Affinity DataIC50: 0.0600nMAssay Description:Antagonist activity against D3R in human U2OS cells assessed as inhibition of (+)-PD128907-induced beta-arrestin translocation by beta-galactosidase ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0750nMAssay Description:In vivo binding affinity of the compound against dopamine (D2) receptor in rat caudate-putamen tissue using [3H]-nemonapride as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 0.160nMAssay Description:Antagonist activity against human D2LR expressed in CHOK1 cells assessed as inhibition of pergolide-induced beta-arrestin translocation by beta-galac...More data for this Ligand-Target Pair
Affinity DataIC50: 0.160nMAssay Description:Antagonist activity at recombinant human D2 receptor expressed in CHOK1 cells assessed as inhibition of quinpirole-induced beta arrestin2 recruitment...More data for this Ligand-Target Pair
Affinity DataIC50: 0.25nMAssay Description:Antagonist activity at recombinant human D3 receptor expressed in CHOK1 cells assessed as inhibition of dopamine-induced beta arrestin2 recruitment p...More data for this Ligand-Target Pair
Affinity DataIC50: 0.280nMAssay Description:Ability to inhibit [3H]haloperidol binding to dopamine receptor in rat striatal homogenateMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Binding affinity against dopamine receptor in rat striatal membrane using [3H]haloperidolMore data for this Ligand-Target Pair
Affinity DataIC50: 0.650nMAssay Description:Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay.More data for this Ligand-Target Pair
Affinity DataIC50: 0.650nMAssay Description:Binding affinity towards sigma receptor binding site 1 using [3H](+)-pentazocineMore data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Antagonist activity at human dopamine D2 short receptor transiently expressed in HEK293 cells assessed as inhibition of beta-arrestin recruitment aft...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of 0.1 nM of [125I]- (S)-N-(1-Ethyl-pyrrolidin-2-ylmethyl)-5-iodo-2-methoxy-benzamide binding in striatal homogenates of rat brainMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(BOVINE)
Institut De Chimie Pharmaceutique Albert Lespagnol
Curated by ChEMBL
Institut De Chimie Pharmaceutique Albert Lespagnol
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Affinity towards Dopamine receptor D2 in membranes from bovine striatum using [3H]-racloprideMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:In vitro binding affinity at human cloned Dopamine receptor D4.2 by [3H]-YM-09151-2 displacement.More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Compound was tested in vitro for its ability to displace radioligand (+)-[3H]-3-PPP from rat cortical sigma receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Inhibition of [3H]haloperidol binding to Dopamine receptor in calf caudate nuclei.More data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Inhibitory concentration against opioid receptor sigma 1 of guinea pig cerebral cortex using [3H]-(+)-pentazocine upon incubation for 150 minutes at ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H]-(+)-pentazocine as radio ligand at pH 7.5 for 150 min at...More data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Displacement of [3H]spiroperidol from D2 dopamine receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibitory activity against Sigma opioid receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 3.10nMAssay Description:Compound was evaluated In vitro for its activity by binding to Dopamine receptor D2 in the rat brain using [3H]-NPA as radioligand.More data for this Ligand-Target Pair
TargetD(3) dopamine receptor(Homo sapiens)
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
National Institute On Drug Abuse-Intramural Research Program
Curated by ChEMBL
Affinity DataIC50: 3.5nMAssay Description:Antagonist activity at human dopamine D3 opioid receptor expressed in HEK293T cells assessed as GalphaoA activation preincubated with compound in D-P...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of specific binding of [125I]PIPAG to sigma receptor in Guinea pig brain membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Binding affinity to dopamine receptor D2 cloned from human, using [3H]- YM09151 as competitive ligandMore data for this Ligand-Target Pair
Affinity DataIC50: 4.10nMAssay Description:In vitro binding affinity at human cloned Dopamine receptor D2 by [3H]-spiroperidol displacement.More data for this Ligand-Target Pair
Affinity DataIC50: 4.20nMAssay Description:Ability to inhibit the specific binding of [3H]- spiroperidol to Dopamine receptor D2 in rat striatal membrane preparation by 50%More data for this Ligand-Target Pair
Affinity DataIC50: 4.20nMAssay Description:Neuroleptic activity in terms of [3H]-spiroperidol binding in rat striatal membraneto Dopamine receptor D2More data for this Ligand-Target Pair
Affinity DataIC50: 4.80nMAssay Description:Affinity towards Dopamine receptor D2 was evaluated in rat striatal membrane using [3H]spiperone as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 4.80nMAssay Description:Binding affinity to rat Dopamine receptor D2 expressed in CHO cells was determined using [125 I ] iodosulpride as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 4.90nMAssay Description:Binding affinity towards human Dopamine receptor D2More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]-DTG from sigma opioid receptor of homogenized guinea pig whole brainMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:The IC50 value was reported as apparent, since [3H]NCA was purported to be irreversible. Result indicates the mean of two separate experiments, each ...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of specific binding of [3H]NANM of sigma binding site in Guinea pig brain membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Binding affinity to dopamine receptor D4 cloned from human, using [3H]- YM09151 as competitive ligandMore data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:Compound was tested for its binding affinity towards Dopamine receptor D2 by using [3H]-domperidone as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 5.64nMAssay Description:In vitro binding affinity measured on sigma opioid receptor using [3H]-DTG as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibitory concentration against human Dopamine receptor D4.2 in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of [3H](S)-sulpiride binding in striatal homogenates of rat brainMore data for this Ligand-Target Pair
Affinity DataIC50: 6.5nMAssay Description:Binding affinity towards human D4.2 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 6.60nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Compound was tested in vitro for its affinity towards rat striatal Dopamine receptor D2 labeled with [3H]- spiperoneMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:In vitro inhibitory concentration against radioligand [3H]spiperone binding to rat striatal dopamine receptor D2More data for this Ligand-Target Pair
Affinity DataIC50: 7.5nMAssay Description:Compound was tested for the inhibition of [3H]-spiperone binding to dopamine receptor D2More data for this Ligand-Target Pair
Affinity DataIC50: 7.5nMAssay Description:Binding affinity towards Dopamine receptor D2 of rat corpus striatum using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 7.5nMAssay Description:Inhibitory binding of [3H]-spiperone to Dopamine receptor D2 in membranes from rat corpus striatumMore data for this Ligand-Target Pair
Affinity DataIC50: 7.5nMAssay Description:Binding affinity towards Dopamine receptor D2 binding site using [3H]spiroperidol.More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of specific binding of [125I]-PIPAG to sigma binding site in Guinea pig brain membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Affinity for Dopamine receptors in the rat striatum using [3H]spiroperidol displacement.More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Displacement of [3H]spiroperidol from dopamine receptor of rat corpus striatum homogenateMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:compound was tested for inhibition of 0.5 nM [3H]spiroperidol binding to dopamine receptor from rat striatal membrane.More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Binding affinity towards human Dopamine receptor D3More data for this Ligand-Target Pair