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Found 2 Enz. Inhib. hit(s) with Target = 'DNA topoisomerase 2-alpha' and Ligand = 'BDBM50259247'
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
University Of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259247(CHEMBL4065223 | US10266550, Compound 11g)
Affinity DataIC50:  1.95E+3nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
University Of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259247(CHEMBL4065223 | US10266550, Compound 11g)
Affinity DataIC50:  2.93E+3nMAssay Description:Human Topoisomerase IIα assays were carried out by adding the compounds to 185 ng of kinetoplast DNA (kDNA, from TopoGen) in the buffer supplied...More data for this Ligand-Target Pair
In DepthDetails US Patent