Found 73 of ic50 for monomerid = 50009672 TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
University Of Michigan Medical School
Curated by ChEMBL
University Of Michigan Medical School
Curated by ChEMBL
Affinity DataIC50: 71nMAssay Description:Inhibition of recombinant human DNMT1 using poly(dl-dC) as substrate by hotspot assayMore data for this Ligand-Target Pair
3D Structure (crystal)TargetProtein arginine N-methyltransferase 7(Homo sapiens (Human))
University Of Michigan Medical School
Curated by ChEMBL
University Of Michigan Medical School
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant human PRMT7 using GST-GAR as substrate by hotspot assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 3(Homo sapiens)
University Of Michigan Medical School
Curated by ChEMBL
University Of Michigan Medical School
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant human PRMT8 using histone H4 as substrate by hotspot assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Sapienza University Of Rome
Curated by ChEMBL
Sapienza University Of Rome
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of DOTL1 (unknown origin) using [3H]SAM and HeLa oligo nucleosomes as substrates incubated for 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Inhibition of SMYD2 (unknown origin) by HMT assayMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of human recombinant DNMT3b2More data for this Ligand-Target Pair
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
University Of Michigan Medical School
Curated by ChEMBL
University Of Michigan Medical School
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of DNMT1 (unknown origin)More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Sapienza University Of Rome
Curated by ChEMBL
Sapienza University Of Rome
Curated by ChEMBL
Affinity DataIC50: 220nMAssay Description:Inhibition of human recombinant DOT1L (1 to 420 amino acids) expressed in Escherichia coliMore data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Inhibition of EHMT1 (unknown origin) by HMT assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 1(Homo sapiens)
Sapienza University Of Rome
Curated by ChEMBL
Sapienza University Of Rome
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Inhibition of PRMT1 (unknown origin) using [3H]SAM and chicken histone 4 as substrates incubated for 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of human recombinant DNMT3B expressed in baculovirus-insect cell system by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 263nMpH: 7.6Assay Description:S-Adenosyl-L-homocysteine (SAH) was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive c...More data for this Ligand-Target Pair
Affinity DataIC50: 263nMpH: 7.6Assay Description:S-Adenosyl-L-homocysteine (SAH) was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive c...More data for this Ligand-Target Pair
Affinity DataIC50: 263nMpH: 7.6Assay Description:Compound 75 was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive control (100% inhibit...More data for this Ligand-Target Pair
Affinity DataIC50: 283nMpH: 7.6Assay Description:Compound 75 was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive control (100% inhibit...More data for this Ligand-Target Pair
Affinity DataIC50: 283nMpH: 7.6Assay Description:S-Adenosyl-L-homocysteine (SAH) was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive c...More data for this Ligand-Target Pair
Affinity DataIC50: 283nMpH: 7.6Assay Description:S-Adenosyl-L-homocysteine (SAH) was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive c...More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of human recombinant DNMT3b2 expressed in baculovirus infected high five insect cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 380nMpH: 7.6Assay Description:S-Adenosyl-L-homocysteine (SAH) was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive c...More data for this Ligand-Target Pair
Affinity DataIC50: 380nMpH: 7.6Assay Description:Compound 75 was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive control (100% inhibit...More data for this Ligand-Target Pair
Affinity DataIC50: 380nMpH: 7.6Assay Description:S-Adenosyl-L-homocysteine (SAH) was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive c...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 1 [11-371](Homo sapiens (Human))
The University Of Georgia
Curated by ChEMBL
The University Of Georgia
Curated by ChEMBL
Affinity DataIC50: 420nMAssay Description:Displacement of [3H]-SAM from recombinant His6-tagged PRMT1 (unknown origin) expressed in Escherichia coli BL21(DE3) incubated for 5 mins prior to H4...More data for this Ligand-Target Pair
Affinity DataIC50: 467nMpH: 7.6Assay Description:S-Adenosyl-L-homocysteine (SAH) was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive c...More data for this Ligand-Target Pair
Affinity DataIC50: 467nMpH: 7.6Assay Description:Compound 75 was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive control (100% inhibit...More data for this Ligand-Target Pair
Affinity DataIC50: 467nMpH: 7.6Assay Description:S-Adenosyl-L-homocysteine (SAH) was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive c...More data for this Ligand-Target Pair
Affinity DataIC50: 490nMAssay Description:Inhibition of Dengue virus ribose 2'-O methyltransferase using RNA substrate after 20 mins in presence of [methyl-3H]-AdoMet by microbeta counting an...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 1 [11-371](Homo sapiens (Human))
The University Of Georgia
Curated by ChEMBL
The University Of Georgia
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of PRMT1 (unknown origin) using biotinylated histone H4-derived peptide as substrate after 60 mins by AlphaLISA assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 1(Homo sapiens)
Sapienza University Of Rome
Curated by ChEMBL
Sapienza University Of Rome
Curated by ChEMBL
Affinity DataIC50: 550nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged PRMT1 (2 to end residues) expressed in baculovirus infected Sf9 insect cells using biotinylated...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
University Of Jinan
Curated by ChEMBL
University Of Jinan
Curated by ChEMBL
Affinity DataIC50: 560nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in ...More data for this Ligand-Target Pair
TargetN6-adenosine-methyltransferase catalytic subunit(Homo sapiens)
University Of Zurich
Curated by ChEMBL
University Of Zurich
Curated by ChEMBL
Affinity DataIC50: 590nMAssay Description:Inhibition of recombinant METLL3 (unknown origin) expressed in baculovirus infected Sf9 cells assessed as decrease in N6-methyladenosine level in oli...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Sapienza University Of Rome
Curated by ChEMBL
Sapienza University Of Rome
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Competitive inhibition of human recombinant DOT1L (1 to 420 amino acid residues) overexpressed in Escherichia coli BL21 (DE3) using [3H]-SAM as subst...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Sapienza University Of Rome
Curated by ChEMBL
Sapienza University Of Rome
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Competitive inhibition of human recombinant DOT1L (1 to 472 amino acid residues) expressed in Escherichia coli BL21 (DE3) using [3H]-SAM assessed as ...More data for this Ligand-Target Pair
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
University Of Michigan Medical School
Curated by ChEMBL
University Of Michigan Medical School
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of DNMT1 (unknown origin) using biotinylated substrate using [3H]-SAM after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
University Of Jinan
Curated by ChEMBL
University Of Jinan
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in ...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 3(Homo sapiens)
University Of Michigan Medical School
Curated by ChEMBL
University Of Michigan Medical School
Curated by ChEMBL
Affinity DataIC50: 760nMAssay Description:Inhibition of recombinant human PRMT3 using histone H4 as substrate by hotspot assayMore data for this Ligand-Target Pair
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
University Of Michigan Medical School
Curated by ChEMBL
University Of Michigan Medical School
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibition of human recombinant DNMT1More data for this Ligand-Target Pair
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
University Of Michigan Medical School
Curated by ChEMBL
University Of Michigan Medical School
Curated by ChEMBL
Affinity DataIC50: 900nMAssay Description:Inhibition of full length N-terminal His6-tagged human DNMT1 after 1 hr by fluorescence analysisMore data for this Ligand-Target Pair
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
University Of Michigan Medical School
Curated by ChEMBL
University Of Michigan Medical School
Curated by ChEMBL
Affinity DataIC50: 941nMAssay Description:Inhibition of human Dnmt1 using oligonucleotide 2 as substrate after 5000 sec by micro plate reader based real-time break-light assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of SUV39H1 (unknown origin) by HMT assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University Of Michigan Medical School
Curated by ChEMBL
University Of Michigan Medical School
Curated by ChEMBL
Affinity DataIC50: 1.82E+3nMAssay Description:Inhibition of recombinant human G9a using histone H3 (1 to 21) as substrate by hotspot assayMore data for this Ligand-Target Pair
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
University Of Michigan Medical School
Curated by ChEMBL
University Of Michigan Medical School
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cellsMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 3(Homo sapiens)
University Of Michigan Medical School
Curated by ChEMBL
University Of Michigan Medical School
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PRMT3 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University Of Michigan Medical School
Curated by ChEMBL
University Of Michigan Medical School
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of G9a (unknown origin) by HMT assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of SETDB1 (unknown origin) by HMT assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of MLL (unknown origin) by HMT assayMore data for this Ligand-Target Pair
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
University Of Michigan Medical School
Curated by ChEMBL
University Of Michigan Medical School
Curated by ChEMBL
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human recombinant DNMT1 expressed in Sf9 cells assessed as incorporation of [3H]S-adenosyl methionine into hemimethylated oligonucleoti...More data for this Ligand-Target Pair
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
University Of Michigan Medical School
Curated by ChEMBL
University Of Michigan Medical School
Curated by ChEMBL
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human recombinant DNMT1 expressed in baculovirus-insect cell system by scintillation countingMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University Of Michigan Medical School
Curated by ChEMBL
University Of Michigan Medical School
Curated by ChEMBL
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of G9a (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4.80E+3nMpH: 7.6Assay Description:S-Adenosyl-L-homocysteine (SAH) was serially diluted 3 fold in DMSO for 10 points and 1 μL was plated in a 384 well microtiter plate. Positive c...More data for this Ligand-Target Pair
