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Found 5 Enz. Inhib. hit(s) with Target = 'ALK tyrosine kinase receptor' and Ligand = 'BDBM50193811'
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50193811(CHEMBL3951811)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of human ALK expressed in baculovirus using recombinant GST PLC-gamma as substrate assessed as phosphorylation of the substrate after 15 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50193811(CHEMBL3951811)
Affinity DataIC50:  22nMAssay Description:Inhibition of NPM-ALK phosphorylation in human SUP-M2 cells after 2 to 3 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50193811(CHEMBL3951811)
Affinity DataIC50:  85nMAssay Description:Inhibition of EML4-ALK tyrosine phosphorylation in human NCI-H3122 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50193811(CHEMBL3951811)
Affinity DataIC50:  175nMAssay Description:Inhibition of EML4-ALK tyrosine phosphorylation in human NCI-H2228 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50193811(CHEMBL3951811)
Affinity DataKd:  2.30nMAssay Description:Binding affinity to human ALK (1088 to 1409 residues) expressed in mammalian system by KINOMEscan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed