Compile Data Set for Download or QSAR
maximum 50k data
Found 3 Enz. Inhib. hit(s) with Target = '[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial' and Ligand = 'BDBM472696'
LigandPNGBDBM472696((2R)-3,3,3-trifluoro-1-[1-(4-fluorophenyl)-7-methy...)
Affinity DataIC50: <300nMAssay Description:The PDC inactivation assay is performed in Greiner 384-well microtiter plates and is used for high throughput screen. 4 μl of PDHK2 (human, rec,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM472696((2R)-3,3,3-trifluoro-1-[1-(4-fluorophenyl)-7-methy...)
Affinity DataIC50: <300nMAssay Description:The biochemical activity assay for PDHK2 is based on the inactivation of PDC through phosphorylation by PDHK2. The assay is run in two steps: the enz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM472696((2R)-3,3,3-trifluoro-1-[1-(4-fluorophenyl)-7-methy...)
Affinity DataKd: <300nMAssay Description:ITC measurements were performed with a VP-ITC micro calorimeter (Microcal, LLC/GE Healthcare Bio-Sciences AB, Uppsala, Sweden). In general titrations...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent