Affinity DataIC50: <1.5nMAssay Description:In determination of the Weel kinase activity, a synthetic peptide, Poly(Lys,Tyr) Hydrobromide (Lys:Tyr (4:1)) bought from Sigma was used as the subst...More data for this Ligand-Target Pair
Affinity DataIC50: 3.90nMAssay Description:Displacement of Alexa Fluor labelled kinase tracer178 from WEE1 (unknown origin) incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.20nMAssay Description:Inhibition of recombinant human Wee1 using poly(Lys,Tyr) as substrate after 30 mins in presence of [gamma-33P]-ATP by liquid scintillation counting m...More data for this Ligand-Target Pair
Affinity DataIC50: 5.20nMAssay Description:Inhibition of WEE1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5.20nMAssay Description:Inhibition of N-terminal GST-fused human WEE1 (215 to 646 residues) expressed in baculovirus expression system using poly(Lys,Tyr) as substrate incub...More data for this Ligand-Target Pair
Affinity DataIC50: 8.70nMAssay Description:In the present disclosure, Wee1 enzyme catalysis assay was carried out using the ATP-Glo Max kinase luminescence detection kit (Promega). Kinase acti...More data for this Ligand-Target Pair
Affinity DataIC50: <10nMAssay Description:Wee 1 kinase was determined by using Flurorescence Resonance Energy Transfer (FRET) assay. In 384-well plates, Wee1 kinase (2 nM final concentration)...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
West China Hospital
Curated by ChEMBL
West China Hospital
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of human PLK1 in the presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of WEE1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of human Wee1 in the presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 101nMAssay Description:Inhibition of human WEE1 using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
West China Hospital
Curated by ChEMBL
West China Hospital
Curated by ChEMBL
Affinity DataIC50: 350nMAssay Description:Inhibition of PLK (unknown origin)More data for this Ligand-Target Pair
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Martin-Luther-University Halle-Wittenberg
Curated by ChEMBL
Martin-Luther-University Halle-Wittenberg
Curated by ChEMBL
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of N-[3',6'-dihydroxy-3-oxo-3H-spiro(2-benzofuran-1,9'-xanthen)-5-yl]-N'-[2-(4-{4-[N-(2-chloro-6-methylphenyl)-5-carboxamido]-thiazol-2-yl...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase WNK3(Homo sapiens (Human))
University Of Florida
Curated by ChEMBL
University Of Florida
Curated by ChEMBL
Affinity DataIC50: 2.31E+3nMAssay Description:Inhibition of human WNK3 using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Martin-Luther-University Halle-Wittenberg
Curated by ChEMBL
Martin-Luther-University Halle-Wittenberg
Curated by ChEMBL
Affinity DataIC50: 4.94E+3nMAssay Description:Inhibition of human full length PKMYT1 expressed in HEK293 cells using EFS (247 to 259 residues) as substrate after 1 hr by fluorescence polarization...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair