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Found 15 Enz. Inhib. hit(s) with Target = 'Adenosine receptor A1' and Ligand = 'BDBM50080550'
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50080550((2-Amino-4,5-dimethyl-thiophen-3-yl)-(3-trifluorom...)
Affinity DataKi:  1.10E+4nMAssay Description:Displacement of [3H]DPCPX from adenosine A1 receptor in rat membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50080550((2-Amino-4,5-dimethyl-thiophen-3-yl)-(3-trifluorom...)
Affinity DataKi:  1.10E+4nMAssay Description:Displacement of [3H]DPCPX from adenosine A1 receptor in rat membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50080550((2-Amino-4,5-dimethyl-thiophen-3-yl)-(3-trifluorom...)
Affinity DataKi:  1.10E+4nMAssay Description:Displacement of [3H]DPCPX from A1 adenosine receptor in rat membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50080550((2-Amino-4,5-dimethyl-thiophen-3-yl)-(3-trifluorom...)
Affinity DataKi:  1.10E+4nMAssay Description:Displacement of [3H]-DPCPX from rat brain membrane adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50080550((2-Amino-4,5-dimethyl-thiophen-3-yl)-(3-trifluorom...)
Affinity DataKi:  1.10E+4nMAssay Description:Displacement of [3H]DPCPX from adenosine A1 receptor in rat membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50080550((2-Amino-4,5-dimethyl-thiophen-3-yl)-(3-trifluorom...)
Affinity DataKi:  1.10E+7nMAssay Description:Displacement of [3H]DPCPX from adenosine A1 receptor in rat membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50080550((2-Amino-4,5-dimethyl-thiophen-3-yl)-(3-trifluorom...)
Affinity DataEC50:  1.74E+3nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50080550((2-Amino-4,5-dimethyl-thiophen-3-yl)-(3-trifluorom...)
Affinity DataEC50: >1.00E+4nMAssay Description:Antagonist activity against adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50080550((2-Amino-4,5-dimethyl-thiophen-3-yl)-(3-trifluorom...)
Affinity DataEC50:  1.36E+4nMAssay Description:Allosteric modulatory activity at human adenosine A1 receptor expressed in CHOk1 cells assessed as drug level causing half maximal allosteric effect ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50080550((2-Amino-4,5-dimethyl-thiophen-3-yl)-(3-trifluorom...)
Affinity DataKd:  1.80nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50080550((2-Amino-4,5-dimethyl-thiophen-3-yl)-(3-trifluorom...)
Affinity DataKd:  1.10nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50080550((2-Amino-4,5-dimethyl-thiophen-3-yl)-(3-trifluorom...)
Affinity DataEC50:  1.36E+4nMAssay Description:Modulation of human adenosine A1 receptor expressed in CHO-K1 cells assessed as allosteric effect on [125I]ABA dissociationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50080550((2-Amino-4,5-dimethyl-thiophen-3-yl)-(3-trifluorom...)
Affinity DataKd:  0.75nMAssay Description:Allosteric enhancer activity at human adenosine A1 receptor expressed in CHO cell membranes assessed as [3H]NECA affinity constant at 1 uM (Kd = 0.87...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50080550((2-Amino-4,5-dimethyl-thiophen-3-yl)-(3-trifluorom...)
Affinity DataEC50:  1.47E+4nMAssay Description:Enhanced 0.5 nM [3H]-CCPA dissociation from adenosine A1 receptor of rat brain cortex membranes compared to 100 uM CPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50080550((2-Amino-4,5-dimethyl-thiophen-3-yl)-(3-trifluorom...)
Affinity DataEC50:  8.40E+3nMAssay Description:Effective dose as dissociation of [3H]-N6-cyclohexyladenosine ([3H]-CHA) from CHO-K1 membrane after treatment with allosteric enhancer and (R)-PIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed