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Found 2 Enz. Inhib. hit(s) with Target = 'Beta-lactamase' and Ligand = 'BDBM466989'
TargetBeta-lactamase(Escherichia coli)
Entasis Therapeutics

US Patent
LigandPNGBDBM466989((2S)-2-fluoro-2-[[(2S,5R)-3-methyl-7-oxo-2-[2-(5-o...)
Affinity DataIC50:  10nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-lactamase(Klebsiella pneumoniae)
Entasis Therapeutics

US Patent
LigandPNGBDBM466989((2S)-2-fluoro-2-[[(2S,5R)-3-methyl-7-oxo-2-[2-(5-o...)
Affinity DataIC50:  530nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent