TargetFalcipain 2(Plasmodium falciparum)
Delhi Institute Of Pharmaceutical Sciences And Research
Curated by ChEMBL
Delhi Institute Of Pharmaceutical Sciences And Research
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of falcipain-2 in chloroquine sensitive Plasmodium falciparum MRC-02 schizont stage infected in human erythrocytes assessed as reduction i...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Bos taurus (Cattle))
P.D. Patel Institute Of Applied Sciences
Curated by ChEMBL
P.D. Patel Institute Of Applied Sciences
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of bovine liver DHFR pre-incubated 2 mins before dihydrofolic acid substrate addition and measured over 10 mins in presence of NADPHMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Bos taurus (Cattle))
P.D. Patel Institute Of Applied Sciences
Curated by ChEMBL
P.D. Patel Institute Of Applied Sciences
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of bovine liver DHFRMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Bos taurus (Cattle))
P.D. Patel Institute Of Applied Sciences
Curated by ChEMBL
P.D. Patel Institute Of Applied Sciences
Curated by ChEMBL
Affinity DataIC50: 31.3nMAssay Description:Inhibition of bovine liver DHFR using FH2 as substrate preincubated for 2 mins followed by substrate addition in presence of NADPHMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Bos taurus (Cattle))
P.D. Patel Institute Of Applied Sciences
Curated by ChEMBL
P.D. Patel Institute Of Applied Sciences
Curated by ChEMBL
Affinity DataIC50: 31.3nMAssay Description:Inhibition of bovine liver DHFR using FH2 as substrate incubated for 2 mins followed by substrate additionMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Bos taurus (Cattle))
P.D. Patel Institute Of Applied Sciences
Curated by ChEMBL
P.D. Patel Institute Of Applied Sciences
Curated by ChEMBL
Affinity DataIC50: 31.3nMAssay Description:Inhibition of bovine liver DHFR using FH2 as substrate preincubated for 2 mins followed by substrate additionMore data for this Ligand-Target Pair
Affinity DataIC50: 76.5nMAssay Description:Inhibitory activity against beta-hematin formationMore data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected in human 293T/ACE2 cells assessed as inhibition of viral infection pretreated t...More data for this Ligand-Target Pair
TargetFalcipain-2(Plasmodium falciparum)
Delhi Institute Of Pharmaceutical Sciences And Research
Curated by ChEMBL
Delhi Institute Of Pharmaceutical Sciences And Research
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of falcipain-2 in chloroquine resistant Plasmodium falciparum RKL9 schizont stage infected in human erythrocytes assessed as reduction in ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Hefei University Of Technology
Curated by ChEMBL
Hefei University Of Technology
Curated by ChEMBL
Affinity DataIC50: 270nMAssay Description:Inhibition of mTOR (unknown origin) activationMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of beta-hematin polymerizationMore data for this Ligand-Target Pair
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Homo sapiens (Human))
University Of Manchester And Manchester Cancer Research Center
Curated by ChEMBL
University Of Manchester And Manchester Cancer Research Center
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human recombinant NQO2More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Karl-Franzens-University
Curated by ChEMBL
Karl-Franzens-University
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cells assessed as reduction in tail current at membrane potential of +20 mVMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Karl-Franzens-University
Curated by ChEMBL
Karl-Franzens-University
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibitory concentration against IKr potassium channelMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Karl-Franzens-University
Curated by ChEMBL
Karl-Franzens-University
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human cloned ERGMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Karl-Franzens-University
Curated by ChEMBL
Karl-Franzens-University
Curated by ChEMBL
Affinity DataIC50: 2.51E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 5.47E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of BACE1 in human SH-SY5Y cells harboring wild type APP695 assessed as reduction in amyloid beta (1 to 40) level after 24 hrs by ELISA met...More data for this Ligand-Target Pair
Affinity DataIC50: 7.00E+3nMAssay Description:Modulation of human wild-type APP695 expressed in SH-SY5Y cells assessed as inhibition of amyloid beta (1 to 40 residues) production measured after 2...More data for this Ligand-Target Pair
Affinity DataIC50: 7.28E+3nMAssay Description:Ten-point DRCs were generated for each drug. Vero cells were seeded at 1.2 × 104 cells per well in DMEM, supplemented with 2% FBS and 1× ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMAssay Description:Ten-point DRCs were generated for each drug. Vero cells were seeded at 1.2 × 104 cells per well in DMEM, supplemented with 2% FBS and 1× ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.27E+4nMAssay Description:Inhibition of BACE1 in human SH-SY5Y cells harboring wild type APP695 assessed as reduction in amyloid beta (1 to 42) level after 24 hrs by ELISA met...More data for this Ligand-Target Pair
Affinity DataIC50: 1.28E+4nMAssay Description:Modulation of human wild-type APP695 expressed in SH-SY5Y cells assessed as inhibition of amyloid beta (1 to 42 residues) production measured after 2...More data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of hematin polymerizationMore data for this Ligand-Target Pair
Affinity DataIC50: 1.52E+4nMAssay Description:Antiplasmodial activity as inhibition of beta-hematin against Plasmodium yoelii N67 infected Swiss mice (Mus musculus) erythrocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.54E+4nMAssay Description:Inhibition of beta-hematin formation after 16 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibition of beta-hematin formationMore data for this Ligand-Target Pair
Affinity DataIC50: 4.60E+4nMpH: 8.0 T: 2°CAssay Description:The assay was performed using a 40-bp double-stranded DNA substrate carrying a single-strand nick between bases 22 and 23. The reaction products were...More data for this Ligand-Target Pair
Affinity DataIC50: 4.60E+4nMpH: 8.0 T: 2°CAssay Description:The assay was performed using a 40-bp double-stranded DNA substrate carrying a single-strand nick between bases 22 and 23. The reaction products were...More data for this Ligand-Target Pair
Affinity DataIC50: 4.63E+4nMAssay Description:Inhibition of lipid-induced beta-hematin formationMore data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of 1-monooleoyl glycerol induced beta-hematin formationMore data for this Ligand-Target Pair
Affinity DataIC50: 7.50E+4nMAssay Description:Inhibition of beta-hematin formation in Plasmodium falciparumMore data for this Ligand-Target Pair
Affinity DataIC50: 7.65E+4nMAssay Description:Inhibition of 1-monooleoyl glycerol (MOG) induced beta-hematin formationMore data for this Ligand-Target Pair
Affinity DataIC50: 1.04E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
TargetMO15-related protein kinase Pfmrk(Plasmodium falciparum)
Walter Reed Army Institute Of Research
Curated by ChEMBL
Walter Reed Army Institute Of Research
Curated by ChEMBL
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of Plasmodium falciparum cyclin-dependent kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2.52E+5nMAssay Description:Inhibition of Tween 20-induced beta-hematin formation by colorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+5nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
TargetPhosphoethanolamine N-methyltransferase(Plasmodium falciparum)
Washington University
Curated by ChEMBL
Washington University
Curated by ChEMBL
Affinity DataIC50: 5.54E+5nMAssay Description:Inhibition of Plasmodium falciparum phosphoethanolamine methyltransferase using phospethanolamine as substrate by radiochemical assay in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+6nMpH: 7.6 T: 2°CAssay Description:The assay was performed using a 40-bp double-stranded DNA substrate carrying a single-strand nick between bases 22 and 23. The reaction products were...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+6nMpH: 7.6 T: 2°CAssay Description:The assay was performed using a 40-bp double-stranded DNA substrate carrying a single-strand nick between bases 22 and 23. The reaction products were...More data for this Ligand-Target Pair
Affinity DataIC50: 5.90E+6nMAssay Description:Inhibition of beta-hematin formationMore data for this Ligand-Target Pair
Affinity DataIC50: 9.10E+8nMAssay Description:Inhibition of beta-hematin formation by BHIA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.69E+9nMAssay Description:Inhibition of beta-hematin formationMore data for this Ligand-Target Pair
Affinity DataIC50: 2.56E+9nMAssay Description:Inhibition of beta-hematin formation by BHIA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.07E+12nMAssay Description:Inhibition of Human immunodeficiency virus 1 integrase strand transfer activityMore data for this Ligand-Target Pair