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Found 3 Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2' and Ligand = 'BDBM189706'
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM189706(US10213433, Compound 276 | US11369599, Compound 27...)
Affinity DataKi: <0.0100nM ΔG°: <-62.8kJ/moleT: 2°CAssay Description:Representative compounds were serially diluted in dimethyl sulfoxide (DMSO) starting at 50 uM (2x starting concentration; 10% DMSO) and 10 uL were tr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM189706(US10213433, Compound 276 | US11369599, Compound 27...)
Affinity DataKi: <0.0100nMAssay Description:The inhibition constant (Ki) for binding of representative compounds to Bcl-2 protein, as determined by a TR-FRET (Time-Resolved Fluorescence-Resonan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM189706(US10213433, Compound 276 | US11369599, Compound 27...)
Affinity DataKi: <0.0100nMAssay Description:TR-FRET (Time-Resolved Fluorescence-Resonance-Energy-Transfer) assay.More data for this Ligand-Target Pair
In DepthDetails US Patent