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Found 8 Enz. Inhib. hit(s) with Target = 'Catechol O-methyltransferase' and Ligand = 'BDBM50108879'
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50108879((2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-d...)
Affinity DataIC50:  3.47nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50108879((2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-d...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50108879((2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-d...)
Affinity DataIC50:  12.8nMAssay Description:Inhibition of Catechol O-methyltransferase activity in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50108879((2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-d...)
Affinity DataIC50:  34nMAssay Description:Inhibition of S-COMT in Wistar rat liver assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50108879((2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-d...)
Affinity DataIC50:  230nMAssay Description:Inhibition of rat liver COMT using esculetin as substrate by fluorescence based spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50108879((2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-d...)
Affinity DataIC50:  2.32E+3nMAssay Description:Inhibitory activity against COMT in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50108879((2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-d...)
Affinity DataIC50:  1.28E+4nMAssay Description:Inhibitory activity against COMT in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
University Of Porto

Curated by ChEMBL
LigandPNGBDBM50108879((2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-d...)
Affinity DataIC50:  2.32E+6nMAssay Description:Inhibition of Catechol O-methyltransferase activity in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed