BindingDB PrimarySearch_ki

Found 26 Enz. Inhib. hit(s) with Target = 'Mast/stem cell growth factor receptor Kit' and Ligand = 'BDBM13216'

Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Ambit Biosciences

Curated by PubChem BioAssay

PNG

BDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)

Ki: 620nM ΔG°: -35.4kJ/molepH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Ambit Biosciences

Curated by PubChem BioAssay

PNG

BDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)

Ki: 680nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Ambit Biosciences

Curated by PubChem BioAssay

PNG

BDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)

Ki: 2.60E+3nM ΔG°: -31.9kJ/molepH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Ambit Biosciences

Curated by PubChem BioAssay

PNG

BDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)

Ki: 2.70E+3nM ΔG°: -31.8kJ/molepH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Ambit Biosciences

Curated by PubChem BioAssay

PNG

BDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)

IC50: 1nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Ambit Biosciences

Curated by PubChem BioAssay

PNG

BDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)

IC50: 2.40nMAssay Description:Inhibition of c-KIT (unknown origin) using Ser/Thr 6 peptide as substrate incubated for 1 hr prior to substrate addition measured after 2 hrs by FRET...More data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Ambit Biosciences

Curated by PubChem BioAssay

PNG

BDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)

IC50: 5nMAssay Description:Inhibition of c-kitMore data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Ambit Biosciences

Curated by PubChem BioAssay

PNG

BDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)

IC50: 13nMAssay Description:Inhibition of c-Kit (unknown origin)More data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Ambit Biosciences

Curated by PubChem BioAssay

PNG

BDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)

IC50: 39nMAssay Description:Inhibition of human KIT using poly[Glu,Tyr]4:1 as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Ambit Biosciences

Curated by PubChem BioAssay

PNG

BDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)

IC50: 55nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Ambit Biosciences

Curated by PubChem BioAssay

PNG

BDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)

IC50: 55nMAssay Description:Compound IC50 values were determined from 10-point, 1:3 dilution curves starting at either 100 μM or 10 μM with 10 μM ATP, by Reaction...More data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Ambit Biosciences

Curated by PubChem BioAssay

PNG

BDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)

IC50: 93nMAssay Description:Inhibition of cKITMore data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Ambit Biosciences

Curated by PubChem BioAssay

PNG

BDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)

Kd: >1.00E+4nMAssay Description:Binding constant for KIT(V559D,T670I) kinase domainMore data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Ambit Biosciences

Curated by PubChem BioAssay

PNG

BDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)

Kd: 0.620nMAssay Description:Binding constant for KIT kinase domainMore data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Ambit Biosciences

Curated by PubChem BioAssay

PNG

BDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)

Kd: 0.680nMAssay Description:Binding constant for KIT(V559D) kinase domainMore data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Ambit Biosciences

Curated by PubChem BioAssay

PNG

BDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)

Kd: 0.660nMAssay Description:Binding constant for KIT(A829P) kinase domainMore data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Ambit Biosciences

Curated by PubChem BioAssay

PNG

BDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)

Kd: 0.680nMAssay Description:Binding constant for KIT(V559D) kinase domainMore data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Ambit Biosciences

Curated by PubChem BioAssay

PNG

BDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)

Kd: 2.60nMAssay Description:Binding constant for KIT(D816V) kinase domainMore data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Ambit Biosciences

Curated by PubChem BioAssay

PNG

BDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)

Kd: 2.70nMAssay Description:Binding constant for KIT kinase domainMore data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Ambit Biosciences

Curated by PubChem BioAssay

PNG

BDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)

Kd: 0.570nMAssay Description:Binding constant for KIT(L576P) kinase domainMore data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Ambit Biosciences

Curated by PubChem BioAssay

PNG

BDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)

Kd: 2.70nMAssay Description:Binding constant for KIT(V559D,V654A) kinase domainMore data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Ambit Biosciences

Curated by PubChem BioAssay

PNG

BDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)

Kd: 0.620nMAssay Description:Binding affinity to human KIT incubated for 1 hr by kinase binding assayMore data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Ambit Biosciences

Curated by PubChem BioAssay

PNG

BDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)

Kd: 0.810nMAssay Description:Binding constant for KIT kinase domainMore data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Ambit Biosciences

Curated by PubChem BioAssay

PNG

BDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)

Kd: 1.60nMAssay Description:Binding constant for KIT(D816H) kinase domainMore data for this Ligand-Target Pair

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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Ambit Biosciences

Curated by PubChem BioAssay

PNG

BDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)

Kd: 2.60nMAssay Description:Binding constant for KIT(D816V) kinase domainMore data for this Ligand-Target Pair

PDB Reactome pathway
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Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Ambit Biosciences

Curated by PubChem BioAssay

PNG

BDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)

Kd: >1.00E+4nMAssay Description:Binding constant for KIT(V559D,T670I) kinase domainMore data for this Ligand-Target Pair

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Filter my 26 hits

Targets 1▿
- Mast/stem cell growth factor receptor Kit 26
Publications 11▿
- Nat Biotechnol 29: 1046-51 (2011) 8
- Nat Biotechnol 26: 127-32 (2008) 5
- PubChem Bioassay (2008) 4
- US Patent US10294227 (2019) 2
- J Med Chem 56: 3281-95 (2013) 1
- J Med Chem 59: 4697-710 (2016) 1
- J Med Chem 47: 6658-61 (2004) 1
- Leukemia 23: 477-85 (2009) 1
- Proc Natl Acad Sci U S A 104: 3520-5 (2007) 1
- Eur J Med Chem 46: 2043-57 (2011) 1
- Bioorg Med Chem 28: (2020) 1
Institutions 9▿
- Ambit Biosciences 17
- University Court Of The University Of Edinburgh 2
- Center For Molecular Medicine Of The Austrian Academy Of Sciences 1
- University Of The Pacific 1
- Harvard Medical School 1
- Chinese Academy Of Sciences 1
- University Of Edinburgh 1
- Bristol-Myers Squibb Pharmaceutical Research Institute 1
- National Research Centre 1
Affinity: 0.57 to 1.0E+4 nM▿
- Ki 4
- IC50 8
- Kd 14
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1