TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Anhui University Of Chinese Medicine
Curated by ChEMBL
Anhui University Of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 0.490nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate and measured by fluorometric assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Anhui University Of Chinese Medicine
Curated by ChEMBL
Anhui University Of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of COX-1 (unknown origin) using arachidonic acid as substrate and measured by fluorometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 151nMAssay Description:Inhibition of mouse COX-2 expressed in baculovirus infected Sf21 insect cells assessed as reduction in oxygen consumption using arachidonic acid as s...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Anhui University Of Chinese Medicine
Curated by ChEMBL
Anhui University Of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Concentration that caused a 50% decrease in the maximal inhibition of Prostaglandin G/H synthase 2 activity as measured by PGE-2 production.More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Anhui University Of Chinese Medicine
Curated by ChEMBL
Anhui University Of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 330nMAssay Description:Inhibition of human recombinant COX2 assessed as reduction in PGH2 formation using arachidonic acid as substrate preincubated for 10 mins measured af...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Anhui University Of Chinese Medicine
Curated by ChEMBL
Anhui University Of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 490nMAssay Description:Concentration of drug that causes a 50% decrease in the maximal inhibition of Prostaglandin G/H synthase 2 activity as measured by PGE-2 productionMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Anhui University Of Chinese Medicine
Curated by ChEMBL
Anhui University Of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:In vitro inhibitory activity against human whole blood Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of sheep seminal vesicle COX-1 assessed as reduction in oxygen consumption using arachidonic acid as substrate incubated for 12 mins follo...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Anhui University Of Chinese Medicine
Curated by ChEMBL
Anhui University Of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:In vitro for its inhibitory activity against human whole blood Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Anhui University Of Chinese Medicine
Curated by ChEMBL
Anhui University Of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 2.20E+3nMAssay Description:Concentration that caused a 50% decrease in the maximal inhibition of Prostaglandin G/H synthase 1 activity as measured by PGE-2 production.More data for this Ligand-Target Pair
Affinity DataKi: 1.01E+4nM IC50: 1.20E+4nMAssay Description:In order to determine the effects of some drugs on human 6PGD, concentrations of ketotifen (0.0018-0.0282 mM), dacarbazine (0.0049-0.054 mM), meloxic...More data for this Ligand-Target Pair
Affinity DataKi: 6.10E+3nM ΔG°: -29.8kJ/mole IC50: 2.90E+4nMpH: 8.0 T: 2°CAssay Description:GR activity was determined by the method of Carlberg and Mannervik [Carlberg et al., FL:Academic Press, 72:248-254] with a Shimadzu Spectrophotometer...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Anhui University Of Chinese Medicine
Curated by ChEMBL
Anhui University Of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 3.12E+4nMAssay Description:Inhibition of human recombinant COX1 assessed as reduction in PGF2alpha formation using arachidonic acid as substrate preincubated for 10 mins measur...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Anhui University Of Chinese Medicine
Curated by ChEMBL
Anhui University Of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 3.66E+4nMAssay Description:Concentration of drug that causes a 50% decrease in the maximal inhibition of Prostaglandin G/H synthase 1 activity as measured by PGE-2 production('...More data for this Ligand-Target Pair
Affinity DataKi: 5.09E+4nM IC50: 5.50E+4nMAssay Description:In order to determine the effects of some drugs on human 6PGD, concentrations of ketotifen (0.0018-0.0282 mM), dacarbazine (0.0049-0.054 mM), meloxic...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Anhui University Of Chinese Medicine
Curated by ChEMBL
Anhui University Of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 5.73E+4nMAssay Description:Inhibition of COX2 (unknown origin) assessed as suppression of PGG2 conversion to PGH2 incubated fro 2 mins by TMPD based colorimetric assayMore data for this Ligand-Target Pair
Affinity DataKi: 5.79E+4nM IC50: 6.70E+4nMAssay Description:Ketotifen, dacarbazine, thiocolchicoside, meloxicam, methotrexate, furosemide, olanzapine, methylprednizolone acetate, paricalcitol, ritodrine hydroc...More data for this Ligand-Target Pair
Affinity DataIC50: 7.75E+4nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Anhui University Of Chinese Medicine
Curated by ChEMBL
Anhui University Of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 8.58E+4nMAssay Description:Inhibition of COX1 (unknown origin) assessed as suppression of PGG2 conversion to PGH2 incubated fro 2 mins by TMPD based colorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair