro-10H-3,5- ethenodipyrazolo[3$#8243;,4$#8243;:10',11';4$#8243;,3':14', 15'][1,5]dioxacyclopentadecino[6',7':3,4] pyrazolo[1,5-a]pyrazin-19(18H)-one::US20250353864, Example 91 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 400 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789988 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789988&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580214 Cn1ncc2c1OCCCOc1nn3ccn(C)c(=O)c3c1/C=C/c1n[nH]c3ccc-2cc13 789988 (20E)-8,18-dimethyl-2,8,11,12- tetrahydro-10H-3,5- ethenodipyrazolo[3$#8243;,4$#8243;:10',11';4$#8243;,3':14', 15'][1,5]dioxacyclopentadecino[6',7':3,4] pyrazolo[1,5-a]pyrazin-19(18H)-one::US20250353864, Example 91 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789988 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789988&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580215 Cn1ncc2c1OCCCOc1nn3ccn(C)c(=O)c3c1/C=C/c1n[nH]c3ccc-2cc13 789988 (20E)-8,18-dimethyl-2,8,11,12- tetrahydro-10H-3,5- ethenodipyrazolo[3$#8243;,4$#8243;:10',11';4$#8243;,3':14', 15'][1,5]dioxacyclopentadecino[6',7':3,4] pyrazolo[1,5-a]pyrazin-19(18H)-one::US20250353864, Example 91 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789988 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789988&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580216 Cn1ncc2c1OCCCOc1nn3ccn(C)c(=O)c3c1/C=C/c1n[nH]c3ccc-2cc13 789988 (20E)-8,18-dimethyl-2,8,11,12- tetrahydro-10H-3,5- ethenodipyrazolo[3$#8243;,4$#8243;:10',11';4$#8243;,3':14', 15'][1,5]dioxacyclopentadecino[6',7':3,4] pyrazolo[1,5-a]pyrazin-19(18H)-one::US20250353864, Example 91 Epidermal growth factor receptor [1-745,751-1210,C797S] >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789988 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789988&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580217 Cn1ncc2c1OCCCOc1nn3ccn(C)c(=O)c3c1/C=C/c1n[nH]c3ccc-2cc13 789988 (20E)-8,18-dimethyl-2,8,11,12- tetrahydro-10H-3,5- ethenodipyrazolo[3$#8243;,4$#8243;:10',11';4$#8243;,3':14', 15'][1,5]dioxacyclopentadecino[6',7':3,4] pyrazolo[1,5-a]pyrazin-19(18H)-one::US20250353864, Example 91 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789988 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789988&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580218 Cn1ncc2c1OCCCOc1nn3ccn(C)c(=O)c3c1/C=C/c1n[nH]c3ccc-2cc13 789988 (20E)-8,18-dimethyl-2,8,11,12- tetrahydro-10H-3,5- ethenodipyrazolo[3$#8243;,4$#8243;:10',11';4$#8243;,3':14', 15'][1,5]dioxacyclopentadecino[6',7':3,4] pyrazolo[1,5-a]pyrazin-19(18H)-one::US20250353864, Example 91 Epidermal growth factor receptor Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789988 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789988&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580219 CN1CCN(Cc2ccc3c(c2)O[C@@H]2CCN(CCOc4c(cnn4C)-c4ccc5[nH]nc(c5c4)/C=C/3)C2=O)CC1 789989 (10R,16E)-3-methyl-13-[(4- methylpiperazin-1-yl)methyl]- 3,5,6,9,10,19-hexahydro-8H-20,22- etheno-7,10-methanodipyrazolo[3,4- i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 92 Epidermal growth factor receptor [L858R] Homo sapiens 4.10 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789989 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789989&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580220 CN1CCN(Cc2ccc3c(c2)O[C@@H]2CCN(CCOc4c(cnn4C)-c4ccc5[nH]nc(c5c4)/C=C/3)C2=O)CC1 789989 (10R,16E)-3-methyl-13-[(4- methylpiperazin-1-yl)methyl]- 3,5,6,9,10,19-hexahydro-8H-20,22- etheno-7,10-methanodipyrazolo[3,4- i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 92 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.410 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789989 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789989&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580221 CN1CCN(Cc2ccc3c(c2)O[C@@H]2CCN(CCOc4c(cnn4C)-c4ccc5[nH]nc(c5c4)/C=C/3)C2=O)CC1 789989 (10R,16E)-3-methyl-13-[(4- methylpiperazin-1-yl)methyl]- 3,5,6,9,10,19-hexahydro-8H-20,22- etheno-7,10-methanodipyrazolo[3,4- i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 92 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 3.26 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789989 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789989&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580222 CN1CCN(Cc2ccc3c(c2)O[C@@H]2CCN(CCOc4c(cnn4C)-c4ccc5[nH]nc(c5c4)/C=C/3)C2=O)CC1 789989 (10R,16E)-3-methyl-13-[(4- methylpiperazin-1-yl)methyl]- 3,5,6,9,10,19-hexahydro-8H-20,22- etheno-7,10-methanodipyrazolo[3,4- i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 92 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 7.95 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789989 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789989&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580223 CN1CCN(Cc2ccc3c(c2)O[C@@H]2CCN(CCOc4c(cnn4C)-c4ccc5[nH]nc(c5c4)/C=C/3)C2=O)CC1 789989 (10R,16E)-3-methyl-13-[(4- methylpiperazin-1-yl)methyl]- 3,5,6,9,10,19-hexahydro-8H-20,22- etheno-7,10-methanodipyrazolo[3,4- i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 92 Epidermal growth factor receptor [1-745,751-1210,C797S] 6.65 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789989 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789989&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580224 CN1CCN(Cc2ccc3c(c2)O[C@@H]2CCN(CCOc4c(cnn4C)-c4ccc5[nH]nc(c5c4)/C=C/3)C2=O)CC1 789989 (10R,16E)-3-methyl-13-[(4- methylpiperazin-1-yl)methyl]- 3,5,6,9,10,19-hexahydro-8H-20,22- etheno-7,10-methanodipyrazolo[3,4- i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 92 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 6.34 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789989 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789989&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580225 CN1CCN(Cc2ccc3c(c2)O[C@@H]2CCN(CCOc4c(cnn4C)-c4ccc5[nH]nc(c5c4)/C=C/3)C2=O)CC1 789989 (10R,16E)-3-methyl-13-[(4- methylpiperazin-1-yl)methyl]- 3,5,6,9,10,19-hexahydro-8H-20,22- etheno-7,10-methanodipyrazolo[3,4- i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 92 Epidermal growth factor receptor Homo sapiens 14.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789989 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789989&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580226 Cc1c2c(nn1CCN1CCOCC1)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789990 (10S,17E)-8,10,12,16-tetramethyl-15-[2- (morpholin-4-yl)ethyl]-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 93 Epidermal growth factor receptor [L858R] Homo sapiens 11.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789990 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789990&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580227 Cc1c2c(nn1CCN1CCOCC1)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789990 (10S,17E)-8,10,12,16-tetramethyl-15-[2- (morpholin-4-yl)ethyl]-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 93 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.860 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789990 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789990&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580228 Cc1c2c(nn1CCN1CCOCC1)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789990 (10S,17E)-8,10,12,16-tetramethyl-15-[2- (morpholin-4-yl)ethyl]-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 93 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 5.02 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789990 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789990&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580229 Cc1c2c(nn1CCN1CCOCC1)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789990 (10S,17E)-8,10,12,16-tetramethyl-15-[2- (morpholin-4-yl)ethyl]-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 93 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 49.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789990 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789990&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580230 Cc1c2c(nn1CCN1CCOCC1)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789990 (10S,17E)-8,10,12,16-tetramethyl-15-[2- (morpholin-4-yl)ethyl]-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 93 Epidermal growth factor receptor [1-745,751-1210,C797S] 16.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789990 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789990&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580231 Cc1c2c(nn1CCN1CCOCC1)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789990 (10S,17E)-8,10,12,16-tetramethyl-15-[2- (morpholin-4-yl)ethyl]-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 93 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 138 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789990 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789990&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580232 Cc1c2c(nn1CCN1CCOCC1)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789990 (10S,17E)-8,10,12,16-tetramethyl-15-[2- (morpholin-4-yl)ethyl]-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 93 Epidermal growth factor receptor Homo sapiens 69.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789990 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789990&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580233 CN(C)Cc1ccc2c(c1)O[C@@H]1CCN(CCOc3c(cnn3C)-c3ccc4[nH]nc(c4c3)/C=C/2)C1=O 789991 (10R,16E)-13-[(dimethylamino)methyl]- 3-methyl-3,5,6,9,10,19-hexahydro-8H- 20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 94 Epidermal growth factor receptor [L858R] Homo sapiens 9.99 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789991 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789991&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580234 CN(C)Cc1ccc2c(c1)O[C@@H]1CCN(CCOc3c(cnn3C)-c3ccc4[nH]nc(c4c3)/C=C/2)C1=O 789991 (10R,16E)-13-[(dimethylamino)methyl]- 3-methyl-3,5,6,9,10,19-hexahydro-8H- 20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 94 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.820 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789991 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789991&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580235 CN(C)Cc1ccc2c(c1)O[C@@H]1CCN(CCOc3c(cnn3C)-c3ccc4[nH]nc(c4c3)/C=C/2)C1=O 789991 (10R,16E)-13-[(dimethylamino)methyl]- 3-methyl-3,5,6,9,10,19-hexahydro-8H- 20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 94 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 5.75 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789991 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789991&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580236 CN(C)Cc1ccc2c(c1)O[C@@H]1CCN(CCOc3c(cnn3C)-c3ccc4[nH]nc(c4c3)/C=C/2)C1=O 789991 (10R,16E)-13-[(dimethylamino)methyl]- 3-methyl-3,5,6,9,10,19-hexahydro-8H- 20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 94 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 17.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789991 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789991&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580237 CN(C)Cc1ccc2c(c1)O[C@@H]1CCN(CCOc3c(cnn3C)-c3ccc4[nH]nc(c4c3)/C=C/2)C1=O 789991 (10R,16E)-13-[(dimethylamino)methyl]- 3-methyl-3,5,6,9,10,19-hexahydro-8H- 20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 94 Epidermal growth factor receptor [1-745,751-1210,C797S] 14.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789991 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789991&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580238 CN(C)Cc1ccc2c(c1)O[C@@H]1CCN(CCOc3c(cnn3C)-c3ccc4[nH]nc(c4c3)/C=C/2)C1=O 789991 (10R,16E)-13-[(dimethylamino)methyl]- 3-methyl-3,5,6,9,10,19-hexahydro-8H- 20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 94 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 17.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789991 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789991&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580239 CN(C)Cc1ccc2c(c1)O[C@@H]1CCN(CCOc3c(cnn3C)-c3ccc4[nH]nc(c4c3)/C=C/2)C1=O 789991 (10R,16E)-13-[(dimethylamino)methyl]- 3-methyl-3,5,6,9,10,19-hexahydro-8H- 20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 94 Epidermal growth factor receptor Homo sapiens 44.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789991 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789991&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580240 Cc1c2c(nn1CCC(C)O)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789992 4-[(10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-15H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-15- yl]butan-2-ol::US20250353864, Example 95 Epidermal growth factor receptor [L858R] Homo sapiens 30.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789992 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789992&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580241 Cc1c2c(nn1CCC(C)O)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789992 4-[(10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-15H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-15- yl]butan-2-ol::US20250353864, Example 95 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 1.95 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789992 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789992&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580242 Cc1c2c(nn1CCC(C)O)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789992 4-[(10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-15H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-15- yl]butan-2-ol::US20250353864, Example 95 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 4.93 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789992 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789992&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580243 Cc1c2c(nn1CCC(C)O)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789992 4-[(10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-15H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-15- yl]butan-2-ol::US20250353864, Example 95 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 121 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789992 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789992&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580244 Cc1c2c(nn1CCC(C)O)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789992 4-[(10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-15H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-15- yl]butan-2-ol::US20250353864, Example 95 Epidermal growth factor receptor [1-745,751-1210,C797S] 23.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789992 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789992&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580245 Cc1c2c(nn1CCC(C)O)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789992 4-[(10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-15H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-15- yl]butan-2-ol::US20250353864, Example 95 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 524 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789992 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789992&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580246 Cc1c2c(nn1CCC(C)O)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789992 4-[(10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-15H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-15- yl]butan-2-ol::US20250353864, Example 95 Epidermal growth factor receptor Homo sapiens 167 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789992 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789992&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580247 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)C[C@@H](C)O2 789993 (12R,17E)-8,10,12,14,16-pentamethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n[1,4]oxazacyclopentadecine::US20250353864, Example 96 Epidermal growth factor receptor [L858R] Homo sapiens 74.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789993 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789993&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580248 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)C[C@@H](C)O2 789993 (12R,17E)-8,10,12,14,16-pentamethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n[1,4]oxazacyclopentadecine::US20250353864, Example 96 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 5.29 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789993 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789993&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580249 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)C[C@@H](C)O2 789993 (12R,17E)-8,10,12,14,16-pentamethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n[1,4]oxazacyclopentadecine::US20250353864, Example 96 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 9.45 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789993 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789993&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580250 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)C[C@@H](C)O2 789993 (12R,17E)-8,10,12,14,16-pentamethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n[1,4]oxazacyclopentadecine::US20250353864, Example 96 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 285 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789993 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789993&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580251 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)C[C@@H](C)O2 789993 (12R,17E)-8,10,12,14,16-pentamethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n[1,4]oxazacyclopentadecine::US20250353864, Example 96 Epidermal growth factor receptor [1-745,751-1210,C797S] 94.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789993 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789993&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580252 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)C[C@@H](C)O2 789993 (12R,17E)-8,10,12,14,16-pentamethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n[1,4]oxazacyclopentadecine::US20250353864, Example 96 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 196 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789993 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789993&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580253 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)C[C@@H](C)O2 789993 (12R,17E)-8,10,12,14,16-pentamethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n[1,4]oxazacyclopentadecine::US20250353864, Example 96 Epidermal growth factor receptor Homo sapiens 242 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789993 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789993&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580254 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)C[C@H](C)O2 789994 (12S,17E)-8,10,12,14,16-pentamethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 97 Epidermal growth factor receptor [L858R] Homo sapiens 132 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789994 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789994&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580255 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)C[C@H](C)O2 789994 (12S,17E)-8,10,12,14,16-pentamethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 97 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 10.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789994 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789994&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580256 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)C[C@H](C)O2 789994 (12S,17E)-8,10,12,14,16-pentamethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 97 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 28.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789994 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789994&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580257 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)C[C@H](C)O2 789994 (12S,17E)-8,10,12,14,16-pentamethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 97 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 221 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789994 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789994&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580258 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)C[C@H](C)O2 789994 (12S,17E)-8,10,12,14,16-pentamethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 97 Epidermal growth factor receptor [1-745,751-1210,C797S] 101 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789994 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789994&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580259 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)C[C@H](C)O2 789994 (12S,17E)-8,10,12,14,16-pentamethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 97 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 304 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789994 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789994&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580260 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)C[C@H](C)O2 789994 (12S,17E)-8,10,12,14,16-pentamethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 97 Epidermal growth factor receptor Homo sapiens 413 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789994 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789994&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580261 Cc1nn([C@H]2CN(C)C[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 789995 (rac)-(3S,4S)-1-methyl-4-[(17E)-8,10,16- trimethyl-2,8,9,10,11,12-hexahydro-14H- 3,5-ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;'- n][1,4]oxazacyclopentadecin-14- yl]pyrrolidin-3-ol::US20250353864, Example 98 Epidermal growth factor receptor [L858R] Homo sapiens 41.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789995 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789995&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580262 Cc1nn([C@H]2CN(C)C[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 789995 (rac)-(3S,4S)-1-methyl-4-[(17E)-8,10,16- trimethyl-2,8,9,10,11,12-hexahydro-14H- 3,5-ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;'- n][1,4]oxazacyclopentadecin-14- yl]pyrrolidin-3-ol::US20250353864, Example 98 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 3.56 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789995 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789995&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580263 Cc1nn([C@H]2CN(C)C[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 789995 (rac)-(3S,4S)-1-methyl-4-[(17E)-8,10,16- trimethyl-2,8,9,10,11,12-hexahydro-14H- 3,5-ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;'- n][1,4]oxazacyclopentadecin-14- yl]pyrrolidin-3-ol::US20250353864, Example 98 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 12.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789995 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789995&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580264 Cc1nn([C@H]2CN(C)C[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 789995 (rac)-(3S,4S)-1-methyl-4-[(17E)-8,10,16- trimethyl-2,8,9,10,11,12-hexahydro-14H- 3,5-ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;'- n][1,4]oxazacyclopentadecin-14- yl]pyrrolidin-3-ol::US20250353864, Example 98 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 84.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789995 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789995&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580265 Cc1nn([C@H]2CN(C)C[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 789995 (rac)-(3S,4S)-1-methyl-4-[(17E)-8,10,16- trimethyl-2,8,9,10,11,12-hexahydro-14H- 3,5-ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;'- n][1,4]oxazacyclopentadecin-14- yl]pyrrolidin-3-ol::US20250353864, Example 98 Epidermal growth factor receptor [1-745,751-1210,C797S] 27.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789995 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789995&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580266 Cc1nn([C@H]2CN(C)C[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 789995 (rac)-(3S,4S)-1-methyl-4-[(17E)-8,10,16- trimethyl-2,8,9,10,11,12-hexahydro-14H- 3,5-ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;'- n][1,4]oxazacyclopentadecin-14- yl]pyrrolidin-3-ol::US20250353864, Example 98 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 148 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789995 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789995&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580267 Cc1nn([C@H]2CN(C)C[C@@H]2O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 789995 (rac)-(3S,4S)-1-methyl-4-[(17E)-8,10,16- trimethyl-2,8,9,10,11,12-hexahydro-14H- 3,5-ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;'- n][1,4]oxazacyclopentadecin-14- yl]pyrrolidin-3-ol::US20250353864, Example 98 Epidermal growth factor receptor Homo sapiens 119 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789995 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789995&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580268 CC(=N)C1=C(\NCCN2CCCC2)OCCOC(C)c2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 789996 (17E)-8,9,16-trimethyl-14-[2-(pyrrolidin- 1-yl)ethyl]-2,8,9,11,12,14-hexahydro- 3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 100 Epidermal growth factor receptor [L858R] Homo sapiens 87.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789996 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789996&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580269 CC(=N)C1=C(\NCCN2CCCC2)OCCOC(C)c2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 789996 (17E)-8,9,16-trimethyl-14-[2-(pyrrolidin- 1-yl)ethyl]-2,8,9,11,12,14-hexahydro- 3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 100 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 10.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789996 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789996&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580270 CC(=N)C1=C(\NCCN2CCCC2)OCCOC(C)c2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 789996 (17E)-8,9,16-trimethyl-14-[2-(pyrrolidin- 1-yl)ethyl]-2,8,9,11,12,14-hexahydro- 3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 100 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 19.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789996 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789996&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580271 CC(=N)C1=C(\NCCN2CCCC2)OCCOC(C)c2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 789996 (17E)-8,9,16-trimethyl-14-[2-(pyrrolidin- 1-yl)ethyl]-2,8,9,11,12,14-hexahydro- 3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 100 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 198 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789996 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789996&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580272 CC(=N)C1=C(\NCCN2CCCC2)OCCOC(C)c2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 789996 (17E)-8,9,16-trimethyl-14-[2-(pyrrolidin- 1-yl)ethyl]-2,8,9,11,12,14-hexahydro- 3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 100 Epidermal growth factor receptor [1-745,751-1210,C797S] 91.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789996 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789996&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580273 CC(=N)C1=C(\NCCN2CCCC2)OCCOC(C)c2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 789996 (17E)-8,9,16-trimethyl-14-[2-(pyrrolidin- 1-yl)ethyl]-2,8,9,11,12,14-hexahydro- 3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 100 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 250 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789996 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789996&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580274 CC(=N)C1=C(\NCCN2CCCC2)OCCOC(C)c2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 789996 (17E)-8,9,16-trimethyl-14-[2-(pyrrolidin- 1-yl)ethyl]-2,8,9,11,12,14-hexahydro- 3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 100 Epidermal growth factor receptor Homo sapiens 290 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789996 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789996&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580275 Cc1c2c(nn1[C@H]1C[C@@H](N(C)CCN(C)C)C1)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789997 N1-{(1s,3s)-3-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15- yl]cyclobutyl}-N1,N2,N2-trimethylethane- 1,2-diamine::US20250353864, Example 102 Epidermal growth factor receptor [L858R] Homo sapiens 25.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789997 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789997&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580276 Cc1c2c(nn1[C@H]1C[C@@H](N(C)CCN(C)C)C1)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789997 N1-{(1s,3s)-3-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15- yl]cyclobutyl}-N1,N2,N2-trimethylethane- 1,2-diamine::US20250353864, Example 102 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 4.10 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789997 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789997&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580277 Cc1c2c(nn1[C@H]1C[C@@H](N(C)CCN(C)C)C1)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789997 N1-{(1s,3s)-3-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15- yl]cyclobutyl}-N1,N2,N2-trimethylethane- 1,2-diamine::US20250353864, Example 102 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 13.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789997 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789997&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580278 Cc1c2c(nn1[C@H]1C[C@@H](N(C)CCN(C)C)C1)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789997 N1-{(1s,3s)-3-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15- yl]cyclobutyl}-N1,N2,N2-trimethylethane- 1,2-diamine::US20250353864, Example 102 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 48.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789997 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789997&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580279 Cc1c2c(nn1[C@H]1C[C@@H](N(C)CCN(C)C)C1)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789997 N1-{(1s,3s)-3-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15- yl]cyclobutyl}-N1,N2,N2-trimethylethane- 1,2-diamine::US20250353864, Example 102 Epidermal growth factor receptor [1-745,751-1210,C797S] 44.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789997 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789997&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580280 Cc1c2c(nn1[C@H]1C[C@@H](N(C)CCN(C)C)C1)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789997 N1-{(1s,3s)-3-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15- yl]cyclobutyl}-N1,N2,N2-trimethylethane- 1,2-diamine::US20250353864, Example 102 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 94.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789997 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789997&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580281 Cc1c2c(nn1[C@H]1C[C@@H](N(C)CCN(C)C)C1)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789997 N1-{(1s,3s)-3-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15- yl]cyclobutyl}-N1,N2,N2-trimethylethane- 1,2-diamine::US20250353864, Example 102 Epidermal growth factor receptor Homo sapiens 62.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789997 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789997&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580282 Cc1nn([C@H]2C[C@@H](N(C)CCN(C)C)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789998 N1-{(1s,3s)-3-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]cyclobutyl}-N1,N2,N2-trimethylethane- 1,2-diamine::US20250353864, Example 103 Epidermal growth factor receptor [L858R] Homo sapiens 103 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789998 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789998&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580283 Cc1nn([C@H]2C[C@@H](N(C)CCN(C)C)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789998 N1-{(1s,3s)-3-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]cyclobutyl}-N1,N2,N2-trimethylethane- 1,2-diamine::US20250353864, Example 103 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 11.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789998 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789998&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580284 Cc1nn([C@H]2C[C@@H](N(C)CCN(C)C)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789998 N1-{(1s,3s)-3-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]cyclobutyl}-N1,N2,N2-trimethylethane- 1,2-diamine::US20250353864, Example 103 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 40.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789998 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789998&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580285 Cc1nn([C@H]2C[C@@H](N(C)CCN(C)C)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789998 N1-{(1s,3s)-3-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]cyclobutyl}-N1,N2,N2-trimethylethane- 1,2-diamine::US20250353864, Example 103 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 105 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789998 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789998&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580286 Cc1nn([C@H]2C[C@@H](N(C)CCN(C)C)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789998 N1-{(1s,3s)-3-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]cyclobutyl}-N1,N2,N2-trimethylethane- 1,2-diamine::US20250353864, Example 103 Epidermal growth factor receptor [1-745,751-1210,C797S] 171 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789998 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789998&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580287 Cc1nn([C@H]2C[C@@H](N(C)CCN(C)C)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789998 N1-{(1s,3s)-3-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]cyclobutyl}-N1,N2,N2-trimethylethane- 1,2-diamine::US20250353864, Example 103 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 344 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789998 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789998&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580288 Cc1nn([C@H]2C[C@@H](N(C)CCN(C)C)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789998 N1-{(1s,3s)-3-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]cyclobutyl}-N1,N2,N2-trimethylethane- 1,2-diamine::US20250353864, Example 103 Epidermal growth factor receptor Homo sapiens 358 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789998 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789998&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580289 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)[C@@H](C)CO2 789999 (11S,17E)-8,10,11,14,16-pentamethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 106 Epidermal growth factor receptor [L858R] Homo sapiens 34.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789999 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789999&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580290 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)[C@@H](C)CO2 789999 (11S,17E)-8,10,11,14,16-pentamethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 106 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 2.49 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789999 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789999&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580291 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)[C@@H](C)CO2 789999 (11S,17E)-8,10,11,14,16-pentamethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 106 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 10.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789999 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789999&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580292 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)[C@@H](C)CO2 789999 (11S,17E)-8,10,11,14,16-pentamethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 106 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 57.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789999 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789999&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580293 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)[C@@H](C)CO2 789999 (11S,17E)-8,10,11,14,16-pentamethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 106 Epidermal growth factor receptor [1-745,751-1210,C797S] 68.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789999 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789999&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580294 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)[C@@H](C)CO2 789999 (11S,17E)-8,10,11,14,16-pentamethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 106 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 112 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789999 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789999&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580295 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)[C@@H](C)CO2 789999 (11S,17E)-8,10,11,14,16-pentamethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 106 Epidermal growth factor receptor Homo sapiens 107 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789999 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789999&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580296 Cc1c2c(nn1[C@H]1C[C@@H](NCCN(C)C)C1)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790000 N2-{(1s,3s)-3-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15- yl]cyclobutyl}-N1,N1-dimethylethane- 1,2-diamine::US20250353864, Example 107 Epidermal growth factor receptor [L858R] Homo sapiens 13.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790000 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790000&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580297 Cc1c2c(nn1[C@H]1C[C@@H](NCCN(C)C)C1)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790000 N2-{(1s,3s)-3-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15- yl]cyclobutyl}-N1,N1-dimethylethane- 1,2-diamine::US20250353864, Example 107 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 2.28 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790000 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790000&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580298 Cc1c2c(nn1[C@H]1C[C@@H](NCCN(C)C)C1)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790000 N2-{(1s,3s)-3-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15- yl]cyclobutyl}-N1,N1-dimethylethane- 1,2-diamine::US20250353864, Example 107 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 11.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790000 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790000&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580299 Cc1c2c(nn1[C@H]1C[C@@H](NCCN(C)C)C1)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790000 N2-{(1s,3s)-3-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15- yl]cyclobutyl}-N1,N1-dimethylethane- 1,2-diamine::US20250353864, Example 107 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 34.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790000 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790000&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580300 Cc1c2c(nn1[C@H]1C[C@@H](NCCN(C)C)C1)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790000 N2-{(1s,3s)-3-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15- yl]cyclobutyl}-N1,N1-dimethylethane- 1,2-diamine::US20250353864, Example 107 Epidermal growth factor receptor [1-745,751-1210,C797S] 42.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790000 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790000&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580301 Cc1c2c(nn1[C@H]1C[C@@H](NCCN(C)C)C1)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790000 N2-{(1s,3s)-3-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15- yl]cyclobutyl}-N1,N1-dimethylethane- 1,2-diamine::US20250353864, Example 107 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 66.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790000 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790000&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580302 Cc1c2c(nn1[C@H]1C[C@@H](NCCN(C)C)C1)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790000 N2-{(1s,3s)-3-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,15H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-15- yl]cyclobutyl}-N1,N1-dimethylethane- 1,2-diamine::US20250353864, Example 107 Epidermal growth factor receptor Homo sapiens 41.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790000 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790000&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580303 Cc1nn([C@H]2C[C@@H](NCCN(C)C)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 790001 N2-{(1s,3s)-3-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]cyclobutyl}-N1,N1-dimethylethane- 1,2-diamine::US20250353864, Example 108 Epidermal growth factor receptor [L858R] Homo sapiens 26.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790001 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790001&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580304 Cc1nn([C@H]2C[C@@H](NCCN(C)C)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 790001 N2-{(1s,3s)-3-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]cyclobutyl}-N1,N1-dimethylethane- 1,2-diamine::US20250353864, Example 108 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 3.86 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790001 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790001&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580305 Cc1nn([C@H]2C[C@@H](NCCN(C)C)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 790001 N2-{(1s,3s)-3-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]cyclobutyl}-N1,N1-dimethylethane- 1,2-diamine::US20250353864, Example 108 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 11.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790001 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790001&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580306 Cc1nn([C@H]2C[C@@H](NCCN(C)C)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 790001 N2-{(1s,3s)-3-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]cyclobutyl}-N1,N1-dimethylethane- 1,2-diamine::US20250353864, Example 108 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 30.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790001 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790001&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580307 Cc1nn([C@H]2C[C@@H](NCCN(C)C)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 790001 N2-{(1s,3s)-3-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]cyclobutyl}-N1,N1-dimethylethane- 1,2-diamine::US20250353864, Example 108 Epidermal growth factor receptor [1-745,751-1210,C797S] 49.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790001 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790001&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580308 Cc1nn([C@H]2C[C@@H](NCCN(C)C)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 790001 N2-{(1s,3s)-3-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]cyclobutyl}-N1,N1-dimethylethane- 1,2-diamine::US20250353864, Example 108 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 103 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790001 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790001&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580309 Cc1nn([C@H]2C[C@@H](NCCN(C)C)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 790001 N2-{(1s,3s)-3-[(17E)-8,16-dimethyl- 2,8,11,12-tetrahydro-10H,14H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14- yl]cyclobutyl}-N1,N1-dimethylethane- 1,2-diamine::US20250353864, Example 108 Epidermal growth factor receptor Homo sapiens 101 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790001 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790001&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580310 CN/C1=C(C(C)=N)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2OCCN2CC[C@@H](O1)C2=O 790002 (10R,15E)-3,12,14-trimethyl- 5,6,9,10,12,18-hexahydro-3H,8H-19,21- etheno-7,10-methanotripyrazolo[3,4- i:3',4'-m:4$#8243;,3$#8243;- q][1,8,4]dioxazacyclooctadecin-24-one::US20250353864, Example 109 Epidermal growth factor receptor [L858R] Homo sapiens 165 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790002 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790002&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580311 CN/C1=C(C(C)=N)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2OCCN2CC[C@@H](O1)C2=O 790002 (10R,15E)-3,12,14-trimethyl- 5,6,9,10,12,18-hexahydro-3H,8H-19,21- etheno-7,10-methanotripyrazolo[3,4- i:3',4'-m:4$#8243;,3$#8243;- q][1,8,4]dioxazacyclooctadecin-24-one::US20250353864, Example 109 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 15.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790002 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790002&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580312 CN/C1=C(C(C)=N)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2OCCN2CC[C@@H](O1)C2=O 790002 (10R,15E)-3,12,14-trimethyl- 5,6,9,10,12,18-hexahydro-3H,8H-19,21- etheno-7,10-methanotripyrazolo[3,4- i:3',4'-m:4$#8243;,3$#8243;- q][1,8,4]dioxazacyclooctadecin-24-one::US20250353864, Example 109 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 47.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790002 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790002&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580313 CN/C1=C(C(C)=N)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2OCCN2CC[C@@H](O1)C2=O 790002 (10R,15E)-3,12,14-trimethyl- 5,6,9,10,12,18-hexahydro-3H,8H-19,21- etheno-7,10-methanotripyrazolo[3,4- i:3',4'-m:4$#8243;,3$#8243;- q][1,8,4]dioxazacyclooctadecin-24-one::US20250353864, Example 109 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 38.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790002 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790002&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580314 CN/C1=C(C(C)=N)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2OCCN2CC[C@@H](O1)C2=O 790002 (10R,15E)-3,12,14-trimethyl- 5,6,9,10,12,18-hexahydro-3H,8H-19,21- etheno-7,10-methanotripyrazolo[3,4- i:3',4'-m:4$#8243;,3$#8243;- q][1,8,4]dioxazacyclooctadecin-24-one::US20250353864, Example 109 Epidermal growth factor receptor [1-745,751-1210,C797S] 152 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790002 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790002&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580315 CN/C1=C(C(C)=N)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2OCCN2CC[C@@H](O1)C2=O 790002 (10R,15E)-3,12,14-trimethyl- 5,6,9,10,12,18-hexahydro-3H,8H-19,21- etheno-7,10-methanotripyrazolo[3,4- i:3',4'-m:4$#8243;,3$#8243;- q][1,8,4]dioxazacyclooctadecin-24-one::US20250353864, Example 109 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 298 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790002 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790002&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580316 CN/C1=C(C(C)=N)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2OCCN2CC[C@@H](O1)C2=O 790002 (10R,15E)-3,12,14-trimethyl- 5,6,9,10,12,18-hexahydro-3H,8H-19,21- etheno-7,10-methanotripyrazolo[3,4- i:3',4'-m:4$#8243;,3$#8243;- q][1,8,4]dioxazacyclooctadecin-24-one::US20250353864, Example 109 Epidermal growth factor receptor Homo sapiens 856 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790002 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790002&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580317 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 790003 (17E)-16-ethyl-8,10,14-trimethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 110 Epidermal growth factor receptor [L858R] Homo sapiens 30.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790003 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790003&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580318 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 790003 (17E)-16-ethyl-8,10,14-trimethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 110 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 4.99 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790003 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790003&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580319 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 790003 (17E)-16-ethyl-8,10,14-trimethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 110 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 8.54 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790003 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790003&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580320 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 790003 (17E)-16-ethyl-8,10,14-trimethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 110 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 14.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790003 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790003&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580321 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 790003 (17E)-16-ethyl-8,10,14-trimethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 110 Epidermal growth factor receptor [1-745,751-1210,C797S] 28.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790003 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790003&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580322 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 790003 (17E)-16-ethyl-8,10,14-trimethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 110 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 112 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790003 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790003&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580323 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 790003 (17E)-16-ethyl-8,10,14-trimethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 110 Epidermal growth factor receptor Homo sapiens 150 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790003 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790003&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580324 CCN1CCOc2c(c(C)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2C1 790004 (17E)-10-ethyl-8,14,16-trimethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 111 Epidermal growth factor receptor [L858R] Homo sapiens 8.04 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790004 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790004&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580325 CCN1CCOc2c(c(C)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2C1 790004 (17E)-10-ethyl-8,14,16-trimethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 111 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.390 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790004 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790004&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580326 CCN1CCOc2c(c(C)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2C1 790004 (17E)-10-ethyl-8,14,16-trimethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 111 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 1.91 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790004 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790004&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580327 CCN1CCOc2c(c(C)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2C1 790004 (17E)-10-ethyl-8,14,16-trimethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 111 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 3.29 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790004 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790004&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580328 CCN1CCOc2c(c(C)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2C1 790004 (17E)-10-ethyl-8,14,16-trimethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 111 Epidermal growth factor receptor [1-745,751-1210,C797S] 9.18 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790004 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790004&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580329 CCN1CCOc2c(c(C)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2C1 790004 (17E)-10-ethyl-8,14,16-trimethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 111 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 16.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790004 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790004&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580330 CCN1CCOc2c(c(C)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2C1 790004 (17E)-10-ethyl-8,14,16-trimethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 111 Epidermal growth factor receptor Homo sapiens 63.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790004 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790004&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580331 CN1CCC(c2ccc3c(c2)O[C@@H]2CCN(CCOc4c(cnn4C)-c4ccc5[nH]nc(c5c4)/C=C/3)C2=O)CC1 790005 (10R,16E)-3-methyl-13-(1- methylpiperidin-4-yl)-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 112 Epidermal growth factor receptor [L858R] Homo sapiens 1.31 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790005 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790005&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580332 CN1CCC(c2ccc3c(c2)O[C@@H]2CCN(CCOc4c(cnn4C)-c4ccc5[nH]nc(c5c4)/C=C/3)C2=O)CC1 790005 (10R,16E)-3-methyl-13-(1- methylpiperidin-4-yl)-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 112 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.210 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790005 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790005&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580333 CN1CCC(c2ccc3c(c2)O[C@@H]2CCN(CCOc4c(cnn4C)-c4ccc5[nH]nc(c5c4)/C=C/3)C2=O)CC1 790005 (10R,16E)-3-methyl-13-(1- methylpiperidin-4-yl)-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 112 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.980 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790005 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790005&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580334 CN1CCC(c2ccc3c(c2)O[C@@H]2CCN(CCOc4c(cnn4C)-c4ccc5[nH]nc(c5c4)/C=C/3)C2=O)CC1 790005 (10R,16E)-3-methyl-13-(1- methylpiperidin-4-yl)-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 112 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 0.610 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790005 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790005&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580335 CN1CCC(c2ccc3c(c2)O[C@@H]2CCN(CCOc4c(cnn4C)-c4ccc5[nH]nc(c5c4)/C=C/3)C2=O)CC1 790005 (10R,16E)-3-methyl-13-(1- methylpiperidin-4-yl)-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 112 Epidermal growth factor receptor [1-745,751-1210,C797S] 2.75 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790005 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790005&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580336 CN1CCC(c2ccc3c(c2)O[C@@H]2CCN(CCOc4c(cnn4C)-c4ccc5[nH]nc(c5c4)/C=C/3)C2=O)CC1 790005 (10R,16E)-3-methyl-13-(1- methylpiperidin-4-yl)-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 112 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 1.12 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790005 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790005&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580337 CN1CCC(c2ccc3c(c2)O[C@@H]2CCN(CCOc4c(cnn4C)-c4ccc5[nH]nc(c5c4)/C=C/3)C2=O)CC1 790005 (10R,16E)-3-methyl-13-(1- methylpiperidin-4-yl)-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 112 Epidermal growth factor receptor Homo sapiens 8.28 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790005 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790005&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580338 C[C@H]1CN(C)Cc2cnn(C)c2/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790006 (10S,17E)-8,10,12,16-tetramethyl- 2,10,11,12,13,16-hexahydro-8H-3,5- ethenotripyrazolo[4,3-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 113 Epidermal growth factor receptor [L858R] Homo sapiens 96.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790006 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790006&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580339 C[C@H]1CN(C)Cc2cnn(C)c2/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790006 (10S,17E)-8,10,12,16-tetramethyl- 2,10,11,12,13,16-hexahydro-8H-3,5- ethenotripyrazolo[4,3-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 113 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 8.66 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790006 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790006&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580340 C[C@H]1CN(C)Cc2cnn(C)c2/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790006 (10S,17E)-8,10,12,16-tetramethyl- 2,10,11,12,13,16-hexahydro-8H-3,5- ethenotripyrazolo[4,3-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 113 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 9.91 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790006 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790006&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580341 C[C@H]1CN(C)Cc2cnn(C)c2/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790006 (10S,17E)-8,10,12,16-tetramethyl- 2,10,11,12,13,16-hexahydro-8H-3,5- ethenotripyrazolo[4,3-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 113 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 69.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790006 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790006&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580342 C[C@H]1CN(C)Cc2cnn(C)c2/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790006 (10S,17E)-8,10,12,16-tetramethyl- 2,10,11,12,13,16-hexahydro-8H-3,5- ethenotripyrazolo[4,3-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 113 Epidermal growth factor receptor [1-745,751-1210,C797S] 67.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790006 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790006&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580343 C[C@H]1CN(C)Cc2cnn(C)c2/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790006 (10S,17E)-8,10,12,16-tetramethyl- 2,10,11,12,13,16-hexahydro-8H-3,5- ethenotripyrazolo[4,3-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 113 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 728 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790006 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790006&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580344 C[C@H]1CN(C)Cc2cnn(C)c2/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790006 (10S,17E)-8,10,12,16-tetramethyl- 2,10,11,12,13,16-hexahydro-8H-3,5- ethenotripyrazolo[4,3-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 113 Epidermal growth factor receptor Homo sapiens 488 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790006 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790006&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580345 CC(=N)C1=C(\NCCO)CN(C(C)C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790007 2-[(10S,17E)-8,10,16-trimethyl-12- (propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 114 Epidermal growth factor receptor [L858R] Homo sapiens 0.100 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790007 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790007&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580346 CC(=N)C1=C(\NCCO)CN(C(C)C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790007 2-[(10S,17E)-8,10,16-trimethyl-12- (propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 114 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.110 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790007 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790007&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580347 CC(=N)C1=C(\NCCO)CN(C(C)C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790007 2-[(10S,17E)-8,10,16-trimethyl-12- (propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 114 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.980 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790007 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790007&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580348 CC(=N)C1=C(\NCCO)CN(C(C)C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790007 2-[(10S,17E)-8,10,16-trimethyl-12- (propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 114 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 0.170 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790007 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790007&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580349 CC(=N)C1=C(\NCCO)CN(C(C)C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790007 2-[(10S,17E)-8,10,16-trimethyl-12- (propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 114 Epidermal growth factor receptor [1-745,751-1210,C797S] 0.920 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790007 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790007&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580350 CC(=N)C1=C(\NCCO)CN(C(C)C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790007 2-[(10S,17E)-8,10,16-trimethyl-12- (propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 114 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 0.910 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790007 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790007&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580351 CC(=N)C1=C(\NCCO)CN(C(C)C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790007 2-[(10S,17E)-8,10,16-trimethyl-12- (propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 114 Epidermal growth factor receptor Homo sapiens 0.380 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790007 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790007&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580352 COC(C)(C)c1ccc2c(c1)O[C@@H]1CCN(CCOc3c(cnn3C)-c3ccc4[nH]nc(c4c3)/C=C/2)C1=O 790008 (10R,16E)-13-(2-methoxypropan-2-yl)-3- methyl-3,5,6,9,10,19-hexahydro-8H- 20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 115 Epidermal growth factor receptor [L858R] Homo sapiens 37.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790008 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790008&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580353 COC(C)(C)c1ccc2c(c1)O[C@@H]1CCN(CCOc3c(cnn3C)-c3ccc4[nH]nc(c4c3)/C=C/2)C1=O 790008 (10R,16E)-13-(2-methoxypropan-2-yl)-3- methyl-3,5,6,9,10,19-hexahydro-8H- 20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 115 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 1.60 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790008 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790008&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580354 COC(C)(C)c1ccc2c(c1)O[C@@H]1CCN(CCOc3c(cnn3C)-c3ccc4[nH]nc(c4c3)/C=C/2)C1=O 790008 (10R,16E)-13-(2-methoxypropan-2-yl)-3- methyl-3,5,6,9,10,19-hexahydro-8H- 20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 115 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 14.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790008 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790008&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580355 COC(C)(C)c1ccc2c(c1)O[C@@H]1CCN(CCOc3c(cnn3C)-c3ccc4[nH]nc(c4c3)/C=C/2)C1=O 790008 (10R,16E)-13-(2-methoxypropan-2-yl)-3- methyl-3,5,6,9,10,19-hexahydro-8H- 20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 115 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 12.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790008 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790008&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580356 COC(C)(C)c1ccc2c(c1)O[C@@H]1CCN(CCOc3c(cnn3C)-c3ccc4[nH]nc(c4c3)/C=C/2)C1=O 790008 (10R,16E)-13-(2-methoxypropan-2-yl)-3- methyl-3,5,6,9,10,19-hexahydro-8H- 20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 115 Epidermal growth factor receptor [1-745,751-1210,C797S] 60.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790008 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790008&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580357 COC(C)(C)c1ccc2c(c1)O[C@@H]1CCN(CCOc3c(cnn3C)-c3ccc4[nH]nc(c4c3)/C=C/2)C1=O 790008 (10R,16E)-13-(2-methoxypropan-2-yl)-3- methyl-3,5,6,9,10,19-hexahydro-8H- 20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 115 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 32.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790008 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790008&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580358 COC(C)(C)c1ccc2c(c1)O[C@@H]1CCN(CCOc3c(cnn3C)-c3ccc4[nH]nc(c4c3)/C=C/2)C1=O 790008 (10R,16E)-13-(2-methoxypropan-2-yl)-3- methyl-3,5,6,9,10,19-hexahydro-8H- 20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 115 Epidermal growth factor receptor Homo sapiens 147 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790008 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790008&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580359 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790009 2-[(10S,17E)-19-fluoro-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 116 Epidermal growth factor receptor [L858R] Homo sapiens 0.580 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790009 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790009&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580360 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790009 2-[(10S,17E)-19-fluoro-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 116 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.380 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790009 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790009&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580361 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790009 2-[(10S,17E)-19-fluoro-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 116 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 2.71 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790009 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790009&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580362 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790009 2-[(10S,17E)-19-fluoro-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 116 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 1.06 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790009 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790009&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580363 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790009 2-[(10S,17E)-19-fluoro-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 116 Epidermal growth factor receptor [1-745,751-1210,C797S] 2.85 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790009 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790009&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580364 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790009 2-[(10S,17E)-19-fluoro-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 116 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 18.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790009 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790009&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580365 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790009 2-[(10S,17E)-19-fluoro-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 116 Epidermal growth factor receptor Homo sapiens 3.98 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790009 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790009&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580366 Cc1c2c(nn1C1CCN(C)C1)OCCN(C)Cc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790010 (17E)-8,10,16-trimethyl-15-(1- methylpyrrolidin-3-yl)-2,9,10,11,12,15- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 117 Epidermal growth factor receptor [L858R] Homo sapiens 20.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790010 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790010&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580367 Cc1c2c(nn1C1CCN(C)C1)OCCN(C)Cc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790010 (17E)-8,10,16-trimethyl-15-(1- methylpyrrolidin-3-yl)-2,9,10,11,12,15- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 117 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 2.20 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790010 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790010&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580368 Cc1c2c(nn1C1CCN(C)C1)OCCN(C)Cc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790010 (17E)-8,10,16-trimethyl-15-(1- methylpyrrolidin-3-yl)-2,9,10,11,12,15- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 117 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 6.18 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790010 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790010&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580369 Cc1c2c(nn1C1CCN(C)C1)OCCN(C)Cc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790010 (17E)-8,10,16-trimethyl-15-(1- methylpyrrolidin-3-yl)-2,9,10,11,12,15- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 117 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 6.91 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790010 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790010&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580370 Cc1c2c(nn1C1CCN(C)C1)OCCN(C)Cc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790010 (17E)-8,10,16-trimethyl-15-(1- methylpyrrolidin-3-yl)-2,9,10,11,12,15- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 117 Epidermal growth factor receptor [1-745,751-1210,C797S] 8.36 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790010 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790010&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580371 Cc1c2c(nn1C1CCN(C)C1)OCCN(C)Cc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790010 (17E)-8,10,16-trimethyl-15-(1- methylpyrrolidin-3-yl)-2,9,10,11,12,15- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 117 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 53.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790010 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790010&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580372 Cc1c2c(nn1C1CCN(C)C1)OCCN(C)Cc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790010 (17E)-8,10,16-trimethyl-15-(1- methylpyrrolidin-3-yl)-2,9,10,11,12,15- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 117 Epidermal growth factor receptor Homo sapiens 70.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790010 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790010&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580373 Cc1nn(C2CCN(C)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 790011 (17E)-8,10,16-trimethyl-14-(1- methylpyrrolidin-3-yl)-2,9,10,11,12,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 118 Epidermal growth factor receptor [L858R] Homo sapiens 34.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790011 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790011&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580374 Cc1nn(C2CCN(C)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 790011 (17E)-8,10,16-trimethyl-14-(1- methylpyrrolidin-3-yl)-2,9,10,11,12,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 118 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 4.65 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790011 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790011&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580375 Cc1nn(C2CCN(C)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 790011 (17E)-8,10,16-trimethyl-14-(1- methylpyrrolidin-3-yl)-2,9,10,11,12,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 118 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 8.42 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790011 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790011&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580376 Cc1nn(C2CCN(C)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 790011 (17E)-8,10,16-trimethyl-14-(1- methylpyrrolidin-3-yl)-2,9,10,11,12,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 118 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 21.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790011 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790011&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580377 Cc1nn(C2CCN(C)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 790011 (17E)-8,10,16-trimethyl-14-(1- methylpyrrolidin-3-yl)-2,9,10,11,12,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 118 Epidermal growth factor receptor [1-745,751-1210,C797S] 31.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790011 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790011&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580378 Cc1nn(C2CCN(C)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 790011 (17E)-8,10,16-trimethyl-14-(1- methylpyrrolidin-3-yl)-2,9,10,11,12,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 118 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 65.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790011 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790011&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580379 Cc1nn(C2CCN(C)C2)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 790011 (17E)-8,10,16-trimethyl-14-(1- methylpyrrolidin-3-yl)-2,9,10,11,12,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 118 Epidermal growth factor receptor Homo sapiens 130 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790011 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790011&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580380 CCOC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790012 2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 119 Epidermal growth factor receptor [L858R] Homo sapiens 0.610 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790012 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790012&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580381 CCOC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790012 2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 119 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.260 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790012 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790012&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580382 CCOC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790012 2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 119 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 2.12 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790012 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790012&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580383 CCOC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790012 2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 119 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 0.630 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790012 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790012&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580384 CCOC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790012 2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 119 Epidermal growth factor receptor [1-745,751-1210,C797S] 1.25 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790012 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790012&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580385 CCOC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790012 2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 119 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 8.50 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790012 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790012&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580386 CCOC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790012 2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 119 Epidermal growth factor receptor Homo sapiens 2.34 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790012 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790012&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580387 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790013 (10S,17E)-8,10,12,14,16-pentamethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 120 Epidermal growth factor receptor [L858R] Homo sapiens 7.91 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790013 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790013&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580388 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790013 (10S,17E)-8,10,12,14,16-pentamethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 120 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.330 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790013 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790013&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580389 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790013 (10S,17E)-8,10,12,14,16-pentamethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 120 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 2.62 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790013 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790013&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580390 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790013 (10S,17E)-8,10,12,14,16-pentamethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 120 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 7.76 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790013 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790013&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580391 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790013 (10S,17E)-8,10,12,14,16-pentamethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 120 Epidermal growth factor receptor [1-745,751-1210,C797S] 5.80 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790013 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790013&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580392 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790013 (10S,17E)-8,10,12,14,16-pentamethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 120 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 99.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790013 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790013&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580393 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790013 (10S,17E)-8,10,12,14,16-pentamethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 120 Epidermal growth factor receptor Homo sapiens 41.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790013 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790013&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580394 Cc1c2c(nn1CCN1CCCC1)CN(C)C[C@@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790014 (10R,17E)-8,10,12,16-tetramethyl-15-[2- (pyrrolidin-1-yl)ethyl]-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 121 Epidermal growth factor receptor [L858R] Homo sapiens 94.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790014 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790014&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580395 Cc1c2c(nn1CCN1CCCC1)CN(C)C[C@@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790014 (10R,17E)-8,10,12,16-tetramethyl-15-[2- (pyrrolidin-1-yl)ethyl]-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 121 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 6.14 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790014 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790014&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580396 Cc1c2c(nn1CCN1CCCC1)CN(C)C[C@@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790014 (10R,17E)-8,10,12,16-tetramethyl-15-[2- (pyrrolidin-1-yl)ethyl]-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 121 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 13.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790014 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790014&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580397 Cc1c2c(nn1CCN1CCCC1)CN(C)C[C@@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790014 (10R,17E)-8,10,12,16-tetramethyl-15-[2- (pyrrolidin-1-yl)ethyl]-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 121 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 40.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790014 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790014&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580398 Cc1c2c(nn1CCN1CCCC1)CN(C)C[C@@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790014 (10R,17E)-8,10,12,16-tetramethyl-15-[2- (pyrrolidin-1-yl)ethyl]-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 121 Epidermal growth factor receptor [1-745,751-1210,C797S] 41.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790014 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790014&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580399 Cc1c2c(nn1CCN1CCCC1)CN(C)C[C@@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790014 (10R,17E)-8,10,12,16-tetramethyl-15-[2- (pyrrolidin-1-yl)ethyl]-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 121 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 283 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790014 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790014&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580400 Cc1c2c(nn1CCN1CCCC1)CN(C)C[C@@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790014 (10R,17E)-8,10,12,16-tetramethyl-15-[2- (pyrrolidin-1-yl)ethyl]-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 121 Epidermal growth factor receptor Homo sapiens 296 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790014 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790014&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580401 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790015 (10R,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 122 Epidermal growth factor receptor [L858R] Homo sapiens 11.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790015 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790015&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580402 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790015 (10R,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 122 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 1.46 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790015 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790015&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580403 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790015 (10R,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 122 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 2.09 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790015 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790015&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580404 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790015 (10R,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 122 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 7.45 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790015 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790015&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580405 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790015 (10R,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 122 Epidermal growth factor receptor [1-745,751-1210,C797S] 6.79 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790015 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790015&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580406 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790015 (10R,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 122 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 58.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790015 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790015&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580407 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790015 (10R,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 122 Epidermal growth factor receptor Homo sapiens 94.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790015 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790015&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580408 Cc1nn(C[C@H](C)O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790016 (2S)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-2-ol::US20250353864, Example 123 Epidermal growth factor receptor [L858R] Homo sapiens 1.50 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790016 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790016&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580409 Cc1nn(C[C@H](C)O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790016 (2S)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-2-ol::US20250353864, Example 123 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.330 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790016 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790016&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580410 Cc1nn(C[C@H](C)O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790016 (2S)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-2-ol::US20250353864, Example 123 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.750 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790016 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790016&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580411 Cc1nn(C[C@H](C)O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790016 (2S)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-2-ol::US20250353864, Example 123 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 1.30 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790016 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790016&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580412 Cc1nn(C[C@H](C)O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790016 (2S)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-2-ol::US20250353864, Example 123 Epidermal growth factor receptor [1-745,751-1210,C797S] 0.800 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790016 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790016&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580413 Cc1nn(C[C@H](C)O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790016 (2S)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-2-ol::US20250353864, Example 123 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 10.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790016 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790016&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580414 Cc1nn(C[C@H](C)O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790016 (2S)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-2-ol::US20250353864, Example 123 Epidermal growth factor receptor Homo sapiens 11.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790016 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790016&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580415 Cc1c2c(nn1C[C@H](C)O)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790017 (2S)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 15H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-15- yl]propan-2-ol::US20250353864, Example 124 Epidermal growth factor receptor [L858R] Homo sapiens 18.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790017 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790017&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580416 Cc1c2c(nn1C[C@H](C)O)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790017 (2S)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 15H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-15- yl]propan-2-ol::US20250353864, Example 124 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 3.32 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790017 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790017&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580417 Cc1c2c(nn1C[C@H](C)O)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790017 (2S)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 15H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-15- yl]propan-2-ol::US20250353864, Example 124 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 2.32 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790017 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790017&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580418 Cc1c2c(nn1C[C@H](C)O)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790017 (2S)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 15H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-15- yl]propan-2-ol::US20250353864, Example 124 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 18.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790017 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790017&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580419 Cc1c2c(nn1C[C@H](C)O)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790017 (2S)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 15H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-15- yl]propan-2-ol::US20250353864, Example 124 Epidermal growth factor receptor [1-745,751-1210,C797S] 13.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790017 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790017&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580420 Cc1c2c(nn1C[C@H](C)O)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790017 (2S)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 15H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-15- yl]propan-2-ol::US20250353864, Example 124 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 140 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790017 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790017&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580421 Cc1c2c(nn1C[C@H](C)O)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790017 (2S)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 15H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-15- yl]propan-2-ol::US20250353864, Example 124 Epidermal growth factor receptor Homo sapiens 168 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790017 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790017&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580422 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(Cl)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790018 2-[(10S,17E)-19-chloro-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 125 Epidermal growth factor receptor [L858R] Homo sapiens 11.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790018 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790018&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580423 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(Cl)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790018 2-[(10S,17E)-19-chloro-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 125 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 43.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790018 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790018&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580424 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(Cl)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790018 2-[(10S,17E)-19-chloro-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 125 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 7.49 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790018 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790018&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580425 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(Cl)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790018 2-[(10S,17E)-19-chloro-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 125 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 20.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790018 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790018&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580426 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(Cl)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790018 2-[(10S,17E)-19-chloro-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 125 Epidermal growth factor receptor [1-745,751-1210,C797S] 4.99 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790018 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790018&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580427 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(Cl)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790018 2-[(10S,17E)-19-chloro-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 125 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 175 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790018 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790018&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580428 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(Cl)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790018 2-[(10S,17E)-19-chloro-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 125 Epidermal growth factor receptor Homo sapiens 138 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790018 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790018&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580429 Cc1c2c(nn1C)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790019 (10S,17E)-8,10,12,14,15-pentamethyl- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[4,3-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 126 Epidermal growth factor receptor [L858R] Homo sapiens 18.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790019 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790019&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580430 Cc1c2c(nn1C)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790019 (10S,17E)-8,10,12,14,15-pentamethyl- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[4,3-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 126 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 2.07 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790019 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790019&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580431 Cc1c2c(nn1C)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790019 (10S,17E)-8,10,12,14,15-pentamethyl- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[4,3-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 126 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 2.80 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790019 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790019&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580432 Cc1c2c(nn1C)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790019 (10S,17E)-8,10,12,14,15-pentamethyl- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[4,3-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 126 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 16.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790019 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790019&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580433 Cc1c2c(nn1C)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790019 (10S,17E)-8,10,12,14,15-pentamethyl- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[4,3-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 126 Epidermal growth factor receptor [1-745,751-1210,C797S] 19.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790019 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790019&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580434 Cc1c2c(nn1C)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790019 (10S,17E)-8,10,12,14,15-pentamethyl- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[4,3-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 126 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 133 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790019 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790019&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580435 Cc1c2c(nn1C)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790019 (10S,17E)-8,10,12,14,15-pentamethyl- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[4,3-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 126 Epidermal growth factor receptor Homo sapiens 164 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790019 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790019&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580436 Cc2nn(C[C@@H](C)O)c3CN(C)C[C@H](C)Oc1c(cnn1C)c5ccc4[nH]nc(/C=C\c23)c4c5 790020 (2R)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-2-ol::US20250353864, Example 127 Epidermal growth factor receptor [L858R] Homo sapiens 1.81 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790020 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790020&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580437 Cc2nn(C[C@@H](C)O)c3CN(C)C[C@H](C)Oc1c(cnn1C)c5ccc4[nH]nc(/C=C\c23)c4c5 790020 (2R)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-2-ol::US20250353864, Example 127 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.150 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790020 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790020&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580438 Cc2nn(C[C@@H](C)O)c3CN(C)C[C@H](C)Oc1c(cnn1C)c5ccc4[nH]nc(/C=C\c23)c4c5 790020 (2R)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-2-ol::US20250353864, Example 127 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.430 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790020 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790020&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580439 Cc2nn(C[C@@H](C)O)c3CN(C)C[C@H](C)Oc1c(cnn1C)c5ccc4[nH]nc(/C=C\c23)c4c5 790020 (2R)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-2-ol::US20250353864, Example 127 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 2.82 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790020 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790020&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580440 Cc2nn(C[C@@H](C)O)c3CN(C)C[C@H](C)Oc1c(cnn1C)c5ccc4[nH]nc(/C=C\c23)c4c5 790020 (2R)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-2-ol::US20250353864, Example 127 Epidermal growth factor receptor [1-745,751-1210,C797S] 0.850 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790020 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790020&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580441 Cc2nn(C[C@@H](C)O)c3CN(C)C[C@H](C)Oc1c(cnn1C)c5ccc4[nH]nc(/C=C\c23)c4c5 790020 (2R)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-2-ol::US20250353864, Example 127 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 25.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790020 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790020&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580442 Cc2nn(C[C@@H](C)O)c3CN(C)C[C@H](C)Oc1c(cnn1C)c5ccc4[nH]nc(/C=C\c23)c4c5 790020 (2R)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-2-ol::US20250353864, Example 127 Epidermal growth factor receptor Homo sapiens 11.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790020 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790020&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580443 Cc5c4/C=C\c1n[nH]c2ccc(cc12)c3cnn(C)c3O[C@@H](C)CN(C)Cc4nn5C[C@H](C)O 790021 (2R)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 15H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-15- yl]propan-2-ol::US20250353864, Example 128 Epidermal growth factor receptor [L858R] Homo sapiens 21.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790021 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790021&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580444 Cc5c4/C=C\c1n[nH]c2ccc(cc12)c3cnn(C)c3O[C@@H](C)CN(C)Cc4nn5C[C@H](C)O 790021 (2R)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 15H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-15- yl]propan-2-ol::US20250353864, Example 128 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.770 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790021 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790021&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580445 Cc5c4/C=C\c1n[nH]c2ccc(cc12)c3cnn(C)c3O[C@@H](C)CN(C)Cc4nn5C[C@H](C)O 790021 (2R)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 15H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-15- yl]propan-2-ol::US20250353864, Example 128 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 1.01 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790021 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790021&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580446 Cc5c4/C=C\c1n[nH]c2ccc(cc12)c3cnn(C)c3O[C@@H](C)CN(C)Cc4nn5C[C@H](C)O 790021 (2R)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 15H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-15- yl]propan-2-ol::US20250353864, Example 128 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 33.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790021 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790021&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580447 Cc5c4/C=C\c1n[nH]c2ccc(cc12)c3cnn(C)c3O[C@@H](C)CN(C)Cc4nn5C[C@H](C)O 790021 (2R)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 15H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-15- yl]propan-2-ol::US20250353864, Example 128 Epidermal growth factor receptor [1-745,751-1210,C797S] 15.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790021 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790021&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580448 Cc5c4/C=C\c1n[nH]c2ccc(cc12)c3cnn(C)c3O[C@@H](C)CN(C)Cc4nn5C[C@H](C)O 790021 (2R)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 15H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-15- yl]propan-2-ol::US20250353864, Example 128 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 383 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790021 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790021&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580449 Cc5c4/C=C\c1n[nH]c2ccc(cc12)c3cnn(C)c3O[C@@H](C)CN(C)Cc4nn5C[C@H](C)O 790021 (2R)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 15H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-15- yl]propan-2-ol::US20250353864, Example 128 Epidermal growth factor receptor Homo sapiens 264 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790021 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790021&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580450 CCc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790022 2-[(10S,17E)-16-ethyl-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 129 Epidermal growth factor receptor [L858R] Homo sapiens 0.470 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790022 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790022&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580451 CCc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790022 2-[(10S,17E)-16-ethyl-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 129 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.090 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790022 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790022&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580452 CCc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790022 2-[(10S,17E)-16-ethyl-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 129 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.330 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790022 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790022&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580453 CCc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790022 2-[(10S,17E)-16-ethyl-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 129 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 0.580 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790022 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790022&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580454 CCc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790022 2-[(10S,17E)-16-ethyl-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 129 Epidermal growth factor receptor [1-745,751-1210,C797S] 0.400 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790022 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790022&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580455 CCc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790022 2-[(10S,17E)-16-ethyl-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 129 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 6.50 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790022 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790022&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580456 CCc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790022 2-[(10S,17E)-16-ethyl-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 129 Epidermal growth factor receptor Homo sapiens 3.02 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790022 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790022&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580457 Cc1nn(C)c2c1CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790023 (10S,17E)-8,10,12,14,16-pentamethyl- 2,10,11,12,13,16-hexahydro-8H-3,5- ethenotripyrazolo[4,3-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 130 Epidermal growth factor receptor [L858R] Homo sapiens 84.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790023 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790023&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580458 Cc1nn(C)c2c1CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790023 (10S,17E)-8,10,12,14,16-pentamethyl- 2,10,11,12,13,16-hexahydro-8H-3,5- ethenotripyrazolo[4,3-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 130 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 7.32 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790023 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790023&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580459 Cc1nn(C)c2c1CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790023 (10S,17E)-8,10,12,14,16-pentamethyl- 2,10,11,12,13,16-hexahydro-8H-3,5- ethenotripyrazolo[4,3-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 130 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 5.66 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790023 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790023&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580460 Cc1nn(C)c2c1CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790023 (10S,17E)-8,10,12,14,16-pentamethyl- 2,10,11,12,13,16-hexahydro-8H-3,5- ethenotripyrazolo[4,3-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 130 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 81.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790023 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790023&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580461 Cc1nn(C)c2c1CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790023 (10S,17E)-8,10,12,14,16-pentamethyl- 2,10,11,12,13,16-hexahydro-8H-3,5- ethenotripyrazolo[4,3-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 130 Epidermal growth factor receptor [1-745,751-1210,C797S] 38.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790023 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790023&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580462 Cc1nn(C)c2c1CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790023 (10S,17E)-8,10,12,14,16-pentamethyl- 2,10,11,12,13,16-hexahydro-8H-3,5- ethenotripyrazolo[4,3-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 130 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 851 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790023 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790023&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580463 Cc1nn(C)c2c1CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790023 (10S,17E)-8,10,12,14,16-pentamethyl- 2,10,11,12,13,16-hexahydro-8H-3,5- ethenotripyrazolo[4,3-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 130 Epidermal growth factor receptor Homo sapiens 457 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790023 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790023&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580464 CN1CCN(c2ccc3c(c2)O[C@@H]2CCN(CCOc4c(cnn4C)-c4ccc5[nH]nc(c5c4)/C=C/3)C2=O)CC1 790024 (10R,16E)-3-methyl-13-(4- methylpiperazin-1-yl)-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 131 Epidermal growth factor receptor [L858R] Homo sapiens 4.02 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790024 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790024&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580465 CN1CCN(c2ccc3c(c2)O[C@@H]2CCN(CCOc4c(cnn4C)-c4ccc5[nH]nc(c5c4)/C=C/3)C2=O)CC1 790024 (10R,16E)-3-methyl-13-(4- methylpiperazin-1-yl)-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 131 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.570 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790024 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790024&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580466 CN1CCN(c2ccc3c(c2)O[C@@H]2CCN(CCOc4c(cnn4C)-c4ccc5[nH]nc(c5c4)/C=C/3)C2=O)CC1 790024 (10R,16E)-3-methyl-13-(4- methylpiperazin-1-yl)-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 131 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 1.90 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790024 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790024&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580467 CN1CCN(c2ccc3c(c2)O[C@@H]2CCN(CCOc4c(cnn4C)-c4ccc5[nH]nc(c5c4)/C=C/3)C2=O)CC1 790024 (10R,16E)-3-methyl-13-(4- methylpiperazin-1-yl)-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 131 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 1.65 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790024 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790024&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580468 CN1CCN(c2ccc3c(c2)O[C@@H]2CCN(CCOc4c(cnn4C)-c4ccc5[nH]nc(c5c4)/C=C/3)C2=O)CC1 790024 (10R,16E)-3-methyl-13-(4- methylpiperazin-1-yl)-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 131 Epidermal growth factor receptor [1-745,751-1210,C797S] 4.09 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790024 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790024&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580469 CN1CCN(c2ccc3c(c2)O[C@@H]2CCN(CCOc4c(cnn4C)-c4ccc5[nH]nc(c5c4)/C=C/3)C2=O)CC1 790024 (10R,16E)-3-methyl-13-(4- methylpiperazin-1-yl)-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 131 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 6.79 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790024 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790024&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580470 CN1CCN(c2ccc3c(c2)O[C@@H]2CCN(CCOc4c(cnn4C)-c4ccc5[nH]nc(c5c4)/C=C/3)C2=O)CC1 790024 (10R,16E)-3-methyl-13-(4- methylpiperazin-1-yl)-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 131 Epidermal growth factor receptor Homo sapiens 17.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790024 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790024&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580471 Cn1ncc2c1OCCN1CC[C@@H](Oc3ccc(F)cc3/C=C/c3n[nH]c4ccc-2cc34)C1=O 790025 (10R,16E)-14-fluoro-3-methyl- 3,5,6,9,10,19-hexahydro-8H-20,22- etheno-7,10-methanodipyrazolo[3,4- i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 132 Epidermal growth factor receptor [L858R] Homo sapiens 157 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790025 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790025&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580472 Cn1ncc2c1OCCN1CC[C@@H](Oc3ccc(F)cc3/C=C/c3n[nH]c4ccc-2cc34)C1=O 790025 (10R,16E)-14-fluoro-3-methyl- 3,5,6,9,10,19-hexahydro-8H-20,22- etheno-7,10-methanodipyrazolo[3,4- i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 132 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 20.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790025 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790025&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580473 Cn1ncc2c1OCCN1CC[C@@H](Oc3ccc(F)cc3/C=C/c3n[nH]c4ccc-2cc34)C1=O 790025 (10R,16E)-14-fluoro-3-methyl- 3,5,6,9,10,19-hexahydro-8H-20,22- etheno-7,10-methanodipyrazolo[3,4- i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 132 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 35.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790025 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790025&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580474 Cn1ncc2c1OCCN1CC[C@@H](Oc3ccc(F)cc3/C=C/c3n[nH]c4ccc-2cc34)C1=O 790025 (10R,16E)-14-fluoro-3-methyl- 3,5,6,9,10,19-hexahydro-8H-20,22- etheno-7,10-methanodipyrazolo[3,4- i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 132 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 39.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790025 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790025&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580475 Cn1ncc2c1OCCN1CC[C@@H](Oc3ccc(F)cc3/C=C/c3n[nH]c4ccc-2cc34)C1=O 790025 (10R,16E)-14-fluoro-3-methyl- 3,5,6,9,10,19-hexahydro-8H-20,22- etheno-7,10-methanodipyrazolo[3,4- i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 132 Epidermal growth factor receptor [1-745,751-1210,C797S] 67.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790025 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790025&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580476 Cn1ncc2c1OCCN1CC[C@@H](Oc3ccc(F)cc3/C=C/c3n[nH]c4ccc-2cc34)C1=O 790025 (10R,16E)-14-fluoro-3-methyl- 3,5,6,9,10,19-hexahydro-8H-20,22- etheno-7,10-methanodipyrazolo[3,4- i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 132 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 284 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790025 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790025&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580477 Cn1ncc2c1OCCN1CC[C@@H](Oc3ccc(F)cc3/C=C/c3n[nH]c4ccc-2cc34)C1=O 790025 (10R,16E)-14-fluoro-3-methyl- 3,5,6,9,10,19-hexahydro-8H-20,22- etheno-7,10-methanodipyrazolo[3,4- i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 132 Epidermal growth factor receptor Homo sapiens 721 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790025 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790025&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580478 CCN1Cc2c(c(C)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790026 2-[(10S,17E)-12-ethyl-8,10,16-trimethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 133 Epidermal growth factor receptor [L858R] Homo sapiens 0.090 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790026 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790026&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580479 CCN1Cc2c(c(C)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790026 2-[(10S,17E)-12-ethyl-8,10,16-trimethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 133 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.070 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790026 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790026&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580480 CCN1Cc2c(c(C)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790026 2-[(10S,17E)-12-ethyl-8,10,16-trimethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 133 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.240 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790026 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790026&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580481 CCN1Cc2c(c(C)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790026 2-[(10S,17E)-12-ethyl-8,10,16-trimethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 133 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 0.120 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790026 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790026&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580482 CCN1Cc2c(c(C)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790026 2-[(10S,17E)-12-ethyl-8,10,16-trimethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 133 Epidermal growth factor receptor [1-745,751-1210,C797S] 0.350 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790026 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790026&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580483 CCN1Cc2c(c(C)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790026 2-[(10S,17E)-12-ethyl-8,10,16-trimethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 133 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 1.62 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790026 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790026&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580484 CCN1Cc2c(c(C)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790026 2-[(10S,17E)-12-ethyl-8,10,16-trimethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 133 Epidermal growth factor receptor Homo sapiens 0.540 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790026 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790026&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580485 Cc1onc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790027 (10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[3,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 134 Epidermal growth factor receptor [L858R] Homo sapiens 182 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790027 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790027&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580486 Cc1onc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790027 (10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[3,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 134 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 24.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790027 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790027&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580487 Cc1onc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790027 (10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[3,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 134 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 12.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790027 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790027&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580488 Cc1onc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790027 (10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[3,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 134 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 173 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790027 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790027&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580489 Cc1onc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790027 (10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[3,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 134 Epidermal growth factor receptor [1-745,751-1210,C797S] 90.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790027 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790027&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580490 Cc1onc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790027 (10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[3,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 134 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790027 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790027&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580491 Cc1onc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790027 (10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[3,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 134 Epidermal growth factor receptor Homo sapiens 1210 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790027 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790027&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580492 Cn1ncc2c1OCCN1CC[C@@H](Oc3ccc(C(C)(C)O)cc3/C=C/c3n[nH]c4ccc-2cc34)C1=O 790028 (10R,16E)-14-(2-hydroxypropan-2-yl)-3- methyl-3,5,6,9,10,19-hexahydro-8H- 20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 135 Epidermal growth factor receptor [L858R] Homo sapiens 128 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790028 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790028&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580493 Cn1ncc2c1OCCN1CC[C@@H](Oc3ccc(C(C)(C)O)cc3/C=C/c3n[nH]c4ccc-2cc34)C1=O 790028 (10R,16E)-14-(2-hydroxypropan-2-yl)-3- methyl-3,5,6,9,10,19-hexahydro-8H- 20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 135 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 20.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790028 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790028&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580494 Cn1ncc2c1OCCN1CC[C@@H](Oc3ccc(C(C)(C)O)cc3/C=C/c3n[nH]c4ccc-2cc34)C1=O 790028 (10R,16E)-14-(2-hydroxypropan-2-yl)-3- methyl-3,5,6,9,10,19-hexahydro-8H- 20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 135 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 38.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790028 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790028&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580495 Cn1ncc2c1OCCN1CC[C@@H](Oc3ccc(C(C)(C)O)cc3/C=C/c3n[nH]c4ccc-2cc34)C1=O 790028 (10R,16E)-14-(2-hydroxypropan-2-yl)-3- methyl-3,5,6,9,10,19-hexahydro-8H- 20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 135 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 48.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790028 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790028&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580496 Cn1ncc2c1OCCN1CC[C@@H](Oc3ccc(C(C)(C)O)cc3/C=C/c3n[nH]c4ccc-2cc34)C1=O 790028 (10R,16E)-14-(2-hydroxypropan-2-yl)-3- methyl-3,5,6,9,10,19-hexahydro-8H- 20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 135 Epidermal growth factor receptor [1-745,751-1210,C797S] 97.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790028 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790028&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580497 Cn1ncc2c1OCCN1CC[C@@H](Oc3ccc(C(C)(C)O)cc3/C=C/c3n[nH]c4ccc-2cc34)C1=O 790028 (10R,16E)-14-(2-hydroxypropan-2-yl)-3- methyl-3,5,6,9,10,19-hexahydro-8H- 20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 135 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 802 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790028 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790028&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580498 Cn1ncc2c1OCCN1CC[C@@H](Oc3ccc(C(C)(C)O)cc3/C=C/c3n[nH]c4ccc-2cc34)C1=O 790028 (10R,16E)-14-(2-hydroxypropan-2-yl)-3- methyl-3,5,6,9,10,19-hexahydro-8H- 20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 135 Epidermal growth factor receptor Homo sapiens 829 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790028 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790028&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580499 CN/C1=C(C(=N)OC2CCNCC2)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)CN(C)C1 790029 (10S,17E)-8,10,12,14-tetramethyl-16- [(piperidin-4-yl)oxy]-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 136 Epidermal growth factor receptor [L858R] Homo sapiens 14.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790029 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790029&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580500 CN/C1=C(C(=N)OC2CCNCC2)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)CN(C)C1 790029 (10S,17E)-8,10,12,14-tetramethyl-16- [(piperidin-4-yl)oxy]-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 136 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.800 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790029 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790029&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580501 CN/C1=C(C(=N)OC2CCNCC2)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)CN(C)C1 790029 (10S,17E)-8,10,12,14-tetramethyl-16- [(piperidin-4-yl)oxy]-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 136 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 1.54 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790029 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790029&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580502 CN/C1=C(C(=N)OC2CCNCC2)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)CN(C)C1 790029 (10S,17E)-8,10,12,14-tetramethyl-16- [(piperidin-4-yl)oxy]-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 136 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 15.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790029 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790029&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580503 CN/C1=C(C(=N)OC2CCNCC2)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)CN(C)C1 790029 (10S,17E)-8,10,12,14-tetramethyl-16- [(piperidin-4-yl)oxy]-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 136 Epidermal growth factor receptor [1-745,751-1210,C797S] 12.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790029 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790029&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580504 CN/C1=C(C(=N)OC2CCNCC2)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)CN(C)C1 790029 (10S,17E)-8,10,12,14-tetramethyl-16- [(piperidin-4-yl)oxy]-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 136 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 334 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790029 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790029&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580505 CN/C1=C(C(=N)OC2CCNCC2)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)CN(C)C1 790029 (10S,17E)-8,10,12,14-tetramethyl-16- [(piperidin-4-yl)oxy]-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 136 Epidermal growth factor receptor Homo sapiens 103 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790029 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790029&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580506 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790030 2-[(10R,19E)-18-ethoxy-8-methyl- 2,10,11,12,13,15-hexahydro-3,5-etheno- 10,14-methanotripyrazolo[3,4-h:3',4'- l:4$#8243;,3$#8243;-p][1,6]oxazacycloheptadecin- 16(8H)-yl]ethan-1-ol::US20250353864, Example 137 Epidermal growth factor receptor [L858R] Homo sapiens 7.80 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790030 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790030&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580507 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790030 2-[(10R,19E)-18-ethoxy-8-methyl- 2,10,11,12,13,15-hexahydro-3,5-etheno- 10,14-methanotripyrazolo[3,4-h:3',4'- l:4$#8243;,3$#8243;-p][1,6]oxazacycloheptadecin- 16(8H)-yl]ethan-1-ol::US20250353864, Example 137 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.600 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790030 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790030&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580508 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790030 2-[(10R,19E)-18-ethoxy-8-methyl- 2,10,11,12,13,15-hexahydro-3,5-etheno- 10,14-methanotripyrazolo[3,4-h:3',4'- l:4$#8243;,3$#8243;-p][1,6]oxazacycloheptadecin- 16(8H)-yl]ethan-1-ol::US20250353864, Example 137 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 1.02 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790030 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790030&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580509 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790030 2-[(10R,19E)-18-ethoxy-8-methyl- 2,10,11,12,13,15-hexahydro-3,5-etheno- 10,14-methanotripyrazolo[3,4-h:3',4'- l:4$#8243;,3$#8243;-p][1,6]oxazacycloheptadecin- 16(8H)-yl]ethan-1-ol::US20250353864, Example 137 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 6.59 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790030 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790030&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580510 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790030 2-[(10R,19E)-18-ethoxy-8-methyl- 2,10,11,12,13,15-hexahydro-3,5-etheno- 10,14-methanotripyrazolo[3,4-h:3',4'- l:4$#8243;,3$#8243;-p][1,6]oxazacycloheptadecin- 16(8H)-yl]ethan-1-ol::US20250353864, Example 137 Epidermal growth factor receptor [1-745,751-1210,C797S] 4.80 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790030 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790030&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580511 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790030 2-[(10R,19E)-18-ethoxy-8-methyl- 2,10,11,12,13,15-hexahydro-3,5-etheno- 10,14-methanotripyrazolo[3,4-h:3',4'- l:4$#8243;,3$#8243;-p][1,6]oxazacycloheptadecin- 16(8H)-yl]ethan-1-ol::US20250353864, Example 137 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 129 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790030 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790030&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580512 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790030 2-[(10R,19E)-18-ethoxy-8-methyl- 2,10,11,12,13,15-hexahydro-3,5-etheno- 10,14-methanotripyrazolo[3,4-h:3',4'- l:4$#8243;,3$#8243;-p][1,6]oxazacycloheptadecin- 16(8H)-yl]ethan-1-ol::US20250353864, Example 137 Epidermal growth factor receptor Homo sapiens 55.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790030 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790030&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580513 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1c(C)nn(C)c1O[C@@H](C)CN(C)C2 790031 2-[(10S,17E)-6,8,10,12,16-pentamethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 138 Epidermal growth factor receptor [L858R] Homo sapiens 3.50 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790031 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790031&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580514 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1c(C)nn(C)c1O[C@@H](C)CN(C)C2 790031 2-[(10S,17E)-6,8,10,12,16-pentamethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 138 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.610 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790031 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790031&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580515 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1c(C)nn(C)c1O[C@@H](C)CN(C)C2 790031 2-[(10S,17E)-6,8,10,12,16-pentamethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 138 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.550 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790031 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790031&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580516 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1c(C)nn(C)c1O[C@@H](C)CN(C)C2 790031 2-[(10S,17E)-6,8,10,12,16-pentamethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 138 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 3.64 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790031 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790031&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580517 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1c(C)nn(C)c1O[C@@H](C)CN(C)C2 790031 2-[(10S,17E)-6,8,10,12,16-pentamethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 138 Epidermal growth factor receptor [1-745,751-1210,C797S] 1.40 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790031 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790031&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580518 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1c(C)nn(C)c1O[C@@H](C)CN(C)C2 790031 2-[(10S,17E)-6,8,10,12,16-pentamethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 138 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 85.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790031 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790031&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580519 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1c(C)nn(C)c1O[C@@H](C)CN(C)C2 790031 2-[(10S,17E)-6,8,10,12,16-pentamethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 138 Epidermal growth factor receptor Homo sapiens 23.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790031 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790031&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580520 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C1COC1)C2 790032 (10S,17E)-8,10,14,16-tetramethyl-12- (oxetan-3-yl)-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 140 Epidermal growth factor receptor [L858R] Homo sapiens 11.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790032 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790032&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580521 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C1COC1)C2 790032 (10S,17E)-8,10,14,16-tetramethyl-12- (oxetan-3-yl)-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 140 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 1.19 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790032 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790032&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580522 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C1COC1)C2 790032 (10S,17E)-8,10,14,16-tetramethyl-12- (oxetan-3-yl)-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 140 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 1.30 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790032 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790032&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580523 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C1COC1)C2 790032 (10S,17E)-8,10,14,16-tetramethyl-12- (oxetan-3-yl)-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 140 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 9.35 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790032 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790032&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580524 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C1COC1)C2 790032 (10S,17E)-8,10,14,16-tetramethyl-12- (oxetan-3-yl)-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 140 Epidermal growth factor receptor [1-745,751-1210,C797S] 6.14 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790032 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790032&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580525 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C1COC1)C2 790032 (10S,17E)-8,10,14,16-tetramethyl-12- (oxetan-3-yl)-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 140 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 186 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790032 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790032&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580526 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C1COC1)C2 790032 (10S,17E)-8,10,14,16-tetramethyl-12- (oxetan-3-yl)-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 140 Epidermal growth factor receptor Homo sapiens 84.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790032 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790032&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580527 CCOC(=N)C1=C(\NCCO)CN(C(C)C)C[C@H](C)Oc2c(c(C)nn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790033 2-[(10S,17E)-16-ethoxy-6,8,10-trimethyl- 12-(propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 142 Epidermal growth factor receptor [L858R] Homo sapiens 0.900 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790033 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790033&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580528 CCOC(=N)C1=C(\NCCO)CN(C(C)C)C[C@H](C)Oc2c(c(C)nn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790033 2-[(10S,17E)-16-ethoxy-6,8,10-trimethyl- 12-(propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 142 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 1.29 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790033 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790033&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580529 CCOC(=N)C1=C(\NCCO)CN(C(C)C)C[C@H](C)Oc2c(c(C)nn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790033 2-[(10S,17E)-16-ethoxy-6,8,10-trimethyl- 12-(propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 142 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 1.83 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790033 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790033&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580530 CCOC(=N)C1=C(\NCCO)CN(C(C)C)C[C@H](C)Oc2c(c(C)nn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790033 2-[(10S,17E)-16-ethoxy-6,8,10-trimethyl- 12-(propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 142 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 1.11 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790033 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790033&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580531 CCOC(=N)C1=C(\NCCO)CN(C(C)C)C[C@H](C)Oc2c(c(C)nn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790033 2-[(10S,17E)-16-ethoxy-6,8,10-trimethyl- 12-(propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 142 Epidermal growth factor receptor [1-745,751-1210,C797S] 1.32 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790033 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790033&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580532 CCOC(=N)C1=C(\NCCO)CN(C(C)C)C[C@H](C)Oc2c(c(C)nn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790033 2-[(10S,17E)-16-ethoxy-6,8,10-trimethyl- 12-(propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 142 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 16.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790033 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790033&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580533 CCOC(=N)C1=C(\NCCO)CN(C(C)C)C[C@H](C)Oc2c(c(C)nn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790033 2-[(10S,17E)-16-ethoxy-6,8,10-trimethyl- 12-(propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 142 Epidermal growth factor receptor Homo sapiens 2.14 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790033 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790033&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580534 C[C@H]1CN(C)Cc2c(c(OC3CCN(S(C)(=O)=O)CC3)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790034 (10S,17E)-16-{[1- (methanesulfonyl)piperidin-4-yl]oxy}- 8,10,12,14-tetramethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 143 Epidermal growth factor receptor [L858R] Homo sapiens 39.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790034 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790034&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580535 C[C@H]1CN(C)Cc2c(c(OC3CCN(S(C)(=O)=O)CC3)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790034 (10S,17E)-16-{[1- (methanesulfonyl)piperidin-4-yl]oxy}- 8,10,12,14-tetramethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 143 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 1.58 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790034 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790034&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580536 C[C@H]1CN(C)Cc2c(c(OC3CCN(S(C)(=O)=O)CC3)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790034 (10S,17E)-16-{[1- (methanesulfonyl)piperidin-4-yl]oxy}- 8,10,12,14-tetramethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 143 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 4.63 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790034 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790034&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580537 C[C@H]1CN(C)Cc2c(c(OC3CCN(S(C)(=O)=O)CC3)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790034 (10S,17E)-16-{[1- (methanesulfonyl)piperidin-4-yl]oxy}- 8,10,12,14-tetramethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 143 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 39.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790034 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790034&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580538 C[C@H]1CN(C)Cc2c(c(OC3CCN(S(C)(=O)=O)CC3)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790034 (10S,17E)-16-{[1- (methanesulfonyl)piperidin-4-yl]oxy}- 8,10,12,14-tetramethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 143 Epidermal growth factor receptor [1-745,751-1210,C797S] 41.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790034 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790034&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580539 C[C@H]1CN(C)Cc2c(c(OC3CCN(S(C)(=O)=O)CC3)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790034 (10S,17E)-16-{[1- (methanesulfonyl)piperidin-4-yl]oxy}- 8,10,12,14-tetramethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 143 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 1626 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790034 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790034&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580540 C[C@H]1CN(C)Cc2c(c(OC3CCN(S(C)(=O)=O)CC3)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790034 (10S,17E)-16-{[1- (methanesulfonyl)piperidin-4-yl]oxy}- 8,10,12,14-tetramethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 143 Epidermal growth factor receptor Homo sapiens 320 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790034 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790034&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580541 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)[C@@H]2C 790035 (10S,13R,17E)-8,10,12,13,14,16- hexamethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 144 Epidermal growth factor receptor [L858R] Homo sapiens 1.47 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790035 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790035&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580542 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)[C@@H]2C 790035 (10S,13R,17E)-8,10,12,13,14,16- hexamethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 144 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.410 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790035 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790035&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580543 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)[C@@H]2C 790035 (10S,13R,17E)-8,10,12,13,14,16- hexamethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 144 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.700 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790035 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790035&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580544 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)[C@@H]2C 790035 (10S,13R,17E)-8,10,12,13,14,16- hexamethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 144 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 1.88 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790035 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790035&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580545 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)[C@@H]2C 790035 (10S,13R,17E)-8,10,12,13,14,16- hexamethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 144 Epidermal growth factor receptor [1-745,751-1210,C797S] 1.93 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790035 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790035&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580546 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)[C@@H]2C 790035 (10S,13R,17E)-8,10,12,13,14,16- hexamethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 144 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 24.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790035 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790035&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580547 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)[C@@H]2C 790035 (10S,13R,17E)-8,10,12,13,14,16- hexamethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 144 Epidermal growth factor receptor Homo sapiens 8.81 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790035 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790035&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580548 CC(C)OC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790036 2-{(10S,17E)-8,10,12-trimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 147 Epidermal growth factor receptor [L858R] Homo sapiens 0.440 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790036 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790036&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580549 CC(C)OC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790036 2-{(10S,17E)-8,10,12-trimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 147 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.110 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790036 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790036&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580550 CC(C)OC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790036 2-{(10S,17E)-8,10,12-trimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 147 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.190 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790036 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790036&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580551 CC(C)OC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790036 2-{(10S,17E)-8,10,12-trimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 147 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 0.590 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790036 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790036&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580552 CC(C)OC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790036 2-{(10S,17E)-8,10,12-trimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 147 Epidermal growth factor receptor [1-745,751-1210,C797S] 0.390 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790036 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790036&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580553 CC(C)OC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790036 2-{(10S,17E)-8,10,12-trimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 147 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 9.08 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790036 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790036&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580554 CC(C)OC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790036 2-{(10S,17E)-8,10,12-trimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 147 Epidermal growth factor receptor Homo sapiens 3.16 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790036 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790036&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580555 C[C@H]1CN(C)Cc2c(c(O)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790037 (10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16-ol::US20250353864, Example 148 Epidermal growth factor receptor [L858R] Homo sapiens 42.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790037 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790037&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580556 C[C@H]1CN(C)Cc2c(c(O)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790037 (10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16-ol::US20250353864, Example 148 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 4.25 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790037 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790037&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580557 C[C@H]1CN(C)Cc2c(c(O)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790037 (10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16-ol::US20250353864, Example 148 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 2.77 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790037 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790037&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580558 C[C@H]1CN(C)Cc2c(c(O)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790037 (10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16-ol::US20250353864, Example 148 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 35.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790037 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790037&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580559 C[C@H]1CN(C)Cc2c(c(O)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790037 (10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16-ol::US20250353864, Example 148 Epidermal growth factor receptor [1-745,751-1210,C797S] 23.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790037 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790037&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580560 C[C@H]1CN(C)Cc2c(c(O)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790037 (10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16-ol::US20250353864, Example 148 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 403 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790037 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790037&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580561 C[C@H]1CN(C)Cc2c(c(O)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790037 (10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16-ol::US20250353864, Example 148 Epidermal growth factor receptor Homo sapiens 372 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790037 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790037&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580562 C=S(C)(=O)N6CC(Oc2nn(C)c3CN(C)C[C@H](C)Oc1c(cnn1C)c5ccc4[nH]nc(/C=C\c23)c4c5)C6 790038 (10S,17E)-16-{[1- (methanesulfonyl)azetidin-3-yl]oxy}- 8,10,12,14-tetramethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 150 Epidermal growth factor receptor [L858R] Homo sapiens 2.31 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790038 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790038&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580563 C=S(C)(=O)N6CC(Oc2nn(C)c3CN(C)C[C@H](C)Oc1c(cnn1C)c5ccc4[nH]nc(/C=C\c23)c4c5)C6 790038 (10S,17E)-16-{[1- (methanesulfonyl)azetidin-3-yl]oxy}- 8,10,12,14-tetramethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 150 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.450 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790038 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790038&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580564 C=S(C)(=O)N6CC(Oc2nn(C)c3CN(C)C[C@H](C)Oc1c(cnn1C)c5ccc4[nH]nc(/C=C\c23)c4c5)C6 790038 (10S,17E)-16-{[1- (methanesulfonyl)azetidin-3-yl]oxy}- 8,10,12,14-tetramethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 150 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.370 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790038 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790038&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580565 C=S(C)(=O)N6CC(Oc2nn(C)c3CN(C)C[C@H](C)Oc1c(cnn1C)c5ccc4[nH]nc(/C=C\c23)c4c5)C6 790038 (10S,17E)-16-{[1- (methanesulfonyl)azetidin-3-yl]oxy}- 8,10,12,14-tetramethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 150 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 3.21 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790038 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790038&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580566 C=S(C)(=O)N6CC(Oc2nn(C)c3CN(C)C[C@H](C)Oc1c(cnn1C)c5ccc4[nH]nc(/C=C\c23)c4c5)C6 790038 (10S,17E)-16-{[1- (methanesulfonyl)azetidin-3-yl]oxy}- 8,10,12,14-tetramethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 150 Epidermal growth factor receptor [1-745,751-1210,C797S] 2.58 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790038 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790038&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580567 C=S(C)(=O)N6CC(Oc2nn(C)c3CN(C)C[C@H](C)Oc1c(cnn1C)c5ccc4[nH]nc(/C=C\c23)c4c5)C6 790038 (10S,17E)-16-{[1- (methanesulfonyl)azetidin-3-yl]oxy}- 8,10,12,14-tetramethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 150 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 33.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790038 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790038&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580568 C=S(C)(=O)N6CC(Oc2nn(C)c3CN(C)C[C@H](C)Oc1c(cnn1C)c5ccc4[nH]nc(/C=C\c23)c4c5)C6 790038 (10S,17E)-16-{[1- (methanesulfonyl)azetidin-3-yl]oxy}- 8,10,12,14-tetramethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 150 Epidermal growth factor receptor Homo sapiens 6.36 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790038 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790038&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580569 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C(C)C)C2 790039 2-[(10S,17E)-16-ethoxy-8,10-dimethyl- 12-(propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 151 Epidermal growth factor receptor [L858R] Homo sapiens 0.220 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790039 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790039&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580570 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C(C)C)C2 790039 2-[(10S,17E)-16-ethoxy-8,10-dimethyl- 12-(propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 151 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.480 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790039 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790039&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580571 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C(C)C)C2 790039 2-[(10S,17E)-16-ethoxy-8,10-dimethyl- 12-(propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 151 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.460 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790039 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790039&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580572 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C(C)C)C2 790039 2-[(10S,17E)-16-ethoxy-8,10-dimethyl- 12-(propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 151 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 0.300 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790039 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790039&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580573 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C(C)C)C2 790039 2-[(10S,17E)-16-ethoxy-8,10-dimethyl- 12-(propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 151 Epidermal growth factor receptor [1-745,751-1210,C797S] 0.720 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790039 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790039&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580574 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C(C)C)C2 790039 2-[(10S,17E)-16-ethoxy-8,10-dimethyl- 12-(propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 151 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 2.55 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790039 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790039&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580575 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C(C)C)C2 790039 2-[(10S,17E)-16-ethoxy-8,10-dimethyl- 12-(propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 151 Epidermal growth factor receptor Homo sapiens 0.870 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790039 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790039&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580576 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC(C1CCC1)CN(C)C2 790040 2-[(17E)-10-cyclobutyl-8,12,16- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 152 Epidermal growth factor receptor [L858R] Homo sapiens 20.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790040 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790040&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580577 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC(C1CCC1)CN(C)C2 790040 2-[(17E)-10-cyclobutyl-8,12,16- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 152 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.580 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790040 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790040&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580578 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC(C1CCC1)CN(C)C2 790040 2-[(17E)-10-cyclobutyl-8,12,16- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 152 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.620 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790040 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790040&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580579 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC(C1CCC1)CN(C)C2 790040 2-[(17E)-10-cyclobutyl-8,12,16- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 152 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 61.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790040 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790040&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580580 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC(C1CCC1)CN(C)C2 790040 2-[(17E)-10-cyclobutyl-8,12,16- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 152 Epidermal growth factor receptor [1-745,751-1210,C797S] 86.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790040 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790040&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580581 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC(C1CCC1)CN(C)C2 790040 2-[(17E)-10-cyclobutyl-8,12,16- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 152 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 94.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790040 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790040&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580582 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC(C1CCC1)CN(C)C2 790040 2-[(17E)-10-cyclobutyl-8,12,16- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 152 Epidermal growth factor receptor Homo sapiens 112 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790040 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790040&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580583 CCOC(=N)C1=C(\N[C@@H](C)CO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790041 (2S)-2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 155 Epidermal growth factor receptor [L858R] Homo sapiens 0.340 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790041 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790041&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580584 CCOC(=N)C1=C(\N[C@@H](C)CO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790041 (2S)-2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 155 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.450 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790041 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790041&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580585 CCOC(=N)C1=C(\N[C@@H](C)CO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790041 (2S)-2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 155 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.620 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790041 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790041&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580586 CCOC(=N)C1=C(\N[C@@H](C)CO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790041 (2S)-2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 155 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 0.620 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790041 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790041&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580587 CCOC(=N)C1=C(\N[C@@H](C)CO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790041 (2S)-2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 155 Epidermal growth factor receptor [1-745,751-1210,C797S] 0.860 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790041 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790041&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580588 CCOC(=N)C1=C(\N[C@@H](C)CO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790041 (2S)-2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 155 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 6.36 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790041 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790041&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580589 CCOC(=N)C1=C(\N[C@@H](C)CO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790041 (2S)-2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 155 Epidermal growth factor receptor Homo sapiens 1.74 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790041 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790041&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580590 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C(C)C)C2 790042 (10S,17E)-16-ethoxy-8,10,14-trimethyl- 12-(propan-2-yl)-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 156 Epidermal growth factor receptor [L858R] Homo sapiens 4.34 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790042 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790042&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580591 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C(C)C)C2 790042 (10S,17E)-16-ethoxy-8,10,14-trimethyl- 12-(propan-2-yl)-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 156 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.880 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790042 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790042&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580592 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C(C)C)C2 790042 (10S,17E)-16-ethoxy-8,10,14-trimethyl- 12-(propan-2-yl)-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 156 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 1.04 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790042 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790042&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580593 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C(C)C)C2 790042 (10S,17E)-16-ethoxy-8,10,14-trimethyl- 12-(propan-2-yl)-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 156 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 1.77 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790042 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790042&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580594 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C(C)C)C2 790042 (10S,17E)-16-ethoxy-8,10,14-trimethyl- 12-(propan-2-yl)-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 156 Epidermal growth factor receptor [1-745,751-1210,C797S] 3.62 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790042 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790042&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580595 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C(C)C)C2 790042 (10S,17E)-16-ethoxy-8,10,14-trimethyl- 12-(propan-2-yl)-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 156 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 64.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790042 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790042&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580596 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C(C)C)C2 790042 (10S,17E)-16-ethoxy-8,10,14-trimethyl- 12-(propan-2-yl)-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 156 Epidermal growth factor receptor Homo sapiens 19.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790042 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790042&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580597 C[C@H]1CN(C)Cc2c(c(C#N)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790043 (10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine-16- carbonitrile::US20250353864, Example 159 Epidermal growth factor receptor [L858R] Homo sapiens 34.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790043 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790043&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580598 C[C@H]1CN(C)Cc2c(c(C#N)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790043 (10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine-16- carbonitrile::US20250353864, Example 159 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 1.54 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790043 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790043&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580599 C[C@H]1CN(C)Cc2c(c(C#N)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790043 (10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine-16- carbonitrile::US20250353864, Example 159 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.740 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790043 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790043&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580600 C[C@H]1CN(C)Cc2c(c(C#N)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790043 (10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine-16- carbonitrile::US20250353864, Example 159 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 27.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790043 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790043&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580601 C[C@H]1CN(C)Cc2c(c(C#N)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790043 (10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine-16- carbonitrile::US20250353864, Example 159 Epidermal growth factor receptor [1-745,751-1210,C797S] 14.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790043 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790043&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580602 C[C@H]1CN(C)Cc2c(c(C#N)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790043 (10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine-16- carbonitrile::US20250353864, Example 159 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 116 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790043 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790043&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580603 C[C@H]1CN(C)Cc2c(c(C#N)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790043 (10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine-16- carbonitrile::US20250353864, Example 159 Epidermal growth factor receptor Homo sapiens 160 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790043 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790043&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580604 CCOC(=N)C1=C(\NC)CN2CCC[C@H](C2)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790044 (10R,19E)-18-ethoxy-8,16-dimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 160 Epidermal growth factor receptor [L858R] Homo sapiens 34.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790044 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790044&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580605 CCOC(=N)C1=C(\NC)CN2CCC[C@H](C2)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790044 (10R,19E)-18-ethoxy-8,16-dimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 160 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 1.42 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790044 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790044&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580606 CCOC(=N)C1=C(\NC)CN2CCC[C@H](C2)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790044 (10R,19E)-18-ethoxy-8,16-dimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 160 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 1.08 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790044 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790044&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580607 CCOC(=N)C1=C(\NC)CN2CCC[C@H](C2)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790044 (10R,19E)-18-ethoxy-8,16-dimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 160 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 13.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790044 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790044&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580608 CCOC(=N)C1=C(\NC)CN2CCC[C@H](C2)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790044 (10R,19E)-18-ethoxy-8,16-dimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 160 Epidermal growth factor receptor [1-745,751-1210,C797S] 19.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790044 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790044&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580609 CCOC(=N)C1=C(\NC)CN2CCC[C@H](C2)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790044 (10R,19E)-18-ethoxy-8,16-dimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 160 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 246 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790044 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790044&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580610 CCOC(=N)C1=C(\NC)CN2CCC[C@H](C2)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790044 (10R,19E)-18-ethoxy-8,16-dimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 160 Epidermal growth factor receptor Homo sapiens 63.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790044 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790044&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580611 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C1CC1)C2 790045 (10S,17E)-12-cyclopropyl-8,10,14,16- tetramethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 161 Epidermal growth factor receptor [L858R] Homo sapiens 47.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790045 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790045&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580612 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C1CC1)C2 790045 (10S,17E)-12-cyclopropyl-8,10,14,16- tetramethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 161 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 3.10 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790045 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790045&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580613 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C1CC1)C2 790045 (10S,17E)-12-cyclopropyl-8,10,14,16- tetramethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 161 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 1.40 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790045 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790045&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580614 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C1CC1)C2 790045 (10S,17E)-12-cyclopropyl-8,10,14,16- tetramethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 161 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 20.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790045 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790045&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580615 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C1CC1)C2 790045 (10S,17E)-12-cyclopropyl-8,10,14,16- tetramethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 161 Epidermal growth factor receptor [1-745,751-1210,C797S] 13.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790045 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790045&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580616 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C1CC1)C2 790045 (10S,17E)-12-cyclopropyl-8,10,14,16- tetramethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 161 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 190 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790045 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790045&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580617 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C1CC1)C2 790045 (10S,17E)-12-cyclopropyl-8,10,14,16- tetramethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 161 Epidermal growth factor receptor Homo sapiens 171 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790045 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790045&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580618 CN/C1=C(C(=N)OCC(F)(F)F)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)CN(C)C1 790046 (10S,17E)-8,10,12,14-tetramethyl-16- (2,2,2-trifluoroethoxy)-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 162 Epidermal growth factor receptor [L858R] Homo sapiens 47.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790046 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790046&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580619 CN/C1=C(C(=N)OCC(F)(F)F)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)CN(C)C1 790046 (10S,17E)-8,10,12,14-tetramethyl-16- (2,2,2-trifluoroethoxy)-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 162 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 1.40 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790046 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790046&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580620 CN/C1=C(C(=N)OCC(F)(F)F)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)CN(C)C1 790046 (10S,17E)-8,10,12,14-tetramethyl-16- (2,2,2-trifluoroethoxy)-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 162 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.900 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790046 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790046&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580621 CN/C1=C(C(=N)OCC(F)(F)F)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)CN(C)C1 790046 (10S,17E)-8,10,12,14-tetramethyl-16- (2,2,2-trifluoroethoxy)-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 162 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 30.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790046 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790046&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580622 CN/C1=C(C(=N)OCC(F)(F)F)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)CN(C)C1 790046 (10S,17E)-8,10,12,14-tetramethyl-16- (2,2,2-trifluoroethoxy)-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 162 Epidermal growth factor receptor [1-745,751-1210,C797S] 33.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790046 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790046&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580623 CN/C1=C(C(=N)OCC(F)(F)F)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)CN(C)C1 790046 (10S,17E)-8,10,12,14-tetramethyl-16- (2,2,2-trifluoroethoxy)-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 162 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 523 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790046 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790046&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580624 CN/C1=C(C(=N)OCC(F)(F)F)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)CN(C)C1 790046 (10S,17E)-8,10,12,14-tetramethyl-16- (2,2,2-trifluoroethoxy)-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 162 Epidermal growth factor receptor Homo sapiens 238 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790046 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790046&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580625 C[C@H]1CN(C)Cc2c(c(OCC#N)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790047 {[(10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}acetonitrile::US20250353864, Example 163 Epidermal growth factor receptor [L858R] Homo sapiens 8.20 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790047 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790047&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580626 C[C@H]1CN(C)Cc2c(c(OCC#N)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790047 {[(10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}acetonitrile::US20250353864, Example 163 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.850 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790047 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790047&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580627 C[C@H]1CN(C)Cc2c(c(OCC#N)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790047 {[(10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}acetonitrile::US20250353864, Example 163 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.860 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790047 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790047&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580628 C[C@H]1CN(C)Cc2c(c(OCC#N)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790047 {[(10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}acetonitrile::US20250353864, Example 163 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 7.33 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790047 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790047&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580629 C[C@H]1CN(C)Cc2c(c(OCC#N)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790047 {[(10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}acetonitrile::US20250353864, Example 163 Epidermal growth factor receptor [1-745,751-1210,C797S] 4.72 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790047 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790047&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580630 C[C@H]1CN(C)Cc2c(c(OCC#N)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790047 {[(10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}acetonitrile::US20250353864, Example 163 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 52.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790047 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790047&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580631 C[C@H]1CN(C)Cc2c(c(OCC#N)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790047 {[(10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}acetonitrile::US20250353864, Example 163 Epidermal growth factor receptor Homo sapiens 29.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790047 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790047&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580632 CSCn1ncc2c1O[C@@H](C)CN(C(C)C)Cc1c(c(C)nn1C)/C=C/c1n[nH]c3ccc-2cc13 790048 (10S,17E)-10,14,16-trimethyl-8- [(methylsulfanyl)methyl]-12-(propan-2- yl)-2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n|[1,4]oxazacyclopentadecine::US20250353864, Example 164 Epidermal growth factor receptor [L858R] Homo sapiens 16.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790048 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790048&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580633 CSCn1ncc2c1O[C@@H](C)CN(C(C)C)Cc1c(c(C)nn1C)/C=C/c1n[nH]c3ccc-2cc13 790048 (10S,17E)-10,14,16-trimethyl-8- [(methylsulfanyl)methyl]-12-(propan-2- yl)-2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n|[1,4]oxazacyclopentadecine::US20250353864, Example 164 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 3.23 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790048 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790048&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580634 CSCn1ncc2c1O[C@@H](C)CN(C(C)C)Cc1c(c(C)nn1C)/C=C/c1n[nH]c3ccc-2cc13 790048 (10S,17E)-10,14,16-trimethyl-8- [(methylsulfanyl)methyl]-12-(propan-2- yl)-2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n|[1,4]oxazacyclopentadecine::US20250353864, Example 164 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 1.76 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790048 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790048&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580635 CSCn1ncc2c1O[C@@H](C)CN(C(C)C)Cc1c(c(C)nn1C)/C=C/c1n[nH]c3ccc-2cc13 790048 (10S,17E)-10,14,16-trimethyl-8- [(methylsulfanyl)methyl]-12-(propan-2- yl)-2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n|[1,4]oxazacyclopentadecine::US20250353864, Example 164 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 33.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790048 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790048&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580636 CSCn1ncc2c1O[C@@H](C)CN(C(C)C)Cc1c(c(C)nn1C)/C=C/c1n[nH]c3ccc-2cc13 790048 (10S,17E)-10,14,16-trimethyl-8- [(methylsulfanyl)methyl]-12-(propan-2- yl)-2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n|[1,4]oxazacyclopentadecine::US20250353864, Example 164 Epidermal growth factor receptor [1-745,751-1210,C797S] 20.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790048 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790048&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580637 CSCn1ncc2c1O[C@@H](C)CN(C(C)C)Cc1c(c(C)nn1C)/C=C/c1n[nH]c3ccc-2cc13 790048 (10S,17E)-10,14,16-trimethyl-8- [(methylsulfanyl)methyl]-12-(propan-2- yl)-2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n|[1,4]oxazacyclopentadecine::US20250353864, Example 164 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 95.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790048 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790048&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580638 CSCn1ncc2c1O[C@@H](C)CN(C(C)C)Cc1c(c(C)nn1C)/C=C/c1n[nH]c3ccc-2cc13 790048 (10S,17E)-10,14,16-trimethyl-8- [(methylsulfanyl)methyl]-12-(propan-2- yl)-2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n|[1,4]oxazacyclopentadecine::US20250353864, Example 164 Epidermal growth factor receptor Homo sapiens 220 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790048 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790048&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580639 CCN1Cc2c(c(C)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790049 (10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 165 Epidermal growth factor receptor [L858R] Homo sapiens 6.08 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790049 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790049&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580640 CCN1Cc2c(c(C)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790049 (10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 165 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.470 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790049 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790049&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580641 CCN1Cc2c(c(C)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790049 (10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 165 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.440 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790049 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790049&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580642 CCN1Cc2c(c(C)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790049 (10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 165 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 4.84 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790049 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790049&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580643 CCN1Cc2c(c(C)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790049 (10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 165 Epidermal growth factor receptor [1-745,751-1210,C797S] 2.33 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790049 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790049&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580644 CCN1Cc2c(c(C)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790049 (10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 165 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 19.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790049 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790049&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580645 CCN1Cc2c(c(C)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790049 (10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 165 Epidermal growth factor receptor Homo sapiens 28.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790049 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790049&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580646 C=S(C)(=O)CCN4CCn3nc2CN(C)C[C@H](C)Oc1c(cnn1C)c6ccc5[nH]nc(/C=C\c2c3C4)c5c6 790050 (10S,20E)-18-[2- (methanesulfonyl)ethyl]-8,10,12- trimethyl-2,8,10,11,12,13,16,17,18,19- decahydro-3,5- ethenopyrazino[1',2':1,5]pyrazolo[3,4- f]dipyrazolo[3,4-j:4',3'-::US20250353864, Example 166 Epidermal growth factor receptor [L858R] Homo sapiens 12.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790050 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790050&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580647 C=S(C)(=O)CCN4CCn3nc2CN(C)C[C@H](C)Oc1c(cnn1C)c6ccc5[nH]nc(/C=C\c2c3C4)c5c6 790050 (10S,20E)-18-[2- (methanesulfonyl)ethyl]-8,10,12- trimethyl-2,8,10,11,12,13,16,17,18,19- decahydro-3,5- ethenopyrazino[1',2':1,5]pyrazolo[3,4- f]dipyrazolo[3,4-j:4',3'-::US20250353864, Example 166 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.720 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790050 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790050&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580648 C=S(C)(=O)CCN4CCn3nc2CN(C)C[C@H](C)Oc1c(cnn1C)c6ccc5[nH]nc(/C=C\c2c3C4)c5c6 790050 (10S,20E)-18-[2- (methanesulfonyl)ethyl]-8,10,12- trimethyl-2,8,10,11,12,13,16,17,18,19- decahydro-3,5- ethenopyrazino[1',2':1,5]pyrazolo[3,4- f]dipyrazolo[3,4-j:4',3'-::US20250353864, Example 166 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.550 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790050 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790050&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580649 C=S(C)(=O)CCN4CCn3nc2CN(C)C[C@H](C)Oc1c(cnn1C)c6ccc5[nH]nc(/C=C\c2c3C4)c5c6 790050 (10S,20E)-18-[2- (methanesulfonyl)ethyl]-8,10,12- trimethyl-2,8,10,11,12,13,16,17,18,19- decahydro-3,5- ethenopyrazino[1',2':1,5]pyrazolo[3,4- f]dipyrazolo[3,4-j:4',3'-::US20250353864, Example 166 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 15.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790050 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790050&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580650 C=S(C)(=O)CCN4CCn3nc2CN(C)C[C@H](C)Oc1c(cnn1C)c6ccc5[nH]nc(/C=C\c2c3C4)c5c6 790050 (10S,20E)-18-[2- (methanesulfonyl)ethyl]-8,10,12- trimethyl-2,8,10,11,12,13,16,17,18,19- decahydro-3,5- ethenopyrazino[1',2':1,5]pyrazolo[3,4- f]dipyrazolo[3,4-j:4',3'-::US20250353864, Example 166 Epidermal growth factor receptor [1-745,751-1210,C797S] 8.10 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790050 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790050&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580651 C=S(C)(=O)CCN4CCn3nc2CN(C)C[C@H](C)Oc1c(cnn1C)c6ccc5[nH]nc(/C=C\c2c3C4)c5c6 790050 (10S,20E)-18-[2- (methanesulfonyl)ethyl]-8,10,12- trimethyl-2,8,10,11,12,13,16,17,18,19- decahydro-3,5- ethenopyrazino[1',2':1,5]pyrazolo[3,4- f]dipyrazolo[3,4-j:4',3'-::US20250353864, Example 166 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 45.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790050 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790050&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580652 C=S(C)(=O)CCN4CCn3nc2CN(C)C[C@H](C)Oc1c(cnn1C)c6ccc5[nH]nc(/C=C\c2c3C4)c5c6 790050 (10S,20E)-18-[2- (methanesulfonyl)ethyl]-8,10,12- trimethyl-2,8,10,11,12,13,16,17,18,19- decahydro-3,5- ethenopyrazino[1',2':1,5]pyrazolo[3,4- f]dipyrazolo[3,4-j:4',3'-::US20250353864, Example 166 Epidermal growth factor receptor Homo sapiens 99.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790050 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790050&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580653 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCN(C2)C1 790051 n][1,4]oxazacyclopentadecine (10R,18E)-8,15,17-trimethyl- 2,8,11,12,14,15-hexahydro-10H-3,5- etheno-10,13-methanotripyrazolo[3,4- g:3',4'-k:4$#8243;,3$#8243;- 0][1,5]oxazacyclohexadecine::US20250353864, Example 167 Epidermal growth factor receptor [L858R] Homo sapiens 35.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790051 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790051&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580654 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCN(C2)C1 790051 n][1,4]oxazacyclopentadecine (10R,18E)-8,15,17-trimethyl- 2,8,11,12,14,15-hexahydro-10H-3,5- etheno-10,13-methanotripyrazolo[3,4- g:3',4'-k:4$#8243;,3$#8243;- 0][1,5]oxazacyclohexadecine::US20250353864, Example 167 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 3.42 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790051 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790051&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580655 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCN(C2)C1 790051 n][1,4]oxazacyclopentadecine (10R,18E)-8,15,17-trimethyl- 2,8,11,12,14,15-hexahydro-10H-3,5- etheno-10,13-methanotripyrazolo[3,4- g:3',4'-k:4$#8243;,3$#8243;- 0][1,5]oxazacyclohexadecine::US20250353864, Example 167 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 8.89 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790051 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790051&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580656 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCN(C2)C1 790051 n][1,4]oxazacyclopentadecine (10R,18E)-8,15,17-trimethyl- 2,8,11,12,14,15-hexahydro-10H-3,5- etheno-10,13-methanotripyrazolo[3,4- g:3',4'-k:4$#8243;,3$#8243;- 0][1,5]oxazacyclohexadecine::US20250353864, Example 167 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 23.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790051 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790051&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580657 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCN(C2)C1 790051 n][1,4]oxazacyclopentadecine (10R,18E)-8,15,17-trimethyl- 2,8,11,12,14,15-hexahydro-10H-3,5- etheno-10,13-methanotripyrazolo[3,4- g:3',4'-k:4$#8243;,3$#8243;- 0][1,5]oxazacyclohexadecine::US20250353864, Example 167 Epidermal growth factor receptor [1-745,751-1210,C797S] 13.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790051 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790051&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580658 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCN(C2)C1 790051 n][1,4]oxazacyclopentadecine (10R,18E)-8,15,17-trimethyl- 2,8,11,12,14,15-hexahydro-10H-3,5- etheno-10,13-methanotripyrazolo[3,4- g:3',4'-k:4$#8243;,3$#8243;- 0][1,5]oxazacyclohexadecine::US20250353864, Example 167 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 47.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790051 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790051&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580659 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCN(C2)C1 790051 n][1,4]oxazacyclopentadecine (10R,18E)-8,15,17-trimethyl- 2,8,11,12,14,15-hexahydro-10H-3,5- etheno-10,13-methanotripyrazolo[3,4- g:3',4'-k:4$#8243;,3$#8243;- 0][1,5]oxazacyclohexadecine::US20250353864, Example 167 Epidermal growth factor receptor Homo sapiens 123 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790051 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790051&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580660 CCOC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2CC)-c2ccc3[nH]nc(c3c2)\C=C\1 790052 2-[(10S,17E)-16-ethoxy-8-ethyl-10,12- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 168 Epidermal growth factor receptor [L858R] Homo sapiens 1.88 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790052 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790052&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580661 CCOC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2CC)-c2ccc3[nH]nc(c3c2)\C=C\1 790052 2-[(10S,17E)-16-ethoxy-8-ethyl-10,12- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 168 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.720 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790052 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790052&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580662 CCOC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2CC)-c2ccc3[nH]nc(c3c2)\C=C\1 790052 2-[(10S,17E)-16-ethoxy-8-ethyl-10,12- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 168 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 2.72 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790052 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790052&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580663 CCOC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2CC)-c2ccc3[nH]nc(c3c2)\C=C\1 790052 2-[(10S,17E)-16-ethoxy-8-ethyl-10,12- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 168 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 5.96 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790052 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790052&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580664 CCOC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2CC)-c2ccc3[nH]nc(c3c2)\C=C\1 790052 2-[(10S,17E)-16-ethoxy-8-ethyl-10,12- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 168 Epidermal growth factor receptor [1-745,751-1210,C797S] 1.38 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790052 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790052&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580665 CCOC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2CC)-c2ccc3[nH]nc(c3c2)\C=C\1 790052 2-[(10S,17E)-16-ethoxy-8-ethyl-10,12- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 168 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 13.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790052 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790052&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580666 CCOC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2CC)-c2ccc3[nH]nc(c3c2)\C=C\1 790052 2-[(10S,17E)-16-ethoxy-8-ethyl-10,12- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 168 Epidermal growth factor receptor Homo sapiens 16.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790052 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790052&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580667 CCn1ncc2c1O[C@@H](C)CN(C)C/C(NCCO)=C(C(=N)OC(C)C)\C=C\c1n[nH]c3ccc-2cc13 790053 2-{(10S,17E)-8-ethyl-10,12-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 169 Epidermal growth factor receptor [L858R] Homo sapiens 2.01 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790053 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790053&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580668 CCn1ncc2c1O[C@@H](C)CN(C)C/C(NCCO)=C(C(=N)OC(C)C)\C=C\c1n[nH]c3ccc-2cc13 790053 2-{(10S,17E)-8-ethyl-10,12-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 169 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.480 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790053 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790053&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580669 CCn1ncc2c1O[C@@H](C)CN(C)C/C(NCCO)=C(C(=N)OC(C)C)\C=C\c1n[nH]c3ccc-2cc13 790053 2-{(10S,17E)-8-ethyl-10,12-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 169 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 1.26 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790053 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790053&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580670 CCn1ncc2c1O[C@@H](C)CN(C)C/C(NCCO)=C(C(=N)OC(C)C)\C=C\c1n[nH]c3ccc-2cc13 790053 2-{(10S,17E)-8-ethyl-10,12-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 169 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 3.24 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790053 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790053&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580671 CCn1ncc2c1O[C@@H](C)CN(C)C/C(NCCO)=C(C(=N)OC(C)C)\C=C\c1n[nH]c3ccc-2cc13 790053 2-{(10S,17E)-8-ethyl-10,12-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 169 Epidermal growth factor receptor [1-745,751-1210,C797S] 1.60 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790053 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790053&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580672 CCn1ncc2c1O[C@@H](C)CN(C)C/C(NCCO)=C(C(=N)OC(C)C)\C=C\c1n[nH]c3ccc-2cc13 790053 2-{(10S,17E)-8-ethyl-10,12-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 169 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 36.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790053 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790053&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580673 CCn1ncc2c1O[C@@H](C)CN(C)C/C(NCCO)=C(C(=N)OC(C)C)\C=C\c1n[nH]c3ccc-2cc13 790053 2-{(10S,17E)-8-ethyl-10,12-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 169 Epidermal growth factor receptor Homo sapiens 19.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790053 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790053&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580674 Cn1ncc2c1OCCN1CC[C@H](C1)Oc1ccccc1/C=C/c1n[nH]c3ccc-2cc13 790054 (10R,16E)-3-methyl-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'-m] [1,8,5]benzodioxazacyclooctadecine::US20250353864, Example 170 Epidermal growth factor receptor [L858R] Homo sapiens 310 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790054 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790054&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580675 Cn1ncc2c1OCCN1CC[C@H](C1)Oc1ccccc1/C=C/c1n[nH]c3ccc-2cc13 790054 (10R,16E)-3-methyl-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'-m] [1,8,5]benzodioxazacyclooctadecine::US20250353864, Example 170 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 36.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790054 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790054&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580676 Cn1ncc2c1OCCN1CC[C@H](C1)Oc1ccccc1/C=C/c1n[nH]c3ccc-2cc13 790054 (10R,16E)-3-methyl-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'-m] [1,8,5]benzodioxazacyclooctadecine::US20250353864, Example 170 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 25.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790054 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790054&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580677 Cn1ncc2c1OCCN1CC[C@H](C1)Oc1ccccc1/C=C/c1n[nH]c3ccc-2cc13 790054 (10R,16E)-3-methyl-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'-m] [1,8,5]benzodioxazacyclooctadecine::US20250353864, Example 170 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 116 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790054 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790054&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580678 Cn1ncc2c1OCCN1CC[C@H](C1)Oc1ccccc1/C=C/c1n[nH]c3ccc-2cc13 790054 (10R,16E)-3-methyl-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'-m] [1,8,5]benzodioxazacyclooctadecine::US20250353864, Example 170 Epidermal growth factor receptor [1-745,751-1210,C797S] 30.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790054 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790054&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580679 Cn1ncc2c1OCCN1CC[C@H](C1)Oc1ccccc1/C=C/c1n[nH]c3ccc-2cc13 790054 (10R,16E)-3-methyl-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'-m] [1,8,5]benzodioxazacyclooctadecine::US20250353864, Example 170 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 329 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790054 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790054&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580680 Cn1ncc2c1OCCN1CC[C@H](C1)Oc1ccccc1/C=C/c1n[nH]c3ccc-2cc13 790054 (10R,16E)-3-methyl-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'-m] [1,8,5]benzodioxazacyclooctadecine::US20250353864, Example 170 Epidermal growth factor receptor Homo sapiens 908 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790054 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790054&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580681 CCOc1nn([C@H](C)CO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790055 (2R)-2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 171 Epidermal growth factor receptor [L858R] Homo sapiens 7.50 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790055 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790055&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580682 CCOc1nn([C@H](C)CO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790055 (2R)-2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 171 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.500 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790055 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790055&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580683 CCOc1nn([C@H](C)CO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790055 (2R)-2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 171 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 1.32 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790055 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790055&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580684 CCOc1nn([C@H](C)CO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790055 (2R)-2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 171 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 38.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790055 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790055&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580685 CCOc1nn([C@H](C)CO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790055 (2R)-2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 171 Epidermal growth factor receptor [1-745,751-1210,C797S] 8.74 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790055 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790055&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580686 CCOc1nn([C@H](C)CO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790055 (2R)-2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 171 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 86.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790055 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790055&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580687 CCOc1nn([C@H](C)CO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790055 (2R)-2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 171 Epidermal growth factor receptor Homo sapiens 67.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790055 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790055&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580688 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790056 2-[(10S,17E)-16-ethoxy-19-fluoro- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 172 Epidermal growth factor receptor [L858R] Homo sapiens 0.600 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790056 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790056&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580689 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790056 2-[(10S,17E)-16-ethoxy-19-fluoro- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 172 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.480 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790056 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790056&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580690 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790056 2-[(10S,17E)-16-ethoxy-19-fluoro- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 172 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 1.34 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790056 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790056&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580691 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790056 2-[(10S,17E)-16-ethoxy-19-fluoro- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 172 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 2.10 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790056 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790056&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580692 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790056 2-[(10S,17E)-16-ethoxy-19-fluoro- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 172 Epidermal growth factor receptor [1-745,751-1210,C797S] 0.690 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790056 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790056&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580693 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790056 2-[(10S,17E)-16-ethoxy-19-fluoro- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 172 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 6.61 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790056 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790056&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580694 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790056 2-[(10S,17E)-16-ethoxy-19-fluoro- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 172 Epidermal growth factor receptor Homo sapiens 1.84 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790056 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790056&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580695 C[C@H]1CN(C)Cc2onc(C3CC3)c2/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790057 (10S,17E)-16-cyclopropyl-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 173 Epidermal growth factor receptor [L858R] Homo sapiens 513 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790057 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790057&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580696 C[C@H]1CN(C)Cc2onc(C3CC3)c2/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790057 (10S,17E)-16-cyclopropyl-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 173 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 45.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790057 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790057&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580697 C[C@H]1CN(C)Cc2onc(C3CC3)c2/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790057 (10S,17E)-16-cyclopropyl-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 173 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 27.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790057 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790057&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580698 C[C@H]1CN(C)Cc2onc(C3CC3)c2/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790057 (10S,17E)-16-cyclopropyl-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 173 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 533 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790057 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790057&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580699 C[C@H]1CN(C)Cc2onc(C3CC3)c2/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790057 (10S,17E)-16-cyclopropyl-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 173 Epidermal growth factor receptor [1-745,751-1210,C797S] 127 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790057 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790057&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580700 C[C@H]1CN(C)Cc2onc(C3CC3)c2/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790057 (10S,17E)-16-cyclopropyl-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 173 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790057 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790057&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580701 C[C@H]1CN(C)Cc2onc(C3CC3)c2/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790057 (10S,17E)-16-cyclopropyl-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 173 Epidermal growth factor receptor Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790057 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790057&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580702 CCc1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790058 (10S,17E)-16-ethyl-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 174 Epidermal growth factor receptor [L858R] Homo sapiens 127 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790058 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790058&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580703 CCc1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790058 (10S,17E)-16-ethyl-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 174 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 10.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790058 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790058&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580704 CCc1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790058 (10S,17E)-16-ethyl-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 174 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 4.88 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790058 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790058&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580705 CCc1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790058 (10S,17E)-16-ethyl-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 174 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 133 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790058 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790058&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580706 CCc1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790058 (10S,17E)-16-ethyl-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 174 Epidermal growth factor receptor [1-745,751-1210,C797S] 27.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790058 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790058&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580707 CCc1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790058 (10S,17E)-16-ethyl-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 174 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 996 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790058 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790058&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580708 CCc1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790058 (10S,17E)-16-ethyl-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 174 Epidermal growth factor receptor Homo sapiens 752 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790058 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790058&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580709 C[C@H]1CN(C)Cc2c(c(OC3CCN(S(C)(=O)=O)CC3)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790059 2-[(10S,17E)-16-{[1- (methanesulfonyl)piperidin-4-yl]oxy}- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 175 Epidermal growth factor receptor [L858R] Homo sapiens 42.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790059 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790059&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580710 C[C@H]1CN(C)Cc2c(c(OC3CCN(S(C)(=O)=O)CC3)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790059 2-[(10S,17E)-16-{[1- (methanesulfonyl)piperidin-4-yl]oxy}- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 175 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 2.06 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790059 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790059&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580711 C[C@H]1CN(C)Cc2c(c(OC3CCN(S(C)(=O)=O)CC3)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790059 2-[(10S,17E)-16-{[1- (methanesulfonyl)piperidin-4-yl]oxy}- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 175 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 3.39 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790059 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790059&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580712 C[C@H]1CN(C)Cc2c(c(OC3CCN(S(C)(=O)=O)CC3)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790059 2-[(10S,17E)-16-{[1- (methanesulfonyl)piperidin-4-yl]oxy}- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 175 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 67.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790059 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790059&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580713 C[C@H]1CN(C)Cc2c(c(OC3CCN(S(C)(=O)=O)CC3)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790059 2-[(10S,17E)-16-{[1- (methanesulfonyl)piperidin-4-yl]oxy}- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 175 Epidermal growth factor receptor [1-745,751-1210,C797S] 8.97 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790059 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790059&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580714 C[C@H]1CN(C)Cc2c(c(OC3CCN(S(C)(=O)=O)CC3)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790059 2-[(10S,17E)-16-{[1- (methanesulfonyl)piperidin-4-yl]oxy}- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 175 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 713 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790059 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790059&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580715 C[C@H]1CN(C)Cc2c(c(OC3CCN(S(C)(=O)=O)CC3)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790059 2-[(10S,17E)-16-{[1- (methanesulfonyl)piperidin-4-yl]oxy}- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 175 Epidermal growth factor receptor Homo sapiens 176 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790059 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790059&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580716 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H]1CCCN(C2)C1 790060 (10S,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 176 Epidermal growth factor receptor [L858R] Homo sapiens 55.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790060 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790060&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580717 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H]1CCCN(C2)C1 790060 (10S,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 176 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 6.94 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790060 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790060&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580718 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H]1CCCN(C2)C1 790060 (10S,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 176 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 13.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790060 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790060&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580719 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H]1CCCN(C2)C1 790060 (10S,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 176 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 24.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790060 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790060&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580720 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H]1CCCN(C2)C1 790060 (10S,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 176 Epidermal growth factor receptor [1-745,751-1210,C797S] 35.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790060 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790060&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580721 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H]1CCCN(C2)C1 790060 (10S,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 176 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 83.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790060 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790060&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580722 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H]1CCCN(C2)C1 790060 (10S,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 176 Epidermal growth factor receptor Homo sapiens 152 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790060 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790060&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580723 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790061 2-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 177 Epidermal growth factor receptor [L858R] Homo sapiens 0.380 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790061 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790061&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580724 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790061 2-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 177 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.600 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790061 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790061&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580725 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790061 2-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 177 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 1.78 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790061 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790061&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580726 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790061 2-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 177 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 0.560 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790061 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790061&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580727 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790061 2-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 177 Epidermal growth factor receptor [1-745,751-1210,C797S] 0.750 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790061 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790061&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580728 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790061 2-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 177 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 1.56 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790061 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790061&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580729 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790061 2-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 177 Epidermal growth factor receptor Homo sapiens 0.670 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790061 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790061&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580730 CCOc1nn(C)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790062 2-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 178 Epidermal growth factor receptor [L858R] Homo sapiens 8.73 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790062 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790062&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580731 CCOc1nn(C)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790062 2-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 178 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 4.35 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790062 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790062&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580732 CCOc1nn(C)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790062 2-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 178 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 19.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790062 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790062&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580733 CCOc1nn(C)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790062 2-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 178 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 6.90 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790062 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790062&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580734 CCOc1nn(C)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790062 2-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 178 Epidermal growth factor receptor [1-745,751-1210,C797S] 5.25 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790062 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790062&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580735 CCOc1nn(C)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790062 2-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 178 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 232 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790062 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790062&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580736 CCOc1nn(C)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790062 2-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 178 Epidermal growth factor receptor Homo sapiens 22.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790062 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790062&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580737 CC(C)c1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790063 (10S,17E)-8,10,12-trimethyl-16-(propan- 2-yl)-2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 179 Epidermal growth factor receptor [L858R] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790063 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790063&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580738 CC(C)c1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790063 (10S,17E)-8,10,12-trimethyl-16-(propan- 2-yl)-2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 179 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 1014 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790063 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790063&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580739 CC(C)c1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790063 (10S,17E)-8,10,12-trimethyl-16-(propan- 2-yl)-2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 179 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 507 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790063 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790063&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580740 CC(C)c1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790063 (10S,17E)-8,10,12-trimethyl-16-(propan- 2-yl)-2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 179 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790063 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790063&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580741 CC(C)c1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790063 (10S,17E)-8,10,12-trimethyl-16-(propan- 2-yl)-2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 179 Epidermal growth factor receptor [1-745,751-1210,C797S] >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790063 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790063&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580742 CC(C)c1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790063 (10S,17E)-8,10,12-trimethyl-16-(propan- 2-yl)-2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 179 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790063 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790063&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580743 CC(C)c1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790063 (10S,17E)-8,10,12-trimethyl-16-(propan- 2-yl)-2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 179 Epidermal growth factor receptor Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790063 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790063&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580744 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790064 2-{(10S,17E)-19-fluoro-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 181 Epidermal growth factor receptor [L858R] Homo sapiens 1.80 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790064 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790064&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580745 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790064 2-{(10S,17E)-19-fluoro-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 181 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 1.29 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790064 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790064&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580746 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790064 2-{(10S,17E)-19-fluoro-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 181 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 2.50 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790064 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790064&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580747 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790064 2-{(10S,17E)-19-fluoro-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 181 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 2.23 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790064 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790064&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580748 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790064 2-{(10S,17E)-19-fluoro-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 181 Epidermal growth factor receptor [1-745,751-1210,C797S] 1.68 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790064 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790064&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580749 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790064 2-{(10S,17E)-19-fluoro-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 181 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 84.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790064 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790064&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580750 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790064 2-{(10S,17E)-19-fluoro-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 181 Epidermal growth factor receptor Homo sapiens 12.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790064 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790064&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580751 C[C@H]1CN(C)Cc2c(c(O[C@H]3CCN(S(C)(=O)=O)C3)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790065 2-[(10S,17E)-16-{[(3S)-1- (methanesulfonyl)pyrrolidin-3-yl]oxy}- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 182 Epidermal growth factor receptor [L858R] Homo sapiens 24.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790065 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790065&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580752 C[C@H]1CN(C)Cc2c(c(O[C@H]3CCN(S(C)(=O)=O)C3)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790065 2-[(10S,17E)-16-{[(3S)-1- (methanesulfonyl)pyrrolidin-3-yl]oxy}- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 182 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.540 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790065 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790065&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580753 C[C@H]1CN(C)Cc2c(c(O[C@H]3CCN(S(C)(=O)=O)C3)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790065 2-[(10S,17E)-16-{[(3S)-1- (methanesulfonyl)pyrrolidin-3-yl]oxy}- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 182 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 1.37 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790065 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790065&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580754 C[C@H]1CN(C)Cc2c(c(O[C@H]3CCN(S(C)(=O)=O)C3)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790065 2-[(10S,17E)-16-{[(3S)-1- (methanesulfonyl)pyrrolidin-3-yl]oxy}- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 182 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 24.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790065 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790065&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580755 C[C@H]1CN(C)Cc2c(c(O[C@H]3CCN(S(C)(=O)=O)C3)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790065 2-[(10S,17E)-16-{[(3S)-1- (methanesulfonyl)pyrrolidin-3-yl]oxy}- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 182 Epidermal growth factor receptor [1-745,751-1210,C797S] 6.60 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790065 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790065&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580756 C[C@H]1CN(C)Cc2c(c(O[C@H]3CCN(S(C)(=O)=O)C3)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790065 2-[(10S,17E)-16-{[(3S)-1- (methanesulfonyl)pyrrolidin-3-yl]oxy}- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 182 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 300 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790065 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790065&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580757 C[C@H]1CN(C)Cc2c(c(O[C@H]3CCN(S(C)(=O)=O)C3)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790065 2-[(10S,17E)-16-{[(3S)-1- (methanesulfonyl)pyrrolidin-3-yl]oxy}- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 182 Epidermal growth factor receptor Homo sapiens 139 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790065 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790065&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580758 CCOc1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790066 (10S,17E)-16-ethoxy-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 183 Epidermal growth factor receptor [L858R] Homo sapiens 61.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790066 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790066&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580759 CCOc1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790066 (10S,17E)-16-ethoxy-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 183 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.650 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790066 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790066&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580760 CCOc1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790066 (10S,17E)-16-ethoxy-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 183 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 1.05 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790066 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790066&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580761 CCOc1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790066 (10S,17E)-16-ethoxy-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 183 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 53.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790066 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790066&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580762 CCOc1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790066 (10S,17E)-16-ethoxy-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 183 Epidermal growth factor receptor [1-745,751-1210,C797S] 17.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790066 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790066&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580763 CCOc1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790066 (10S,17E)-16-ethoxy-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 183 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 534 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790066 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790066&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580764 CCOc1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790066 (10S,17E)-16-ethoxy-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 183 Epidermal growth factor receptor Homo sapiens 195 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790066 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790066&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580765 C[C@H]1CN(C)Cc2c(c(O)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790067 (10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-16- ol::US20250353864, Example 186 Epidermal growth factor receptor [L858R] Homo sapiens 14.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790067 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790067&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580766 C[C@H]1CN(C)Cc2c(c(O)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790067 (10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-16- ol::US20250353864, Example 186 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 1.48 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790067 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790067&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580767 C[C@H]1CN(C)Cc2c(c(O)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790067 (10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-16- ol::US20250353864, Example 186 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.460 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790067 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790067&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580768 C[C@H]1CN(C)Cc2c(c(O)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790067 (10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-16- ol::US20250353864, Example 186 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 12.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790067 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790067&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580769 C[C@H]1CN(C)Cc2c(c(O)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790067 (10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-16- ol::US20250353864, Example 186 Epidermal growth factor receptor [1-745,751-1210,C797S] 3.06 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790067 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790067&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580770 C[C@H]1CN(C)Cc2c(c(O)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790067 (10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-16- ol::US20250353864, Example 186 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 59.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790067 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790067&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580771 C[C@H]1CN(C)Cc2c(c(O)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790067 (10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-16- ol::US20250353864, Example 186 Epidermal growth factor receptor Homo sapiens 43.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790067 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790067&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580772 C[C@H]1CN(C)Cc2c(c(OC3CC(S(C)(=O)=O)C3)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790068 (10S,17E)-16-{[3- (methanesulfonyl)cyclobutyl]oxy}- 8,10,12,14-tetramethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 187 Epidermal growth factor receptor [L858R] Homo sapiens 6.88 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790068 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790068&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580773 C[C@H]1CN(C)Cc2c(c(OC3CC(S(C)(=O)=O)C3)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790068 (10S,17E)-16-{[3- (methanesulfonyl)cyclobutyl]oxy}- 8,10,12,14-tetramethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 187 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.470 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790068 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790068&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580774 C[C@H]1CN(C)Cc2c(c(OC3CC(S(C)(=O)=O)C3)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790068 (10S,17E)-16-{[3- (methanesulfonyl)cyclobutyl]oxy}- 8,10,12,14-tetramethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 187 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.330 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790068 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790068&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580775 C[C@H]1CN(C)Cc2c(c(OC3CC(S(C)(=O)=O)C3)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790068 (10S,17E)-16-{[3- (methanesulfonyl)cyclobutyl]oxy}- 8,10,12,14-tetramethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 187 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 8.88 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790068 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790068&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580776 C[C@H]1CN(C)Cc2c(c(OC3CC(S(C)(=O)=O)C3)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790068 (10S,17E)-16-{[3- (methanesulfonyl)cyclobutyl]oxy}- 8,10,12,14-tetramethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 187 Epidermal growth factor receptor [1-745,751-1210,C797S] 7.84 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790068 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790068&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580777 C[C@H]1CN(C)Cc2c(c(OC3CC(S(C)(=O)=O)C3)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790068 (10S,17E)-16-{[3- (methanesulfonyl)cyclobutyl]oxy}- 8,10,12,14-tetramethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 187 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 74.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790068 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790068&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580778 C[C@H]1CN(C)Cc2c(c(OC3CC(S(C)(=O)=O)C3)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790068 (10S,17E)-16-{[3- (methanesulfonyl)cyclobutyl]oxy}- 8,10,12,14-tetramethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 187 Epidermal growth factor receptor Homo sapiens 25.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790068 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790068&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580779 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790069 2-[(10R,19E)-18-ethoxy-22-fluoro-8- methyl-2,10,11,12,13,15-hexahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecin-16(8H)- yl]ethan-1-ol::US20250353864, Example 191 Epidermal growth factor receptor [L858R] Homo sapiens 5.61 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790069 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790069&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580780 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790069 2-[(10R,19E)-18-ethoxy-22-fluoro-8- methyl-2,10,11,12,13,15-hexahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecin-16(8H)- yl]ethan-1-ol::US20250353864, Example 191 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 4.23 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790069 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790069&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580781 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790069 2-[(10R,19E)-18-ethoxy-22-fluoro-8- methyl-2,10,11,12,13,15-hexahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecin-16(8H)- yl]ethan-1-ol::US20250353864, Example 191 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 2.63 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790069 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790069&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580782 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790069 2-[(10R,19E)-18-ethoxy-22-fluoro-8- methyl-2,10,11,12,13,15-hexahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecin-16(8H)- yl]ethan-1-ol::US20250353864, Example 191 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 9.04 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790069 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790069&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580783 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790069 2-[(10R,19E)-18-ethoxy-22-fluoro-8- methyl-2,10,11,12,13,15-hexahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecin-16(8H)- yl]ethan-1-ol::US20250353864, Example 191 Epidermal growth factor receptor [1-745,751-1210,C797S] 4.19 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790069 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790069&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580784 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790069 2-[(10R,19E)-18-ethoxy-22-fluoro-8- methyl-2,10,11,12,13,15-hexahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecin-16(8H)- yl]ethan-1-ol::US20250353864, Example 191 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 102 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790069 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790069&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580785 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790069 2-[(10R,19E)-18-ethoxy-22-fluoro-8- methyl-2,10,11,12,13,15-hexahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecin-16(8H)- yl]ethan-1-ol::US20250353864, Example 191 Epidermal growth factor receptor Homo sapiens 19.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790069 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790069&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580786 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790070 2-{(10R,17E)-8,10-dimethyl-12-(propan- 2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 193 Epidermal growth factor receptor [L858R] Homo sapiens 36.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790070 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790070&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580787 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790070 2-{(10R,17E)-8,10-dimethyl-12-(propan- 2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 193 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 2.42 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790070 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790070&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580788 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790070 2-{(10R,17E)-8,10-dimethyl-12-(propan- 2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 193 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 1.05 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790070 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790070&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580789 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790070 2-{(10R,17E)-8,10-dimethyl-12-(propan- 2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 193 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 10.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790070 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790070&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580790 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790070 2-{(10R,17E)-8,10-dimethyl-12-(propan- 2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 193 Epidermal growth factor receptor [1-745,751-1210,C797S] 5.92 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790070 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790070&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580791 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790070 2-{(10R,17E)-8,10-dimethyl-12-(propan- 2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 193 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 77.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790070 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790070&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580792 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790070 2-{(10R,17E)-8,10-dimethyl-12-(propan- 2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 193 Epidermal growth factor receptor Homo sapiens 90.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790070 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790070&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580793 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790071 2-{(10R,17E)-19-fluoro-8,10-dimethyl- 12-(propan-2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 195 Epidermal growth factor receptor [L858R] Homo sapiens 39.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790071 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790071&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580794 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790071 2-{(10R,17E)-19-fluoro-8,10-dimethyl- 12-(propan-2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 195 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 6.18 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790071 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790071&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580795 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790071 2-{(10R,17E)-19-fluoro-8,10-dimethyl- 12-(propan-2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 195 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 3.67 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790071 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790071&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580796 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790071 2-{(10R,17E)-19-fluoro-8,10-dimethyl- 12-(propan-2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 195 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 18.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790071 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790071&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580797 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790071 2-{(10R,17E)-19-fluoro-8,10-dimethyl- 12-(propan-2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 195 Epidermal growth factor receptor [1-745,751-1210,C797S] 8.68 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790071 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790071&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580798 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790071 2-{(10R,17E)-19-fluoro-8,10-dimethyl- 12-(propan-2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 195 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 156 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790071 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790071&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580799 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790071 2-{(10R,17E)-19-fluoro-8,10-dimethyl- 12-(propan-2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 195 Epidermal growth factor receptor Homo sapiens 99.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790071 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790071&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580800 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CNC2 790072 2-[(10R,17E)-16-ethoxy-8,10-dimethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 197 Epidermal growth factor receptor [L858R] Homo sapiens 95.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790072 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790072&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580801 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CNC2 790072 2-[(10R,17E)-16-ethoxy-8,10-dimethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 197 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 4.58 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790072 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790072&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580802 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CNC2 790072 2-[(10R,17E)-16-ethoxy-8,10-dimethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 197 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 2.18 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790072 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790072&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580803 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CNC2 790072 2-[(10R,17E)-16-ethoxy-8,10-dimethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 197 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 62.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790072 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790072&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580804 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CNC2 790072 2-[(10R,17E)-16-ethoxy-8,10-dimethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 197 Epidermal growth factor receptor [1-745,751-1210,C797S] 29.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790072 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790072&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580805 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CNC2 790072 2-[(10R,17E)-16-ethoxy-8,10-dimethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 197 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 217 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790072 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790072&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580806 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CNC2 790072 2-[(10R,17E)-16-ethoxy-8,10-dimethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 197 Epidermal growth factor receptor Homo sapiens 194 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790072 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790072&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580807 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC[C@H](C)N(C1CC1)C2 790073 2-[(11S,17E)-12-cyclopropyl-16-ethoxy- 8,11-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 198 Epidermal growth factor receptor [L858R] Homo sapiens 13.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790073 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790073&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580808 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC[C@H](C)N(C1CC1)C2 790073 2-[(11S,17E)-12-cyclopropyl-16-ethoxy- 8,11-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 198 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.890 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790073 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790073&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580809 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC[C@H](C)N(C1CC1)C2 790073 2-[(11S,17E)-12-cyclopropyl-16-ethoxy- 8,11-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 198 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.260 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790073 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790073&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580810 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC[C@H](C)N(C1CC1)C2 790073 2-[(11S,17E)-12-cyclopropyl-16-ethoxy- 8,11-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 198 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 5.84 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790073 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790073&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580811 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC[C@H](C)N(C1CC1)C2 790073 2-[(11S,17E)-12-cyclopropyl-16-ethoxy- 8,11-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 198 Epidermal growth factor receptor [1-745,751-1210,C797S] 1.96 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790073 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790073&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580812 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC[C@H](C)N(C1CC1)C2 790073 2-[(11S,17E)-12-cyclopropyl-16-ethoxy- 8,11-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 198 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 47.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790073 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790073&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580813 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC[C@H](C)N(C1CC1)C2 790073 2-[(11S,17E)-12-cyclopropyl-16-ethoxy- 8,11-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 198 Epidermal growth factor receptor Homo sapiens 36.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790073 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790073&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580814 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790074 2-[(10R,19E)-22-fluoro-8-methyl-18- [(propan-2-yl)oxy]-2,10,11,12,13,15- hexahydro-3,5-etheno-10,14- methanotripyrazolo[3,4-h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecin-16(8H)- yl]ethan-1-ol::US20250353864, Example 199 Epidermal growth factor receptor [L858R] Homo sapiens 87.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790074 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790074&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580815 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790074 2-[(10R,19E)-22-fluoro-8-methyl-18- [(propan-2-yl)oxy]-2,10,11,12,13,15- hexahydro-3,5-etheno-10,14- methanotripyrazolo[3,4-h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecin-16(8H)- yl]ethan-1-ol::US20250353864, Example 199 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 64.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790074 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790074&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580816 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790074 2-[(10R,19E)-22-fluoro-8-methyl-18- [(propan-2-yl)oxy]-2,10,11,12,13,15- hexahydro-3,5-etheno-10,14- methanotripyrazolo[3,4-h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecin-16(8H)- yl]ethan-1-ol::US20250353864, Example 199 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 43.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790074 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790074&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580817 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790074 2-[(10R,19E)-22-fluoro-8-methyl-18- [(propan-2-yl)oxy]-2,10,11,12,13,15- hexahydro-3,5-etheno-10,14- methanotripyrazolo[3,4-h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecin-16(8H)- yl]ethan-1-ol::US20250353864, Example 199 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 147 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790074 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790074&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580818 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790074 2-[(10R,19E)-22-fluoro-8-methyl-18- [(propan-2-yl)oxy]-2,10,11,12,13,15- hexahydro-3,5-etheno-10,14- methanotripyrazolo[3,4-h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecin-16(8H)- yl]ethan-1-ol::US20250353864, Example 199 Epidermal growth factor receptor [1-745,751-1210,C797S] 42.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790074 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790074&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580819 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790074 2-[(10R,19E)-22-fluoro-8-methyl-18- [(propan-2-yl)oxy]-2,10,11,12,13,15- hexahydro-3,5-etheno-10,14- methanotripyrazolo[3,4-h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecin-16(8H)- yl]ethan-1-ol::US20250353864, Example 199 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790074 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790074&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580820 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790074 2-[(10R,19E)-22-fluoro-8-methyl-18- [(propan-2-yl)oxy]-2,10,11,12,13,15- hexahydro-3,5-etheno-10,14- methanotripyrazolo[3,4-h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecin-16(8H)- yl]ethan-1-ol::US20250353864, Example 199 Epidermal growth factor receptor Homo sapiens 1284 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790074 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790074&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580821 CC(C)Oc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790075 (2S)-2-{(10S,17E)-19-fluoro-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-1-ol::US20250353864, Example 200 Epidermal growth factor receptor [L858R] Homo sapiens 2.01 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790075 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790075&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580822 CC(C)Oc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790075 (2S)-2-{(10S,17E)-19-fluoro-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-1-ol::US20250353864, Example 200 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 1.41 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790075 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790075&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580823 CC(C)Oc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790075 (2S)-2-{(10S,17E)-19-fluoro-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-1-ol::US20250353864, Example 200 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.690 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790075 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790075&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580824 CC(C)Oc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790075 (2S)-2-{(10S,17E)-19-fluoro-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-1-ol::US20250353864, Example 200 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 4.08 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790075 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790075&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580825 CC(C)Oc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790075 (2S)-2-{(10S,17E)-19-fluoro-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-1-ol::US20250353864, Example 200 Epidermal growth factor receptor [1-745,751-1210,C797S] 1.93 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790075 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790075&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580826 CC(C)Oc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790075 (2S)-2-{(10S,17E)-19-fluoro-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-1-ol::US20250353864, Example 200 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 59.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790075 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790075&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580827 CC(C)Oc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790075 (2S)-2-{(10S,17E)-19-fluoro-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-1-ol::US20250353864, Example 200 Epidermal growth factor receptor Homo sapiens 6.46 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790075 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790075&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580828 Cc1nn(C)c2c1-c1ccc3[nH]nc(c3c1)/C=C/c1c(OC(C)C)nn(CCO)c1CN(C(C)C)C[C@@H](C)O2 790076 2-{(10R,17E)-6,8,10-trimethyl-12- (propan-2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 202 Epidermal growth factor receptor [L858R] Homo sapiens 98.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790076 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790076&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580829 Cc1nn(C)c2c1-c1ccc3[nH]nc(c3c1)/C=C/c1c(OC(C)C)nn(CCO)c1CN(C(C)C)C[C@@H](C)O2 790076 2-{(10R,17E)-6,8,10-trimethyl-12- (propan-2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 202 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 3.38 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790076 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790076&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580830 Cc1nn(C)c2c1-c1ccc3[nH]nc(c3c1)/C=C/c1c(OC(C)C)nn(CCO)c1CN(C(C)C)C[C@@H](C)O2 790076 2-{(10R,17E)-6,8,10-trimethyl-12- (propan-2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 202 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 2.00 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790076 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790076&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580831 Cc1nn(C)c2c1-c1ccc3[nH]nc(c3c1)/C=C/c1c(OC(C)C)nn(CCO)c1CN(C(C)C)C[C@@H](C)O2 790076 2-{(10R,17E)-6,8,10-trimethyl-12- (propan-2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 202 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 45.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790076 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790076&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580832 Cc1nn(C)c2c1-c1ccc3[nH]nc(c3c1)/C=C/c1c(OC(C)C)nn(CCO)c1CN(C(C)C)C[C@@H](C)O2 790076 2-{(10R,17E)-6,8,10-trimethyl-12- (propan-2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 202 Epidermal growth factor receptor [1-745,751-1210,C797S] 20.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790076 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790076&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580833 Cc1nn(C)c2c1-c1ccc3[nH]nc(c3c1)/C=C/c1c(OC(C)C)nn(CCO)c1CN(C(C)C)C[C@@H](C)O2 790076 2-{(10R,17E)-6,8,10-trimethyl-12- (propan-2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 202 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 423 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790076 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790076&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580834 Cc1nn(C)c2c1-c1ccc3[nH]nc(c3c1)/C=C/c1c(OC(C)C)nn(CCO)c1CN(C(C)C)C[C@@H](C)O2 790076 2-{(10R,17E)-6,8,10-trimethyl-12- (propan-2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 202 Epidermal growth factor receptor Homo sapiens 179 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790076 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790076&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580835 C[C@H]1CN(C)Cc2c(c(OCC#N)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790077 {[(10S,17E)-14-(2-hydroxyethyl)- 8,10,12-trimethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}acetonitrile::US20250353864, Example 203 Epidermal growth factor receptor [L858R] Homo sapiens 0.120 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790077 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790077&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580836 C[C@H]1CN(C)Cc2c(c(OCC#N)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790077 {[(10S,17E)-14-(2-hydroxyethyl)- 8,10,12-trimethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}acetonitrile::US20250353864, Example 203 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.170 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790077 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790077&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580837 C[C@H]1CN(C)Cc2c(c(OCC#N)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790077 {[(10S,17E)-14-(2-hydroxyethyl)- 8,10,12-trimethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}acetonitrile::US20250353864, Example 203 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.780 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790077 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790077&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580838 C[C@H]1CN(C)Cc2c(c(OCC#N)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790077 {[(10S,17E)-14-(2-hydroxyethyl)- 8,10,12-trimethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}acetonitrile::US20250353864, Example 203 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 0.110 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790077 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790077&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580839 C[C@H]1CN(C)Cc2c(c(OCC#N)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790077 {[(10S,17E)-14-(2-hydroxyethyl)- 8,10,12-trimethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}acetonitrile::US20250353864, Example 203 Epidermal growth factor receptor [1-745,751-1210,C797S] 0.230 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790077 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790077&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580840 C[C@H]1CN(C)Cc2c(c(OCC#N)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790077 {[(10S,17E)-14-(2-hydroxyethyl)- 8,10,12-trimethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}acetonitrile::US20250353864, Example 203 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 0.650 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790077 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790077&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580841 C[C@H]1CN(C)Cc2c(c(OCC#N)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790077 {[(10S,17E)-14-(2-hydroxyethyl)- 8,10,12-trimethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}acetonitrile::US20250353864, Example 203 Epidermal growth factor receptor Homo sapiens 0.230 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790077 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790077&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580842 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1c(C)nn(C)c1O[C@H](C)CN(C1CC1)C2 790078 2-[(10R,17E)-12-cyclopropyl-16-ethoxy- 6,8,10-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo|3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 204 Epidermal growth factor receptor [L858R] Homo sapiens 5.50 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790078 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790078&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580843 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1c(C)nn(C)c1O[C@H](C)CN(C1CC1)C2 790078 2-[(10R,17E)-12-cyclopropyl-16-ethoxy- 6,8,10-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo|3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 204 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 1.77 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790078 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790078&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580844 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1c(C)nn(C)c1O[C@H](C)CN(C1CC1)C2 790078 2-[(10R,17E)-12-cyclopropyl-16-ethoxy- 6,8,10-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo|3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 204 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 2.53 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790078 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790078&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580845 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1c(C)nn(C)c1O[C@H](C)CN(C1CC1)C2 790078 2-[(10R,17E)-12-cyclopropyl-16-ethoxy- 6,8,10-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo|3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 204 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 1.85 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790078 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790078&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580846 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1c(C)nn(C)c1O[C@H](C)CN(C1CC1)C2 790078 2-[(10R,17E)-12-cyclopropyl-16-ethoxy- 6,8,10-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo|3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 204 Epidermal growth factor receptor [1-745,751-1210,C797S] 1.93 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790078 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790078&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580847 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1c(C)nn(C)c1O[C@H](C)CN(C1CC1)C2 790078 2-[(10R,17E)-12-cyclopropyl-16-ethoxy- 6,8,10-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo|3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 204 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 20.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790078 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790078&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580848 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1c(C)nn(C)c1O[C@H](C)CN(C1CC1)C2 790078 2-[(10R,17E)-12-cyclopropyl-16-ethoxy- 6,8,10-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo|3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 204 Epidermal growth factor receptor Homo sapiens 5.49 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790078 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790078&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580849 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1c(C)nn(C)c1OC[C@H](C)N(C1CC1)C2 790079 2-[(11S,17E)-12-cyclopropyl-16-ethoxy- 6,8,11-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 205 Epidermal growth factor receptor [L858R] Homo sapiens 16.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790079 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790079&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580850 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1c(C)nn(C)c1OC[C@H](C)N(C1CC1)C2 790079 2-[(11S,17E)-12-cyclopropyl-16-ethoxy- 6,8,11-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 205 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 1.000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790079 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790079&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580851 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1c(C)nn(C)c1OC[C@H](C)N(C1CC1)C2 790079 2-[(11S,17E)-12-cyclopropyl-16-ethoxy- 6,8,11-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 205 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 1.13 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790079 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790079&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580852 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1c(C)nn(C)c1OC[C@H](C)N(C1CC1)C2 790079 2-[(11S,17E)-12-cyclopropyl-16-ethoxy- 6,8,11-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 205 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 5.17 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790079 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790079&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580853 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1c(C)nn(C)c1OC[C@H](C)N(C1CC1)C2 790079 2-[(11S,17E)-12-cyclopropyl-16-ethoxy- 6,8,11-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 205 Epidermal growth factor receptor [1-745,751-1210,C797S] 1.42 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790079 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790079&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580854 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1c(C)nn(C)c1OC[C@H](C)N(C1CC1)C2 790079 2-[(11S,17E)-12-cyclopropyl-16-ethoxy- 6,8,11-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 205 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 137 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790079 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790079&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580855 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1c(C)nn(C)c1OC[C@H](C)N(C1CC1)C2 790079 2-[(11S,17E)-12-cyclopropyl-16-ethoxy- 6,8,11-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 205 Epidermal growth factor receptor Homo sapiens 58.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790079 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790079&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580856 CCOc1nn(C)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790080 (10S,17E)-16-ethoxy-12-ethyl-19-fluoro- 8,10,14-trimethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 206 Epidermal growth factor receptor [L858R] Homo sapiens 1.69 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790080 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790080&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580857 CCOc1nn(C)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790080 (10S,17E)-16-ethoxy-12-ethyl-19-fluoro- 8,10,14-trimethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 206 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.520 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790080 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790080&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580858 CCOc1nn(C)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790080 (10S,17E)-16-ethoxy-12-ethyl-19-fluoro- 8,10,14-trimethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 206 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 1.46 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790080 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790080&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580859 CCOc1nn(C)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790080 (10S,17E)-16-ethoxy-12-ethyl-19-fluoro- 8,10,14-trimethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 206 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 0.760 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790080 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790080&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580860 CCOc1nn(C)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790080 (10S,17E)-16-ethoxy-12-ethyl-19-fluoro- 8,10,14-trimethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 206 Epidermal growth factor receptor [1-745,751-1210,C797S] 0.740 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790080 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790080&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580861 CCOc1nn(C)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790080 (10S,17E)-16-ethoxy-12-ethyl-19-fluoro- 8,10,14-trimethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 206 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 43.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790080 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790080&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580862 CCOc1nn(C)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790080 (10S,17E)-16-ethoxy-12-ethyl-19-fluoro- 8,10,14-trimethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 206 Epidermal growth factor receptor Homo sapiens 3.33 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790080 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790080&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580863 CC(C)Oc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790081 (2S)-2-{(10R,17E)-8,10-dimethyl-12- (propan-2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-1-ol::US20250353864, Example 207 Epidermal growth factor receptor [L858R] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790081 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790081&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580864 CC(C)Oc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790081 (2S)-2-{(10R,17E)-8,10-dimethyl-12- (propan-2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-1-ol::US20250353864, Example 207 Epidermal growth factor receptor [T790M,L858R] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790081 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790081&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580865 CC(C)Oc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790081 (2S)-2-{(10R,17E)-8,10-dimethyl-12- (propan-2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-1-ol::US20250353864, Example 207 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790081 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790081&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580866 CC(C)Oc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790081 (2S)-2-{(10R,17E)-8,10-dimethyl-12- (propan-2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-1-ol::US20250353864, Example 207 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790081 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790081&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580867 CC(C)Oc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790081 (2S)-2-{(10R,17E)-8,10-dimethyl-12- (propan-2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-1-ol::US20250353864, Example 207 Epidermal growth factor receptor [1-745,751-1210,C797S] >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790081 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790081&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580868 CC(C)Oc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790081 (2S)-2-{(10R,17E)-8,10-dimethyl-12- (propan-2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-1-ol::US20250353864, Example 207 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790081 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790081&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580869 CC(C)Oc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790081 (2S)-2-{(10R,17E)-8,10-dimethyl-12- (propan-2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-1-ol::US20250353864, Example 207 Epidermal growth factor receptor Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790081 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790081&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580870 C[C@H]1CN(C)Cc2c(c(OCC(F)(F)F)nn2CCO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O1 790082 2-[(10S,17E)-19-fluoro-8,10,12- trimethyl-16-(2,2,2-trifluoroethoxy)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 211 Epidermal growth factor receptor [L858R] Homo sapiens 400 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790082 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790082&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580871 C[C@H]1CN(C)Cc2c(c(OCC(F)(F)F)nn2CCO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O1 790082 2-[(10S,17E)-19-fluoro-8,10,12- trimethyl-16-(2,2,2-trifluoroethoxy)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 211 Epidermal growth factor receptor [T790M,L858R] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790082 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790082&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580872 C[C@H]1CN(C)Cc2c(c(OCC(F)(F)F)nn2CCO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O1 790082 2-[(10S,17E)-19-fluoro-8,10,12- trimethyl-16-(2,2,2-trifluoroethoxy)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 211 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790082 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790082&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580873 C[C@H]1CN(C)Cc2c(c(OCC(F)(F)F)nn2CCO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O1 790082 2-[(10S,17E)-19-fluoro-8,10,12- trimethyl-16-(2,2,2-trifluoroethoxy)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 211 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790082 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790082&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580874 C[C@H]1CN(C)Cc2c(c(OCC(F)(F)F)nn2CCO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O1 790082 2-[(10S,17E)-19-fluoro-8,10,12- trimethyl-16-(2,2,2-trifluoroethoxy)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 211 Epidermal growth factor receptor [1-745,751-1210,C797S] 2872 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790082 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790082&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580875 C[C@H]1CN(C)Cc2c(c(OCC(F)(F)F)nn2CCO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O1 790082 2-[(10S,17E)-19-fluoro-8,10,12- trimethyl-16-(2,2,2-trifluoroethoxy)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 211 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790082 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790082&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580876 C[C@H]1CN(C)Cc2c(c(OCC(F)(F)F)nn2CCO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O1 790082 2-[(10S,17E)-19-fluoro-8,10,12- trimethyl-16-(2,2,2-trifluoroethoxy)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 211 Epidermal growth factor receptor Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790082 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790082&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580877 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C1CC1)C2 790083 2-{(10R,17E)-12-cyclopropyl-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 212 Epidermal growth factor receptor [L858R] Homo sapiens 52.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790083 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790083&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580878 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C1CC1)C2 790083 2-{(10R,17E)-12-cyclopropyl-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 212 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.570 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790083 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790083&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580879 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C1CC1)C2 790083 2-{(10R,17E)-12-cyclopropyl-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 212 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.420 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790083 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790083&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580880 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C1CC1)C2 790083 2-{(10R,17E)-12-cyclopropyl-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 212 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 16.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790083 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790083&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580881 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C1CC1)C2 790083 2-{(10R,17E)-12-cyclopropyl-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 212 Epidermal growth factor receptor [1-745,751-1210,C797S] 3.87 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790083 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790083&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580882 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C1CC1)C2 790083 2-{(10R,17E)-12-cyclopropyl-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 212 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 139 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790083 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790083&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580883 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C1CC1)C2 790083 2-{(10R,17E)-12-cyclopropyl-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 212 Epidermal growth factor receptor Homo sapiens 154 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790083 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790083&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580884 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC[C@H](C)N(C1CC1)C2 790084 2-{(11S,17E)-12-cyclopropyl-8,11- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 213 Epidermal growth factor receptor [L858R] Homo sapiens 82.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790084 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790084&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580885 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC[C@H](C)N(C1CC1)C2 790084 2-{(11S,17E)-12-cyclopropyl-8,11- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 213 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.420 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790084 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790084&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580886 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC[C@H](C)N(C1CC1)C2 790084 2-{(11S,17E)-12-cyclopropyl-8,11- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 213 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.200 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790084 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790084&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580887 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC[C@H](C)N(C1CC1)C2 790084 2-{(11S,17E)-12-cyclopropyl-8,11- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 213 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 21.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790084 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790084&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580888 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC[C@H](C)N(C1CC1)C2 790084 2-{(11S,17E)-12-cyclopropyl-8,11- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 213 Epidermal growth factor receptor [1-745,751-1210,C797S] 5.07 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790084 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790084&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580889 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC[C@H](C)N(C1CC1)C2 790084 2-{(11S,17E)-12-cyclopropyl-8,11- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 213 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 431 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790084 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790084&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580890 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC[C@H](C)N(C1CC1)C2 790084 2-{(11S,17E)-12-cyclopropyl-8,11- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 213 Epidermal growth factor receptor Homo sapiens 296 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790084 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790084&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580891 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790085 (2S)-2-[(10S,17E)-16-ethoxy-19-fluoro- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 214 Epidermal growth factor receptor [L858R] Homo sapiens 0.350 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790085 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790085&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580892 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790085 (2S)-2-[(10S,17E)-16-ethoxy-19-fluoro- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 214 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.200 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790085 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790085&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580893 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790085 (2S)-2-[(10S,17E)-16-ethoxy-19-fluoro- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 214 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.170 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790085 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790085&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580894 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790085 (2S)-2-[(10S,17E)-16-ethoxy-19-fluoro- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 214 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 0.220 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790085 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790085&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580895 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790085 (2S)-2-[(10S,17E)-16-ethoxy-19-fluoro- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 214 Epidermal growth factor receptor [1-745,751-1210,C797S] 0.480 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790085 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790085&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580896 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790085 (2S)-2-[(10S,17E)-16-ethoxy-19-fluoro- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 214 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 8.31 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790085 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790085&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580897 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790085 (2S)-2-[(10S,17E)-16-ethoxy-19-fluoro- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 214 Epidermal growth factor receptor Homo sapiens 0.770 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790085 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790085&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580898 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790086 (2S)-2-[(10S,17E)-16-ethoxy-12-ethyl- 19-fluoro-8,10-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo|3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 215 Epidermal growth factor receptor [L858R] Homo sapiens 1.70 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790086 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790086&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580899 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790086 (2S)-2-[(10S,17E)-16-ethoxy-12-ethyl- 19-fluoro-8,10-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo|3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 215 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 1.49 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790086 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790086&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580900 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790086 (2S)-2-[(10S,17E)-16-ethoxy-12-ethyl- 19-fluoro-8,10-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo|3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 215 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.890 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790086 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790086&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580901 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790086 (2S)-2-[(10S,17E)-16-ethoxy-12-ethyl- 19-fluoro-8,10-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo|3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 215 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 0.690 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790086 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790086&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580902 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790086 (2S)-2-[(10S,17E)-16-ethoxy-12-ethyl- 19-fluoro-8,10-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo|3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 215 Epidermal growth factor receptor [1-745,751-1210,C797S] 1.93 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790086 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790086&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580903 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790086 (2S)-2-[(10S,17E)-16-ethoxy-12-ethyl- 19-fluoro-8,10-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo|3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 215 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 3.75 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790086 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790086&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580904 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790086 (2S)-2-[(10S,17E)-16-ethoxy-12-ethyl- 19-fluoro-8,10-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo|3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 215 Epidermal growth factor receptor Homo sapiens 1.71 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790086 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790086&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580905 CCN1Cc2c(c(OC(C)C)nn2CCO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O[C@@H](C)C1 790087 2-{(10S,17E)-12-ethyl-19-fluoro-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 216 Epidermal growth factor receptor [L858R] Homo sapiens 2.22 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790087 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790087&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580906 CCN1Cc2c(c(OC(C)C)nn2CCO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O[C@@H](C)C1 790087 2-{(10S,17E)-12-ethyl-19-fluoro-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 216 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.440 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790087 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790087&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580907 CCN1Cc2c(c(OC(C)C)nn2CCO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O[C@@H](C)C1 790087 2-{(10S,17E)-12-ethyl-19-fluoro-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 216 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.370 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790087 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790087&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580908 CCN1Cc2c(c(OC(C)C)nn2CCO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O[C@@H](C)C1 790087 2-{(10S,17E)-12-ethyl-19-fluoro-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 216 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 0.470 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790087 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790087&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580909 CCN1Cc2c(c(OC(C)C)nn2CCO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O[C@@H](C)C1 790087 2-{(10S,17E)-12-ethyl-19-fluoro-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 216 Epidermal growth factor receptor [1-745,751-1210,C797S] 0.630 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790087 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790087&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580910 CCN1Cc2c(c(OC(C)C)nn2CCO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O[C@@H](C)C1 790087 2-{(10S,17E)-12-ethyl-19-fluoro-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 216 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 28.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790087 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790087&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580911 CCN1Cc2c(c(OC(C)C)nn2CCO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O[C@@H](C)C1 790087 2-{(10S,17E)-12-ethyl-19-fluoro-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 216 Epidermal growth factor receptor Homo sapiens 2.43 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790087 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790087&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580912 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)=O)C2 790088 1-[(10R,17E)-16-ethoxy-14-(2- hydroxyethyl)-8,10-dimethyl- 2,8,10,11,13,14-hexahydro-12H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-12- yl]ethan-1-one::US20250353864, Example 217 Epidermal growth factor receptor [L858R] Homo sapiens 37.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790088 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790088&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580913 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)=O)C2 790088 1-[(10R,17E)-16-ethoxy-14-(2- hydroxyethyl)-8,10-dimethyl- 2,8,10,11,13,14-hexahydro-12H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-12- yl]ethan-1-one::US20250353864, Example 217 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.690 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790088 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790088&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580914 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)=O)C2 790088 1-[(10R,17E)-16-ethoxy-14-(2- hydroxyethyl)-8,10-dimethyl- 2,8,10,11,13,14-hexahydro-12H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-12- yl]ethan-1-one::US20250353864, Example 217 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 1.42 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790088 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790088&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580915 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)=O)C2 790088 1-[(10R,17E)-16-ethoxy-14-(2- hydroxyethyl)-8,10-dimethyl- 2,8,10,11,13,14-hexahydro-12H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-12- yl]ethan-1-one::US20250353864, Example 217 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 3.61 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790088 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790088&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580916 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)=O)C2 790088 1-[(10R,17E)-16-ethoxy-14-(2- hydroxyethyl)-8,10-dimethyl- 2,8,10,11,13,14-hexahydro-12H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-12- yl]ethan-1-one::US20250353864, Example 217 Epidermal growth factor receptor [1-745,751-1210,C797S] 1.94 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790088 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790088&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580917 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)=O)C2 790088 1-[(10R,17E)-16-ethoxy-14-(2- hydroxyethyl)-8,10-dimethyl- 2,8,10,11,13,14-hexahydro-12H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-12- yl]ethan-1-one::US20250353864, Example 217 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 107 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790088 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790088&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580918 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)=O)C2 790088 1-[(10R,17E)-16-ethoxy-14-(2- hydroxyethyl)-8,10-dimethyl- 2,8,10,11,13,14-hexahydro-12H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-12- yl]ethan-1-one::US20250353864, Example 217 Epidermal growth factor receptor Homo sapiens 71.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790088 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790088&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580919 CCOC(=O)Cn1nc(OCC)c2c1CN(CC)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790089 ethyl[(10S,17E)-16-ethoxy-12-ethyl- 8,10-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]acetate::US20250353864, Example 218 Epidermal growth factor receptor [L858R] Homo sapiens 28.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790089 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790089&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580920 CCOC(=O)Cn1nc(OCC)c2c1CN(CC)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790089 ethyl[(10S,17E)-16-ethoxy-12-ethyl- 8,10-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]acetate::US20250353864, Example 218 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 1.99 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790089 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790089&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580921 CCOC(=O)Cn1nc(OCC)c2c1CN(CC)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790089 ethyl[(10S,17E)-16-ethoxy-12-ethyl- 8,10-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]acetate::US20250353864, Example 218 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 2.04 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790089 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790089&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580922 CCOC(=O)Cn1nc(OCC)c2c1CN(CC)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790089 ethyl[(10S,17E)-16-ethoxy-12-ethyl- 8,10-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]acetate::US20250353864, Example 218 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 8.48 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790089 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790089&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580923 CCOC(=O)Cn1nc(OCC)c2c1CN(CC)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790089 ethyl[(10S,17E)-16-ethoxy-12-ethyl- 8,10-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]acetate::US20250353864, Example 218 Epidermal growth factor receptor [1-745,751-1210,C797S] 16.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790089 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790089&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580924 CCOC(=O)Cn1nc(OCC)c2c1CN(CC)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790089 ethyl[(10S,17E)-16-ethoxy-12-ethyl- 8,10-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]acetate::US20250353864, Example 218 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 161 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790089 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790089&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580925 CCOC(=O)Cn1nc(OCC)c2c1CN(CC)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790089 ethyl[(10S,17E)-16-ethoxy-12-ethyl- 8,10-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]acetate::US20250353864, Example 218 Epidermal growth factor receptor Homo sapiens 119 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790089 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790089&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580926 CCN1Cc2c(c(OC(C)C)nn2[C@@H](C)CO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O[C@@H](C)C1 790090 (2S)-2-{(10S,17E)-12-ethyl-19-fluoro- 8,10-dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-1-ol::US20250353864, Example 219 Epidermal growth factor receptor [L858R] Homo sapiens 4.73 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790090 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790090&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580927 CCN1Cc2c(c(OC(C)C)nn2[C@@H](C)CO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O[C@@H](C)C1 790090 (2S)-2-{(10S,17E)-12-ethyl-19-fluoro- 8,10-dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-1-ol::US20250353864, Example 219 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 5.30 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790090 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790090&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580928 CCN1Cc2c(c(OC(C)C)nn2[C@@H](C)CO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O[C@@H](C)C1 790090 (2S)-2-{(10S,17E)-12-ethyl-19-fluoro- 8,10-dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-1-ol::US20250353864, Example 219 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 3.84 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790090 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790090&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580929 CCN1Cc2c(c(OC(C)C)nn2[C@@H](C)CO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O[C@@H](C)C1 790090 (2S)-2-{(10S,17E)-12-ethyl-19-fluoro- 8,10-dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-1-ol::US20250353864, Example 219 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 3.02 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790090 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790090&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580930 CCN1Cc2c(c(OC(C)C)nn2[C@@H](C)CO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O[C@@H](C)C1 790090 (2S)-2-{(10S,17E)-12-ethyl-19-fluoro- 8,10-dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-1-ol::US20250353864, Example 219 Epidermal growth factor receptor [1-745,751-1210,C797S] 5.13 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790090 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790090&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580931 CCN1Cc2c(c(OC(C)C)nn2[C@@H](C)CO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O[C@@H](C)C1 790090 (2S)-2-{(10S,17E)-12-ethyl-19-fluoro- 8,10-dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-1-ol::US20250353864, Example 219 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 21.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790090 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790090&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580932 CCN1Cc2c(c(OC(C)C)nn2[C@@H](C)CO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O[C@@H](C)C1 790090 (2S)-2-{(10S,17E)-12-ethyl-19-fluoro- 8,10-dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-1-ol::US20250353864, Example 219 Epidermal growth factor receptor Homo sapiens 7.25 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790090 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790090&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580933 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)C(=O)N(C)C2 790091 (10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,12,13,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-11(10H)- one::US20250353864, Example 220 Epidermal growth factor receptor [L858R] Homo sapiens 515 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790091 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790091&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580934 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)C(=O)N(C)C2 790091 (10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,12,13,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-11(10H)- one::US20250353864, Example 220 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 23.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790091 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790091&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580935 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)C(=O)N(C)C2 790091 (10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,12,13,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-11(10H)- one::US20250353864, Example 220 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 27.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790091 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790091&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580936 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)C(=O)N(C)C2 790091 (10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,12,13,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-11(10H)- one::US20250353864, Example 220 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 398 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790091 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790091&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580937 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)C(=O)N(C)C2 790091 (10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,12,13,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-11(10H)- one::US20250353864, Example 220 Epidermal growth factor receptor [1-745,751-1210,C797S] 475 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790091 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790091&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580938 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)C(=O)N(C)C2 790091 (10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,12,13,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-11(10H)- one::US20250353864, Example 220 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 574 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790091 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790091&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580939 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)C(=O)N(C)C2 790091 (10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,12,13,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-11(10H)- one::US20250353864, Example 220 Epidermal growth factor receptor Homo sapiens 1441 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790091 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790091&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580940 C[C@H]1CN(C)Cc2c(c(OC3CN(S(C)(=O)=O)C3)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790092 2-[(10S,17E)-16-{[1- (methanesulfonyl)azetidin-3-ylJoxy}- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 221 Epidermal growth factor receptor [L858R] Homo sapiens 0.970 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790092 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790092&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580941 C[C@H]1CN(C)Cc2c(c(OC3CN(S(C)(=O)=O)C3)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790092 2-[(10S,17E)-16-{[1- (methanesulfonyl)azetidin-3-ylJoxy}- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 221 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.210 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790092 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790092&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580942 C[C@H]1CN(C)Cc2c(c(OC3CN(S(C)(=O)=O)C3)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790092 2-[(10S,17E)-16-{[1- (methanesulfonyl)azetidin-3-ylJoxy}- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 221 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.140 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790092 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790092&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580943 C[C@H]1CN(C)Cc2c(c(OC3CN(S(C)(=O)=O)C3)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790092 2-[(10S,17E)-16-{[1- (methanesulfonyl)azetidin-3-ylJoxy}- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 221 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 0.550 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790092 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790092&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580944 C[C@H]1CN(C)Cc2c(c(OC3CN(S(C)(=O)=O)C3)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790092 2-[(10S,17E)-16-{[1- (methanesulfonyl)azetidin-3-ylJoxy}- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 221 Epidermal growth factor receptor [1-745,751-1210,C797S] 0.350 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790092 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790092&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580945 C[C@H]1CN(C)Cc2c(c(OC3CN(S(C)(=O)=O)C3)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790092 2-[(10S,17E)-16-{[1- (methanesulfonyl)azetidin-3-ylJoxy}- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 221 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 10.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790092 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790092&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580946 C[C@H]1CN(C)Cc2c(c(OC3CN(S(C)(=O)=O)C3)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790092 2-[(10S,17E)-16-{[1- (methanesulfonyl)azetidin-3-ylJoxy}- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 221 Epidermal growth factor receptor Homo sapiens 4.14 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790092 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790092&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580947 CCOc1nn(CC(C)(C)O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790093 1-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]-2-methylpropan-2-ol::US20250353864, Example 222 Epidermal growth factor receptor [L858R] Homo sapiens 4.75 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790093 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790093&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580948 CCOc1nn(CC(C)(C)O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790093 1-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]-2-methylpropan-2-ol::US20250353864, Example 222 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.310 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790093 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790093&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580949 CCOc1nn(CC(C)(C)O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790093 1-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]-2-methylpropan-2-ol::US20250353864, Example 222 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.180 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790093 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790093&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580950 CCOc1nn(CC(C)(C)O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790093 1-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]-2-methylpropan-2-ol::US20250353864, Example 222 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 1.77 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790093 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790093&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580951 CCOc1nn(CC(C)(C)O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790093 1-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]-2-methylpropan-2-ol::US20250353864, Example 222 Epidermal growth factor receptor [1-745,751-1210,C797S] 2.17 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790093 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790093&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580952 CCOc1nn(CC(C)(C)O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790093 1-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]-2-methylpropan-2-ol::US20250353864, Example 222 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 57.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790093 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790093&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580953 CCOc1nn(CC(C)(C)O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790093 1-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]-2-methylpropan-2-ol::US20250353864, Example 222 Epidermal growth factor receptor Homo sapiens 27.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790093 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790093&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580954 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)[C@@H]2C 790094 2-{(10S,13R,17E)-8,10,12,13- tetramethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 223 Epidermal growth factor receptor [L858R] Homo sapiens 7.07 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790094 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790094&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580955 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)[C@@H]2C 790094 2-{(10S,13R,17E)-8,10,12,13- tetramethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 223 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.610 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790094 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790094&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580956 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)[C@@H]2C 790094 2-{(10S,13R,17E)-8,10,12,13- tetramethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 223 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.340 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790094 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790094&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580957 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)[C@@H]2C 790094 2-{(10S,13R,17E)-8,10,12,13- tetramethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 223 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 4.07 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790094 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790094&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580958 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)[C@@H]2C 790094 2-{(10S,13R,17E)-8,10,12,13- tetramethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 223 Epidermal growth factor receptor [1-745,751-1210,C797S] 3.12 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790094 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790094&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580959 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)[C@@H]2C 790094 2-{(10S,13R,17E)-8,10,12,13- tetramethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 223 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 102 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790094 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790094&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580960 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)[C@@H]2C 790094 2-{(10S,13R,17E)-8,10,12,13- tetramethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 223 Epidermal growth factor receptor Homo sapiens 42.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790094 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790094&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580961 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC(CF)CN(C)C2 790095 2-{(17E)-10-(fluoromethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 225 Epidermal growth factor receptor [L858R] Homo sapiens 12.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790095 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790095&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580962 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC(CF)CN(C)C2 790095 2-{(17E)-10-(fluoromethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 225 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.570 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790095 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790095&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580963 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC(CF)CN(C)C2 790095 2-{(17E)-10-(fluoromethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 225 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.210 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790095 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790095&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580964 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC(CF)CN(C)C2 790095 2-{(17E)-10-(fluoromethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 225 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 5.39 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790095 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790095&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580965 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC(CF)CN(C)C2 790095 2-{(17E)-10-(fluoromethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 225 Epidermal growth factor receptor [1-745,751-1210,C797S] 1.44 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790095 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790095&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580966 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC(CF)CN(C)C2 790095 2-{(17E)-10-(fluoromethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 225 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 65.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790095 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790095&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580967 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC(CF)CN(C)C2 790095 2-{(17E)-10-(fluoromethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 225 Epidermal growth factor receptor Homo sapiens 51.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790095 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790095&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580968 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCC(CF)N(C)C2 790096 2-{(17E)-11-(fluoromethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 226 Epidermal growth factor receptor [L858R] Homo sapiens 50.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790096 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790096&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580969 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCC(CF)N(C)C2 790096 2-{(17E)-11-(fluoromethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 226 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 1.19 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790096 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790096&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580970 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCC(CF)N(C)C2 790096 2-{(17E)-11-(fluoromethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 226 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.600 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790096 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790096&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580971 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCC(CF)N(C)C2 790096 2-{(17E)-11-(fluoromethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 226 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 8.98 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790096 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790096&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580972 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCC(CF)N(C)C2 790096 2-{(17E)-11-(fluoromethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 226 Epidermal growth factor receptor [1-745,751-1210,C797S] 6.43 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790096 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790096&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580973 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCC(CF)N(C)C2 790096 2-{(17E)-11-(fluoromethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 226 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 222 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790096 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790096&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580974 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCC(CF)N(C)C2 790096 2-{(17E)-11-(fluoromethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 226 Epidermal growth factor receptor Homo sapiens 121 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790096 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790096&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580975 CCN1Cc2c(c(OC(C)C)nn2C[C@H](C)O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@H](C)C1 790097 (2S)-1-{(10R,17E)-12-ethyl-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-2-ol::US20250353864, Example 227 Epidermal growth factor receptor [L858R] Homo sapiens 60.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790097 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790097&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580976 CCN1Cc2c(c(OC(C)C)nn2C[C@H](C)O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@H](C)C1 790097 (2S)-1-{(10R,17E)-12-ethyl-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-2-ol::US20250353864, Example 227 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.840 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790097 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790097&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580977 CCN1Cc2c(c(OC(C)C)nn2C[C@H](C)O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@H](C)C1 790097 (2S)-1-{(10R,17E)-12-ethyl-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-2-ol::US20250353864, Example 227 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.360 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790097 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790097&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580978 CCN1Cc2c(c(OC(C)C)nn2C[C@H](C)O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@H](C)C1 790097 (2S)-1-{(10R,17E)-12-ethyl-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-2-ol::US20250353864, Example 227 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 9.86 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790097 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790097&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580979 CCN1Cc2c(c(OC(C)C)nn2C[C@H](C)O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@H](C)C1 790097 (2S)-1-{(10R,17E)-12-ethyl-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-2-ol::US20250353864, Example 227 Epidermal growth factor receptor [1-745,751-1210,C797S] 6.82 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790097 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790097&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580980 CCN1Cc2c(c(OC(C)C)nn2C[C@H](C)O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@H](C)C1 790097 (2S)-1-{(10R,17E)-12-ethyl-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-2-ol::US20250353864, Example 227 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 167 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790097 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790097&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580981 CCN1Cc2c(c(OC(C)C)nn2C[C@H](C)O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@H](C)C1 790097 (2S)-1-{(10R,17E)-12-ethyl-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-2-ol::US20250353864, Example 227 Epidermal growth factor receptor Homo sapiens 251 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790097 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790097&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580982 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1OC[C@H](C)N(C(C)C)C2 790098 (2S)-2-[(11S,17E)-16-ethoxy-19-fluoro- 8,11-dimethyl-12-(propan-2-yl)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 228 Epidermal growth factor receptor [L858R] Homo sapiens 25.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790098 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790098&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580983 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1OC[C@H](C)N(C(C)C)C2 790098 (2S)-2-[(11S,17E)-16-ethoxy-19-fluoro- 8,11-dimethyl-12-(propan-2-yl)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 228 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 25.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790098 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790098&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580984 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1OC[C@H](C)N(C(C)C)C2 790098 (2S)-2-[(11S,17E)-16-ethoxy-19-fluoro- 8,11-dimethyl-12-(propan-2-yl)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 228 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 10.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790098 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790098&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580985 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1OC[C@H](C)N(C(C)C)C2 790098 (2S)-2-[(11S,17E)-16-ethoxy-19-fluoro- 8,11-dimethyl-12-(propan-2-yl)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 228 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 12.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790098 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790098&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580986 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1OC[C@H](C)N(C(C)C)C2 790098 (2S)-2-[(11S,17E)-16-ethoxy-19-fluoro- 8,11-dimethyl-12-(propan-2-yl)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 228 Epidermal growth factor receptor [1-745,751-1210,C797S] 44.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790098 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790098&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580987 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1OC[C@H](C)N(C(C)C)C2 790098 (2S)-2-[(11S,17E)-16-ethoxy-19-fluoro- 8,11-dimethyl-12-(propan-2-yl)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 228 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 482 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790098 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790098&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580988 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1OC[C@H](C)N(C(C)C)C2 790098 (2S)-2-[(11S,17E)-16-ethoxy-19-fluoro- 8,11-dimethyl-12-(propan-2-yl)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 228 Epidermal growth factor receptor Homo sapiens 52.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790098 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790098&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580989 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790099 (2S)-2-[(10R,17E)-16-ethoxy-19-fluoro- 8,10-dimethyl-12-(propan-2-yl)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 229 Epidermal growth factor receptor [L858R] Homo sapiens 7.10 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790099 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790099&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580990 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790099 (2S)-2-[(10R,17E)-16-ethoxy-19-fluoro- 8,10-dimethyl-12-(propan-2-yl)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 229 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 4.07 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790099 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790099&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580991 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790099 (2S)-2-[(10R,17E)-16-ethoxy-19-fluoro- 8,10-dimethyl-12-(propan-2-yl)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 229 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 1.24 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790099 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790099&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580992 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790099 (2S)-2-[(10R,17E)-16-ethoxy-19-fluoro- 8,10-dimethyl-12-(propan-2-yl)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 229 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 1.94 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790099 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790099&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580993 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790099 (2S)-2-[(10R,17E)-16-ethoxy-19-fluoro- 8,10-dimethyl-12-(propan-2-yl)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 229 Epidermal growth factor receptor [1-745,751-1210,C797S] 4.05 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790099 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790099&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580994 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790099 (2S)-2-[(10R,17E)-16-ethoxy-19-fluoro- 8,10-dimethyl-12-(propan-2-yl)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 229 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 38.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790099 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790099&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580995 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790099 (2S)-2-[(10R,17E)-16-ethoxy-19-fluoro- 8,10-dimethyl-12-(propan-2-yl)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 229 Epidermal growth factor receptor Homo sapiens 24.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790099 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790099&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580996 CCN1Cc2c(c(OC(C)C)nn2CC(N)=O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790100 2-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}acetamide::US20250353864, Example 232 Epidermal growth factor receptor [L858R] Homo sapiens 0.220 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790100 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790100&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580997 CCN1Cc2c(c(OC(C)C)nn2CC(N)=O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790100 2-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}acetamide::US20250353864, Example 232 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.130 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790100 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790100&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580998 CCN1Cc2c(c(OC(C)C)nn2CC(N)=O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790100 2-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}acetamide::US20250353864, Example 232 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.110 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790100 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790100&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1580999 CCN1Cc2c(c(OC(C)C)nn2CC(N)=O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790100 2-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}acetamide::US20250353864, Example 232 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 0.080 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790100 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790100&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581000 CCN1Cc2c(c(OC(C)C)nn2CC(N)=O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790100 2-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}acetamide::US20250353864, Example 232 Epidermal growth factor receptor [1-745,751-1210,C797S] 0.550 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790100 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790100&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581001 CCN1Cc2c(c(OC(C)C)nn2CC(N)=O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790100 2-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}acetamide::US20250353864, Example 232 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 1.39 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790100 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790100&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581002 CCN1Cc2c(c(OC(C)C)nn2CC(N)=O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790100 2-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}acetamide::US20250353864, Example 232 Epidermal growth factor receptor Homo sapiens 0.410 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790100 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790100&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581003 Cc1c2c(nn1C)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C(C)C)C2 790101 (10S,17E)-8,10,14,15-tetramethyl-12- (propan-2-yl)-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[4,3- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 233 Epidermal growth factor receptor [L858R] Homo sapiens 41.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790101 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790101&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581004 Cc1c2c(nn1C)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C(C)C)C2 790101 (10S,17E)-8,10,14,15-tetramethyl-12- (propan-2-yl)-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[4,3- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 233 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 1.32 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790101 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790101&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581005 Cc1c2c(nn1C)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C(C)C)C2 790101 (10S,17E)-8,10,14,15-tetramethyl-12- (propan-2-yl)-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[4,3- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 233 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 1.61 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790101 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790101&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581006 Cc1c2c(nn1C)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C(C)C)C2 790101 (10S,17E)-8,10,14,15-tetramethyl-12- (propan-2-yl)-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[4,3- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 233 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 10.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790101 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790101&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581007 Cc1c2c(nn1C)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C(C)C)C2 790101 (10S,17E)-8,10,14,15-tetramethyl-12- (propan-2-yl)-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[4,3- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 233 Epidermal growth factor receptor [1-745,751-1210,C797S] 25.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790101 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790101&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581008 Cc1c2c(nn1C)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C(C)C)C2 790101 (10S,17E)-8,10,14,15-tetramethyl-12- (propan-2-yl)-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[4,3- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 233 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 256 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790101 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790101&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581009 Cc1c2c(nn1C)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C(C)C)C2 790101 (10S,17E)-8,10,14,15-tetramethyl-12- (propan-2-yl)-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[4,3- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 233 Epidermal growth factor receptor Homo sapiens 151 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790101 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790101&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581010 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCN(C2)C1 790102 (10R,18E)-17-ethoxy-8,15-dimethyl- 2,8,11,12,14,15-hexahydro-10H-3,5- etheno-10,13-methanotripyrazolo[3,4- g:3',4'-k:4$#8243;,3$#8243;- o][1,5]oxazacyclohexadecine::US20250353864, Example 236 Epidermal growth factor receptor [L858R] Homo sapiens 12.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790102 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790102&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581011 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCN(C2)C1 790102 (10R,18E)-17-ethoxy-8,15-dimethyl- 2,8,11,12,14,15-hexahydro-10H-3,5- etheno-10,13-methanotripyrazolo[3,4- g:3',4'-k:4$#8243;,3$#8243;- o][1,5]oxazacyclohexadecine::US20250353864, Example 236 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.800 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790102 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790102&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581012 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCN(C2)C1 790102 (10R,18E)-17-ethoxy-8,15-dimethyl- 2,8,11,12,14,15-hexahydro-10H-3,5- etheno-10,13-methanotripyrazolo[3,4- g:3',4'-k:4$#8243;,3$#8243;- o][1,5]oxazacyclohexadecine::US20250353864, Example 236 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 1.06 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790102 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790102&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581013 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCN(C2)C1 790102 (10R,18E)-17-ethoxy-8,15-dimethyl- 2,8,11,12,14,15-hexahydro-10H-3,5- etheno-10,13-methanotripyrazolo[3,4- g:3',4'-k:4$#8243;,3$#8243;- o][1,5]oxazacyclohexadecine::US20250353864, Example 236 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 5.11 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790102 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790102&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581014 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCN(C2)C1 790102 (10R,18E)-17-ethoxy-8,15-dimethyl- 2,8,11,12,14,15-hexahydro-10H-3,5- etheno-10,13-methanotripyrazolo[3,4- g:3',4'-k:4$#8243;,3$#8243;- o][1,5]oxazacyclohexadecine::US20250353864, Example 236 Epidermal growth factor receptor [1-745,751-1210,C797S] 11.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790102 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790102&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581015 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCN(C2)C1 790102 (10R,18E)-17-ethoxy-8,15-dimethyl- 2,8,11,12,14,15-hexahydro-10H-3,5- etheno-10,13-methanotripyrazolo[3,4- g:3',4'-k:4$#8243;,3$#8243;- o][1,5]oxazacyclohexadecine::US20250353864, Example 236 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 68.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790102 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790102&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581016 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCN(C2)C1 790102 (10R,18E)-17-ethoxy-8,15-dimethyl- 2,8,11,12,14,15-hexahydro-10H-3,5- etheno-10,13-methanotripyrazolo[3,4- g:3',4'-k:4$#8243;,3$#8243;- o][1,5]oxazacyclohexadecine::US20250353864, Example 236 Epidermal growth factor receptor Homo sapiens 26.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790102 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790102&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581017 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC1CN(C2)C1 790103 (17E)-16-ethoxy-8,14-dimethyl- 2,8,10,11,13,14-hexahydro-3,5-etheno- 10,12-methanotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 238 Epidermal growth factor receptor [L858R] Homo sapiens 73.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790103 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790103&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581018 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC1CN(C2)C1 790103 (17E)-16-ethoxy-8,14-dimethyl- 2,8,10,11,13,14-hexahydro-3,5-etheno- 10,12-methanotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 238 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 10.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790103 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790103&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581019 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC1CN(C2)C1 790103 (17E)-16-ethoxy-8,14-dimethyl- 2,8,10,11,13,14-hexahydro-3,5-etheno- 10,12-methanotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 238 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 11.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790103 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790103&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581020 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC1CN(C2)C1 790103 (17E)-16-ethoxy-8,14-dimethyl- 2,8,10,11,13,14-hexahydro-3,5-etheno- 10,12-methanotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 238 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 17.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790103 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790103&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581021 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC1CN(C2)C1 790103 (17E)-16-ethoxy-8,14-dimethyl- 2,8,10,11,13,14-hexahydro-3,5-etheno- 10,12-methanotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 238 Epidermal growth factor receptor [1-745,751-1210,C797S] 41.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790103 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790103&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581022 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC1CN(C2)C1 790103 (17E)-16-ethoxy-8,14-dimethyl- 2,8,10,11,13,14-hexahydro-3,5-etheno- 10,12-methanotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 238 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 220 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790103 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790103&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581023 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC1CN(C2)C1 790103 (17E)-16-ethoxy-8,14-dimethyl- 2,8,10,11,13,14-hexahydro-3,5-etheno- 10,12-methanotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 238 Epidermal growth factor receptor Homo sapiens 203 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790103 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790103&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581024 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1c(C)nn(C)c1O[C@@H](C)CN(C(C)C)C2 790104 2-[(10S,17E)-16-ethoxy-19-fluoro- 6,8,10-trimethyl-12-(propan-2-yl)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 239 Epidermal growth factor receptor [L858R] Homo sapiens 30.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790104 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790104&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581025 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1c(C)nn(C)c1O[C@@H](C)CN(C(C)C)C2 790104 2-[(10S,17E)-16-ethoxy-19-fluoro- 6,8,10-trimethyl-12-(propan-2-yl)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 239 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 36.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790104 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790104&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581026 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1c(C)nn(C)c1O[C@@H](C)CN(C(C)C)C2 790104 2-[(10S,17E)-16-ethoxy-19-fluoro- 6,8,10-trimethyl-12-(propan-2-yl)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 239 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 8.44 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790104 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790104&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581027 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1c(C)nn(C)c1O[C@@H](C)CN(C(C)C)C2 790104 2-[(10S,17E)-16-ethoxy-19-fluoro- 6,8,10-trimethyl-12-(propan-2-yl)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 239 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 18.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790104 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790104&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581028 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1c(C)nn(C)c1O[C@@H](C)CN(C(C)C)C2 790104 2-[(10S,17E)-16-ethoxy-19-fluoro- 6,8,10-trimethyl-12-(propan-2-yl)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 239 Epidermal growth factor receptor [1-745,751-1210,C797S] 9.44 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790104 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790104&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581029 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1c(C)nn(C)c1O[C@@H](C)CN(C(C)C)C2 790104 2-[(10S,17E)-16-ethoxy-19-fluoro- 6,8,10-trimethyl-12-(propan-2-yl)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 239 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 528 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790104 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790104&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581030 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1c(C)nn(C)c1O[C@@H](C)CN(C(C)C)C2 790104 2-[(10S,17E)-16-ethoxy-19-fluoro- 6,8,10-trimethyl-12-(propan-2-yl)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 239 Epidermal growth factor receptor Homo sapiens 62.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790104 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790104&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581031 CCOc1nccc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790105 (10S,18E)-17-ethoxy-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- ethenodipyrazolo[3,4-j:4',3'-n]pyrido[4,3- f][1,4]oxazacyclopentadecine::US20250353864, Example 240 Epidermal growth factor receptor [L858R] Homo sapiens 775 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790105 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790105&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581032 CCOc1nccc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790105 (10S,18E)-17-ethoxy-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- ethenodipyrazolo[3,4-j:4',3'-n]pyrido[4,3- f][1,4]oxazacyclopentadecine::US20250353864, Example 240 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 5.92 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790105 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790105&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581033 CCOc1nccc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790105 (10S,18E)-17-ethoxy-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- ethenodipyrazolo[3,4-j:4',3'-n]pyrido[4,3- f][1,4]oxazacyclopentadecine::US20250353864, Example 240 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 10.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790105 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790105&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581034 CCOc1nccc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790105 (10S,18E)-17-ethoxy-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- ethenodipyrazolo[3,4-j:4',3'-n]pyrido[4,3- f][1,4]oxazacyclopentadecine::US20250353864, Example 240 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 826 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790105 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790105&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581035 CCOc1nccc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790105 (10S,18E)-17-ethoxy-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- ethenodipyrazolo[3,4-j:4',3'-n]pyrido[4,3- f][1,4]oxazacyclopentadecine::US20250353864, Example 240 Epidermal growth factor receptor [1-745,751-1210,C797S] 653 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790105 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790105&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581036 CCOc1nccc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790105 (10S,18E)-17-ethoxy-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- ethenodipyrazolo[3,4-j:4',3'-n]pyrido[4,3- f][1,4]oxazacyclopentadecine::US20250353864, Example 240 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790105 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790105&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581037 CCOc1nccc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790105 (10S,18E)-17-ethoxy-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- ethenodipyrazolo[3,4-j:4',3'-n]pyrido[4,3- f][1,4]oxazacyclopentadecine::US20250353864, Example 240 Epidermal growth factor receptor Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790105 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790105&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581038 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)[C@H]1CCCN1C2 790106 2-[(8aR,9R,19E)-1-ethoxy-9,11-dimethyl- 7,8,8a,9,11,17-hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 241 Epidermal growth factor receptor [L858R] Homo sapiens 0.300 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790106 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790106&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581039 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)[C@H]1CCCN1C2 790106 2-[(8aR,9R,19E)-1-ethoxy-9,11-dimethyl- 7,8,8a,9,11,17-hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 241 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.300 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790106 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790106&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581040 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)[C@H]1CCCN1C2 790106 2-[(8aR,9R,19E)-1-ethoxy-9,11-dimethyl- 7,8,8a,9,11,17-hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 241 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.280 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790106 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790106&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581041 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)[C@H]1CCCN1C2 790106 2-[(8aR,9R,19E)-1-ethoxy-9,11-dimethyl- 7,8,8a,9,11,17-hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 241 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 0.130 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790106 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790106&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581042 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)[C@H]1CCCN1C2 790106 2-[(8aR,9R,19E)-1-ethoxy-9,11-dimethyl- 7,8,8a,9,11,17-hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 241 Epidermal growth factor receptor [1-745,751-1210,C797S] 0.310 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790106 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790106&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581043 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)[C@H]1CCCN1C2 790106 2-[(8aR,9R,19E)-1-ethoxy-9,11-dimethyl- 7,8,8a,9,11,17-hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 241 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 0.180 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790106 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790106&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581044 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)[C@H]1CCCN1C2 790106 2-[(8aR,9R,19E)-1-ethoxy-9,11-dimethyl- 7,8,8a,9,11,17-hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 241 Epidermal growth factor receptor Homo sapiens 0.400 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790106 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790106&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581045 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)[C@H]1CCCN1C2 790106 2-[(8aR,9R,19E)-1-ethoxy-9,11-dimethyl- 7,8,8a,9,11,17-hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 241 Epidermal growth factor receptor [L858R] Homo sapiens 0.270 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790106 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790106&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581046 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)[C@H]1CCCN1C2 790106 2-[(8aR,9R,19E)-1-ethoxy-9,11-dimethyl- 7,8,8a,9,11,17-hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 241 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.190 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790106 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790106&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581047 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)[C@H]1CCCN1C2 790106 2-[(8aR,9R,19E)-1-ethoxy-9,11-dimethyl- 7,8,8a,9,11,17-hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 241 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.180 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790106 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790106&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581048 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)[C@H]1CCCN1C2 790106 2-[(8aR,9R,19E)-1-ethoxy-9,11-dimethyl- 7,8,8a,9,11,17-hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 241 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 0.150 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790106 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790106&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581049 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)[C@H]1CCCN1C2 790106 2-[(8aR,9R,19E)-1-ethoxy-9,11-dimethyl- 7,8,8a,9,11,17-hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 241 Epidermal growth factor receptor [1-745,751-1210,C797S] 0.230 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790106 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790106&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581050 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)[C@H]1CCCN1C2 790106 2-[(8aR,9R,19E)-1-ethoxy-9,11-dimethyl- 7,8,8a,9,11,17-hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 241 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 0.730 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790106 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790106&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581051 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)[C@H]1CCCN1C2 790106 2-[(8aR,9R,19E)-1-ethoxy-9,11-dimethyl- 7,8,8a,9,11,17-hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 241 Epidermal growth factor receptor Homo sapiens 0.520 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790106 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790106&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581052 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC1CCCN(C2)C1C 790107 2-[(19E)-18-ethoxy-8,21-dimethyl- 2,10,11,12,13,15-hexahydro-3,5-etheno- 10,14-methanotripyrazolo[3,4-h:3',4'- l:4$#8243;,3$#8243;-p][1,6]oxazacycloheptadecin- 16(8H)-yl]ethan-1-ol::US20250353864, Example 242 Epidermal growth factor receptor [L858R] Homo sapiens 124 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790107 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790107&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581053 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC1CCCN(C2)C1C 790107 2-[(19E)-18-ethoxy-8,21-dimethyl- 2,10,11,12,13,15-hexahydro-3,5-etheno- 10,14-methanotripyrazolo[3,4-h:3',4'- l:4$#8243;,3$#8243;-p][1,6]oxazacycloheptadecin- 16(8H)-yl]ethan-1-ol::US20250353864, Example 242 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 9.27 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790107 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790107&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581054 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC1CCCN(C2)C1C 790107 2-[(19E)-18-ethoxy-8,21-dimethyl- 2,10,11,12,13,15-hexahydro-3,5-etheno- 10,14-methanotripyrazolo[3,4-h:3',4'- l:4$#8243;,3$#8243;-p][1,6]oxazacycloheptadecin- 16(8H)-yl]ethan-1-ol::US20250353864, Example 242 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 4.93 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790107 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790107&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581055 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC1CCCN(C2)C1C 790107 2-[(19E)-18-ethoxy-8,21-dimethyl- 2,10,11,12,13,15-hexahydro-3,5-etheno- 10,14-methanotripyrazolo[3,4-h:3',4'- l:4$#8243;,3$#8243;-p][1,6]oxazacycloheptadecin- 16(8H)-yl]ethan-1-ol::US20250353864, Example 242 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 55.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790107 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790107&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581056 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC1CCCN(C2)C1C 790107 2-[(19E)-18-ethoxy-8,21-dimethyl- 2,10,11,12,13,15-hexahydro-3,5-etheno- 10,14-methanotripyrazolo[3,4-h:3',4'- l:4$#8243;,3$#8243;-p][1,6]oxazacycloheptadecin- 16(8H)-yl]ethan-1-ol::US20250353864, Example 242 Epidermal growth factor receptor [1-745,751-1210,C797S] 40.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790107 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790107&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581057 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC1CCCN(C2)C1C 790107 2-[(19E)-18-ethoxy-8,21-dimethyl- 2,10,11,12,13,15-hexahydro-3,5-etheno- 10,14-methanotripyrazolo[3,4-h:3',4'- l:4$#8243;,3$#8243;-p][1,6]oxazacycloheptadecin- 16(8H)-yl]ethan-1-ol::US20250353864, Example 242 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 304 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790107 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790107&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581058 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC1CCCN(C2)C1C 790107 2-[(19E)-18-ethoxy-8,21-dimethyl- 2,10,11,12,13,15-hexahydro-3,5-etheno- 10,14-methanotripyrazolo[3,4-h:3',4'- l:4$#8243;,3$#8243;-p][1,6]oxazacycloheptadecin- 16(8H)-yl]ethan-1-ol::US20250353864, Example 242 Epidermal growth factor receptor Homo sapiens 381 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790107 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790107&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581059 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C3CC3)c1O[C@@H](C)CN(C)C2 790108 2-{(10S,17E)-8-cyclopropyl-10,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 246 Epidermal growth factor receptor [L858R] Homo sapiens 5.14 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790108 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790108&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581060 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C3CC3)c1O[C@@H](C)CN(C)C2 790108 2-{(10S,17E)-8-cyclopropyl-10,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 246 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 1.71 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790108 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790108&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581061 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C3CC3)c1O[C@@H](C)CN(C)C2 790108 2-{(10S,17E)-8-cyclopropyl-10,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 246 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 4.42 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790108 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790108&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581062 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C3CC3)c1O[C@@H](C)CN(C)C2 790108 2-{(10S,17E)-8-cyclopropyl-10,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 246 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 8.71 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790108 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790108&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581063 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C3CC3)c1O[C@@H](C)CN(C)C2 790108 2-{(10S,17E)-8-cyclopropyl-10,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 246 Epidermal growth factor receptor [1-745,751-1210,C797S] 3.18 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790108 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790108&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581064 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C3CC3)c1O[C@@H](C)CN(C)C2 790108 2-{(10S,17E)-8-cyclopropyl-10,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 246 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 39.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790108 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790108&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581065 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C3CC3)c1O[C@@H](C)CN(C)C2 790108 2-{(10S,17E)-8-cyclopropyl-10,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 246 Epidermal growth factor receptor Homo sapiens 23.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790108 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790108&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581066 CC(C)OC(=N)C1=C(\NCCO)CN2CCC[C@@H]2[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790109 2-[(8aR,9S,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy]-7,8,8a,9,11,17- hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 252 Epidermal growth factor receptor [L858R] Homo sapiens 2.38 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790109 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790109&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581067 CC(C)OC(=N)C1=C(\NCCO)CN2CCC[C@@H]2[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790109 2-[(8aR,9S,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy]-7,8,8a,9,11,17- hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 252 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 1.91 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790109 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790109&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581068 CC(C)OC(=N)C1=C(\NCCO)CN2CCC[C@@H]2[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790109 2-[(8aR,9S,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy]-7,8,8a,9,11,17- hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 252 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 5.35 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790109 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790109&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581069 CC(C)OC(=N)C1=C(\NCCO)CN2CCC[C@@H]2[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790109 2-[(8aR,9S,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy]-7,8,8a,9,11,17- hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 252 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 1.31 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790109 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790109&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581070 CC(C)OC(=N)C1=C(\NCCO)CN2CCC[C@@H]2[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790109 2-[(8aR,9S,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy]-7,8,8a,9,11,17- hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 252 Epidermal growth factor receptor [1-745,751-1210,C797S] 2.29 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790109 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790109&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581071 CC(C)OC(=N)C1=C(\NCCO)CN2CCC[C@@H]2[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790109 2-[(8aR,9S,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy]-7,8,8a,9,11,17- hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 252 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 15.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790109 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790109&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581072 CC(C)OC(=N)C1=C(\NCCO)CN2CCC[C@@H]2[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790109 2-[(8aR,9S,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy]-7,8,8a,9,11,17- hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 252 Epidermal growth factor receptor Homo sapiens 4.74 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790109 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790109&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581073 CC(C)OC(=N)C1=C(\NCCO)CN2CCC[C@@H]2[C@@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790110 2-[(8aR,9R,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy]-7,8,8a,9,11,17- hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 253 Epidermal growth factor receptor [L858R] Homo sapiens 1.66 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790110 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790110&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581074 CC(C)OC(=N)C1=C(\NCCO)CN2CCC[C@@H]2[C@@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790110 2-[(8aR,9R,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy]-7,8,8a,9,11,17- hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 253 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 2.55 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790110 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790110&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581075 CC(C)OC(=N)C1=C(\NCCO)CN2CCC[C@@H]2[C@@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790110 2-[(8aR,9R,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy]-7,8,8a,9,11,17- hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 253 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 5.27 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790110 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790110&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581076 CC(C)OC(=N)C1=C(\NCCO)CN2CCC[C@@H]2[C@@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790110 2-[(8aR,9R,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy]-7,8,8a,9,11,17- hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 253 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 0.750 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790110 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790110&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581077 CC(C)OC(=N)C1=C(\NCCO)CN2CCC[C@@H]2[C@@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790110 2-[(8aR,9R,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy]-7,8,8a,9,11,17- hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 253 Epidermal growth factor receptor [1-745,751-1210,C797S] 1.98 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790110 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790110&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581078 CC(C)OC(=N)C1=C(\NCCO)CN2CCC[C@@H]2[C@@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790110 2-[(8aR,9R,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy]-7,8,8a,9,11,17- hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 253 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 3.21 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790110 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790110&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581079 CC(C)OC(=N)C1=C(\NCCO)CN2CCC[C@@H]2[C@@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790110 2-[(8aR,9R,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy]-7,8,8a,9,11,17- hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 253 Epidermal growth factor receptor Homo sapiens 1.63 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790110 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790110&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581080 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)[C@H]1CCCN1C2 790111 2-[(8aR,9R,19E)-22-fluoro-9,11- dimethyl-1-[(propan-2-yl)oxy]- 7,8,8a,9,11,17-hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 255 Epidermal growth factor receptor [L858R] Homo sapiens 1.18 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790111 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790111&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581081 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)[C@H]1CCCN1C2 790111 2-[(8aR,9R,19E)-22-fluoro-9,11- dimethyl-1-[(propan-2-yl)oxy]- 7,8,8a,9,11,17-hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 255 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 3.01 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790111 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790111&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581082 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)[C@H]1CCCN1C2 790111 2-[(8aR,9R,19E)-22-fluoro-9,11- dimethyl-1-[(propan-2-yl)oxy]- 7,8,8a,9,11,17-hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 255 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 6.62 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790111 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790111&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581083 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)[C@H]1CCCN1C2 790111 2-[(8aR,9R,19E)-22-fluoro-9,11- dimethyl-1-[(propan-2-yl)oxy]- 7,8,8a,9,11,17-hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 255 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 0.950 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790111 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790111&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581084 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)[C@H]1CCCN1C2 790111 2-[(8aR,9R,19E)-22-fluoro-9,11- dimethyl-1-[(propan-2-yl)oxy]- 7,8,8a,9,11,17-hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 255 Epidermal growth factor receptor [1-745,751-1210,C797S] 1.98 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790111 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790111&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581085 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)[C@H]1CCCN1C2 790111 2-[(8aR,9R,19E)-22-fluoro-9,11- dimethyl-1-[(propan-2-yl)oxy]- 7,8,8a,9,11,17-hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 255 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 4.05 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790111 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790111&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581086 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)[C@H]1CCCN1C2 790111 2-[(8aR,9R,19E)-22-fluoro-9,11- dimethyl-1-[(propan-2-yl)oxy]- 7,8,8a,9,11,17-hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 255 Epidermal growth factor receptor Homo sapiens 1.43 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790111 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790111&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581087 CC(C)OC(=N)C1=C(\NCCO)CN(C)C[C@H](CO)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790112 2-{(10R,17E)-10-(hydroxymethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 258 Epidermal growth factor receptor [L858R] Homo sapiens 1.56 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790112 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790112&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581088 CC(C)OC(=N)C1=C(\NCCO)CN(C)C[C@H](CO)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790112 2-{(10R,17E)-10-(hydroxymethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 258 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.480 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790112 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790112&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581089 CC(C)OC(=N)C1=C(\NCCO)CN(C)C[C@H](CO)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790112 2-{(10R,17E)-10-(hydroxymethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 258 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 2.17 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790112 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790112&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581090 CC(C)OC(=N)C1=C(\NCCO)CN(C)C[C@H](CO)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790112 2-{(10R,17E)-10-(hydroxymethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 258 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 1.22 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790112 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790112&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581091 CC(C)OC(=N)C1=C(\NCCO)CN(C)C[C@H](CO)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790112 2-{(10R,17E)-10-(hydroxymethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 258 Epidermal growth factor receptor [1-745,751-1210,C797S] 1.26 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790112 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790112&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581092 CC(C)OC(=N)C1=C(\NCCO)CN(C)C[C@H](CO)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790112 2-{(10R,17E)-10-(hydroxymethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 258 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 15.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790112 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790112&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581093 CC(C)OC(=N)C1=C(\NCCO)CN(C)C[C@H](CO)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790112 2-{(10R,17E)-10-(hydroxymethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 258 Epidermal growth factor receptor Homo sapiens 5.72 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790112 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790112&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581094 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](CC)CN(C)C2 790113 2-[(11S,17E)-16-ethoxy-11-ethyl-8,12- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 259 Epidermal growth factor receptor [L858R] Homo sapiens 66.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790113 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790113&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581095 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](CC)CN(C)C2 790113 2-[(11S,17E)-16-ethoxy-11-ethyl-8,12- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 259 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 9.39 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790113 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790113&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581096 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](CC)CN(C)C2 790113 2-[(11S,17E)-16-ethoxy-11-ethyl-8,12- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 259 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 21.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790113 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790113&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581097 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](CC)CN(C)C2 790113 2-[(11S,17E)-16-ethoxy-11-ethyl-8,12- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 259 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 40.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790113 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790113&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581098 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](CC)CN(C)C2 790113 2-[(11S,17E)-16-ethoxy-11-ethyl-8,12- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 259 Epidermal growth factor receptor [1-745,751-1210,C797S] 22.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790113 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790113&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581099 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](CC)CN(C)C2 790113 2-[(11S,17E)-16-ethoxy-11-ethyl-8,12- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 259 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 500 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790113 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790113&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581100 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](CC)CN(C)C2 790113 2-[(11S,17E)-16-ethoxy-11-ethyl-8,12- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 259 Epidermal growth factor receptor Homo sapiens 329 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790113 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790113&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581101 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](CC)CN(C)C2 790114 2-[(10S,17E)-16-ethoxy-10-ethyl-8,12- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 260 Epidermal growth factor receptor [L858R] Homo sapiens 4.55 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790114 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790114&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581102 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](CC)CN(C)C2 790114 2-[(10S,17E)-16-ethoxy-10-ethyl-8,12- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 260 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.900 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790114 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790114&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581103 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](CC)CN(C)C2 790114 2-[(10S,17E)-16-ethoxy-10-ethyl-8,12- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 260 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 3.19 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790114 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790114&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581104 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](CC)CN(C)C2 790114 2-[(10S,17E)-16-ethoxy-10-ethyl-8,12- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 260 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 3.50 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790114 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790114&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581105 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](CC)CN(C)C2 790114 2-[(10S,17E)-16-ethoxy-10-ethyl-8,12- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 260 Epidermal growth factor receptor [1-745,751-1210,C797S] 3.74 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790114 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790114&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581106 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](CC)CN(C)C2 790114 2-[(10S,17E)-16-ethoxy-10-ethyl-8,12- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 260 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 25.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790114 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790114&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581107 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](CC)CN(C)C2 790114 2-[(10S,17E)-16-ethoxy-10-ethyl-8,12- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 260 Epidermal growth factor receptor Homo sapiens 13.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790114 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790114&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581108 COCc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790115 2-[(10S,17E)-16-(methoxymethyl)- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 261 Epidermal growth factor receptor [L858R] Homo sapiens 21.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790115 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790115&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581109 COCc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790115 2-[(10S,17E)-16-(methoxymethyl)- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 261 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 1.92 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790115 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790115&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581110 COCc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790115 2-[(10S,17E)-16-(methoxymethyl)- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 261 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 5.10 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790115 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790115&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581111 COCc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790115 2-[(10S,17E)-16-(methoxymethyl)- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 261 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 23.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790115 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790115&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581112 COCc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790115 2-[(10S,17E)-16-(methoxymethyl)- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 261 Epidermal growth factor receptor [1-745,751-1210,C797S] 5.93 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790115 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790115&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581113 COCc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790115 2-[(10S,17E)-16-(methoxymethyl)- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 261 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 230 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790115 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790115&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581114 COCc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790115 2-[(10S,17E)-16-(methoxymethyl)- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 261 Epidermal growth factor receptor Homo sapiens 93.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790115 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790115&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581115 CCN1Cc2c(c(OC(C)C)nn2CC(C)(C)O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790116 1-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14-yl}-2- methylpropan-2-ol::US20250353864, Example 262 Epidermal growth factor receptor [L858R] Homo sapiens 40.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790116 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790116&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581116 CCN1Cc2c(c(OC(C)C)nn2CC(C)(C)O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790116 1-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14-yl}-2- methylpropan-2-ol::US20250353864, Example 262 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 4.98 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790116 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790116&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581117 CCN1Cc2c(c(OC(C)C)nn2CC(C)(C)O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790116 1-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14-yl}-2- methylpropan-2-ol::US20250353864, Example 262 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 1.67 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790116 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790116&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581118 CCN1Cc2c(c(OC(C)C)nn2CC(C)(C)O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790116 1-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14-yl}-2- methylpropan-2-ol::US20250353864, Example 262 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 8.48 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790116 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790116&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581119 CCN1Cc2c(c(OC(C)C)nn2CC(C)(C)O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790116 1-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14-yl}-2- methylpropan-2-ol::US20250353864, Example 262 Epidermal growth factor receptor [1-745,751-1210,C797S] 7.12 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790116 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790116&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581120 CCN1Cc2c(c(OC(C)C)nn2CC(C)(C)O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790116 1-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14-yl}-2- methylpropan-2-ol::US20250353864, Example 262 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 98.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790116 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790116&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581121 CCN1Cc2c(c(OC(C)C)nn2CC(C)(C)O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790116 1-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14-yl}-2- methylpropan-2-ol::US20250353864, Example 262 Epidermal growth factor receptor Homo sapiens 94.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790116 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790116&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581122 CCN1Cc2c(c(OC(C)C)nn2CC(C)=O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790117 1-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-2-one::US20250353864, Example 263 Epidermal growth factor receptor [L858R] Homo sapiens 3.97 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790117 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790117&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581123 CCN1Cc2c(c(OC(C)C)nn2CC(C)=O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790117 1-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-2-one::US20250353864, Example 263 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 0.750 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790117 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790117&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581124 CCN1Cc2c(c(OC(C)C)nn2CC(C)=O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790117 1-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-2-one::US20250353864, Example 263 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.500 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790117 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790117&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581125 CCN1Cc2c(c(OC(C)C)nn2CC(C)=O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790117 1-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-2-one::US20250353864, Example 263 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 1.28 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790117 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790117&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581126 CCN1Cc2c(c(OC(C)C)nn2CC(C)=O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790117 1-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-2-one::US20250353864, Example 263 Epidermal growth factor receptor [1-745,751-1210,C797S] 1.79 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790117 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790117&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581127 CCN1Cc2c(c(OC(C)C)nn2CC(C)=O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790117 1-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-2-one::US20250353864, Example 263 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 18.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790117 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790117&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581128 CCN1Cc2c(c(OC(C)C)nn2CC(C)=O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790117 1-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-2-one::US20250353864, Example 263 Epidermal growth factor receptor Homo sapiens 6.94 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790117 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790117&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581129 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C#N)CN(C)C2 790118 (10R,17E)-14-(2-hydroxyethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine-10- carbonitrile::US20250353864, Example 264 Epidermal growth factor receptor [L858R] Homo sapiens 491 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790118 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790118&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581130 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C#N)CN(C)C2 790118 (10R,17E)-14-(2-hydroxyethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine-10- carbonitrile::US20250353864, Example 264 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 18.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790118 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790118&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581131 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C#N)CN(C)C2 790118 (10R,17E)-14-(2-hydroxyethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine-10- carbonitrile::US20250353864, Example 264 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 8.63 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790118 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790118&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581132 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C#N)CN(C)C2 790118 (10R,17E)-14-(2-hydroxyethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine-10- carbonitrile::US20250353864, Example 264 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 162 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790118 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790118&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581133 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C#N)CN(C)C2 790118 (10R,17E)-14-(2-hydroxyethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine-10- carbonitrile::US20250353864, Example 264 Epidermal growth factor receptor [1-745,751-1210,C797S] 70.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790118 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790118&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581134 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C#N)CN(C)C2 790118 (10R,17E)-14-(2-hydroxyethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine-10- carbonitrile::US20250353864, Example 264 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 826 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790118 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790118&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581135 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C#N)CN(C)C2 790118 (10R,17E)-14-(2-hydroxyethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine-10- carbonitrile::US20250353864, Example 264 Epidermal growth factor receptor Homo sapiens 815 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790118 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790118&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581136 C[C@H]1CN(C)Cc2c(c(CN(C)C)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790119 2-{(10S,17E)-16- [(dimethylamino)methyl]-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 266 Epidermal growth factor receptor [L858R] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790119 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790119&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581137 C[C@H]1CN(C)Cc2c(c(CN(C)C)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790119 2-{(10S,17E)-16- [(dimethylamino)methyl]-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 266 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 282 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790119 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790119&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581138 C[C@H]1CN(C)Cc2c(c(CN(C)C)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790119 2-{(10S,17E)-16- [(dimethylamino)methyl]-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 266 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 60.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790119 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790119&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581139 C[C@H]1CN(C)Cc2c(c(CN(C)C)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790119 2-{(10S,17E)-16- [(dimethylamino)methyl]-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 266 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 971 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790119 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790119&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581140 C[C@H]1CN(C)Cc2c(c(CN(C)C)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790119 2-{(10S,17E)-16- [(dimethylamino)methyl]-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 266 Epidermal growth factor receptor [1-745,751-1210,C797S] 577 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790119 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790119&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581141 C[C@H]1CN(C)Cc2c(c(CN(C)C)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790119 2-{(10S,17E)-16- [(dimethylamino)methyl]-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 266 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790119 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790119&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581142 C[C@H]1CN(C)Cc2c(c(CN(C)C)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790119 2-{(10S,17E)-16- [(dimethylamino)methyl]-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 266 Epidermal growth factor receptor Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790119 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790119&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581143 CCOc1ccc2c(n1)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790120 (10S,18E)-16-ethoxy-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- ethenodipyrazolo[3,4-j:4',3'-n]pyrido[3,2- f][1,4]oxazacyclopentadecine::US20250353864, Example 267 Epidermal growth factor receptor [L858R] Homo sapiens 241 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790120 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790120&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581144 CCOc1ccc2c(n1)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790120 (10S,18E)-16-ethoxy-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- ethenodipyrazolo[3,4-j:4',3'-n]pyrido[3,2- f][1,4]oxazacyclopentadecine::US20250353864, Example 267 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 8.31 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790120 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790120&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581145 CCOc1ccc2c(n1)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790120 (10S,18E)-16-ethoxy-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- ethenodipyrazolo[3,4-j:4',3'-n]pyrido[3,2- f][1,4]oxazacyclopentadecine::US20250353864, Example 267 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 5.42 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790120 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790120&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581146 CCOc1ccc2c(n1)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790120 (10S,18E)-16-ethoxy-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- ethenodipyrazolo[3,4-j:4',3'-n]pyrido[3,2- f][1,4]oxazacyclopentadecine::US20250353864, Example 267 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 117 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790120 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790120&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581147 CCOc1ccc2c(n1)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790120 (10S,18E)-16-ethoxy-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- ethenodipyrazolo[3,4-j:4',3'-n]pyrido[3,2- f][1,4]oxazacyclopentadecine::US20250353864, Example 267 Epidermal growth factor receptor [1-745,751-1210,C797S] 107 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790120 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790120&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581148 CCOc1ccc2c(n1)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790120 (10S,18E)-16-ethoxy-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- ethenodipyrazolo[3,4-j:4',3'-n]pyrido[3,2- f][1,4]oxazacyclopentadecine::US20250353864, Example 267 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 1234 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790120 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790120&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581149 CCOc1ccc2c(n1)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790120 (10S,18E)-16-ethoxy-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- ethenodipyrazolo[3,4-j:4',3'-n]pyrido[3,2- f][1,4]oxazacyclopentadecine::US20250353864, Example 267 Epidermal growth factor receptor Homo sapiens 769 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790120 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790120&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581150 C[C@H](C#N)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790121 (2R)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-8,10,12-trimethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}propanenitrile::US20250353864, Example 268 Epidermal growth factor receptor [L858R] Homo sapiens 4.35 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790121 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790121&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581151 C[C@H](C#N)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790121 (2R)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-8,10,12-trimethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}propanenitrile::US20250353864, Example 268 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 1.04 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790121 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790121&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581152 C[C@H](C#N)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790121 (2R)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-8,10,12-trimethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}propanenitrile::US20250353864, Example 268 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.520 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790121 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790121&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581153 C[C@H](C#N)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790121 (2R)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-8,10,12-trimethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}propanenitrile::US20250353864, Example 268 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 2.01 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790121 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790121&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581154 C[C@H](C#N)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790121 (2R)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-8,10,12-trimethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}propanenitrile::US20250353864, Example 268 Epidermal growth factor receptor [1-745,751-1210,C797S] 1.32 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790121 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790121&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581155 C[C@H](C#N)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790121 (2R)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-8,10,12-trimethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}propanenitrile::US20250353864, Example 268 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 30.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790121 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790121&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581156 C[C@H](C#N)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790121 (2R)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-8,10,12-trimethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}propanenitrile::US20250353864, Example 268 Epidermal growth factor receptor Homo sapiens 7.91 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790121 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790121&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581157 C[C@@H](C#N)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790122 (2S)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-8,10,12-trimethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}propanenitrile::US20250353864, Example 269 Epidermal growth factor receptor [L858R] Homo sapiens 8.53 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790122 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790122&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581158 C[C@@H](C#N)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790122 (2S)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-8,10,12-trimethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}propanenitrile::US20250353864, Example 269 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 1.82 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790122 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790122&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581159 C[C@@H](C#N)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790122 (2S)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-8,10,12-trimethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}propanenitrile::US20250353864, Example 269 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 0.670 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790122 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790122&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581160 C[C@@H](C#N)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790122 (2S)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-8,10,12-trimethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}propanenitrile::US20250353864, Example 269 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 5.25 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790122 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790122&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581161 C[C@@H](C#N)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790122 (2S)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-8,10,12-trimethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}propanenitrile::US20250353864, Example 269 Epidermal growth factor receptor [1-745,751-1210,C797S] 2.56 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790122 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790122&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581162 C[C@@H](C#N)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790122 (2S)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-8,10,12-trimethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}propanenitrile::US20250353864, Example 269 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 102 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790122 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790122&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581163 C[C@@H](C#N)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790122 (2S)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-8,10,12-trimethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}propanenitrile::US20250353864, Example 269 Epidermal growth factor receptor Homo sapiens 20.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790122 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790122&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581164 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H]1CN(C)C[C@@H]1N(C)C2 790123 2-[(4aS,7aS,13E)-12-ethoxy-3,6,8- trimethyl-4a,5,6,7,7a,8,9,16-octahydro- 17,19-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n|pyrrolo|3,4- b][1,4]oxazacyclopentadecin-10(3H)- yl]ethan-1-ol::US20250353864, Example 270 Epidermal growth factor receptor [L858R] Homo sapiens 161 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790123 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790123&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581165 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H]1CN(C)C[C@@H]1N(C)C2 790123 2-[(4aS,7aS,13E)-12-ethoxy-3,6,8- trimethyl-4a,5,6,7,7a,8,9,16-octahydro- 17,19-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n|pyrrolo|3,4- b][1,4]oxazacyclopentadecin-10(3H)- yl]ethan-1-ol::US20250353864, Example 270 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 4.58 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790123 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790123&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581166 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H]1CN(C)C[C@@H]1N(C)C2 790123 2-[(4aS,7aS,13E)-12-ethoxy-3,6,8- trimethyl-4a,5,6,7,7a,8,9,16-octahydro- 17,19-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n|pyrrolo|3,4- b][1,4]oxazacyclopentadecin-10(3H)- yl]ethan-1-ol::US20250353864, Example 270 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 1.10 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790123 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790123&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581167 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H]1CN(C)C[C@@H]1N(C)C2 790123 2-[(4aS,7aS,13E)-12-ethoxy-3,6,8- trimethyl-4a,5,6,7,7a,8,9,16-octahydro- 17,19-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n|pyrrolo|3,4- b][1,4]oxazacyclopentadecin-10(3H)- yl]ethan-1-ol::US20250353864, Example 270 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 93.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790123 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790123&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581168 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H]1CN(C)C[C@@H]1N(C)C2 790123 2-[(4aS,7aS,13E)-12-ethoxy-3,6,8- trimethyl-4a,5,6,7,7a,8,9,16-octahydro- 17,19-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n|pyrrolo|3,4- b][1,4]oxazacyclopentadecin-10(3H)- yl]ethan-1-ol::US20250353864, Example 270 Epidermal growth factor receptor [1-745,751-1210,C797S] 20.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790123 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790123&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581169 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H]1CN(C)C[C@@H]1N(C)C2 790123 2-[(4aS,7aS,13E)-12-ethoxy-3,6,8- trimethyl-4a,5,6,7,7a,8,9,16-octahydro- 17,19-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n|pyrrolo|3,4- b][1,4]oxazacyclopentadecin-10(3H)- yl]ethan-1-ol::US20250353864, Example 270 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 634 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790123 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790123&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581170 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H]1CN(C)C[C@@H]1N(C)C2 790123 2-[(4aS,7aS,13E)-12-ethoxy-3,6,8- trimethyl-4a,5,6,7,7a,8,9,16-octahydro- 17,19-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n|pyrrolo|3,4- b][1,4]oxazacyclopentadecin-10(3H)- yl]ethan-1-ol::US20250353864, Example 270 Epidermal growth factor receptor Homo sapiens 543 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790123 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790123&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581171 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CN(C)C[C@H]1N(C)C2 790124 2-[(4aR,7aR,13E)-12-ethoxy-3,6,8- trimethyl-4a,5,6,7,7a,8,9,16-octahydro- 17,19-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n]pyrrolo[3,4- b][1,4]oxazacyclopentadecin-10(3H)- yl]ethan-1-ol::US20250353864, Example 271 Epidermal growth factor receptor [L858R] Homo sapiens 1580 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790124 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790124&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581172 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CN(C)C[C@H]1N(C)C2 790124 2-[(4aR,7aR,13E)-12-ethoxy-3,6,8- trimethyl-4a,5,6,7,7a,8,9,16-octahydro- 17,19-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n]pyrrolo[3,4- b][1,4]oxazacyclopentadecin-10(3H)- yl]ethan-1-ol::US20250353864, Example 271 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 56.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790124 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790124&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581173 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CN(C)C[C@H]1N(C)C2 790124 2-[(4aR,7aR,13E)-12-ethoxy-3,6,8- trimethyl-4a,5,6,7,7a,8,9,16-octahydro- 17,19-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n]pyrrolo[3,4- b][1,4]oxazacyclopentadecin-10(3H)- yl]ethan-1-ol::US20250353864, Example 271 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 31.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790124 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790124&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581174 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CN(C)C[C@H]1N(C)C2 790124 2-[(4aR,7aR,13E)-12-ethoxy-3,6,8- trimethyl-4a,5,6,7,7a,8,9,16-octahydro- 17,19-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n]pyrrolo[3,4- b][1,4]oxazacyclopentadecin-10(3H)- yl]ethan-1-ol::US20250353864, Example 271 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 472 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790124 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790124&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581175 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CN(C)C[C@H]1N(C)C2 790124 2-[(4aR,7aR,13E)-12-ethoxy-3,6,8- trimethyl-4a,5,6,7,7a,8,9,16-octahydro- 17,19-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n]pyrrolo[3,4- b][1,4]oxazacyclopentadecin-10(3H)- yl]ethan-1-ol::US20250353864, Example 271 Epidermal growth factor receptor [1-745,751-1210,C797S] 422 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790124 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790124&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581176 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CN(C)C[C@H]1N(C)C2 790124 2-[(4aR,7aR,13E)-12-ethoxy-3,6,8- trimethyl-4a,5,6,7,7a,8,9,16-octahydro- 17,19-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n]pyrrolo[3,4- b][1,4]oxazacyclopentadecin-10(3H)- yl]ethan-1-ol::US20250353864, Example 271 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790124 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790124&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581177 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CN(C)C[C@H]1N(C)C2 790124 2-[(4aR,7aR,13E)-12-ethoxy-3,6,8- trimethyl-4a,5,6,7,7a,8,9,16-octahydro- 17,19-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n]pyrrolo[3,4- b][1,4]oxazacyclopentadecin-10(3H)- yl]ethan-1-ol::US20250353864, Example 271 Epidermal growth factor receptor Homo sapiens >1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790124 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790124&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581178 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)COC2 790125 (10S,17E)-16-ethyl-8,10,14-trimethyl- 2,8,10,11,13,14-hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 319 Epidermal growth factor receptor [L858R] Homo sapiens 182 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790125 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=51&target=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790125&enzyme=Epidermal+growth+factor+receptor+%5BL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,2EB3,6JWL,5X28,5X27,5X26,2ITZ,2ITV,2ITU,2ITT,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581179 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)COC2 790125 (10S,17E)-16-ethyl-8,10,14-trimethyl- 2,8,10,11,13,14-hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 319 Epidermal growth factor receptor [T790M,L858R] Homo sapiens 24.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790125 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=60&target=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790125&enzyme=Epidermal+growth+factor+receptor+%5BT790M%2CL858R%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,4I21,9KLW,5Y25,3W2R,3W2Q,3W2P,3W2O,7OXB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581180 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)COC2 790125 (10S,17E)-16-ethyl-8,10,14-trimethyl- 2,8,10,11,13,14-hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 319 Epidermal growth factor receptor [L858R,T790M,C797S] Homo sapiens 60.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790125 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1058&target=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790125&enzyme=Epidermal+growth+factor+receptor+%5BL858R%2CT790M%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,5CNN,7VRE,7VRA,7ER2,6JRJ,6S9D,6S9C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581181 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)COC2 790125 (10S,17E)-16-ethyl-8,10,14-trimethyl- 2,8,10,11,13,14-hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 319 Epidermal growth factor receptor [1-745,751-1210] Homo sapiens 218 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790125 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=535&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790125&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,3GOP,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,4TKS,1M17,1M14,7SI1,5EM8,5CAV,3VJO,1XKK,8PNZ,7UKV,7AEI,5UGB,4I23,9QXN,7TVD,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FZS,9FZR,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581182 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)COC2 790125 (10S,17E)-16-ethyl-8,10,14-trimethyl- 2,8,10,11,13,14-hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 319 Epidermal growth factor receptor [1-745,751-1210,C797S] 425 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790125 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1655&target=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790125&enzyme=Epidermal+growth+factor+receptor+%5B1-745%2C751-1210%2CC797S%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,7TVD,7VRE,7VRA,7ER2,6JRJ,8HVA,8HV9,8HV8,8HV7,8HV6,8HV4,6LUD,6LUB Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581183 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)COC2 790125 (10S,17E)-16-ethyl-8,10,14-trimethyl- 2,8,10,11,13,14-hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 319 Epidermal growth factor receptor [1-770,'NPG',771-1210] Homo sapiens 1489 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790125 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1253&target=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790125&enzyme=Epidermal+growth+factor+receptor+%5B1-770%2C%27NPG%27%2C771-1210%5D&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 7SZ7,7SZ5,7SYE,7SYD,7SZ1,7SZ0,3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,8UKV,9P9U,8PO0,9U8C,7AEM,7SI1,5EM8,5CAV,4TKS,9GHV,9GHU,9GHT,9GHS,9GHR,7B85,3VJO,1M17,1M14,8PNZ,7UKV,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9H47,9H46,9H42,9DM8,8G63,6VHP,6VHN,6VH4,6D8E,3POZ,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,9KL4,9GL9,9GI9,9FRD,8SC7,7T4I,5FED,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,2RF9,2GS6,2GS2,9BY6,9BY4,9FZS,9FZR,6JZ0,4JRV,4JR3,4JQ8,4JQ7,4LI5 Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581184 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)COC2 790125 (10S,17E)-16-ethyl-8,10,14-trimethyl- 2,8,10,11,13,14-hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 319 Epidermal growth factor receptor Homo sapiens 766 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790125 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=520&target=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790125&enzyme=Epidermal+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 3QWQ,1IVO,4UV7,9IPE,9IPD,9IPC,9IPB,9IPA,9IP9,9IP8,9IP7,4KRO,3B2V,4KRP,4UIP,1MOX,5WB8,5WB7,3GOP,8UKV,9P9U,7AEM,9GHV,9GHU,9GHT,9GHS,9GHR,7SI1,7B85,5EM8,5CAV,1M17,1M14,4TKS,7UKV,3VJO,8PNZ,7AEI,5UGB,4I23,1XKK,9QXN,9Q0S,9PMZ,9OU9,9OS6,9NM0,9NJN,9NJ7,9NIS,9NHW,9NGP,9MST,9MSS,9MSR,9KL4,9H47,9H46,9H42,9GL9,9GI9,9FRD,9DM8,8SC7,8G63,6VHP,6VHN,6VH4,6D8E,4ZAU,4WRG,4WKQ,4G5J,3W33,3W32,3W2S,3POZ,2RF9,2J6M,2J5F,2J5E,2ITY,2ITX,2ITW,2GS6,2GS2,7T4I,5FED,9FZS,9FZR,9BY6,9BY4,6JZ0,4JRV,4JR3,4JQ8,4JQ7,8PO0,4LI5,9U8C Epidermal growth factor receptor EGFR_HUMAN P00533 O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9 Q9UMD7 Q9UMD8 Q9UMG5 1581185 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789926 (17E)-8,14,16-trimethyl-2,11,12,14- tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 8 ALK tyrosine kinase receptor Homo sapiens 2.09 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789926 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789926&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 1581186 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCCO2 789947 2-[(17E)-8,16-dimethyl-2,8,11,12- tetrahydro-10H,14H-3,5-etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14-yl]ethan- 1-ol::US20250353864, Example 22 ALK tyrosine kinase receptor Homo sapiens 1.35 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789947 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789947&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 1581187 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CCO2 789956 (10S,17E)-8,10,14,16-tetramethyl- 2,11,12,14-tetrahydro-8H,10H-3,5- etheno[1,5]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 35 ALK tyrosine kinase receptor Homo sapiens 6.93 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789956 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789956&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 1581188 Cc1c2c(nn1C)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789965 (10S,17E)-8,10,12,15,16-pentamethyl- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 58 ALK tyrosine kinase receptor Homo sapiens 4.79 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789965 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789965&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 1581189 CCOC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790012 2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 119 ALK tyrosine kinase receptor Homo sapiens 1.05 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790012 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790012&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 1581190 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790013 (10S,17E)-8,10,12,14,16-pentamethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 120 ALK tyrosine kinase receptor Homo sapiens 1.82 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790013 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790013&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 1581191 Cc1onc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790027 (10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[3,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 134 ALK tyrosine kinase receptor Homo sapiens 21.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790027 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790027&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 1581192 CC(C)OC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790036 2-{(10S,17E)-8,10,12-trimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 147 ALK tyrosine kinase receptor Homo sapiens 0.990 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790036 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790036&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 1581193 C[C@H]1CN(C)Cc2c(c(C#N)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790043 (10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine-16- carbonitrile::US20250353864, Example 159 ALK tyrosine kinase receptor Homo sapiens 3.72 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790043 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790043&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 1581194 C[C@H]1CN(C)Cc2c(c(OCC#N)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790047 {[(10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}acetonitrile::US20250353864, Example 163 ALK tyrosine kinase receptor Homo sapiens 1.13 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790047 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790047&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 1581195 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790064 2-{(10S,17E)-19-fluoro-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 181 ALK tyrosine kinase receptor Homo sapiens 1.05 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790064 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790064&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 1581196 CC(C)Oc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790075 (2S)-2-{(10S,17E)-19-fluoro-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-1-ol::US20250353864, Example 200 ALK tyrosine kinase receptor Homo sapiens 1.49 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790075 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790075&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 1581197 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790085 (2S)-2-[(10S,17E)-16-ethoxy-19-fluoro- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 214 ALK tyrosine kinase receptor Homo sapiens 2.47 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790085 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790085&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 1581198 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790086 (2S)-2-[(10S,17E)-16-ethoxy-12-ethyl- 19-fluoro-8,10-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo|3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 215 ALK tyrosine kinase receptor Homo sapiens 2.58 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790086 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790086&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 1581199 CCN1Cc2c(c(OC(C)C)nn2CCO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O[C@@H](C)C1 790087 2-{(10S,17E)-12-ethyl-19-fluoro-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 216 ALK tyrosine kinase receptor Homo sapiens 2.04 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790087 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790087&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 1581200 CCN1Cc2c(c(OC(C)C)nn2[C@@H](C)CO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O[C@@H](C)C1 790090 (2S)-2-{(10S,17E)-12-ethyl-19-fluoro- 8,10-dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-1-ol::US20250353864, Example 219 ALK tyrosine kinase receptor Homo sapiens 1.31 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790090 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790090&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 1581201 CCN1Cc2c(c(OC(C)C)nn2CC(N)=O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790100 2-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}acetamide::US20250353864, Example 232 ALK tyrosine kinase receptor Homo sapiens 0.900 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790100 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790100&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 1581202 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)[C@H]1CCCN1C2 790126 2-[(8aR,9S,19E)-22-fluoro-9,11- dimethyl-1-[(propan-2-yl)oxy]- 7,8,8a,9,11,17-hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 256 ALK tyrosine kinase receptor Homo sapiens 2.00 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790126 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790126&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 1581203 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C(F)F)CN(C)C2 790127 2-{(10R,17E)-10-(difluoromethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 275 ALK tyrosine kinase receptor Homo sapiens 1.46 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790127 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790127&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 1581204 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)CN(CC)C2 790128 2-[(10R,17E)-16-ethoxy-12-ethyl-19- fluoro-8,10-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 277 ALK tyrosine kinase receptor Homo sapiens 9.87 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790128 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790128&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 1581205 CCN1Cc2c(c(OC(C)C)nn2C[C@H](C)O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790129 (2S)-1-{(10S,17E)-12-ethyl-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-2-ol::US20250353864, Example 280 ALK tyrosine kinase receptor Homo sapiens 1.08 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790129 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790129&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 1581206 CCOC(=N)C1=C(\NCCO)CN(CC)C[C@H](C)Oc2c(cnn2C)-c2cc3c(n[nH]c3cc2F)\C=C\1 790130 2-[(10S,17E)-16-ethoxy-12-ethyl-19- fluoro-8,10-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 288 ALK tyrosine kinase receptor Homo sapiens 1.82 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790130 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790130&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 1581207 CCN1C/C(N[C@@H](C)CO)=C(C(=N)OC)\C=C\c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O[C@H](C)C1 790131 (2S)-2-[(10R,17E)-12-ethyl-19-fluoro-16- methoxy-8,10-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 289 ALK tyrosine kinase receptor Homo sapiens 15.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790131 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790131&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 1581208 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCOC2 790132 (17E)-16-ethyl-8,14-dimethyl- 2,8,10,11,13,14-hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 300 ALK tyrosine kinase receptor Homo sapiens 5.79 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790132 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790132&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 1581209 CCNC(=O)Cn1nc(C)c2c1COCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790133 2-[(17E)-8,16-dimethyl-2,10,11,13- tetrahydro-3,5- etheno[1,4]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazol-14(8H)-yl]- N-ethylacetamide::US20250353864, Example 301 ALK tyrosine kinase receptor Homo sapiens 29.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790133 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790133&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 1581210 Cn1nc(C#N)c2c1COCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790134 (17E)-8,14-dimethyl-2,8,10,11,13,14- hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole-16- carbonitrile::US20250353864, Example 302 ALK tyrosine kinase receptor Homo sapiens 19.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790134 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790134&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 1581211 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCOC2 790135 (17E)-8,14,16-trimethyl-2,8,10,11,13,14- hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 303 ALK tyrosine kinase receptor Homo sapiens 27.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790135 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790135&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 1581212 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)COC2 790125 (10S,17E)-16-ethyl-8,10,14-trimethyl- 2,8,10,11,13,14-hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 319 ALK tyrosine kinase receptor Homo sapiens 5.05 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790125 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790125&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 1581213 Cc1onc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCOC2 790136 (17E)-8,16-dimethyl-2,8,10,11- tetrahydro-13H-3,5- ethenodipyrazolo[3',4':10,11;4$#8243;,3$#8243;:14,15] [1,4]dioxacyclopentadecino[6,7- c][1,2]oxazole::US20250353864, Example 320 ALK tyrosine kinase receptor Homo sapiens 32.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790136 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790136&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 1581214 Cc1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCOC2 790137 (17E)-8,16-dimethyl-2,10,11,13- tetrahydro-8H-3,5- ethenodipyrazolo[3',4':10,11;4$#8243;,3$#8243;:14,15] [1,4]dioxacyclopentadecino[7,6- d][1,2]oxazole::US20250353864, Example 321 ALK tyrosine kinase receptor Homo sapiens 20.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790137 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790137&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 1581215 Cc1snc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCOC2 790138 (17E)-8,16-dimethyl-2,8,10,11- tetrahydro-13H-3,5- ethenodipyrazolo[3',4':10,11;4$#8243;,3$#8243;:14,15] [1,4]dioxacyclopentadecino[6,7- c][1,2]thiazole::US20250353864, Example 322 ALK tyrosine kinase receptor Homo sapiens 59.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790138 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5809&target=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790138&enzyme=ALK+tyrosine+kinase+receptor&column=ki&startPg=0&Increment=50&submit=Search 1 MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP 7NX4,7NX3,9G5I,7N00,7LS0,7MZW,3AOX,7NWZ,8ARJ,7JYT,7JYS,7JYR,7JY4,6EDL,6EBW,6E0R,5FTQ,5FTO,2XBA,2XB7,6MX8,7MZY ALK tyrosine kinase receptor ALK_HUMAN Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6 1581216 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1COCCO2 790139 (17E)-8,14,16-trimethyl-2,8,9,11,12,14- hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 6 Dual specificity protein kinase CLK1 Homo sapiens 0.340 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790139 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790139&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581217 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1COCCO2 790139 (17E)-8,14,16-trimethyl-2,8,9,11,12,14- hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 6 Dual specificity protein kinase CLK2 Homo sapiens 0.230 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790139 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790139&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581218 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1COCCO2 790139 (17E)-8,14,16-trimethyl-2,8,9,11,12,14- hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 6 Dual specificity protein kinase CLK3 178 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790139 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790139&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581219 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1COCCO2 790139 (17E)-8,14,16-trimethyl-2,8,9,11,12,14- hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 6 Dual specificity protein kinase CLK4 Homo sapiens 0.520 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790139 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790139&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581220 Cc1c2c(nn1C)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789922 (17E)-8,15,16-trimethyl-2,8,9,11,12,15- hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 7 Dual specificity protein kinase CLK1 Homo sapiens 0.200 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789922 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789922&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581221 Cc1c2c(nn1C)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789922 (17E)-8,15,16-trimethyl-2,8,9,11,12,15- hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 7 Dual specificity protein kinase CLK2 Homo sapiens 0.080 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789922 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789922&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581222 Cc1c2c(nn1C)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789922 (17E)-8,15,16-trimethyl-2,8,9,11,12,15- hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 7 Dual specificity protein kinase CLK3 45.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789922 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789922&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581223 Cc1c2c(nn1C)OCCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789922 (17E)-8,15,16-trimethyl-2,8,9,11,12,15- hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[11,10- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 7 Dual specificity protein kinase CLK4 Homo sapiens 0.480 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789922 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789922&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581224 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2 789959 (17E)-8,12,14,16-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 43 Dual specificity protein kinase CLK1 Homo sapiens 0.100 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789959 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789959&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581225 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2 789959 (17E)-8,12,14,16-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 43 Dual specificity protein kinase CLK2 Homo sapiens 0.140 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789959 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789959&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581226 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2 789959 (17E)-8,12,14,16-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 43 Dual specificity protein kinase CLK3 236 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789959 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789959&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581227 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2 789959 (17E)-8,12,14,16-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 43 Dual specificity protein kinase CLK4 Homo sapiens 0.250 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789959 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789959&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581228 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1c(C)nn(C)c1OCCN(C)C2 789961 (17E)-6,8,12,14,16-pentamethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 47 Dual specificity protein kinase CLK1 Homo sapiens 9.92 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789961&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581229 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1c(C)nn(C)c1OCCN(C)C2 789961 (17E)-6,8,12,14,16-pentamethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 47 Dual specificity protein kinase CLK2 Homo sapiens 48.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789961&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581230 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1c(C)nn(C)c1OCCN(C)C2 789961 (17E)-6,8,12,14,16-pentamethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 47 Dual specificity protein kinase CLK3 1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789961&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581231 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1c(C)nn(C)c1OCCN(C)C2 789961 (17E)-6,8,12,14,16-pentamethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 47 Dual specificity protein kinase CLK4 Homo sapiens 2.70 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789961&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581232 CC(=O)N1CCOc2c(cnn2C)-c2ccc3[nH]nc(c3c2)/C=C/c2c(nn(C)c2C)C1 790140 1-[(17E)-8,15,16-trimethyl- 2,8,10,11,13,15-hexahydro-12H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-12- yl]ethan-1-one::US20250353864, Example 52 Dual specificity protein kinase CLK1 Homo sapiens 0.240 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790140 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790140&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581233 CC(=O)N1CCOc2c(cnn2C)-c2ccc3[nH]nc(c3c2)/C=C/c2c(nn(C)c2C)C1 790140 1-[(17E)-8,15,16-trimethyl- 2,8,10,11,13,15-hexahydro-12H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-12- yl]ethan-1-one::US20250353864, Example 52 Dual specificity protein kinase CLK2 Homo sapiens 0.190 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790140 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790140&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581234 CC(=O)N1CCOc2c(cnn2C)-c2ccc3[nH]nc(c3c2)/C=C/c2c(nn(C)c2C)C1 790140 1-[(17E)-8,15,16-trimethyl- 2,8,10,11,13,15-hexahydro-12H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-12- yl]ethan-1-one::US20250353864, Example 52 Dual specificity protein kinase CLK3 148 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790140 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790140&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581235 CC(=O)N1CCOc2c(cnn2C)-c2ccc3[nH]nc(c3c2)/C=C/c2c(nn(C)c2C)C1 790140 1-[(17E)-8,15,16-trimethyl- 2,8,10,11,13,15-hexahydro-12H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-12- yl]ethan-1-one::US20250353864, Example 52 Dual specificity protein kinase CLK4 Homo sapiens 0.560 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790140 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790140&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581236 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 789963 (17E)-8,10,14,16-tetramethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 55 Dual specificity protein kinase CLK1 Homo sapiens 0.090 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789963 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789963&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581237 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 789963 (17E)-8,10,14,16-tetramethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 55 Dual specificity protein kinase CLK2 Homo sapiens 0.130 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789963 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789963&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581238 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 789963 (17E)-8,10,14,16-tetramethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 55 Dual specificity protein kinase CLK3 185 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789963 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789963&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581239 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1CN(C)CCO2 789963 (17E)-8,10,14,16-tetramethyl- 2,9,10,11,12,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:4',3'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 55 Dual specificity protein kinase CLK4 Homo sapiens 0.580 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789963 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789963&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581240 Cc1c2c(nn1C)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789965 (10S,17E)-8,10,12,15,16-pentamethyl- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 58 Dual specificity protein kinase CLK1 Homo sapiens 0.200 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789965 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789965&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581241 Cc1c2c(nn1C)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789965 (10S,17E)-8,10,12,15,16-pentamethyl- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 58 Dual specificity protein kinase CLK2 Homo sapiens 0.380 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789965 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789965&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581242 Cc1c2c(nn1C)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789965 (10S,17E)-8,10,12,15,16-pentamethyl- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 58 Dual specificity protein kinase CLK3 160 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789965 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789965&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581243 Cc1c2c(nn1C)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 789965 (10S,17E)-8,10,12,15,16-pentamethyl- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 58 Dual specificity protein kinase CLK4 Homo sapiens 0.530 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789965 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789965&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581244 CCN1Cc2nn(C)c(C)c2/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 789966 (10S,17E)-12-ethyl-8,10,15,16- tetramethyl-2,10,11,12,13,15-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 59 Dual specificity protein kinase CLK1 Homo sapiens 0.820 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789966 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789966&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581245 CCN1Cc2nn(C)c(C)c2/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 789966 (10S,17E)-12-ethyl-8,10,15,16- tetramethyl-2,10,11,12,13,15-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 59 Dual specificity protein kinase CLK2 Homo sapiens 2.13 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789966 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789966&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581246 CCN1Cc2nn(C)c(C)c2/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 789966 (10S,17E)-12-ethyl-8,10,15,16- tetramethyl-2,10,11,12,13,15-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 59 Dual specificity protein kinase CLK3 541 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789966 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789966&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581247 CCN1Cc2nn(C)c(C)c2/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 789966 (10S,17E)-12-ethyl-8,10,15,16- tetramethyl-2,10,11,12,13,15-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 59 Dual specificity protein kinase CLK4 Homo sapiens 2.03 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789966 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789966&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581248 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 789968 2-[(10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 61 Dual specificity protein kinase CLK1 Homo sapiens 0.210 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789968 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789968&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581249 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 789968 2-[(10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 61 Dual specificity protein kinase CLK2 Homo sapiens 0.060 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789968 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789968&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581250 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 789968 2-[(10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 61 Dual specificity protein kinase CLK3 21.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789968 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789968&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581251 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 789968 2-[(10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 61 Dual specificity protein kinase CLK4 Homo sapiens 0.760 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=789968 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=789968&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581252 CN/C1=C(C(C)=N)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2OCCN2CC[C@@H](O1)C2=O 790002 (10R,15E)-3,12,14-trimethyl- 5,6,9,10,12,18-hexahydro-3H,8H-19,21- etheno-7,10-methanotripyrazolo[3,4- i:3',4'-m:4$#8243;,3$#8243;- q][1,8,4]dioxazacyclooctadecin-24-one::US20250353864, Example 109 Dual specificity protein kinase CLK1 Homo sapiens 0.460 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790002 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790002&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581253 CN/C1=C(C(C)=N)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2OCCN2CC[C@@H](O1)C2=O 790002 (10R,15E)-3,12,14-trimethyl- 5,6,9,10,12,18-hexahydro-3H,8H-19,21- etheno-7,10-methanotripyrazolo[3,4- i:3',4'-m:4$#8243;,3$#8243;- q][1,8,4]dioxazacyclooctadecin-24-one::US20250353864, Example 109 Dual specificity protein kinase CLK2 Homo sapiens 0.090 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790002 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790002&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581254 CN/C1=C(C(C)=N)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2OCCN2CC[C@@H](O1)C2=O 790002 (10R,15E)-3,12,14-trimethyl- 5,6,9,10,12,18-hexahydro-3H,8H-19,21- etheno-7,10-methanotripyrazolo[3,4- i:3',4'-m:4$#8243;,3$#8243;- q][1,8,4]dioxazacyclooctadecin-24-one::US20250353864, Example 109 Dual specificity protein kinase CLK3 2.00 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790002 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790002&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581255 CN/C1=C(C(C)=N)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2OCCN2CC[C@@H](O1)C2=O 790002 (10R,15E)-3,12,14-trimethyl- 5,6,9,10,12,18-hexahydro-3H,8H-19,21- etheno-7,10-methanotripyrazolo[3,4- i:3',4'-m:4$#8243;,3$#8243;- q][1,8,4]dioxazacyclooctadecin-24-one::US20250353864, Example 109 Dual specificity protein kinase CLK4 Homo sapiens 0.850 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790002 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790002&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581256 CN1CCC(c2ccc3c(c2)O[C@@H]2CCN(CCOc4c(cnn4C)-c4ccc5[nH]nc(c5c4)/C=C/3)C2=O)CC1 790005 (10R,16E)-3-methyl-13-(1- methylpiperidin-4-yl)-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 112 Dual specificity protein kinase CLK1 Homo sapiens 0.170 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790005 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790005&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581257 CN1CCC(c2ccc3c(c2)O[C@@H]2CCN(CCOc4c(cnn4C)-c4ccc5[nH]nc(c5c4)/C=C/3)C2=O)CC1 790005 (10R,16E)-3-methyl-13-(1- methylpiperidin-4-yl)-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 112 Dual specificity protein kinase CLK2 Homo sapiens 0.040 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790005 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790005&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581258 CN1CCC(c2ccc3c(c2)O[C@@H]2CCN(CCOc4c(cnn4C)-c4ccc5[nH]nc(c5c4)/C=C/3)C2=O)CC1 790005 (10R,16E)-3-methyl-13-(1- methylpiperidin-4-yl)-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 112 Dual specificity protein kinase CLK3 0.190 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790005 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790005&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581259 CN1CCC(c2ccc3c(c2)O[C@@H]2CCN(CCOc4c(cnn4C)-c4ccc5[nH]nc(c5c4)/C=C/3)C2=O)CC1 790005 (10R,16E)-3-methyl-13-(1- methylpiperidin-4-yl)-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 112 Dual specificity protein kinase CLK4 Homo sapiens 0.500 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790005 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790005&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581260 CC(=N)C1=C(\NCCO)CN(C(C)C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790007 2-[(10S,17E)-8,10,16-trimethyl-12- (propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 114 Dual specificity protein kinase CLK1 Homo sapiens 0.230 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790007 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790007&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581261 CC(=N)C1=C(\NCCO)CN(C(C)C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790007 2-[(10S,17E)-8,10,16-trimethyl-12- (propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 114 Dual specificity protein kinase CLK2 Homo sapiens 0.120 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790007 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790007&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581262 CC(=N)C1=C(\NCCO)CN(C(C)C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790007 2-[(10S,17E)-8,10,16-trimethyl-12- (propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 114 Dual specificity protein kinase CLK3 20.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790007 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790007&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581263 CC(=N)C1=C(\NCCO)CN(C(C)C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790007 2-[(10S,17E)-8,10,16-trimethyl-12- (propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 114 Dual specificity protein kinase CLK4 Homo sapiens 0.460 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790007 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790007&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581264 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790009 2-[(10S,17E)-19-fluoro-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 116 Dual specificity protein kinase CLK1 Homo sapiens 0.110 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790009 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790009&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581265 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790009 2-[(10S,17E)-19-fluoro-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 116 Dual specificity protein kinase CLK2 Homo sapiens 0.040 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790009 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790009&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581266 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790009 2-[(10S,17E)-19-fluoro-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 116 Dual specificity protein kinase CLK3 10.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790009 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790009&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581267 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790009 2-[(10S,17E)-19-fluoro-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 116 Dual specificity protein kinase CLK4 Homo sapiens 0.400 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790009 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790009&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581268 CCOC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790012 2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 119 Dual specificity protein kinase CLK1 Homo sapiens 0.140 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790012 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790012&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581269 CCOC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790012 2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 119 Dual specificity protein kinase CLK2 Homo sapiens 0.040 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790012 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790012&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581270 CCOC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790012 2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 119 Dual specificity protein kinase CLK3 19.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790012 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790012&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581271 CCOC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790012 2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 119 Dual specificity protein kinase CLK4 Homo sapiens 0.330 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790012 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790012&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581272 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790013 (10S,17E)-8,10,12,14,16-pentamethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 120 Dual specificity protein kinase CLK1 Homo sapiens 0.120 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790013 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790013&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581273 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790013 (10S,17E)-8,10,12,14,16-pentamethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 120 Dual specificity protein kinase CLK2 Homo sapiens 0.080 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790013 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790013&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581274 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790013 (10S,17E)-8,10,12,14,16-pentamethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 120 Dual specificity protein kinase CLK3 112 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790013 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790013&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581275 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790013 (10S,17E)-8,10,12,14,16-pentamethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 120 Dual specificity protein kinase CLK4 Homo sapiens 0.270 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790013 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790013&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581276 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790015 (10R,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 122 Dual specificity protein kinase CLK1 Homo sapiens 0.270 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790015 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790015&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581277 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790015 (10R,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 122 Dual specificity protein kinase CLK2 Homo sapiens 0.150 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790015 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790015&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581278 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790015 (10R,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 122 Dual specificity protein kinase CLK3 21.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790015 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790015&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581279 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790015 (10R,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 122 Dual specificity protein kinase CLK4 Homo sapiens 0.600 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790015 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790015&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581280 Cc1nn(C[C@H](C)O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790016 (2S)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-2-ol::US20250353864, Example 123 Dual specificity protein kinase CLK1 Homo sapiens 0.170 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790016 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790016&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581281 Cc1nn(C[C@H](C)O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790016 (2S)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-2-ol::US20250353864, Example 123 Dual specificity protein kinase CLK2 Homo sapiens 0.100 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790016 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790016&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581282 Cc1nn(C[C@H](C)O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790016 (2S)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-2-ol::US20250353864, Example 123 Dual specificity protein kinase CLK3 171 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790016 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790016&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581283 Cc1nn(C[C@H](C)O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790016 (2S)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-2-ol::US20250353864, Example 123 Dual specificity protein kinase CLK4 Homo sapiens 0.450 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790016 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790016&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581284 Cc1c2c(nn1C[C@H](C)O)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790017 (2S)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 15H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-15- yl]propan-2-ol::US20250353864, Example 124 Dual specificity protein kinase CLK1 Homo sapiens 0.150 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790017 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790017&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581285 Cc1c2c(nn1C[C@H](C)O)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790017 (2S)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 15H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-15- yl]propan-2-ol::US20250353864, Example 124 Dual specificity protein kinase CLK2 Homo sapiens 0.290 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790017 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790017&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581286 Cc1c2c(nn1C[C@H](C)O)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790017 (2S)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 15H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-15- yl]propan-2-ol::US20250353864, Example 124 Dual specificity protein kinase CLK3 186 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790017 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790017&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581287 Cc1c2c(nn1C[C@H](C)O)CN(C)C[C@H](C)Oc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790017 (2S)-1-[(10S,17E)-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 15H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-15- yl]propan-2-ol::US20250353864, Example 124 Dual specificity protein kinase CLK4 Homo sapiens 0.370 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790017 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790017&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581288 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(Cl)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790018 2-[(10S,17E)-19-chloro-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 125 Dual specificity protein kinase CLK1 Homo sapiens 3.44 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790018 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790018&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581289 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(Cl)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790018 2-[(10S,17E)-19-chloro-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 125 Dual specificity protein kinase CLK2 Homo sapiens 2.81 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790018 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790018&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581290 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(Cl)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790018 2-[(10S,17E)-19-chloro-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 125 Dual specificity protein kinase CLK3 1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790018 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790018&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581291 Cc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(Cl)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790018 2-[(10S,17E)-19-chloro-8,10,12,16- tetramethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 125 Dual specificity protein kinase CLK4 Homo sapiens 4.31 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790018 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790018&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581292 Cc1c2c(nn1C)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790019 (10S,17E)-8,10,12,14,15-pentamethyl- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[4,3-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 126 Dual specificity protein kinase CLK1 Homo sapiens 0.320 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790019 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790019&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581293 Cc1c2c(nn1C)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790019 (10S,17E)-8,10,12,14,15-pentamethyl- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[4,3-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 126 Dual specificity protein kinase CLK2 Homo sapiens 0.120 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790019 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790019&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581294 Cc1c2c(nn1C)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790019 (10S,17E)-8,10,12,14,15-pentamethyl- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[4,3-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 126 Dual specificity protein kinase CLK3 188 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790019 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790019&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581295 Cc1c2c(nn1C)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790019 (10S,17E)-8,10,12,14,15-pentamethyl- 2,10,11,12,13,15-hexahydro-8H-3,5- ethenotripyrazolo[4,3-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 126 Dual specificity protein kinase CLK4 Homo sapiens 0.490 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790019 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790019&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581296 Cn1ncc2c1OCCN1CC[C@@H](Oc3ccc(F)cc3/C=C/c3n[nH]c4ccc-2cc34)C1=O 790025 (10R,16E)-14-fluoro-3-methyl- 3,5,6,9,10,19-hexahydro-8H-20,22- etheno-7,10-methanodipyrazolo[3,4- i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 132 Dual specificity protein kinase CLK1 Homo sapiens 0.190 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790025 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790025&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581297 Cn1ncc2c1OCCN1CC[C@@H](Oc3ccc(F)cc3/C=C/c3n[nH]c4ccc-2cc34)C1=O 790025 (10R,16E)-14-fluoro-3-methyl- 3,5,6,9,10,19-hexahydro-8H-20,22- etheno-7,10-methanodipyrazolo[3,4- i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 132 Dual specificity protein kinase CLK2 Homo sapiens 0.020 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790025 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790025&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581298 Cn1ncc2c1OCCN1CC[C@@H](Oc3ccc(F)cc3/C=C/c3n[nH]c4ccc-2cc34)C1=O 790025 (10R,16E)-14-fluoro-3-methyl- 3,5,6,9,10,19-hexahydro-8H-20,22- etheno-7,10-methanodipyrazolo[3,4- i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 132 Dual specificity protein kinase CLK3 0.280 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790025 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790025&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581299 Cn1ncc2c1OCCN1CC[C@@H](Oc3ccc(F)cc3/C=C/c3n[nH]c4ccc-2cc34)C1=O 790025 (10R,16E)-14-fluoro-3-methyl- 3,5,6,9,10,19-hexahydro-8H-20,22- etheno-7,10-methanodipyrazolo[3,4- i:4',3'- m][1,8,5]benzodioxazacyclooctadecin- 25-one::US20250353864, Example 132 Dual specificity protein kinase CLK4 Homo sapiens 0.300 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790025 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790025&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581300 Cc1onc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790027 (10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[3,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 134 Dual specificity protein kinase CLK1 Homo sapiens 0.290 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790027 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790027&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581301 Cc1onc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790027 (10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[3,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 134 Dual specificity protein kinase CLK2 Homo sapiens 0.190 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790027 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790027&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581302 Cc1onc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790027 (10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[3,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 134 Dual specificity protein kinase CLK3 230 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790027 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790027&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581303 Cc1onc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790027 (10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[3,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 134 Dual specificity protein kinase CLK4 Homo sapiens 0.610 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790027 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790027&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581304 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790030 2-[(10R,19E)-18-ethoxy-8-methyl- 2,10,11,12,13,15-hexahydro-3,5-etheno- 10,14-methanotripyrazolo[3,4-h:3',4'- l:4$#8243;,3$#8243;-p][1,6]oxazacycloheptadecin- 16(8H)-yl]ethan-1-ol::US20250353864, Example 137 Dual specificity protein kinase CLK1 Homo sapiens 1.37 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790030 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790030&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581305 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790030 2-[(10R,19E)-18-ethoxy-8-methyl- 2,10,11,12,13,15-hexahydro-3,5-etheno- 10,14-methanotripyrazolo[3,4-h:3',4'- l:4$#8243;,3$#8243;-p][1,6]oxazacycloheptadecin- 16(8H)-yl]ethan-1-ol::US20250353864, Example 137 Dual specificity protein kinase CLK2 Homo sapiens 2.13 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790030 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790030&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581306 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790030 2-[(10R,19E)-18-ethoxy-8-methyl- 2,10,11,12,13,15-hexahydro-3,5-etheno- 10,14-methanotripyrazolo[3,4-h:3',4'- l:4$#8243;,3$#8243;-p][1,6]oxazacycloheptadecin- 16(8H)-yl]ethan-1-ol::US20250353864, Example 137 Dual specificity protein kinase CLK3 79.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790030 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790030&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581307 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790030 2-[(10R,19E)-18-ethoxy-8-methyl- 2,10,11,12,13,15-hexahydro-3,5-etheno- 10,14-methanotripyrazolo[3,4-h:3',4'- l:4$#8243;,3$#8243;-p][1,6]oxazacycloheptadecin- 16(8H)-yl]ethan-1-ol::US20250353864, Example 137 Dual specificity protein kinase CLK4 Homo sapiens 1.55 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790030 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790030&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581308 Cc1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790141 (10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 141 Dual specificity protein kinase CLK1 Homo sapiens 0.110 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790141 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790141&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581309 Cc1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790141 (10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 141 Dual specificity protein kinase CLK2 Homo sapiens 0.030 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790141 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790141&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581310 Cc1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790141 (10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 141 Dual specificity protein kinase CLK3 41.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790141 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790141&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581311 Cc1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790141 (10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 141 Dual specificity protein kinase CLK4 Homo sapiens 0.130 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790141 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790141&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581312 CCOC(=N)C1=C(\NCCO)CN(C(C)C)C[C@H](C)Oc2c(c(C)nn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790033 2-[(10S,17E)-16-ethoxy-6,8,10-trimethyl- 12-(propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 142 Dual specificity protein kinase CLK1 Homo sapiens 11.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790033 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790033&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581313 CCOC(=N)C1=C(\NCCO)CN(C(C)C)C[C@H](C)Oc2c(c(C)nn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790033 2-[(10S,17E)-16-ethoxy-6,8,10-trimethyl- 12-(propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 142 Dual specificity protein kinase CLK2 Homo sapiens 13.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790033 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790033&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581314 CCOC(=N)C1=C(\NCCO)CN(C(C)C)C[C@H](C)Oc2c(c(C)nn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790033 2-[(10S,17E)-16-ethoxy-6,8,10-trimethyl- 12-(propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 142 Dual specificity protein kinase CLK3 1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790033 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790033&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581315 CCOC(=N)C1=C(\NCCO)CN(C(C)C)C[C@H](C)Oc2c(c(C)nn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790033 2-[(10S,17E)-16-ethoxy-6,8,10-trimethyl- 12-(propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 142 Dual specificity protein kinase CLK4 Homo sapiens 5.91 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790033 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790033&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581316 C[C@H]1CN(C)Cc2c(c(OC3CCN(S(C)(=O)=O)CC3)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790034 (10S,17E)-16-{[1- (methanesulfonyl)piperidin-4-yl]oxy}- 8,10,12,14-tetramethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 143 Dual specificity protein kinase CLK1 Homo sapiens 0.190 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790034 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790034&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581317 C[C@H]1CN(C)Cc2c(c(OC3CCN(S(C)(=O)=O)CC3)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790034 (10S,17E)-16-{[1- (methanesulfonyl)piperidin-4-yl]oxy}- 8,10,12,14-tetramethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 143 Dual specificity protein kinase CLK2 Homo sapiens 0.020 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790034 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790034&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581318 C[C@H]1CN(C)Cc2c(c(OC3CCN(S(C)(=O)=O)CC3)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790034 (10S,17E)-16-{[1- (methanesulfonyl)piperidin-4-yl]oxy}- 8,10,12,14-tetramethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 143 Dual specificity protein kinase CLK3 12.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790034 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790034&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581319 C[C@H]1CN(C)Cc2c(c(OC3CCN(S(C)(=O)=O)CC3)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790034 (10S,17E)-16-{[1- (methanesulfonyl)piperidin-4-yl]oxy}- 8,10,12,14-tetramethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 143 Dual specificity protein kinase CLK4 Homo sapiens 0.610 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790034 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790034&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581320 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)[C@@H]2C 790035 (10S,13R,17E)-8,10,12,13,14,16- hexamethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 144 Dual specificity protein kinase CLK1 Homo sapiens 0.210 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790035 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790035&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581321 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)[C@@H]2C 790035 (10S,13R,17E)-8,10,12,13,14,16- hexamethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 144 Dual specificity protein kinase CLK2 Homo sapiens 0.050 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790035 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790035&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581322 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)[C@@H]2C 790035 (10S,13R,17E)-8,10,12,13,14,16- hexamethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 144 Dual specificity protein kinase CLK3 168 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790035 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790035&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581323 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)[C@@H]2C 790035 (10S,13R,17E)-8,10,12,13,14,16- hexamethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 144 Dual specificity protein kinase CLK4 Homo sapiens 0.550 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790035 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790035&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581324 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)[C@H]2C 790142 (10S,13S,17E)-8,10,12,13,14,16- hexamethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 145 Dual specificity protein kinase CLK1 Homo sapiens 0.210 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790142 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790142&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581325 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)[C@H]2C 790142 (10S,13S,17E)-8,10,12,13,14,16- hexamethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 145 Dual specificity protein kinase CLK2 Homo sapiens 0.040 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790142 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790142&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581326 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)[C@H]2C 790142 (10S,13S,17E)-8,10,12,13,14,16- hexamethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 145 Dual specificity protein kinase CLK3 99.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790142 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790142&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581327 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)[C@H]2C 790142 (10S,13S,17E)-8,10,12,13,14,16- hexamethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 145 Dual specificity protein kinase CLK4 Homo sapiens 0.520 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790142 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790142&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581328 CC(C)OC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790036 2-{(10S,17E)-8,10,12-trimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 147 Dual specificity protein kinase CLK1 Homo sapiens 0.130 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790036 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790036&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581329 CC(C)OC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790036 2-{(10S,17E)-8,10,12-trimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 147 Dual specificity protein kinase CLK2 Homo sapiens 0.020 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790036 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790036&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581330 CC(C)OC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790036 2-{(10S,17E)-8,10,12-trimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 147 Dual specificity protein kinase CLK3 5.21 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790036 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790036&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581331 CC(C)OC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790036 2-{(10S,17E)-8,10,12-trimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 147 Dual specificity protein kinase CLK4 Homo sapiens 0.320 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790036 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790036&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581332 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C(C)C)C2 790039 2-[(10S,17E)-16-ethoxy-8,10-dimethyl- 12-(propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 151 Dual specificity protein kinase CLK1 Homo sapiens 0.240 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790039 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790039&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581333 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C(C)C)C2 790039 2-[(10S,17E)-16-ethoxy-8,10-dimethyl- 12-(propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 151 Dual specificity protein kinase CLK2 Homo sapiens 0.040 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790039 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790039&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581334 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C(C)C)C2 790039 2-[(10S,17E)-16-ethoxy-8,10-dimethyl- 12-(propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 151 Dual specificity protein kinase CLK3 23.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790039 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790039&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581335 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C(C)C)C2 790039 2-[(10S,17E)-16-ethoxy-8,10-dimethyl- 12-(propan-2-yl)-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 151 Dual specificity protein kinase CLK4 Homo sapiens 0.520 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790039 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790039&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581336 CCOC(=N)C1=C(\N[C@@H](C)CO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790041 (2S)-2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 155 Dual specificity protein kinase CLK1 Homo sapiens 0.430 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790041 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790041&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581337 CCOC(=N)C1=C(\N[C@@H](C)CO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790041 (2S)-2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 155 Dual specificity protein kinase CLK2 Homo sapiens 0.140 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790041 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790041&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581338 CCOC(=N)C1=C(\N[C@@H](C)CO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790041 (2S)-2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 155 Dual specificity protein kinase CLK3 87.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790041 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790041&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581339 CCOC(=N)C1=C(\N[C@@H](C)CO)CN(C)C[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790041 (2S)-2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 155 Dual specificity protein kinase CLK4 Homo sapiens 0.810 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790041 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790041&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581340 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C(C)C)C2 790042 (10S,17E)-16-ethoxy-8,10,14-trimethyl- 12-(propan-2-yl)-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 156 Dual specificity protein kinase CLK1 Homo sapiens 0.420 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790042 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790042&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581341 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C(C)C)C2 790042 (10S,17E)-16-ethoxy-8,10,14-trimethyl- 12-(propan-2-yl)-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 156 Dual specificity protein kinase CLK2 Homo sapiens 0.130 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790042 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790042&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581342 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C(C)C)C2 790042 (10S,17E)-16-ethoxy-8,10,14-trimethyl- 12-(propan-2-yl)-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 156 Dual specificity protein kinase CLK3 63.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790042 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790042&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581343 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C(C)C)C2 790042 (10S,17E)-16-ethoxy-8,10,14-trimethyl- 12-(propan-2-yl)-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 156 Dual specificity protein kinase CLK4 Homo sapiens 0.400 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790042 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790042&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581344 Cc1snc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790143 (10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-3,5- ethenodipyrazolo[3,4-j:4',3'- n][1,2]thiazolo[3,4- f][1,4]oxazacyclopentadecine::US20250353864, Example 158 Dual specificity protein kinase CLK1 Homo sapiens 0.140 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790143 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790143&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581345 Cc1snc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790143 (10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-3,5- ethenodipyrazolo[3,4-j:4',3'- n][1,2]thiazolo[3,4- f][1,4]oxazacyclopentadecine::US20250353864, Example 158 Dual specificity protein kinase CLK2 Homo sapiens 0.400 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790143 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790143&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581346 Cc1snc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790143 (10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-3,5- ethenodipyrazolo[3,4-j:4',3'- n][1,2]thiazolo[3,4- f][1,4]oxazacyclopentadecine::US20250353864, Example 158 Dual specificity protein kinase CLK3 664 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790143 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790143&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581347 Cc1snc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790143 (10S,17E)-8,10,12,16-tetramethyl- 2,8,10,11,12,13-hexahydro-3,5- ethenodipyrazolo[3,4-j:4',3'- n][1,2]thiazolo[3,4- f][1,4]oxazacyclopentadecine::US20250353864, Example 158 Dual specificity protein kinase CLK4 Homo sapiens 0.310 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790143 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790143&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581348 C[C@H]1CN(C)Cc2c(c(C#N)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790043 (10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine-16- carbonitrile::US20250353864, Example 159 Dual specificity protein kinase CLK1 Homo sapiens 0.140 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790043 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790043&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581349 C[C@H]1CN(C)Cc2c(c(C#N)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790043 (10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine-16- carbonitrile::US20250353864, Example 159 Dual specificity protein kinase CLK2 Homo sapiens 0.070 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790043 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790043&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581350 C[C@H]1CN(C)Cc2c(c(C#N)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790043 (10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine-16- carbonitrile::US20250353864, Example 159 Dual specificity protein kinase CLK3 1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790043 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790043&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581351 C[C@H]1CN(C)Cc2c(c(C#N)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790043 (10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine-16- carbonitrile::US20250353864, Example 159 Dual specificity protein kinase CLK4 Homo sapiens 0.380 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790043 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790043&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581352 CCOC(=N)C1=C(\NC)CN2CCC[C@H](C2)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790044 (10R,19E)-18-ethoxy-8,16-dimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 160 Dual specificity protein kinase CLK1 Homo sapiens 0.220 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790044 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790044&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581353 CCOC(=N)C1=C(\NC)CN2CCC[C@H](C2)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790044 (10R,19E)-18-ethoxy-8,16-dimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 160 Dual specificity protein kinase CLK2 Homo sapiens 0.300 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790044 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790044&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581354 CCOC(=N)C1=C(\NC)CN2CCC[C@H](C2)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790044 (10R,19E)-18-ethoxy-8,16-dimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 160 Dual specificity protein kinase CLK3 38.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790044 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790044&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581355 CCOC(=N)C1=C(\NC)CN2CCC[C@H](C2)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790044 (10R,19E)-18-ethoxy-8,16-dimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 160 Dual specificity protein kinase CLK4 Homo sapiens 0.410 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790044 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790044&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581356 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C1CC1)C2 790045 (10S,17E)-12-cyclopropyl-8,10,14,16- tetramethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 161 Dual specificity protein kinase CLK1 Homo sapiens 0.270 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790045 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790045&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581357 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C1CC1)C2 790045 (10S,17E)-12-cyclopropyl-8,10,14,16- tetramethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 161 Dual specificity protein kinase CLK2 Homo sapiens 0.140 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790045 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790045&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581358 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C1CC1)C2 790045 (10S,17E)-12-cyclopropyl-8,10,14,16- tetramethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 161 Dual specificity protein kinase CLK3 164 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790045 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790045&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581359 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C1CC1)C2 790045 (10S,17E)-12-cyclopropyl-8,10,14,16- tetramethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 161 Dual specificity protein kinase CLK4 Homo sapiens 0.570 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790045 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790045&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581360 CN/C1=C(C(=N)OCC(F)(F)F)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)CN(C)C1 790046 (10S,17E)-8,10,12,14-tetramethyl-16- (2,2,2-trifluoroethoxy)-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 162 Dual specificity protein kinase CLK1 Homo sapiens 0.110 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790046 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790046&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581361 CN/C1=C(C(=N)OCC(F)(F)F)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)CN(C)C1 790046 (10S,17E)-8,10,12,14-tetramethyl-16- (2,2,2-trifluoroethoxy)-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 162 Dual specificity protein kinase CLK2 Homo sapiens 0.070 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790046 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790046&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581362 CN/C1=C(C(=N)OCC(F)(F)F)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)CN(C)C1 790046 (10S,17E)-8,10,12,14-tetramethyl-16- (2,2,2-trifluoroethoxy)-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 162 Dual specificity protein kinase CLK3 784 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790046 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790046&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581363 CN/C1=C(C(=N)OCC(F)(F)F)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)CN(C)C1 790046 (10S,17E)-8,10,12,14-tetramethyl-16- (2,2,2-trifluoroethoxy)-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 162 Dual specificity protein kinase CLK4 Homo sapiens 0.250 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790046 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790046&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581364 C[C@H]1CN(C)Cc2c(c(OCC#N)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790047 {[(10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}acetonitrile::US20250353864, Example 163 Dual specificity protein kinase CLK1 Homo sapiens 0.280 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790047 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790047&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581365 C[C@H]1CN(C)Cc2c(c(OCC#N)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790047 {[(10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}acetonitrile::US20250353864, Example 163 Dual specificity protein kinase CLK2 Homo sapiens 0.060 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790047 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790047&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581366 C[C@H]1CN(C)Cc2c(c(OCC#N)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790047 {[(10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}acetonitrile::US20250353864, Example 163 Dual specificity protein kinase CLK3 215 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790047 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790047&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581367 C[C@H]1CN(C)Cc2c(c(OCC#N)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790047 {[(10S,17E)-8,10,12,14-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}acetonitrile::US20250353864, Example 163 Dual specificity protein kinase CLK4 Homo sapiens 0.630 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790047 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790047&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581368 CSCn1ncc2c1O[C@@H](C)CN(C(C)C)Cc1c(c(C)nn1C)/C=C/c1n[nH]c3ccc-2cc13 790048 (10S,17E)-10,14,16-trimethyl-8- [(methylsulfanyl)methyl]-12-(propan-2- yl)-2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n|[1,4]oxazacyclopentadecine::US20250353864, Example 164 Dual specificity protein kinase CLK1 Homo sapiens 0.390 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790048 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790048&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581369 CSCn1ncc2c1O[C@@H](C)CN(C(C)C)Cc1c(c(C)nn1C)/C=C/c1n[nH]c3ccc-2cc13 790048 (10S,17E)-10,14,16-trimethyl-8- [(methylsulfanyl)methyl]-12-(propan-2- yl)-2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n|[1,4]oxazacyclopentadecine::US20250353864, Example 164 Dual specificity protein kinase CLK2 Homo sapiens 0.750 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790048 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790048&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581370 CSCn1ncc2c1O[C@@H](C)CN(C(C)C)Cc1c(c(C)nn1C)/C=C/c1n[nH]c3ccc-2cc13 790048 (10S,17E)-10,14,16-trimethyl-8- [(methylsulfanyl)methyl]-12-(propan-2- yl)-2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n|[1,4]oxazacyclopentadecine::US20250353864, Example 164 Dual specificity protein kinase CLK3 1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790048 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790048&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581371 CSCn1ncc2c1O[C@@H](C)CN(C(C)C)Cc1c(c(C)nn1C)/C=C/c1n[nH]c3ccc-2cc13 790048 (10S,17E)-10,14,16-trimethyl-8- [(methylsulfanyl)methyl]-12-(propan-2- yl)-2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n|[1,4]oxazacyclopentadecine::US20250353864, Example 164 Dual specificity protein kinase CLK4 Homo sapiens 0.590 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790048 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790048&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581372 CCN1Cc2c(c(C)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790049 (10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 165 Dual specificity protein kinase CLK1 Homo sapiens 0.100 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790049 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790049&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581373 CCN1Cc2c(c(C)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790049 (10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 165 Dual specificity protein kinase CLK2 Homo sapiens 0.020 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790049 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790049&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581374 CCN1Cc2c(c(C)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790049 (10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 165 Dual specificity protein kinase CLK3 72.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790049 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790049&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581375 CCN1Cc2c(c(C)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790049 (10S,17E)-12-ethyl-8,10,14,16- tetramethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 165 Dual specificity protein kinase CLK4 Homo sapiens 0.190 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790049 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790049&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581376 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCN(C2)C1 790051 n][1,4]oxazacyclopentadecine (10R,18E)-8,15,17-trimethyl- 2,8,11,12,14,15-hexahydro-10H-3,5- etheno-10,13-methanotripyrazolo[3,4- g:3',4'-k:4$#8243;,3$#8243;- 0][1,5]oxazacyclohexadecine::US20250353864, Example 167 Dual specificity protein kinase CLK1 Homo sapiens 0.380 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790051 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790051&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581377 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCN(C2)C1 790051 n][1,4]oxazacyclopentadecine (10R,18E)-8,15,17-trimethyl- 2,8,11,12,14,15-hexahydro-10H-3,5- etheno-10,13-methanotripyrazolo[3,4- g:3',4'-k:4$#8243;,3$#8243;- 0][1,5]oxazacyclohexadecine::US20250353864, Example 167 Dual specificity protein kinase CLK2 Homo sapiens 0.230 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790051 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790051&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581378 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCN(C2)C1 790051 n][1,4]oxazacyclopentadecine (10R,18E)-8,15,17-trimethyl- 2,8,11,12,14,15-hexahydro-10H-3,5- etheno-10,13-methanotripyrazolo[3,4- g:3',4'-k:4$#8243;,3$#8243;- 0][1,5]oxazacyclohexadecine::US20250353864, Example 167 Dual specificity protein kinase CLK3 108 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790051 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790051&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581379 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCN(C2)C1 790051 n][1,4]oxazacyclopentadecine (10R,18E)-8,15,17-trimethyl- 2,8,11,12,14,15-hexahydro-10H-3,5- etheno-10,13-methanotripyrazolo[3,4- g:3',4'-k:4$#8243;,3$#8243;- 0][1,5]oxazacyclohexadecine::US20250353864, Example 167 Dual specificity protein kinase CLK4 Homo sapiens 0.550 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790051 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790051&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581380 CCOC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2CC)-c2ccc3[nH]nc(c3c2)\C=C\1 790052 2-[(10S,17E)-16-ethoxy-8-ethyl-10,12- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 168 Dual specificity protein kinase CLK1 Homo sapiens 0.390 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790052 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790052&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581381 CCOC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2CC)-c2ccc3[nH]nc(c3c2)\C=C\1 790052 2-[(10S,17E)-16-ethoxy-8-ethyl-10,12- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 168 Dual specificity protein kinase CLK2 Homo sapiens 0.330 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790052 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790052&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581382 CCOC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2CC)-c2ccc3[nH]nc(c3c2)\C=C\1 790052 2-[(10S,17E)-16-ethoxy-8-ethyl-10,12- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 168 Dual specificity protein kinase CLK3 238 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790052 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790052&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581383 CCOC(=N)C1=C(\NCCO)CN(C)C[C@H](C)Oc2c(cnn2CC)-c2ccc3[nH]nc(c3c2)\C=C\1 790052 2-[(10S,17E)-16-ethoxy-8-ethyl-10,12- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 168 Dual specificity protein kinase CLK4 Homo sapiens 0.770 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790052 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790052&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581384 CCn1ncc2c1O[C@@H](C)CN(C)C/C(NCCO)=C(C(=N)OC(C)C)\C=C\c1n[nH]c3ccc-2cc13 790053 2-{(10S,17E)-8-ethyl-10,12-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 169 Dual specificity protein kinase CLK1 Homo sapiens 0.470 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790053 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790053&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581385 CCn1ncc2c1O[C@@H](C)CN(C)C/C(NCCO)=C(C(=N)OC(C)C)\C=C\c1n[nH]c3ccc-2cc13 790053 2-{(10S,17E)-8-ethyl-10,12-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 169 Dual specificity protein kinase CLK2 Homo sapiens 0.490 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790053 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790053&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581386 CCn1ncc2c1O[C@@H](C)CN(C)C/C(NCCO)=C(C(=N)OC(C)C)\C=C\c1n[nH]c3ccc-2cc13 790053 2-{(10S,17E)-8-ethyl-10,12-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 169 Dual specificity protein kinase CLK3 346 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790053 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790053&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581387 CCn1ncc2c1O[C@@H](C)CN(C)C/C(NCCO)=C(C(=N)OC(C)C)\C=C\c1n[nH]c3ccc-2cc13 790053 2-{(10S,17E)-8-ethyl-10,12-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 169 Dual specificity protein kinase CLK4 Homo sapiens 1.13 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790053 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790053&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581388 Cn1ncc2c1OCCN1CC[C@H](C1)Oc1ccccc1/C=C/c1n[nH]c3ccc-2cc13 790054 (10R,16E)-3-methyl-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'-m] [1,8,5]benzodioxazacyclooctadecine::US20250353864, Example 170 Dual specificity protein kinase CLK1 Homo sapiens 0.380 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790054 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790054&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581389 Cn1ncc2c1OCCN1CC[C@H](C1)Oc1ccccc1/C=C/c1n[nH]c3ccc-2cc13 790054 (10R,16E)-3-methyl-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'-m] [1,8,5]benzodioxazacyclooctadecine::US20250353864, Example 170 Dual specificity protein kinase CLK2 Homo sapiens 0.360 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790054 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790054&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581390 Cn1ncc2c1OCCN1CC[C@H](C1)Oc1ccccc1/C=C/c1n[nH]c3ccc-2cc13 790054 (10R,16E)-3-methyl-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'-m] [1,8,5]benzodioxazacyclooctadecine::US20250353864, Example 170 Dual specificity protein kinase CLK3 1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790054 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790054&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581391 Cn1ncc2c1OCCN1CC[C@H](C1)Oc1ccccc1/C=C/c1n[nH]c3ccc-2cc13 790054 (10R,16E)-3-methyl-3,5,6,9,10,19- hexahydro-8H-20,22-etheno-7,10- methanodipyrazolo[3,4-i:4',3'-m] [1,8,5]benzodioxazacyclooctadecine::US20250353864, Example 170 Dual specificity protein kinase CLK4 Homo sapiens 0.430 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790054 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790054&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581392 CCOc1nn([C@H](C)CO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790055 (2R)-2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 171 Dual specificity protein kinase CLK1 Homo sapiens 0.850 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790055 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790055&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581393 CCOc1nn([C@H](C)CO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790055 (2R)-2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 171 Dual specificity protein kinase CLK2 Homo sapiens 0.620 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790055 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790055&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581394 CCOc1nn([C@H](C)CO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790055 (2R)-2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 171 Dual specificity protein kinase CLK3 977 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790055 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790055&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581395 CCOc1nn([C@H](C)CO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790055 (2R)-2-[(10S,17E)-16-ethoxy-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 171 Dual specificity protein kinase CLK4 Homo sapiens 0.570 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790055 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790055&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581396 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790056 2-[(10S,17E)-16-ethoxy-19-fluoro- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 172 Dual specificity protein kinase CLK1 Homo sapiens 0.320 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790056 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790056&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581397 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790056 2-[(10S,17E)-16-ethoxy-19-fluoro- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 172 Dual specificity protein kinase CLK2 Homo sapiens 0.080 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790056 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790056&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581398 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790056 2-[(10S,17E)-16-ethoxy-19-fluoro- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 172 Dual specificity protein kinase CLK3 64.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790056 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790056&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581399 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790056 2-[(10S,17E)-16-ethoxy-19-fluoro- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 172 Dual specificity protein kinase CLK4 Homo sapiens 0.590 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790056 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790056&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581400 C[C@H]1CN(C)Cc2onc(C3CC3)c2/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790057 (10S,17E)-16-cyclopropyl-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 173 Dual specificity protein kinase CLK1 Homo sapiens 0.700 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790057 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790057&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581401 C[C@H]1CN(C)Cc2onc(C3CC3)c2/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790057 (10S,17E)-16-cyclopropyl-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 173 Dual specificity protein kinase CLK2 Homo sapiens 0.890 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790057 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790057&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581402 C[C@H]1CN(C)Cc2onc(C3CC3)c2/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790057 (10S,17E)-16-cyclopropyl-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 173 Dual specificity protein kinase CLK3 1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790057 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790057&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581403 C[C@H]1CN(C)Cc2onc(C3CC3)c2/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790057 (10S,17E)-16-cyclopropyl-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 173 Dual specificity protein kinase CLK4 Homo sapiens 1.26 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790057 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790057&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581404 CCc1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790058 (10S,17E)-16-ethyl-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 174 Dual specificity protein kinase CLK1 Homo sapiens 0.160 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790058 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790058&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581405 CCc1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790058 (10S,17E)-16-ethyl-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 174 Dual specificity protein kinase CLK2 Homo sapiens 0.210 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790058 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790058&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581406 CCc1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790058 (10S,17E)-16-ethyl-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 174 Dual specificity protein kinase CLK3 128 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790058 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790058&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581407 CCc1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790058 (10S,17E)-16-ethyl-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 174 Dual specificity protein kinase CLK4 Homo sapiens 0.510 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790058 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790058&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581408 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H]1CCCN(C2)C1 790060 (10S,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 176 Dual specificity protein kinase CLK1 Homo sapiens 1.54 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790060 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790060&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581409 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H]1CCCN(C2)C1 790060 (10S,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 176 Dual specificity protein kinase CLK2 Homo sapiens 11.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790060 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790060&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581410 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H]1CCCN(C2)C1 790060 (10S,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 176 Dual specificity protein kinase CLK3 1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790060 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790060&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581411 Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H]1CCCN(C2)C1 790060 (10S,19E)-8,16,18-trimethyl- 2,8,10,11,12,13,15,16-octahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecine::US20250353864, Example 176 Dual specificity protein kinase CLK4 Homo sapiens 1.44 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790060 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790060&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581412 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790061 2-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 177 Dual specificity protein kinase CLK1 Homo sapiens 0.470 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790061 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790061&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581413 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790061 2-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 177 Dual specificity protein kinase CLK2 Homo sapiens 0.230 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790061 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790061&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581414 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790061 2-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 177 Dual specificity protein kinase CLK3 59.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790061 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790061&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581415 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790061 2-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 177 Dual specificity protein kinase CLK4 Homo sapiens 1.08 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790061 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790061&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581416 CCOc1nn(C)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790062 2-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 178 Dual specificity protein kinase CLK1 Homo sapiens 1.08 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790062 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790062&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581417 CCOc1nn(C)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790062 2-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 178 Dual specificity protein kinase CLK2 Homo sapiens 2.38 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790062 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790062&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581418 CCOc1nn(C)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790062 2-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 178 Dual specificity protein kinase CLK3 61.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790062 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790062&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581419 CCOc1nn(C)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790062 2-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 178 Dual specificity protein kinase CLK4 Homo sapiens 1.56 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790062 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790062&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581420 CC(C)c1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790063 (10S,17E)-8,10,12-trimethyl-16-(propan- 2-yl)-2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 179 Dual specificity protein kinase CLK1 Homo sapiens 2.75 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790063 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790063&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581421 CC(C)c1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790063 (10S,17E)-8,10,12-trimethyl-16-(propan- 2-yl)-2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 179 Dual specificity protein kinase CLK2 Homo sapiens 9.57 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790063 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790063&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581422 CC(C)c1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790063 (10S,17E)-8,10,12-trimethyl-16-(propan- 2-yl)-2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 179 Dual specificity protein kinase CLK3 1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790063 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790063&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581423 CC(C)c1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790063 (10S,17E)-8,10,12-trimethyl-16-(propan- 2-yl)-2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 179 Dual specificity protein kinase CLK4 Homo sapiens 1.66 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790063 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790063&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581424 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790064 2-{(10S,17E)-19-fluoro-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 181 Dual specificity protein kinase CLK1 Homo sapiens 0.870 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790064 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790064&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581425 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790064 2-{(10S,17E)-19-fluoro-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 181 Dual specificity protein kinase CLK2 Homo sapiens 0.680 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790064 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790064&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581426 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790064 2-{(10S,17E)-19-fluoro-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 181 Dual specificity protein kinase CLK3 56.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790064 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790064&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581427 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790064 2-{(10S,17E)-19-fluoro-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 181 Dual specificity protein kinase CLK4 Homo sapiens 2.60 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790064 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790064&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581428 CCOc1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790066 (10S,17E)-16-ethoxy-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 183 Dual specificity protein kinase CLK1 Homo sapiens 0.820 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790066 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790066&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581429 CCOc1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790066 (10S,17E)-16-ethoxy-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 183 Dual specificity protein kinase CLK2 Homo sapiens 0.240 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790066 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790066&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581430 CCOc1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790066 (10S,17E)-16-ethoxy-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 183 Dual specificity protein kinase CLK3 155 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790066 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790066&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581431 CCOc1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790066 (10S,17E)-16-ethoxy-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- etheno[1,2]oxazolo[5,4-f]dipyrazolo[3,4- j:4',3'-n][1,4]oxazacyclopentadecine::US20250353864, Example 183 Dual specificity protein kinase CLK4 Homo sapiens 1.83 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790066 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790066&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581432 C[C@H]1CN(C)Cc2c(c(O)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790067 (10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-16- ol::US20250353864, Example 186 Dual specificity protein kinase CLK1 Homo sapiens 0.240 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790067 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790067&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581433 C[C@H]1CN(C)Cc2c(c(O)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790067 (10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-16- ol::US20250353864, Example 186 Dual specificity protein kinase CLK2 Homo sapiens 0.180 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790067 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790067&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581434 C[C@H]1CN(C)Cc2c(c(O)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790067 (10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-16- ol::US20250353864, Example 186 Dual specificity protein kinase CLK3 126 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790067 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790067&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581435 C[C@H]1CN(C)Cc2c(c(O)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790067 (10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-16- ol::US20250353864, Example 186 Dual specificity protein kinase CLK4 Homo sapiens 1.000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790067 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790067&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581436 C[C@H]1CN(C)Cc2c(c(OC3CC(S(C)(=O)=O)C3)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790068 (10S,17E)-16-{[3- (methanesulfonyl)cyclobutyl]oxy}- 8,10,12,14-tetramethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 187 Dual specificity protein kinase CLK1 Homo sapiens 0.480 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790068 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790068&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581437 C[C@H]1CN(C)Cc2c(c(OC3CC(S(C)(=O)=O)C3)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790068 (10S,17E)-16-{[3- (methanesulfonyl)cyclobutyl]oxy}- 8,10,12,14-tetramethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 187 Dual specificity protein kinase CLK2 Homo sapiens 0.300 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790068 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790068&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581438 C[C@H]1CN(C)Cc2c(c(OC3CC(S(C)(=O)=O)C3)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790068 (10S,17E)-16-{[3- (methanesulfonyl)cyclobutyl]oxy}- 8,10,12,14-tetramethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 187 Dual specificity protein kinase CLK3 311 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790068 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790068&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581439 C[C@H]1CN(C)Cc2c(c(OC3CC(S(C)(=O)=O)C3)nn2C)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790068 (10S,17E)-16-{[3- (methanesulfonyl)cyclobutyl]oxy}- 8,10,12,14-tetramethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 187 Dual specificity protein kinase CLK4 Homo sapiens 1.35 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790068 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790068&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581440 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790069 2-[(10R,19E)-18-ethoxy-22-fluoro-8- methyl-2,10,11,12,13,15-hexahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecin-16(8H)- yl]ethan-1-ol::US20250353864, Example 191 Dual specificity protein kinase CLK1 Homo sapiens 2.42 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790069 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790069&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581441 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790069 2-[(10R,19E)-18-ethoxy-22-fluoro-8- methyl-2,10,11,12,13,15-hexahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecin-16(8H)- yl]ethan-1-ol::US20250353864, Example 191 Dual specificity protein kinase CLK2 Homo sapiens 4.37 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790069 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790069&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581442 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790069 2-[(10R,19E)-18-ethoxy-22-fluoro-8- methyl-2,10,11,12,13,15-hexahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecin-16(8H)- yl]ethan-1-ol::US20250353864, Example 191 Dual specificity protein kinase CLK3 43.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790069 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790069&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581443 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790069 2-[(10R,19E)-18-ethoxy-22-fluoro-8- methyl-2,10,11,12,13,15-hexahydro-3,5- etheno-10,14-methanotripyrazolo[3,4- h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecin-16(8H)- yl]ethan-1-ol::US20250353864, Example 191 Dual specificity protein kinase CLK4 Homo sapiens 2.41 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790069 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790069&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581444 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790070 2-{(10R,17E)-8,10-dimethyl-12-(propan- 2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 193 Dual specificity protein kinase CLK1 Homo sapiens 31.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790070 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790070&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581445 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790070 2-{(10R,17E)-8,10-dimethyl-12-(propan- 2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 193 Dual specificity protein kinase CLK2 Homo sapiens 45.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790070 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790070&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581446 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790070 2-{(10R,17E)-8,10-dimethyl-12-(propan- 2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 193 Dual specificity protein kinase CLK3 1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790070 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790070&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581447 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790070 2-{(10R,17E)-8,10-dimethyl-12-(propan- 2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 193 Dual specificity protein kinase CLK4 Homo sapiens 21.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790070 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790070&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581448 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790071 2-{(10R,17E)-19-fluoro-8,10-dimethyl- 12-(propan-2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 195 Dual specificity protein kinase CLK1 Homo sapiens 36.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790071 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790071&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581449 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790071 2-{(10R,17E)-19-fluoro-8,10-dimethyl- 12-(propan-2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 195 Dual specificity protein kinase CLK2 Homo sapiens 53.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790071 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790071&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581450 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790071 2-{(10R,17E)-19-fluoro-8,10-dimethyl- 12-(propan-2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 195 Dual specificity protein kinase CLK3 435 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790071 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790071&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581451 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790071 2-{(10R,17E)-19-fluoro-8,10-dimethyl- 12-(propan-2-yl)-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 195 Dual specificity protein kinase CLK4 Homo sapiens 22.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790071 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790071&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581452 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CNC2 790072 2-[(10R,17E)-16-ethoxy-8,10-dimethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 197 Dual specificity protein kinase CLK1 Homo sapiens 1.16 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790072 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790072&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581453 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CNC2 790072 2-[(10R,17E)-16-ethoxy-8,10-dimethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 197 Dual specificity protein kinase CLK2 Homo sapiens 3.06 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790072 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790072&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581454 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CNC2 790072 2-[(10R,17E)-16-ethoxy-8,10-dimethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 197 Dual specificity protein kinase CLK3 78.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790072 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790072&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581455 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CNC2 790072 2-[(10R,17E)-16-ethoxy-8,10-dimethyl- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 197 Dual specificity protein kinase CLK4 Homo sapiens 1.59 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790072 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790072&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581456 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC[C@H](C)N(C1CC1)C2 790073 2-[(11S,17E)-12-cyclopropyl-16-ethoxy- 8,11-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 198 Dual specificity protein kinase CLK1 Homo sapiens 0.760 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790073 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790073&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581457 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC[C@H](C)N(C1CC1)C2 790073 2-[(11S,17E)-12-cyclopropyl-16-ethoxy- 8,11-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 198 Dual specificity protein kinase CLK2 Homo sapiens 1.61 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790073 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790073&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581458 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC[C@H](C)N(C1CC1)C2 790073 2-[(11S,17E)-12-cyclopropyl-16-ethoxy- 8,11-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 198 Dual specificity protein kinase CLK3 1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790073 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790073&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581459 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC[C@H](C)N(C1CC1)C2 790073 2-[(11S,17E)-12-cyclopropyl-16-ethoxy- 8,11-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 198 Dual specificity protein kinase CLK4 Homo sapiens 1.63 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790073 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790073&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581460 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790074 2-[(10R,19E)-22-fluoro-8-methyl-18- [(propan-2-yl)oxy]-2,10,11,12,13,15- hexahydro-3,5-etheno-10,14- methanotripyrazolo[3,4-h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecin-16(8H)- yl]ethan-1-ol::US20250353864, Example 199 Dual specificity protein kinase CLK1 Homo sapiens 1.05 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790074 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790074&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581461 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790074 2-[(10R,19E)-22-fluoro-8-methyl-18- [(propan-2-yl)oxy]-2,10,11,12,13,15- hexahydro-3,5-etheno-10,14- methanotripyrazolo[3,4-h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecin-16(8H)- yl]ethan-1-ol::US20250353864, Example 199 Dual specificity protein kinase CLK2 Homo sapiens 2.29 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790074 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790074&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581462 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790074 2-[(10R,19E)-22-fluoro-8-methyl-18- [(propan-2-yl)oxy]-2,10,11,12,13,15- hexahydro-3,5-etheno-10,14- methanotripyrazolo[3,4-h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecin-16(8H)- yl]ethan-1-ol::US20250353864, Example 199 Dual specificity protein kinase CLK3 19.3 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790074 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790074&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581463 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H]1CCCN(C2)C1 790074 2-[(10R,19E)-22-fluoro-8-methyl-18- [(propan-2-yl)oxy]-2,10,11,12,13,15- hexahydro-3,5-etheno-10,14- methanotripyrazolo[3,4-h:3',4'-l:4$#8243;,3$#8243;- p][1,6]oxazacycloheptadecin-16(8H)- yl]ethan-1-ol::US20250353864, Example 199 Dual specificity protein kinase CLK4 Homo sapiens 1.79 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790074 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790074&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581464 CC(C)Oc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790075 (2S)-2-{(10S,17E)-19-fluoro-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-1-ol::US20250353864, Example 200 Dual specificity protein kinase CLK1 Homo sapiens 0.480 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790075 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790075&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581465 CC(C)Oc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790075 (2S)-2-{(10S,17E)-19-fluoro-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-1-ol::US20250353864, Example 200 Dual specificity protein kinase CLK2 Homo sapiens 1.000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790075 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790075&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581466 CC(C)Oc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790075 (2S)-2-{(10S,17E)-19-fluoro-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-1-ol::US20250353864, Example 200 Dual specificity protein kinase CLK3 194 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790075 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790075&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581467 CC(C)Oc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790075 (2S)-2-{(10S,17E)-19-fluoro-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-1-ol::US20250353864, Example 200 Dual specificity protein kinase CLK4 Homo sapiens 1.53 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790075 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790075&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581468 C[C@H]1CN(C)Cc2c(c(OCC#N)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790077 {[(10S,17E)-14-(2-hydroxyethyl)- 8,10,12-trimethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}acetonitrile::US20250353864, Example 203 Dual specificity protein kinase CLK1 Homo sapiens 0.720 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790077 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790077&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581469 C[C@H]1CN(C)Cc2c(c(OCC#N)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790077 {[(10S,17E)-14-(2-hydroxyethyl)- 8,10,12-trimethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}acetonitrile::US20250353864, Example 203 Dual specificity protein kinase CLK2 Homo sapiens 0.140 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790077 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790077&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581470 C[C@H]1CN(C)Cc2c(c(OCC#N)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790077 {[(10S,17E)-14-(2-hydroxyethyl)- 8,10,12-trimethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}acetonitrile::US20250353864, Example 203 Dual specificity protein kinase CLK3 151 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790077 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790077&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581471 C[C@H]1CN(C)Cc2c(c(OCC#N)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790077 {[(10S,17E)-14-(2-hydroxyethyl)- 8,10,12-trimethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}acetonitrile::US20250353864, Example 203 Dual specificity protein kinase CLK4 Homo sapiens 1.59 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790077 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790077&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581472 CCOc1nn(C)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790080 (10S,17E)-16-ethoxy-12-ethyl-19-fluoro- 8,10,14-trimethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 206 Dual specificity protein kinase CLK1 Homo sapiens 1.67 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790080 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790080&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581473 CCOc1nn(C)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790080 (10S,17E)-16-ethoxy-12-ethyl-19-fluoro- 8,10,14-trimethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 206 Dual specificity protein kinase CLK2 Homo sapiens 1.72 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790080 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790080&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581474 CCOc1nn(C)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790080 (10S,17E)-16-ethoxy-12-ethyl-19-fluoro- 8,10,14-trimethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 206 Dual specificity protein kinase CLK3 477 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790080 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790080&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581475 CCOc1nn(C)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790080 (10S,17E)-16-ethoxy-12-ethyl-19-fluoro- 8,10,14-trimethyl-2,10,11,12,13,14- hexahydro-8H-3,5-ethenotripyrazolo[3,4- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 206 Dual specificity protein kinase CLK4 Homo sapiens 3.69 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790080 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790080&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581476 C[C@H]1CN(C)Cc2c(c(C#N)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790144 (10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine-16- carbonitrile::US20250353864, Example 208 Dual specificity protein kinase CLK1 Homo sapiens 0.590 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790144 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790144&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581477 C[C@H]1CN(C)Cc2c(c(C#N)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790144 (10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine-16- carbonitrile::US20250353864, Example 208 Dual specificity protein kinase CLK2 Homo sapiens 0.130 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790144 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790144&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581478 C[C@H]1CN(C)Cc2c(c(C#N)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790144 (10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine-16- carbonitrile::US20250353864, Example 208 Dual specificity protein kinase CLK3 220 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790144 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790144&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581479 C[C@H]1CN(C)Cc2c(c(C#N)nn2CCO)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O1 790144 (10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-2,10,11,12,13,14-hexahydro- 8H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine-16- carbonitrile::US20250353864, Example 208 Dual specificity protein kinase CLK4 Homo sapiens 1.53 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790144 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790144&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581480 C[C@H]1CN(C)Cc2c(c(OCC(F)(F)F)nn2CCO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O1 790082 2-[(10S,17E)-19-fluoro-8,10,12- trimethyl-16-(2,2,2-trifluoroethoxy)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 211 Dual specificity protein kinase CLK1 Homo sapiens 270 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790082 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790082&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581481 C[C@H]1CN(C)Cc2c(c(OCC(F)(F)F)nn2CCO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O1 790082 2-[(10S,17E)-19-fluoro-8,10,12- trimethyl-16-(2,2,2-trifluoroethoxy)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 211 Dual specificity protein kinase CLK2 Homo sapiens 114 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790082 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790082&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581482 C[C@H]1CN(C)Cc2c(c(OCC(F)(F)F)nn2CCO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O1 790082 2-[(10S,17E)-19-fluoro-8,10,12- trimethyl-16-(2,2,2-trifluoroethoxy)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 211 Dual specificity protein kinase CLK3 1.000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790082 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790082&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581483 C[C@H]1CN(C)Cc2c(c(OCC(F)(F)F)nn2CCO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O1 790082 2-[(10S,17E)-19-fluoro-8,10,12- trimethyl-16-(2,2,2-trifluoroethoxy)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 211 Dual specificity protein kinase CLK4 Homo sapiens 397 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790082 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790082&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581484 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C1CC1)C2 790083 2-{(10R,17E)-12-cyclopropyl-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 212 Dual specificity protein kinase CLK1 Homo sapiens 5.27 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790083 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790083&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581485 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C1CC1)C2 790083 2-{(10R,17E)-12-cyclopropyl-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 212 Dual specificity protein kinase CLK2 Homo sapiens 7.14 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790083 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790083&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581486 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C1CC1)C2 790083 2-{(10R,17E)-12-cyclopropyl-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 212 Dual specificity protein kinase CLK3 237 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790083 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790083&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581487 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](C)CN(C1CC1)C2 790083 2-{(10R,17E)-12-cyclopropyl-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 212 Dual specificity protein kinase CLK4 Homo sapiens 5.31 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790083 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790083&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581488 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC[C@H](C)N(C1CC1)C2 790084 2-{(11S,17E)-12-cyclopropyl-8,11- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 213 Dual specificity protein kinase CLK1 Homo sapiens 5.75 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790084 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790084&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581489 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC[C@H](C)N(C1CC1)C2 790084 2-{(11S,17E)-12-cyclopropyl-8,11- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 213 Dual specificity protein kinase CLK2 Homo sapiens 6.11 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790084 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790084&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581490 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC[C@H](C)N(C1CC1)C2 790084 2-{(11S,17E)-12-cyclopropyl-8,11- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 213 Dual specificity protein kinase CLK3 1.000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790084 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790084&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581491 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC[C@H](C)N(C1CC1)C2 790084 2-{(11S,17E)-12-cyclopropyl-8,11- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 213 Dual specificity protein kinase CLK4 Homo sapiens 5.07 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790084 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790084&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581492 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790085 (2S)-2-[(10S,17E)-16-ethoxy-19-fluoro- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 214 Dual specificity protein kinase CLK1 Homo sapiens 2.37 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790085 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790085&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581493 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790085 (2S)-2-[(10S,17E)-16-ethoxy-19-fluoro- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 214 Dual specificity protein kinase CLK2 Homo sapiens 2.51 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790085 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790085&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581494 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790085 (2S)-2-[(10S,17E)-16-ethoxy-19-fluoro- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 214 Dual specificity protein kinase CLK3 592 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790085 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790085&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581495 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790085 (2S)-2-[(10S,17E)-16-ethoxy-19-fluoro- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 214 Dual specificity protein kinase CLK4 Homo sapiens 7.25 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790085 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790085&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581496 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790086 (2S)-2-[(10S,17E)-16-ethoxy-12-ethyl- 19-fluoro-8,10-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo|3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 215 Dual specificity protein kinase CLK1 Homo sapiens 3.33 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790086 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790086&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581497 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790086 (2S)-2-[(10S,17E)-16-ethoxy-12-ethyl- 19-fluoro-8,10-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo|3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 215 Dual specificity protein kinase CLK2 Homo sapiens 2.10 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790086 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790086&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581498 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790086 (2S)-2-[(10S,17E)-16-ethoxy-12-ethyl- 19-fluoro-8,10-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo|3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 215 Dual specificity protein kinase CLK3 964 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790086 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790086&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581499 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790086 (2S)-2-[(10S,17E)-16-ethoxy-12-ethyl- 19-fluoro-8,10-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo|3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 215 Dual specificity protein kinase CLK4 Homo sapiens 9.08 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790086 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790086&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581500 CCN1Cc2c(c(OC(C)C)nn2CCO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O[C@@H](C)C1 790087 2-{(10S,17E)-12-ethyl-19-fluoro-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 216 Dual specificity protein kinase CLK1 Homo sapiens 2.02 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790087 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790087&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581501 CCN1Cc2c(c(OC(C)C)nn2CCO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O[C@@H](C)C1 790087 2-{(10S,17E)-12-ethyl-19-fluoro-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 216 Dual specificity protein kinase CLK2 Homo sapiens 1.28 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790087 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790087&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581502 CCN1Cc2c(c(OC(C)C)nn2CCO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O[C@@H](C)C1 790087 2-{(10S,17E)-12-ethyl-19-fluoro-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 216 Dual specificity protein kinase CLK3 115 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790087 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790087&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581503 CCN1Cc2c(c(OC(C)C)nn2CCO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O[C@@H](C)C1 790087 2-{(10S,17E)-12-ethyl-19-fluoro-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 216 Dual specificity protein kinase CLK4 Homo sapiens 5.39 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790087 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790087&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581504 CCN1Cc2c(c(OC(C)C)nn2[C@@H](C)CO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O[C@@H](C)C1 790090 (2S)-2-{(10S,17E)-12-ethyl-19-fluoro- 8,10-dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-1-ol::US20250353864, Example 219 Dual specificity protein kinase CLK1 Homo sapiens 2.05 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790090 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790090&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581505 CCN1Cc2c(c(OC(C)C)nn2[C@@H](C)CO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O[C@@H](C)C1 790090 (2S)-2-{(10S,17E)-12-ethyl-19-fluoro- 8,10-dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-1-ol::US20250353864, Example 219 Dual specificity protein kinase CLK2 Homo sapiens 4.51 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790090 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790090&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581506 CCN1Cc2c(c(OC(C)C)nn2[C@@H](C)CO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O[C@@H](C)C1 790090 (2S)-2-{(10S,17E)-12-ethyl-19-fluoro- 8,10-dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-1-ol::US20250353864, Example 219 Dual specificity protein kinase CLK3 146 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790090 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790090&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581507 CCN1Cc2c(c(OC(C)C)nn2[C@@H](C)CO)/C=C/c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O[C@@H](C)C1 790090 (2S)-2-{(10S,17E)-12-ethyl-19-fluoro- 8,10-dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-1-ol::US20250353864, Example 219 Dual specificity protein kinase CLK4 Homo sapiens 5.62 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790090 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790090&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581508 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)C(=O)N(C)C2 790091 (10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,12,13,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-11(10H)- one::US20250353864, Example 220 Dual specificity protein kinase CLK1 Homo sapiens 2.76 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790091 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790091&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581509 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)C(=O)N(C)C2 790091 (10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,12,13,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-11(10H)- one::US20250353864, Example 220 Dual specificity protein kinase CLK2 Homo sapiens 8.84 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790091 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790091&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581510 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)C(=O)N(C)C2 790091 (10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,12,13,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-11(10H)- one::US20250353864, Example 220 Dual specificity protein kinase CLK3 1.000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790091 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790091&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581511 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)C(=O)N(C)C2 790091 (10S,17E)-14-(2-hydroxyethyl)-8,10,12- trimethyl-16-[(propan-2-yl)oxy]- 2,12,13,14-tetrahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-11(10H)- one::US20250353864, Example 220 Dual specificity protein kinase CLK4 Homo sapiens 4.31 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790091 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790091&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581512 CCOc1nn(CC(C)(C)O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790093 1-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]-2-methylpropan-2-ol::US20250353864, Example 222 Dual specificity protein kinase CLK1 Homo sapiens 2.31 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790093 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790093&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581513 CCOc1nn(CC(C)(C)O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790093 1-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]-2-methylpropan-2-ol::US20250353864, Example 222 Dual specificity protein kinase CLK2 Homo sapiens 3.17 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790093 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790093&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581514 CCOc1nn(CC(C)(C)O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790093 1-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]-2-methylpropan-2-ol::US20250353864, Example 222 Dual specificity protein kinase CLK3 306 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790093 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790093&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581515 CCOc1nn(CC(C)(C)O)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(CC)C2 790093 1-[(10S,17E)-16-ethoxy-12-ethyl-8,10- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]-2-methylpropan-2-ol::US20250353864, Example 222 Dual specificity protein kinase CLK4 Homo sapiens 2.46 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790093 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790093&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581516 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)[C@@H]2C 790094 2-{(10S,13R,17E)-8,10,12,13- tetramethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 223 Dual specificity protein kinase CLK1 Homo sapiens 0.850 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790094 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790094&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581517 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)[C@@H]2C 790094 2-{(10S,13R,17E)-8,10,12,13- tetramethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 223 Dual specificity protein kinase CLK2 Homo sapiens 0.280 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790094 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790094&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581518 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)[C@@H]2C 790094 2-{(10S,13R,17E)-8,10,12,13- tetramethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 223 Dual specificity protein kinase CLK3 30.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790094 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790094&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581519 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)[C@@H]2C 790094 2-{(10S,13R,17E)-8,10,12,13- tetramethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 223 Dual specificity protein kinase CLK4 Homo sapiens 2.11 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790094 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790094&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581520 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)[C@H]2C 790145 2-{(10S,13S,17E)-8,10,12,13- tetramethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 224 Dual specificity protein kinase CLK1 Homo sapiens 0.690 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790145 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790145&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581521 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)[C@H]2C 790145 2-{(10S,13S,17E)-8,10,12,13- tetramethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 224 Dual specificity protein kinase CLK2 Homo sapiens 1.16 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790145 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790145&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581522 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)[C@H]2C 790145 2-{(10S,13S,17E)-8,10,12,13- tetramethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 224 Dual specificity protein kinase CLK3 253 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790145 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790145&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581523 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)[C@H]2C 790145 2-{(10S,13S,17E)-8,10,12,13- tetramethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 224 Dual specificity protein kinase CLK4 Homo sapiens 1.46 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790145 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790145&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581524 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC(CF)CN(C)C2 790095 2-{(17E)-10-(fluoromethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 225 Dual specificity protein kinase CLK1 Homo sapiens 1.11 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790095 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790095&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581525 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC(CF)CN(C)C2 790095 2-{(17E)-10-(fluoromethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 225 Dual specificity protein kinase CLK2 Homo sapiens 0.490 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790095 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790095&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581526 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC(CF)CN(C)C2 790095 2-{(17E)-10-(fluoromethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 225 Dual specificity protein kinase CLK3 77.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790095 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790095&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581527 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC(CF)CN(C)C2 790095 2-{(17E)-10-(fluoromethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 225 Dual specificity protein kinase CLK4 Homo sapiens 1.92 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790095 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790095&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581528 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCC(CF)N(C)C2 790096 2-{(17E)-11-(fluoromethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 226 Dual specificity protein kinase CLK1 Homo sapiens 0.870 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790096 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790096&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581529 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCC(CF)N(C)C2 790096 2-{(17E)-11-(fluoromethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 226 Dual specificity protein kinase CLK2 Homo sapiens 0.990 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790096 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790096&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581530 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCC(CF)N(C)C2 790096 2-{(17E)-11-(fluoromethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 226 Dual specificity protein kinase CLK3 369 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790096 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790096&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581531 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCC(CF)N(C)C2 790096 2-{(17E)-11-(fluoromethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 226 Dual specificity protein kinase CLK4 Homo sapiens 1.44 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790096 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790096&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581532 CCN1Cc2c(c(OC(C)C)nn2C[C@H](C)O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@H](C)C1 790097 (2S)-1-{(10R,17E)-12-ethyl-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-2-ol::US20250353864, Example 227 Dual specificity protein kinase CLK1 Homo sapiens 4.90 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790097 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790097&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581533 CCN1Cc2c(c(OC(C)C)nn2C[C@H](C)O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@H](C)C1 790097 (2S)-1-{(10R,17E)-12-ethyl-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-2-ol::US20250353864, Example 227 Dual specificity protein kinase CLK2 Homo sapiens 2.59 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790097 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790097&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581534 CCN1Cc2c(c(OC(C)C)nn2C[C@H](C)O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@H](C)C1 790097 (2S)-1-{(10R,17E)-12-ethyl-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-2-ol::US20250353864, Example 227 Dual specificity protein kinase CLK3 471 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790097 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790097&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581535 CCN1Cc2c(c(OC(C)C)nn2C[C@H](C)O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@H](C)C1 790097 (2S)-1-{(10R,17E)-12-ethyl-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-2-ol::US20250353864, Example 227 Dual specificity protein kinase CLK4 Homo sapiens 4.63 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790097 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790097&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581536 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1OC[C@H](C)N(C(C)C)C2 790098 (2S)-2-[(11S,17E)-16-ethoxy-19-fluoro- 8,11-dimethyl-12-(propan-2-yl)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 228 Dual specificity protein kinase CLK1 Homo sapiens 21.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790098 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790098&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581537 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1OC[C@H](C)N(C(C)C)C2 790098 (2S)-2-[(11S,17E)-16-ethoxy-19-fluoro- 8,11-dimethyl-12-(propan-2-yl)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 228 Dual specificity protein kinase CLK2 Homo sapiens 8.60 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790098 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790098&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581538 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1OC[C@H](C)N(C(C)C)C2 790098 (2S)-2-[(11S,17E)-16-ethoxy-19-fluoro- 8,11-dimethyl-12-(propan-2-yl)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 228 Dual specificity protein kinase CLK3 1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790098 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790098&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581539 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1OC[C@H](C)N(C(C)C)C2 790098 (2S)-2-[(11S,17E)-16-ethoxy-19-fluoro- 8,11-dimethyl-12-(propan-2-yl)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 228 Dual specificity protein kinase CLK4 Homo sapiens 34.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790098 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790098&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581540 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790099 (2S)-2-[(10R,17E)-16-ethoxy-19-fluoro- 8,10-dimethyl-12-(propan-2-yl)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 229 Dual specificity protein kinase CLK1 Homo sapiens 131 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790099 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790099&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581541 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790099 (2S)-2-[(10R,17E)-16-ethoxy-19-fluoro- 8,10-dimethyl-12-(propan-2-yl)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 229 Dual specificity protein kinase CLK2 Homo sapiens 59.6 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790099 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790099&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581542 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790099 (2S)-2-[(10R,17E)-16-ethoxy-19-fluoro- 8,10-dimethyl-12-(propan-2-yl)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 229 Dual specificity protein kinase CLK3 1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790099 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790099&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581543 CCOc1nn([C@@H](C)CO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)CN(C(C)C)C2 790099 (2S)-2-[(10R,17E)-16-ethoxy-19-fluoro- 8,10-dimethyl-12-(propan-2-yl)- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]propan-1-ol::US20250353864, Example 229 Dual specificity protein kinase CLK4 Homo sapiens 68.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790099 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790099&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581544 CCN1Cc2c(c(OC(C)C)nn2CC(N)=O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790100 2-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}acetamide::US20250353864, Example 232 Dual specificity protein kinase CLK1 Homo sapiens 0.770 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790100 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790100&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581545 CCN1Cc2c(c(OC(C)C)nn2CC(N)=O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790100 2-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}acetamide::US20250353864, Example 232 Dual specificity protein kinase CLK2 Homo sapiens 0.450 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790100 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790100&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581546 CCN1Cc2c(c(OC(C)C)nn2CC(N)=O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790100 2-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}acetamide::US20250353864, Example 232 Dual specificity protein kinase CLK3 42.0 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790100 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790100&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581547 CCN1Cc2c(c(OC(C)C)nn2CC(N)=O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790100 2-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}acetamide::US20250353864, Example 232 Dual specificity protein kinase CLK4 Homo sapiens 1.49 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790100 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790100&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581548 Cc1c2c(nn1C)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C(C)C)C2 790101 (10S,17E)-8,10,14,15-tetramethyl-12- (propan-2-yl)-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[4,3- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 233 Dual specificity protein kinase CLK1 Homo sapiens 0.710 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790101 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790101&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581549 Cc1c2c(nn1C)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C(C)C)C2 790101 (10S,17E)-8,10,14,15-tetramethyl-12- (propan-2-yl)-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[4,3- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 233 Dual specificity protein kinase CLK2 Homo sapiens 0.430 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790101 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790101&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581550 Cc1c2c(nn1C)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C(C)C)C2 790101 (10S,17E)-8,10,14,15-tetramethyl-12- (propan-2-yl)-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[4,3- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 233 Dual specificity protein kinase CLK3 403 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790101 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790101&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581551 Cc1c2c(nn1C)/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C(C)C)C2 790101 (10S,17E)-8,10,14,15-tetramethyl-12- (propan-2-yl)-2,10,11,12,13,15- hexahydro-8H-3,5-ethenotripyrazolo[4,3- f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 233 Dual specificity protein kinase CLK4 Homo sapiens 0.890 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790101 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790101&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581552 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCN(C2)C1 790102 (10R,18E)-17-ethoxy-8,15-dimethyl- 2,8,11,12,14,15-hexahydro-10H-3,5- etheno-10,13-methanotripyrazolo[3,4- g:3',4'-k:4$#8243;,3$#8243;- o][1,5]oxazacyclohexadecine::US20250353864, Example 236 Dual specificity protein kinase CLK1 Homo sapiens 0.660 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790102 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790102&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581553 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCN(C2)C1 790102 (10R,18E)-17-ethoxy-8,15-dimethyl- 2,8,11,12,14,15-hexahydro-10H-3,5- etheno-10,13-methanotripyrazolo[3,4- g:3',4'-k:4$#8243;,3$#8243;- o][1,5]oxazacyclohexadecine::US20250353864, Example 236 Dual specificity protein kinase CLK2 Homo sapiens 1.73 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790102 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790102&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581554 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCN(C2)C1 790102 (10R,18E)-17-ethoxy-8,15-dimethyl- 2,8,11,12,14,15-hexahydro-10H-3,5- etheno-10,13-methanotripyrazolo[3,4- g:3',4'-k:4$#8243;,3$#8243;- o][1,5]oxazacyclohexadecine::US20250353864, Example 236 Dual specificity protein kinase CLK3 397 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790102 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790102&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581555 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H]1CCN(C2)C1 790102 (10R,18E)-17-ethoxy-8,15-dimethyl- 2,8,11,12,14,15-hexahydro-10H-3,5- etheno-10,13-methanotripyrazolo[3,4- g:3',4'-k:4$#8243;,3$#8243;- o][1,5]oxazacyclohexadecine::US20250353864, Example 236 Dual specificity protein kinase CLK4 Homo sapiens 1.03 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790102 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790102&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581556 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC1CN(C2)C1 790103 (17E)-16-ethoxy-8,14-dimethyl- 2,8,10,11,13,14-hexahydro-3,5-etheno- 10,12-methanotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 238 Dual specificity protein kinase CLK1 Homo sapiens 0.900 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790103 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790103&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581557 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC1CN(C2)C1 790103 (17E)-16-ethoxy-8,14-dimethyl- 2,8,10,11,13,14-hexahydro-3,5-etheno- 10,12-methanotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 238 Dual specificity protein kinase CLK2 Homo sapiens 2.44 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790103 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790103&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581558 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC1CN(C2)C1 790103 (17E)-16-ethoxy-8,14-dimethyl- 2,8,10,11,13,14-hexahydro-3,5-etheno- 10,12-methanotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 238 Dual specificity protein kinase CLK3 1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790103 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790103&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581559 CCOc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OC1CN(C2)C1 790103 (17E)-16-ethoxy-8,14-dimethyl- 2,8,10,11,13,14-hexahydro-3,5-etheno- 10,12-methanotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecine::US20250353864, Example 238 Dual specificity protein kinase CLK4 Homo sapiens 1.07 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790103 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790103&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581560 CCOc1nccc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790105 (10S,18E)-17-ethoxy-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- ethenodipyrazolo[3,4-j:4',3'-n]pyrido[4,3- f][1,4]oxazacyclopentadecine::US20250353864, Example 240 Dual specificity protein kinase CLK1 Homo sapiens 1.12 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790105 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790105&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581561 CCOc1nccc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790105 (10S,18E)-17-ethoxy-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- ethenodipyrazolo[3,4-j:4',3'-n]pyrido[4,3- f][1,4]oxazacyclopentadecine::US20250353864, Example 240 Dual specificity protein kinase CLK2 Homo sapiens 12.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790105 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790105&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581562 CCOc1nccc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790105 (10S,18E)-17-ethoxy-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- ethenodipyrazolo[3,4-j:4',3'-n]pyrido[4,3- f][1,4]oxazacyclopentadecine::US20250353864, Example 240 Dual specificity protein kinase CLK3 1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790105 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790105&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581563 CCOc1nccc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790105 (10S,18E)-17-ethoxy-8,10,12-trimethyl- 2,8,10,11,12,13-hexahydro-3,5- ethenodipyrazolo[3,4-j:4',3'-n]pyrido[4,3- f][1,4]oxazacyclopentadecine::US20250353864, Example 240 Dual specificity protein kinase CLK4 Homo sapiens 1.52 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790105 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790105&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581564 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C3CC3)c1O[C@@H](C)CN(C)C2 790108 2-{(10S,17E)-8-cyclopropyl-10,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 246 Dual specificity protein kinase CLK1 Homo sapiens 0.750 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790108 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790108&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581565 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C3CC3)c1O[C@@H](C)CN(C)C2 790108 2-{(10S,17E)-8-cyclopropyl-10,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 246 Dual specificity protein kinase CLK2 Homo sapiens 1.36 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790108 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790108&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581566 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C3CC3)c1O[C@@H](C)CN(C)C2 790108 2-{(10S,17E)-8-cyclopropyl-10,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 246 Dual specificity protein kinase CLK3 386 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790108 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790108&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581567 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C3CC3)c1O[C@@H](C)CN(C)C2 790108 2-{(10S,17E)-8-cyclopropyl-10,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 246 Dual specificity protein kinase CLK4 Homo sapiens 1.33 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790108 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790108&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581568 CC(C)OC(=N)C1=C(\NCCO)CN2CCC[C@@H]2[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790109 2-[(8aR,9S,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy]-7,8,8a,9,11,17- hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 252 Dual specificity protein kinase CLK1 Homo sapiens 0.830 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790109 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790109&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581569 CC(C)OC(=N)C1=C(\NCCO)CN2CCC[C@@H]2[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790109 2-[(8aR,9S,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy]-7,8,8a,9,11,17- hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 252 Dual specificity protein kinase CLK2 Homo sapiens 0.420 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790109 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790109&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581570 CC(C)OC(=N)C1=C(\NCCO)CN2CCC[C@@H]2[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790109 2-[(8aR,9S,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy]-7,8,8a,9,11,17- hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 252 Dual specificity protein kinase CLK3 168 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790109 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790109&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581571 CC(C)OC(=N)C1=C(\NCCO)CN2CCC[C@@H]2[C@H](C)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790109 2-[(8aR,9S,19E)-9,11-dimethyl-1- [(propan-2-yl)oxy]-7,8,8a,9,11,17- hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 252 Dual specificity protein kinase CLK4 Homo sapiens 1.59 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790109 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790109&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581572 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)[C@H]1CCCN1C2 790111 2-[(8aR,9R,19E)-22-fluoro-9,11- dimethyl-1-[(propan-2-yl)oxy]- 7,8,8a,9,11,17-hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 255 Dual specificity protein kinase CLK1 Homo sapiens 0.820 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790111 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790111&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581573 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)[C@H]1CCCN1C2 790111 2-[(8aR,9R,19E)-22-fluoro-9,11- dimethyl-1-[(propan-2-yl)oxy]- 7,8,8a,9,11,17-hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 255 Dual specificity protein kinase CLK2 Homo sapiens 0.270 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790111 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790111&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581574 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)[C@H]1CCCN1C2 790111 2-[(8aR,9R,19E)-22-fluoro-9,11- dimethyl-1-[(propan-2-yl)oxy]- 7,8,8a,9,11,17-hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 255 Dual specificity protein kinase CLK3 9.89 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790111 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790111&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581575 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)[C@H]1CCCN1C2 790111 2-[(8aR,9R,19E)-22-fluoro-9,11- dimethyl-1-[(propan-2-yl)oxy]- 7,8,8a,9,11,17-hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 255 Dual specificity protein kinase CLK4 Homo sapiens 1.60 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790111 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790111&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581576 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)[C@H]1CCCN1C2 790126 2-[(8aR,9S,19E)-22-fluoro-9,11- dimethyl-1-[(propan-2-yl)oxy]- 7,8,8a,9,11,17-hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 256 Dual specificity protein kinase CLK1 Homo sapiens 1.38 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790126 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790126&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581577 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)[C@H]1CCCN1C2 790126 2-[(8aR,9S,19E)-22-fluoro-9,11- dimethyl-1-[(propan-2-yl)oxy]- 7,8,8a,9,11,17-hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 256 Dual specificity protein kinase CLK2 Homo sapiens 1.35 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790126 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790126&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581578 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)[C@H]1CCCN1C2 790126 2-[(8aR,9S,19E)-22-fluoro-9,11- dimethyl-1-[(propan-2-yl)oxy]- 7,8,8a,9,11,17-hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 256 Dual specificity protein kinase CLK3 94.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790126 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790126&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581579 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)[C@H]1CCCN1C2 790126 2-[(8aR,9S,19E)-22-fluoro-9,11- dimethyl-1-[(propan-2-yl)oxy]- 7,8,8a,9,11,17-hexahydro-6H-14,16- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n]pyrrolo[2,1- c][1,4]oxazacyclopentadecin-3(4H)- yl]ethan-1-ol::US20250353864, Example 256 Dual specificity protein kinase CLK4 Homo sapiens 4.05 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790126 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790126&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581580 CC(C)OC(=N)C1=C(\NCCO)CN(C)C[C@H](CO)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790112 2-{(10R,17E)-10-(hydroxymethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 258 Dual specificity protein kinase CLK1 Homo sapiens 0.500 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790112 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790112&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581581 CC(C)OC(=N)C1=C(\NCCO)CN(C)C[C@H](CO)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790112 2-{(10R,17E)-10-(hydroxymethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 258 Dual specificity protein kinase CLK2 Homo sapiens 0.230 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790112 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790112&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581582 CC(C)OC(=N)C1=C(\NCCO)CN(C)C[C@H](CO)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790112 2-{(10R,17E)-10-(hydroxymethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 258 Dual specificity protein kinase CLK3 17.2 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790112 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790112&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581583 CC(C)OC(=N)C1=C(\NCCO)CN(C)C[C@H](CO)Oc2c(cnn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790112 2-{(10R,17E)-10-(hydroxymethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 258 Dual specificity protein kinase CLK4 Homo sapiens 1.04 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790112 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790112&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581584 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](CC)CN(C)C2 790113 2-[(11S,17E)-16-ethoxy-11-ethyl-8,12- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 259 Dual specificity protein kinase CLK1 Homo sapiens 0.900 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790113 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790113&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581585 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](CC)CN(C)C2 790113 2-[(11S,17E)-16-ethoxy-11-ethyl-8,12- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 259 Dual specificity protein kinase CLK2 Homo sapiens 4.29 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790113 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790113&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581586 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](CC)CN(C)C2 790113 2-[(11S,17E)-16-ethoxy-11-ethyl-8,12- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 259 Dual specificity protein kinase CLK3 1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790113 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790113&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581587 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@H](CC)CN(C)C2 790113 2-[(11S,17E)-16-ethoxy-11-ethyl-8,12- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 259 Dual specificity protein kinase CLK4 Homo sapiens 1.30 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790113 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790113&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581588 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](CC)CN(C)C2 790114 2-[(10S,17E)-16-ethoxy-10-ethyl-8,12- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 260 Dual specificity protein kinase CLK1 Homo sapiens 4.90 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790114 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790114&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581589 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](CC)CN(C)C2 790114 2-[(10S,17E)-16-ethoxy-10-ethyl-8,12- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 260 Dual specificity protein kinase CLK2 Homo sapiens 5.21 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790114 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790114&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581590 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](CC)CN(C)C2 790114 2-[(10S,17E)-16-ethoxy-10-ethyl-8,12- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 260 Dual specificity protein kinase CLK3 361 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790114 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790114&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581591 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](CC)CN(C)C2 790114 2-[(10S,17E)-16-ethoxy-10-ethyl-8,12- dimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 260 Dual specificity protein kinase CLK4 Homo sapiens 3.15 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790114 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790114&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581592 COCc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790115 2-[(10S,17E)-16-(methoxymethyl)- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 261 Dual specificity protein kinase CLK1 Homo sapiens 0.200 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790115 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790115&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581593 COCc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790115 2-[(10S,17E)-16-(methoxymethyl)- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 261 Dual specificity protein kinase CLK2 Homo sapiens 0.330 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790115 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790115&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581594 COCc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790115 2-[(10S,17E)-16-(methoxymethyl)- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 261 Dual specificity protein kinase CLK3 209 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790115 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790115&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581595 COCc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790115 2-[(10S,17E)-16-(methoxymethyl)- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 261 Dual specificity protein kinase CLK4 Homo sapiens 0.440 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790115 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790115&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581596 CCN1Cc2c(c(OC(C)C)nn2CC(C)(C)O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790116 1-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14-yl}-2- methylpropan-2-ol::US20250353864, Example 262 Dual specificity protein kinase CLK1 Homo sapiens 0.820 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790116 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790116&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581597 CCN1Cc2c(c(OC(C)C)nn2CC(C)(C)O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790116 1-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14-yl}-2- methylpropan-2-ol::US20250353864, Example 262 Dual specificity protein kinase CLK2 Homo sapiens 0.490 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790116 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790116&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581598 CCN1Cc2c(c(OC(C)C)nn2CC(C)(C)O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790116 1-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14-yl}-2- methylpropan-2-ol::US20250353864, Example 262 Dual specificity protein kinase CLK3 104 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790116 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790116&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581599 CCN1Cc2c(c(OC(C)C)nn2CC(C)(C)O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790116 1-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14-yl}-2- methylpropan-2-ol::US20250353864, Example 262 Dual specificity protein kinase CLK4 Homo sapiens 1.50 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790116 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790116&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581600 CCN1Cc2c(c(OC(C)C)nn2CC(C)=O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790117 1-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-2-one::US20250353864, Example 263 Dual specificity protein kinase CLK1 Homo sapiens 0.640 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790117 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790117&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581601 CCN1Cc2c(c(OC(C)C)nn2CC(C)=O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790117 1-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-2-one::US20250353864, Example 263 Dual specificity protein kinase CLK2 Homo sapiens 0.710 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790117 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790117&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581602 CCN1Cc2c(c(OC(C)C)nn2CC(C)=O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790117 1-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-2-one::US20250353864, Example 263 Dual specificity protein kinase CLK3 32.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790117 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790117&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581603 CCN1Cc2c(c(OC(C)C)nn2CC(C)=O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790117 1-{(10S,17E)-12-ethyl-8,10-dimethyl-16- [(propan-2-yl)oxy]-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-2-one::US20250353864, Example 263 Dual specificity protein kinase CLK4 Homo sapiens 1.31 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790117 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790117&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581604 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C#N)CN(C)C2 790118 (10R,17E)-14-(2-hydroxyethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine-10- carbonitrile::US20250353864, Example 264 Dual specificity protein kinase CLK1 Homo sapiens 1.06 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790118 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790118&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581605 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C#N)CN(C)C2 790118 (10R,17E)-14-(2-hydroxyethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine-10- carbonitrile::US20250353864, Example 264 Dual specificity protein kinase CLK2 Homo sapiens 3.08 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790118 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790118&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581606 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C#N)CN(C)C2 790118 (10R,17E)-14-(2-hydroxyethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine-10- carbonitrile::US20250353864, Example 264 Dual specificity protein kinase CLK3 519 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790118 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790118&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581607 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C#N)CN(C)C2 790118 (10R,17E)-14-(2-hydroxyethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine-10- carbonitrile::US20250353864, Example 264 Dual specificity protein kinase CLK4 Homo sapiens 1.59 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790118 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790118&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581608 C[C@H](C#N)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790121 (2R)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-8,10,12-trimethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}propanenitrile::US20250353864, Example 268 Dual specificity protein kinase CLK1 Homo sapiens 0.570 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790121 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790121&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581609 C[C@H](C#N)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790121 (2R)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-8,10,12-trimethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}propanenitrile::US20250353864, Example 268 Dual specificity protein kinase CLK2 Homo sapiens 0.180 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790121 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790121&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581610 C[C@H](C#N)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790121 (2R)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-8,10,12-trimethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}propanenitrile::US20250353864, Example 268 Dual specificity protein kinase CLK3 45.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790121 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790121&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581611 C[C@H](C#N)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790121 (2R)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-8,10,12-trimethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}propanenitrile::US20250353864, Example 268 Dual specificity protein kinase CLK4 Homo sapiens 1.22 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790121 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790121&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581612 C[C@@H](C#N)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790122 (2S)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-8,10,12-trimethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}propanenitrile::US20250353864, Example 269 Dual specificity protein kinase CLK1 Homo sapiens 0.940 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790122 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790122&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581613 C[C@@H](C#N)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790122 (2S)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-8,10,12-trimethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}propanenitrile::US20250353864, Example 269 Dual specificity protein kinase CLK2 Homo sapiens 0.320 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790122 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790122&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581614 C[C@@H](C#N)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790122 (2S)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-8,10,12-trimethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}propanenitrile::US20250353864, Example 269 Dual specificity protein kinase CLK3 238 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790122 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790122&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581615 C[C@@H](C#N)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790122 (2S)-2-{[(10S,17E)-19-fluoro-14-(2- hydroxyethyl)-8,10,12-trimethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-16- yl]oxy}propanenitrile::US20250353864, Example 269 Dual specificity protein kinase CLK4 Homo sapiens 1.76 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790122 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790122&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581616 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C(F)F)CN(C)C2 790127 2-{(10R,17E)-10-(difluoromethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 275 Dual specificity protein kinase CLK1 Homo sapiens 0.800 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790127 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790127&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581617 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C(F)F)CN(C)C2 790127 2-{(10R,17E)-10-(difluoromethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 275 Dual specificity protein kinase CLK2 Homo sapiens 1.03 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790127 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790127&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581618 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C(F)F)CN(C)C2 790127 2-{(10R,17E)-10-(difluoromethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 275 Dual specificity protein kinase CLK3 241 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790127 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790127&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581619 CC(C)Oc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C(F)F)CN(C)C2 790127 2-{(10R,17E)-10-(difluoromethyl)-8,12- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}ethan-1-ol::US20250353864, Example 275 Dual specificity protein kinase CLK4 Homo sapiens 2.25 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790127 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790127&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581620 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)CN(CC)C2 790128 2-[(10R,17E)-16-ethoxy-12-ethyl-19- fluoro-8,10-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 277 Dual specificity protein kinase CLK1 Homo sapiens 4.28 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790128 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790128&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581621 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)CN(CC)C2 790128 2-[(10R,17E)-16-ethoxy-12-ethyl-19- fluoro-8,10-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 277 Dual specificity protein kinase CLK2 Homo sapiens 2.99 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790128 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790128&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581622 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)CN(CC)C2 790128 2-[(10R,17E)-16-ethoxy-12-ethyl-19- fluoro-8,10-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 277 Dual specificity protein kinase CLK3 51.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790128 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790128&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581623 CCOc1nn(CCO)c2c1/C=C/c1n[nH]c3cc(F)c(cc13)-c1cnn(C)c1O[C@H](C)CN(CC)C2 790128 2-[(10R,17E)-16-ethoxy-12-ethyl-19- fluoro-8,10-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 277 Dual specificity protein kinase CLK4 Homo sapiens 2.77 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790128 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790128&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581624 CCN1Cc2c(c(OC(C)C)nn2C[C@H](C)O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790129 (2S)-1-{(10S,17E)-12-ethyl-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-2-ol::US20250353864, Example 280 Dual specificity protein kinase CLK1 Homo sapiens 0.520 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790129 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790129&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581625 CCN1Cc2c(c(OC(C)C)nn2C[C@H](C)O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790129 (2S)-1-{(10S,17E)-12-ethyl-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-2-ol::US20250353864, Example 280 Dual specificity protein kinase CLK2 Homo sapiens 0.240 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790129 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790129&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581626 CCN1Cc2c(c(OC(C)C)nn2C[C@H](C)O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790129 (2S)-1-{(10S,17E)-12-ethyl-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-2-ol::US20250353864, Example 280 Dual specificity protein kinase CLK3 242 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790129 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790129&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581627 CCN1Cc2c(c(OC(C)C)nn2C[C@H](C)O)/C=C/c2n[nH]c3ccc(cc23)-c2cnn(C)c2O[C@@H](C)C1 790129 (2S)-1-{(10S,17E)-12-ethyl-8,10- dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-2-ol::US20250353864, Example 280 Dual specificity protein kinase CLK4 Homo sapiens 1.96 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790129 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790129&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581628 CCOC(=N)C1=C(\NCCO)CN(CC)C[C@H](C)Oc2c(cnn2C)-c2cc3c(n[nH]c3cc2F)\C=C\1 790130 2-[(10S,17E)-16-ethoxy-12-ethyl-19- fluoro-8,10-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 288 Dual specificity protein kinase CLK1 Homo sapiens 0.320 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790130 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790130&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581629 CCOC(=N)C1=C(\NCCO)CN(CC)C[C@H](C)Oc2c(cnn2C)-c2cc3c(n[nH]c3cc2F)\C=C\1 790130 2-[(10S,17E)-16-ethoxy-12-ethyl-19- fluoro-8,10-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 288 Dual specificity protein kinase CLK2 Homo sapiens 0.240 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790130 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790130&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581630 CCOC(=N)C1=C(\NCCO)CN(CC)C[C@H](C)Oc2c(cnn2C)-c2cc3c(n[nH]c3cc2F)\C=C\1 790130 2-[(10S,17E)-16-ethoxy-12-ethyl-19- fluoro-8,10-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 288 Dual specificity protein kinase CLK3 131 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790130 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790130&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581631 CCOC(=N)C1=C(\NCCO)CN(CC)C[C@H](C)Oc2c(cnn2C)-c2cc3c(n[nH]c3cc2F)\C=C\1 790130 2-[(10S,17E)-16-ethoxy-12-ethyl-19- fluoro-8,10-dimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 288 Dual specificity protein kinase CLK4 Homo sapiens 1.31 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790130 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790130&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581632 CCOC(=N)C1=C(\NCCO)CN(CC)C[C@H](C)Oc2c(c(C#N)nn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790146 (10S,17E)-16-ethoxy-12-ethyl-14-(2- hydroxyethyl)-8,10-dimethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine-6- carbonitrile::US20250353864, Example 290 Dual specificity protein kinase CLK1 Homo sapiens 69.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790146 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790146&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581633 CCOC(=N)C1=C(\NCCO)CN(CC)C[C@H](C)Oc2c(c(C#N)nn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790146 (10S,17E)-16-ethoxy-12-ethyl-14-(2- hydroxyethyl)-8,10-dimethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine-6- carbonitrile::US20250353864, Example 290 Dual specificity protein kinase CLK2 Homo sapiens 102 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790146 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790146&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581634 CCOC(=N)C1=C(\NCCO)CN(CC)C[C@H](C)Oc2c(c(C#N)nn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790146 (10S,17E)-16-ethoxy-12-ethyl-14-(2- hydroxyethyl)-8,10-dimethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine-6- carbonitrile::US20250353864, Example 290 Dual specificity protein kinase CLK3 1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790146 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790146&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581635 CCOC(=N)C1=C(\NCCO)CN(CC)C[C@H](C)Oc2c(c(C#N)nn2C)-c2ccc3[nH]nc(c3c2)\C=C\1 790146 (10S,17E)-16-ethoxy-12-ethyl-14-(2- hydroxyethyl)-8,10-dimethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine-6- carbonitrile::US20250353864, Example 290 Dual specificity protein kinase CLK4 Homo sapiens 38.1 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790146 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790146&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581636 C#Cc1nn(C)c2c1-c1ccc3[nH]nc(c3c1)/C=C/c1c(OCC)nn(CCO)c1CN(C)C[C@H](C)O2 790147 2-[(10S,17E)-16-ethoxy-6-ethynyl- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 292 Dual specificity protein kinase CLK1 Homo sapiens 1.01 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790147 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790147&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581637 C#Cc1nn(C)c2c1-c1ccc3[nH]nc(c3c1)/C=C/c1c(OCC)nn(CCO)c1CN(C)C[C@H](C)O2 790147 2-[(10S,17E)-16-ethoxy-6-ethynyl- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 292 Dual specificity protein kinase CLK2 Homo sapiens 4.87 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790147 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790147&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581638 C#Cc1nn(C)c2c1-c1ccc3[nH]nc(c3c1)/C=C/c1c(OCC)nn(CCO)c1CN(C)C[C@H](C)O2 790147 2-[(10S,17E)-16-ethoxy-6-ethynyl- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 292 Dual specificity protein kinase CLK3 1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790147 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790147&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581639 C#Cc1nn(C)c2c1-c1ccc3[nH]nc(c3c1)/C=C/c1c(OCC)nn(CCO)c1CN(C)C[C@H](C)O2 790147 2-[(10S,17E)-16-ethoxy-6-ethynyl- 8,10,12-trimethyl-2,8,10,11,12,13- hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 292 Dual specificity protein kinase CLK4 Homo sapiens 1.36 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790147 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790147&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581640 CCOc1c2c(nn1C)CN(C(C)=O)CCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790148 1-[(17E)-16-ethoxy-8,15-dimethyl- 2,8,10,11,13,15-hexahydro-12H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-12- yl]ethan-1-one::US20250353864, Example 294 Dual specificity protein kinase CLK1 Homo sapiens 1.27 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790148 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790148&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581641 CCOc1c2c(nn1C)CN(C(C)=O)CCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790148 1-[(17E)-16-ethoxy-8,15-dimethyl- 2,8,10,11,13,15-hexahydro-12H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-12- yl]ethan-1-one::US20250353864, Example 294 Dual specificity protein kinase CLK2 Homo sapiens 3.25 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790148 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790148&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581642 CCOc1c2c(nn1C)CN(C(C)=O)CCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790148 1-[(17E)-16-ethoxy-8,15-dimethyl- 2,8,10,11,13,15-hexahydro-12H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-12- yl]ethan-1-one::US20250353864, Example 294 Dual specificity protein kinase CLK3 1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790148 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790148&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581643 CCOc1c2c(nn1C)CN(C(C)=O)CCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790148 1-[(17E)-16-ethoxy-8,15-dimethyl- 2,8,10,11,13,15-hexahydro-12H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-12- yl]ethan-1-one::US20250353864, Example 294 Dual specificity protein kinase CLK4 Homo sapiens 1.37 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790148 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790148&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581644 CCNc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790149 2-[(10S,17E)-16-(ethylamino)-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 295 Dual specificity protein kinase CLK1 Homo sapiens 0.640 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790149 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790149&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581645 CCNc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790149 2-[(10S,17E)-16-(ethylamino)-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 295 Dual specificity protein kinase CLK2 Homo sapiens 0.780 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790149 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790149&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581646 CCNc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790149 2-[(10S,17E)-16-(ethylamino)-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 295 Dual specificity protein kinase CLK3 13.8 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790149 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790149&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581647 CCNc1nn(CCO)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1O[C@@H](C)CN(C)C2 790149 2-[(10S,17E)-16-(ethylamino)-8,10,12- trimethyl-2,8,10,11,12,13-hexahydro- 14H-3,5-ethenotripyrazolo[3,4-f:3',4'- j:4$#8243;,3$#8243;-n][1,4]oxazacyclopentadecin-14- yl]ethan-1-ol::US20250353864, Example 295 Dual specificity protein kinase CLK4 Homo sapiens 1.12 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790149 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790149&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581648 CCN1C/C(NC[C@H](C)O)=C(C(=N)OC(C)C)\C=C\c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O[C@@H](C)C1 790150 (2S)-1-{(10S,17E)-12-ethyl-19-fluoro- 8,10-dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-2-ol::US20250353864, Example 296 Dual specificity protein kinase CLK1 Homo sapiens 1.20 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790150 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790150&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581649 CCN1C/C(NC[C@H](C)O)=C(C(=N)OC(C)C)\C=C\c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O[C@@H](C)C1 790150 (2S)-1-{(10S,17E)-12-ethyl-19-fluoro- 8,10-dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-2-ol::US20250353864, Example 296 Dual specificity protein kinase CLK2 Homo sapiens 1.15 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790150 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790150&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581650 CCN1C/C(NC[C@H](C)O)=C(C(=N)OC(C)C)\C=C\c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O[C@@H](C)C1 790150 (2S)-1-{(10S,17E)-12-ethyl-19-fluoro- 8,10-dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-2-ol::US20250353864, Example 296 Dual specificity protein kinase CLK3 33.4 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790150 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790150&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581651 CCN1C/C(NC[C@H](C)O)=C(C(=N)OC(C)C)\C=C\c2n[nH]c3cc(F)c(cc23)-c2cnn(C)c2O[C@@H](C)C1 790150 (2S)-1-{(10S,17E)-12-ethyl-19-fluoro- 8,10-dimethyl-16-[(propan-2-yl)oxy]- 2,8,10,11,12,13-hexahydro-14H-3,5- ethenotripyrazolo[3,4-f:3',4'-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecin-14- yl}propan-2-ol::US20250353864, Example 296 Dual specificity protein kinase CLK4 Homo sapiens 1.57 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790150 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790150&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581652 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCOC2 790132 (17E)-16-ethyl-8,14-dimethyl- 2,8,10,11,13,14-hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 300 Dual specificity protein kinase CLK1 Homo sapiens 0.332 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790132 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790132&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581653 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCOC2 790132 (17E)-16-ethyl-8,14-dimethyl- 2,8,10,11,13,14-hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 300 Dual specificity protein kinase CLK2 Homo sapiens 36.5 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790132 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790132&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581654 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCOC2 790132 (17E)-16-ethyl-8,14-dimethyl- 2,8,10,11,13,14-hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 300 Dual specificity protein kinase CLK3 0.862 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790132 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790132&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581655 CCc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCOC2 790132 (17E)-16-ethyl-8,14-dimethyl- 2,8,10,11,13,14-hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole::US20250353864, Example 300 Dual specificity protein kinase CLK4 Homo sapiens 0.225 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790132 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790132&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581656 Cn1nc(C#N)c2c1COCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790134 (17E)-8,14-dimethyl-2,8,10,11,13,14- hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole-16- carbonitrile::US20250353864, Example 302 Dual specificity protein kinase CLK1 Homo sapiens 1.19 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790134 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790134&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581657 Cn1nc(C#N)c2c1COCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790134 (17E)-8,14-dimethyl-2,8,10,11,13,14- hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole-16- carbonitrile::US20250353864, Example 302 Dual specificity protein kinase CLK2 Homo sapiens 1000 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790134 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790134&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581658 Cn1nc(C#N)c2c1COCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790134 (17E)-8,14-dimethyl-2,8,10,11,13,14- hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole-16- carbonitrile::US20250353864, Example 302 Dual specificity protein kinase CLK3 1.23 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790134 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790134&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581659 Cn1nc(C#N)c2c1COCCOc1c(cnn1C)-c1ccc3[nH]nc(c3c1)/C=C/2 790134 (17E)-8,14-dimethyl-2,8,10,11,13,14- hexahydro-3,5- etheno[1,4]dioxacyclopentadecino[10,11- c:15,14-c':6,7-c$#8243;]tripyrazole-16- carbonitrile::US20250353864, Example 302 Dual specificity protein kinase CLK4 Homo sapiens 1.33 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790134 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790134&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581660 Cc1onc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCOC2 790136 (17E)-8,16-dimethyl-2,8,10,11- tetrahydro-13H-3,5- ethenodipyrazolo[3',4':10,11;4$#8243;,3$#8243;:14,15] [1,4]dioxacyclopentadecino[6,7- c][1,2]oxazole::US20250353864, Example 320 Dual specificity protein kinase CLK1 Homo sapiens 0.324 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790136 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790136&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581661 Cc1onc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCOC2 790136 (17E)-8,16-dimethyl-2,8,10,11- tetrahydro-13H-3,5- ethenodipyrazolo[3',4':10,11;4$#8243;,3$#8243;:14,15] [1,4]dioxacyclopentadecino[6,7- c][1,2]oxazole::US20250353864, Example 320 Dual specificity protein kinase CLK2 Homo sapiens 69.7 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790136 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790136&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581662 Cc1onc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCOC2 790136 (17E)-8,16-dimethyl-2,8,10,11- tetrahydro-13H-3,5- ethenodipyrazolo[3',4':10,11;4$#8243;,3$#8243;:14,15] [1,4]dioxacyclopentadecino[6,7- c][1,2]oxazole::US20250353864, Example 320 Dual specificity protein kinase CLK3 0.200 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790136 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790136&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581663 Cc1onc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCOC2 790136 (17E)-8,16-dimethyl-2,8,10,11- tetrahydro-13H-3,5- ethenodipyrazolo[3',4':10,11;4$#8243;,3$#8243;:14,15] [1,4]dioxacyclopentadecino[6,7- c][1,2]oxazole::US20250353864, Example 320 Dual specificity protein kinase CLK4 Homo sapiens 0.155 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790136 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790136&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581664 Cc1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCOC2 790137 (17E)-8,16-dimethyl-2,10,11,13- tetrahydro-8H-3,5- ethenodipyrazolo[3',4':10,11;4$#8243;,3$#8243;:14,15] [1,4]dioxacyclopentadecino[7,6- d][1,2]oxazole::US20250353864, Example 321 Dual specificity protein kinase CLK1 Homo sapiens 1.35 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790137 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790137&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581665 Cc1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCOC2 790137 (17E)-8,16-dimethyl-2,10,11,13- tetrahydro-8H-3,5- ethenodipyrazolo[3',4':10,11;4$#8243;,3$#8243;:14,15] [1,4]dioxacyclopentadecino[7,6- d][1,2]oxazole::US20250353864, Example 321 Dual specificity protein kinase CLK2 Homo sapiens 418 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790137 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790137&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581666 Cc1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCOC2 790137 (17E)-8,16-dimethyl-2,10,11,13- tetrahydro-8H-3,5- ethenodipyrazolo[3',4':10,11;4$#8243;,3$#8243;:14,15] [1,4]dioxacyclopentadecino[7,6- d][1,2]oxazole::US20250353864, Example 321 Dual specificity protein kinase CLK3 1.92 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790137 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790137&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581667 Cc1noc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCOC2 790137 (17E)-8,16-dimethyl-2,10,11,13- tetrahydro-8H-3,5- ethenodipyrazolo[3',4':10,11;4$#8243;,3$#8243;:14,15] [1,4]dioxacyclopentadecino[7,6- d][1,2]oxazole::US20250353864, Example 321 Dual specificity protein kinase CLK4 Homo sapiens 0.847 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790137 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790137&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1 1581668 Cc1snc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCOC2 790138 (17E)-8,16-dimethyl-2,8,10,11- tetrahydro-13H-3,5- ethenodipyrazolo[3',4':10,11;4$#8243;,3$#8243;:14,15] [1,4]dioxacyclopentadecino[6,7- c][1,2]thiazole::US20250353864, Example 322 Dual specificity protein kinase CLK1 Homo sapiens 1.04 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790138 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4897&target=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790138&enzyme=Dual+specificity+protein+kinase+CLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 7OA0,7O9Y,6R8J,6R6X,6R6E,6R3D,6QTY,6FYO Dual specificity protein kinase CLK1 CLK1_HUMAN P49759 B4DFW7 Q0P694 Q8N5V8 1581669 Cc1snc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCOC2 790138 (17E)-8,16-dimethyl-2,8,10,11- tetrahydro-13H-3,5- ethenodipyrazolo[3',4':10,11;4$#8243;,3$#8243;:14,15] [1,4]dioxacyclopentadecino[6,7- c][1,2]thiazole::US20250353864, Example 322 Dual specificity protein kinase CLK2 Homo sapiens 34.9 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790138 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4372&target=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790138&enzyme=Dual+specificity+protein+kinase+CLK2&column=ki&startPg=0&Increment=50&submit=Search 1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR 6KHE,5UNP,6FYL,6FYK Dual specificity protein kinase CLK2 CLK2_HUMAN P49760 B1AVS9 B5MBX6 Q96CQ0 1581670 Cc1snc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCOC2 790138 (17E)-8,16-dimethyl-2,8,10,11- tetrahydro-13H-3,5- ethenodipyrazolo[3',4':10,11;4$#8243;,3$#8243;:14,15] [1,4]dioxacyclopentadecino[6,7- c][1,2]thiazole::US20250353864, Example 322 Dual specificity protein kinase CLK3 0.322 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790138 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001440&target=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790138&enzyme=Dual+specificity+protein+kinase+CLK3&column=ki&startPg=0&Increment=50&submit=Search 1 MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR 6FYR,6FYP,2EXE,2EU9 Dual specificity protein kinase CLK3 CLK3_HUMAN P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7 1581671 Cc1snc2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCOC2 790138 (17E)-8,16-dimethyl-2,8,10,11- tetrahydro-13H-3,5- ethenodipyrazolo[3',4':10,11;4$#8243;,3$#8243;:14,15] [1,4]dioxacyclopentadecino[6,7- c][1,2]thiazole::US20250353864, Example 322 Dual specificity protein kinase CLK4 Homo sapiens 0.636 Curated from the literature by BindingDB n/a 11/20/2025 3/11/2026 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790138 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3913&target=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790138&enzyme=Dual+specificity+protein+kinase+CLK4&column=ki&startPg=0&Increment=50&submit=Search 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK 6FYV Dual specificity protein kinase CLK4 CLK4_HUMAN Q9HAZ1