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Found 22 of ic50 for monomerid = 419133
TargetProcathepsin L(Homo sapiens (Human))
University Of Alberta Edmonton

Curated by ChEMBL
LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCathepsin K(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  0.560nMAssay Description:Inhibition of human Cathepsin K using Ac-LR-AMC as fluorogenic substrate incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCathepsin S(Homo sapiens (Human))
University Of Alberta Edmonton

Curated by ChEMBL
LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  23nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  30nMAssay Description:Inhibition of SARS-CoV-2 (BetaCoV/Wuhan/WIV04/2019) MPro expressed in Escherichia coli using FRET susbtrate measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  30nMAssay Description:Inhibition of SARS-CoV-2 MProMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  30nMAssay Description:Inhibition of SARS CoV-2 main protease expressed in Escherichia coli BL21 (DE3) using Dabcyl-KTSAVLQ/SGFRKME-Edans as substrate preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  30nMAssay Description:Inhibition of SARS-CoV-2 main proteaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  30nMAssay Description:Inhibition of SARS-CoV-2 MProMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  30nMAssay Description:Inhibition of SARS CoV-2 3CL protease using dabcyl-KTSAVLQ/SGFRKME-edans as substrate incubated for 30 mins followed by substrate addition measured a...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataKi:  30nM IC50:  31nMAssay Description:The assays were carried out with 20 nM enzyme (except for MPI3, for which 10 nM enzyme was used) and 10 μM substrate at 37oC with continuous sha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  33nMAssay Description:Inhibition of SARS-CoV-2 main protease using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as fluorescent substrate preincubated for 10 mins followed by substrate ad...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCathepsin F(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  74nMAssay Description:Inhibition of human Cathepsin F using Z-Phe-Arg-AMC as fluorogenic substrate incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  190nMAssay Description:Inhibition of SARS-CoV-2 3CL protease by FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetOrf1a protein(MERS-CoV)
Wichita State University

LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  410nMAssay Description:The expression and purification of the 3CLpro of MERS-CoV and SARS-CoV were performed by a standard method described previously by our lab (11, 19, 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  620nMAssay Description:The expression and purification of the 3CLpro of MERS-CoV and SARS-CoV were performed by a standard method described previously by our lab (11, 19, 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of Alberta Edmonton

Curated by ChEMBL
LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  990nMAssay Description:Inhibition of human Cathepsin L using Z-Leu-Arg-AMC as fluorogenic substrate incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCathepsin B(Homo sapiens (Human))
University Of Alberta Edmonton

Curated by ChEMBL
LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human cathepsin BMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1a(Human SARS coronavirus (SARS-CoV))
Wichita State University

LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  2.20E+3nMAssay Description:The expression and purification of the 3CLpro of MERS-CoV and SARS-CoV were performed by a standard method described previously by our lab (11, 19, 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50:  4.35E+3nMAssay Description:Inhibition of SARS CoV 3CL protease using dabcyl-KTSAVLQ/SGFRKME-edans as substrate incubated for 30 mins followed by substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50: >5.00E+4nMAssay Description:Covalent inhibition of SARS-Cov-2 PLpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTrypsin(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50: >5.00E+4nMAssay Description:Covalent inhibition of trypsin (unknown origin) incubated for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataIC50: >6.00E+4nMAssay Description:Non-covalent inhibition of SARS-Cov-2 PLpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails PubMed