TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Homo sapiens (Human))
Ortho Pharmaceutical
Curated by ChEMBL
Ortho Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamineMore data for this Ligand-Target Pair
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Homo sapiens (Human))
Ortho Pharmaceutical
Curated by ChEMBL
Ortho Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 280nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5...More data for this Ligand-Target Pair
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Homo sapiens (Human))
Ortho Pharmaceutical
Curated by ChEMBL
Ortho Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 370nMAssay Description:Inhibition of [14C]-aminopyrine (AP) accumulation stimulated by dibutyryl cyclic AMP in isolated rabbit parietal cellsMore data for this Ligand-Target Pair
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Homo sapiens (Human))
Ortho Pharmaceutical
Curated by ChEMBL
Ortho Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:In vitro inhibitory activity against H+/K+ ATPase prepared from canine fundic mucosaMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Emory University
Curated by PubChem BioAssay
Emory University
Curated by PubChem BioAssay
Affinity DataIC50: 3.14E+3nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Nikolovska-Coleska, Univer...More data for this Ligand-Target Pair
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Homo sapiens (Human))
Ortho Pharmaceutical
Curated by ChEMBL
Ortho Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 3.80E+3nMpH: 7.4Assay Description:Inhibition of H+/K+ ATPase activity in buffered solution (pH 7.4)More data for this Ligand-Target Pair
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Sus scrofa (Pig))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataIC50: 3.80E+3nMAssay Description:In vitro inhibition against H+/K+ ATPase from porcine gastric mucosal membrane vesiclesMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Institute Of Clinical Pharmacology
Curated by ChEMBL
Institute Of Clinical Pharmacology
Curated by ChEMBL
Affinity DataIC50: 1.77E+4nMAssay Description:TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 5 uM) in Caco-2 cellsMore data for this Ligand-Target Pair
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Homo sapiens (Human))
Ortho Pharmaceutical
Curated by ChEMBL
Ortho Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 2.24E+4nMAssay Description:Compound was tested in vitro for H+/K+ ATPase activity in rabbit stomach preparationsMore data for this Ligand-Target Pair
TargetFatty acid synthase(Homo sapiens (Human))
Indiana University School Of Medicine
Curated by ChEMBL
Indiana University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 2.96E+4nMAssay Description:Inhibition of purified recombinant FASN TE activity (unknown origin) using 4-MUH as substrate preincubated for 30 mins before substrate addition meas...More data for this Ligand-Target Pair
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Sus scrofa (Pig))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Activity was evaluated by measuring the inhibition of isolated hog H+/K+ ATPaseMore data for this Ligand-Target Pair
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataIC50: 5.60E+4nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
Affinity DataIC50: 7.80E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Institute Of Clinical Pharmacology
Curated by ChEMBL
Institute Of Clinical Pharmacology
Curated by ChEMBL
Affinity DataIC50: 8.90E+4nMAssay Description:Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity modelMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Institute Of Clinical Pharmacology
Curated by ChEMBL
Institute Of Clinical Pharmacology
Curated by ChEMBL
Affinity DataIC50: 9.12E+4nMAssay Description:Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity modelMore data for this Ligand-Target Pair
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Institute Of Clinical Pharmacology
Curated by ChEMBL
Institute Of Clinical Pharmacology
Curated by ChEMBL
Affinity DataIC50: 9.72E+4nMAssay Description:Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity modelMore data for this Ligand-Target Pair
TargetUDP-glucuronosyltransferase 1-6(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataIC50: 1.85E+5nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
TargetUDP-glucuronosyltransferase 2B10(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataIC50: >3.00E+5nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
TargetUDP-glucuronosyltransferase 2B7(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataIC50: >3.00E+5nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
TargetUDP-glucuronosyltransferase 1A4(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
Affinity DataIC50: >3.00E+5nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair