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Found 4 Enz. Inhib. hit(s) with Target = 'G-protein coupled bile acid receptor 1' and Ligand = 'BDBM50327516'
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50327516(2-(4-bromophenyl)-N-((7-methoxy-2-(thiophen-3-yl)q...)
Affinity DataIC50:  65nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50327516(2-(4-bromophenyl)-N-((7-methoxy-2-(thiophen-3-yl)q...)
Affinity DataIC50:  3.20E+3nMAssay Description:Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50327516(2-(4-bromophenyl)-N-((7-methoxy-2-(thiophen-3-yl)q...)
Affinity DataEC50:  154nMAssay Description:Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50327516(2-(4-bromophenyl)-N-((7-methoxy-2-(thiophen-3-yl)q...)
Affinity DataEC50:  3.22E+3nMAssay Description:Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed