BindingDB PrimarySearch

Found 13 Enz. Inhib. hit(s) with Target = 'Protease' and Ligand = 'BDBM50067593'

Protease(Human immunodeficiency virus 1 (HIV-1))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL

BDBM50067593(CHEBI:44032 | Crixivan | Indinavir | L-735524 | MK...)

Ki: 0.120nMAssay Description:Inhibition of wild-type HIV1 BH10 protease expressed in Escherichia coli by spectrophotometric assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL

BDBM50067593(CHEBI:44032 | Crixivan | Indinavir | L-735524 | MK...)

Ki: 0.300nMAssay Description:Inhibition of HIV1 protease expressed in Escherichia coli by fluorometric assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL

BDBM50067593(CHEBI:44032 | Crixivan | Indinavir | L-735524 | MK...)

Ki: 0.520nMAssay Description:Inhibition of HIV1 protease expressed in Escherichia coliMore data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL

BDBM50067593(CHEBI:44032 | Crixivan | Indinavir | L-735524 | MK...)

Ki: 0.540nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL

BDBM50067593(CHEBI:44032 | Crixivan | Indinavir | L-735524 | MK...)

Ki: 0.739nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL

BDBM50067593(CHEBI:44032 | Crixivan | Indinavir | L-735524 | MK...)

IC50: 0.400nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL

BDBM50067593(CHEBI:44032 | Crixivan | Indinavir | L-735524 | MK...)

IC50: 0.600nMAssay Description:Inhibition of wild type HIV1 NL4-3 proteaseMore data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL

BDBM50067593(CHEBI:44032 | Crixivan | Indinavir | L-735524 | MK...)

IC50: 0.880nMT: 2°CAssay Description:Inhibition of HIV1 protease expressed in Escherichia coli incubated for 20 to 30 mins at room temperature using (Arg-Glu(EDANS)-Ser-Gln-Asn-Tyr-Pro-I...More data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL

BDBM50067593(CHEBI:44032 | Crixivan | Indinavir | L-735524 | MK...)

IC50: <10nMAssay Description:Inhibition of purified HIV-1 protease using [Arg-Glu(EDANS)-Ser-Gin-Asn-Tyr-Ile-Val-Gin-Lys(dabcyl)-Arg) as fluorogenic substrate by fluorescence ass...More data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL

BDBM50067593(CHEBI:44032 | Crixivan | Indinavir | L-735524 | MK...)

IC50: <10nMAssay Description:Inhibition of HIV1 recombinant proteaseMore data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL

BDBM50067593(CHEBI:44032 | Crixivan | Indinavir | L-735524 | MK...)

Kd: 5.5nMAssay Description:Binding affinity to Human immunodeficiency virus 1 protease by SPR biosensor interaction analysis at pH 4.1More data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL

BDBM50067593(CHEBI:44032 | Crixivan | Indinavir | L-735524 | MK...)

Kd: 1.20nMAssay Description:Binding affinity to Human immunodeficiency virus 1 protease by SPR biosensor interaction analysis at pH 7.4More data for this Ligand-Target Pair

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3D Structure (crystal)

Protease(Human immunodeficiency virus 1 (HIV-1))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL

BDBM50067593(CHEBI:44032 | Crixivan | Indinavir | L-735524 | MK...)

Kd: 1.40nMAssay Description:Binding affinity to Human immunodeficiency virus 1 protease by SPR biosensor interaction analysis at pH 5.1More data for this Ligand-Target Pair

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3D Structure (crystal)

Filter my 13 hits

Targets 1▿
- Protease 13
Publications 11▿
- Bioorg Med Chem 20: 4838-47 (2012) 3
- J Med Chem 51: 1053-7 (2008) 1
- J Med Chem 53: 607-15 (2010) 1
- J Med Chem 57: 6266-72 (2014) 1
- Bioorg Med Chem Lett 24: 2465-8 (2014) 1
- J Med Chem 51: 4839-43 (2008) 1
- Bioorg Med Chem Lett 18: 5406-10 (2008) 1
- Bioorg Med Chem Lett 17: 5432-6 (2007) 1
- Bioorg Med Chem Lett 25: 1880-3 (2015) 1
- Eur J Med Chem 45: 4096-103 (2010) 1
- Bioorg Med Chem 16: 1299-308 (2008) 1
Institutions 10▿
- Universidad De Santiago De Compostela 3
- Uppsala University 2
- Philipps-Universit£T Marburg 1
- Merck Research Laboratories 1
- University Of Minnesota 1
- Chinese Academy Of Medical Sciences And Peking Union Medical College 1
- Beijing Institute Of Biotechnology 1
- Dainippon Sumitomo Pharma 1
- Shandong University 1
- Academy Of Sciences Of The Czech Republic 1
Affinity: 0.12 to 10 nM▿
- Ki 5
- IC50 5
- Kd 3
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1