Affinity DataKi: 0.25nMAssay Description:Antagonist activity at human kappa-opioid receptor expressed in CHO cells assessed as inhibition of U69593-induced [35S]GTPgammaS binding after 60 mi...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Biological Research Center Of Hungarian Academy Of Sciences
Curated by PDSP Ki Database
Biological Research Center Of Hungarian Academy Of Sciences
Curated by PDSP Ki Database
Affinity DataKi: 1.10nMAssay Description:Displacement of [3H]U-69593 from human opioid kappa receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Inhibition of [3H]U-69,593 binding to human Opioid receptor kappa 1 expressed in HEK 293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Activity at human cloned kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Displacement of [125I]OXY from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Affinity DataKi: 3.17nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Affinity DataKi: 3.20nMAssay Description:Affinity to opioid receptor kappa 1 using [3H]U-69593 as radioligand in homogenates of guinea pig brain membranesMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Affinity DataKi: 4.5nMAssay Description:Displacement of [3H]DPN from human recombinant kappa-type opioid receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Biological Research Center Of Hungarian Academy Of Sciences
Curated by PDSP Ki Database
Biological Research Center Of Hungarian Academy Of Sciences
Curated by PDSP Ki Database
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Affinity DataKi: 6.90nMAssay Description:Displacement of [3H]-U-69593 from kappa opioid receptor in guinea pig brain membrane after 120 mins by scintillation countingMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Affinity DataKi: 6.90nMAssay Description:Displacement of [3H]U69,593 from kappa opioid receptor in guinea pig brain membrane after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Affinity DataKi: 6.90nMAssay Description:Displacement of [3H]U-69593 from kappa-opoid receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Affinity DataKi: 7.30nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor in guinea pig brain membrane after 150 mins by scintillation countingMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Affinity DataKi: 7.30nMAssay Description:Displacement of [3H]U-69,593 from KOR in guinea pig brain membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Affinity DataKi: 7.30nMAssay Description:Displacement of [3H]-U69593 from KOR in guinea pig brain membranes measured by competitive radioligand receptor binding assayMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Affinity DataKi: 7.30nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor in guinea pig brain membranes after 150 mins by scintillation countingMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Affinity DataKi: 7.30nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor in guinea pig brain membranes after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 9.20nMAssay Description:Binding affinity at cloned human kappa opioid receptor by [3H]diprenorphine displacement.More data for this Ligand-Target Pair
Affinity DataKi: 9.20nMAssay Description:Antagonist activity assessed as inhibition of U50488-stimulated [35S]GTP-gamma-S binding to human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 9.20nMAssay Description:Partial agonist activity at human cloned kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:In vitro binding affinity towards human Opioid receptor kappa 1 on CHO cell membranes using [3H]diprenorphine displacement.More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Affinity DataKi: 12nMAssay Description:In vivo binding affinity against kappa opioid receptor was measured by using labeled ligand [3H]-ethylketocyclazocine (1 nM) with 500 nM DADLE and 20...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Affinity DataKi: 15nMAssay Description:Displacement of [3H]Cl-977 from kappa opioid receptor in guinea pig brain membranes after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Agonist activity at human recombinant kappa opioid receptor expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding after 45 mins...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Biological Research Center Of Hungarian Academy Of Sciences
Curated by PDSP Ki Database
Biological Research Center Of Hungarian Academy Of Sciences
Curated by PDSP Ki Database
Affinity DataKi: 16nMAssay Description:Binding affinity to kappa-opioid receptor (unknown origin)More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Affinity DataKi: 66nMAssay Description:Tested for binding affinity towards kappa receptor in presence of [3H]-EKC radioligandMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Affinity DataKi: 66nMAssay Description:Binding affinity towards kappa opioid receptor by displacement of [3H]-EKC in guinea pig cortical tissueMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Affinity DataKi: 66nMAssay Description:Binding affinity towards kappa-opioid receptor by displacement of [3H]-EKC at from guinea pig cortical tissueMore data for this Ligand-Target Pair
Affinity DataKi: 362nMAssay Description:Displacement of [3H]U-69593 from human KOR expressed in HEK293 cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Biological Research Center Of Hungarian Academy Of Sciences
Curated by PDSP Ki Database
Biological Research Center Of Hungarian Academy Of Sciences
Curated by PDSP Ki Database
Affinity DataIC50: 1.5nMAssay Description:Binding affinity against opioid receptor kappa 1 using [3H]- U-69,593 radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Antagonistic activity in the Opioid receptor kappa 1-mediated [35S]GTP-gamma-S, binding assay against 50 nM U-50,488More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of opioid receptor kappa by displacing 0.5 nM [3H]bremazocine in guinea pig brain membraneMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Institut F£R Pharmazeutische Und Medizinische Chemie
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Displacement of 0.5 nM [3H]bremazocine from guinea pig brain membrane opioid receptor kappa with 100 nM DAGO and 100 nM DPDPEMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Antagonist activity at human KOR expressed in CHO cell membranes assessed as reduction in U50,488 induced response incubated for 1 hr by liquid scint...More data for this Ligand-Target Pair
Affinity DataIC50: 320nMAssay Description:Antagonist activity at human opioid kappa receptor expressed in CHO cells assessed as inhibition of U-50488-stimulated [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
Affinity DataIC50: 704nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Biological Research Center Of Hungarian Academy Of Sciences
Curated by PDSP Ki Database
Biological Research Center Of Hungarian Academy Of Sciences
Curated by PDSP Ki Database
Affinity DataKd: 1nMAssay Description:Compound was evaluated for Opioid receptor kappa 1 affinity against the receptor site model site 4(kappa)More data for this Ligand-Target Pair
Affinity DataEC50: 6.60nMAssay Description:Effective concentration for half-maximal stimulation was determined by [35S]GTP-gamma-S, assayMore data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Agonist activity at human opioid kappa receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
Biological Research Center Of Hungarian Academy Of Sciences
Curated by PDSP Ki Database
Biological Research Center Of Hungarian Academy Of Sciences
Curated by PDSP Ki Database
Affinity DataKd: 4.5nMAssay Description:Inhibition against binding of radioligand [N-allyl-2-3-3H]-naloxone to membrane of baby hamster kidney cells infected with forest virus encoding the...More data for this Ligand-Target Pair