Affinity DataIC50: 0.310nMAssay Description:Inhibitory activity against purified rat liver phosphodiesterase 4More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Binding affinity to rolipram binding site in isolated rat brain by rolipram binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMAssay Description:Inhibition of [3H]- rolipram binding to phosphodiesterase 4 of rat cerebral cortex membranes.More data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMAssay Description:Displacement of [3H]rolipram binding to Phosphodiesterase 4 in rat brainMore data for this Ligand-Target Pair
TargetPhosphodiesterase/cAMP-specific 3',5'-cyclic phosphodiesterase 4A/cAMP-specific 3',5'-cyclic phosphodiesterase 4C/cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Mus musculus)TBA
Affinity DataIC50: 4nMAssay Description:Displacement of [3H]-Rolipram from mouse brain homogenatesMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human PDE4A expressed in Sf9 cellsMore data for this Ligand-Target Pair
TargetPhosphodiesterase/cAMP-specific 3',5'-cyclic phosphodiesterase 4A/cAMP-specific 3',5'-cyclic phosphodiesterase 4C/cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Mus musculus)TBA
Affinity DataIC50: 4nMAssay Description:Inhibition of [3H]rolipram binding to Phosphodiesterase 4 (PDE IV)More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Displacement of [3H]rolipram from mouse brain homogenatesMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Binding affinity against high affinity rolipram binding site (HARBS) was determined by displacing radioactive [3H]rolipram from brain membrane suspen...More data for this Ligand-Target Pair
Affinity DataIC50: 5.30nMAssay Description:Inhibition of [3H]rolipram binding to Wistar rat brain membranesMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(RAT)
Novartis Horsham Research Center
Curated by ChEMBL
Novartis Horsham Research Center
Curated by ChEMBL
Affinity DataIC50: 5.70nMAssay Description:Inhibition of phosphodiesterase (PDE) 4BMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 5.90nMAssay Description:Inhibition of phosphodiesterase (PDE) 4AMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]rolipram from rat brain membranesMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(RAT)
RhôNe-Poulenc Rorer
Curated by ChEMBL
RhôNe-Poulenc Rorer
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]rolipram from high affinity binding site (HARBS) in rat brain membrane.More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Affinity for the high affinity rolipram binding site of phosphodiesterase (PDE IV) by [3H]rolipram displacement.More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Novartis Horsham Research Center
Curated by ChEMBL
Novartis Horsham Research Center
Curated by ChEMBL
Affinity DataIC50: 6.40nMAssay Description:Inhibition of phosphodiesterase (PDE) 4DMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of [3H]rolipram binding to rat cortexMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 10.7nMAssay Description:Evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase type 4A (PDE4A).More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of rolipram binding in rat brainMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Matrix Laboratories
Curated by ChEMBL
Matrix Laboratories
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of human PDE4B2 in cytosolic fraction of lungMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiroscience
Curated by ChEMBL
Chiroscience
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Relative inhibition of phosphodiesterase 4 activity and Rolipram binding to PDE4More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of rolipram binding to rat brainMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of rolipram binding to rat brain tissue at 20 uMMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiroscience
Curated by ChEMBL
Chiroscience
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of Rolipram binding to PDE4 at 1 uMMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Novartis Horsham Research Center
Curated by ChEMBL
Novartis Horsham Research Center
Curated by ChEMBL
Affinity DataIC50: 31.6nMAssay Description:Compound was evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase 4DMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Novartis Horsham Research Center
Curated by ChEMBL
Novartis Horsham Research Center
Curated by ChEMBL
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Matrix Laboratories
Curated by ChEMBL
Matrix Laboratories
Curated by ChEMBL
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Matrix Laboratories
Curated by ChEMBL
Matrix Laboratories
Curated by ChEMBL
Affinity DataIC50: 35.7nMAssay Description:Inhibition of recombinant human Phosphodiesterase 4BMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Novartis Horsham Research Center
Curated by ChEMBL
Novartis Horsham Research Center
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of release of LTE4 in human whole bloodMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Novartis Horsham Research Center
Curated by ChEMBL
Novartis Horsham Research Center
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of release of LTE4 in human whole bloodMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Matrix Laboratories
Curated by ChEMBL
Matrix Laboratories
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of human PDE4B1 in particular fraction of lungMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Chiroscience
Curated by ChEMBL
Chiroscience
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibitory activity against phosphodiesterase 4 carried out in the cytosol of human neutrophilsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Novartis Horsham Research Center
Curated by ChEMBL
Novartis Horsham Research Center
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of human PDE4D4 in particular fraction of lungMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Novartis Horsham Research Center
Curated by ChEMBL
Novartis Horsham Research Center
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of human PDE4D2 in cytosolic fraction of lungMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Novartis Horsham Research Center
Curated by ChEMBL
Novartis Horsham Research Center
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of human PDE4D1 in cytosolic fraction of lungMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Matrix Laboratories
Curated by ChEMBL
Matrix Laboratories
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of human PDE4B3 in cytosolic fraction of lungMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Matrix Laboratories
Curated by ChEMBL
Matrix Laboratories
Curated by ChEMBL
Affinity DataIC50: 52nMAssay Description:Inhibition of human recombinant PDE4B1 activity assessed as residual cAMP concentration by HTRF assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Novartis Horsham Research Center
Curated by ChEMBL
Novartis Horsham Research Center
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of human PDE4D4 in cytosolic fraction of lungMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 67nMAssay Description:Inhibition of PDE4A (unknown origin)More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Novartis Horsham Research Center
Curated by ChEMBL
Novartis Horsham Research Center
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of PDE4D3 expressed in yeastMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Novartis Horsham Research Center
Curated by ChEMBL
Novartis Horsham Research Center
Curated by ChEMBL
Affinity DataIC50: 79nMAssay Description:Inhibition of PDE4D (unknown origin)More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Matrix Laboratories
Curated by ChEMBL
Matrix Laboratories
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of human PDE4B1 in cytosolic fraction of lungMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Novartis Horsham Research Center
Curated by ChEMBL
Novartis Horsham Research Center
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of human PDE4D5 in cytosolic fraction of lungMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Novartis Horsham Research Center
Curated by ChEMBL
Novartis Horsham Research Center
Curated by ChEMBL
Affinity DataIC50: 83nMAssay Description:Inhibition of human recombinant PDE4D3 assessed after 60 mins by IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Matrix Laboratories
Curated by ChEMBL
Matrix Laboratories
Curated by ChEMBL
Affinity DataIC50: 86nMAssay Description:Inhibition of full length human PDE4B1 using FAM-3',5'-cAMP as substrate after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Matrix Laboratories
Curated by ChEMBL
Matrix Laboratories
Curated by ChEMBL
Affinity DataIC50: 86nMAssay Description:Inhibition of human full-length PDE4B1 using AM-Cyclic-3',5'-AMP after 60 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Novartis Horsham Research Center
Curated by ChEMBL
Novartis Horsham Research Center
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of recombinant human PDE4D3 expressed in baculoviral systemMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Novartis Horsham Research Center
Curated by ChEMBL
Novartis Horsham Research Center
Curated by ChEMBL
Affinity DataIC50: 92nMAssay Description:Inhibition of human recombinant PDE4D expressed in Sf9 cellsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Matrix Laboratories
Curated by ChEMBL
Matrix Laboratories
Curated by ChEMBL
Affinity DataIC50: 98nMAssay Description:Inhibition of human recombinant PDE4B2 assessed after 60 mins by IMAP fluorescence polarization assayMore data for this Ligand-Target Pair