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Found 4 Enz. Inhib. hit(s) with Target = 'Caspase-3' and Ligand = 'BDBM10348'
TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM10348(5-(2-(Pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfon...)
Affinity DataKi:  16.1nMAssay Description:Enzyme activities with or without inhibitors were measured using a fluorescence assay. The formation of the cleavage product AFC was monitored for 90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM10348(5-(2-(Pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfon...)
Affinity DataIC50:  58.3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM10348(5-(2-(Pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfon...)
Affinity DataIC50:  58.9nMAssay Description:Inhibition of caspase3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM10348(5-(2-(Pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfon...)
Affinity DataEC50:  1.83E+3nMAssay Description:Inhibition of staurosporine induced activation of caspase 3 activation in human Hela cells assessed as hydrolysis of Z-DEVD-R110 substrate by micropl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed