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Found 3 Enz. Inhib. hit(s) with Target = 'Protein arginine N-methyltransferase 5' and Ligand = 'BDBM486484'
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM486484(7-((1-acetylpiperidin-4-yl)amino)-4-ethyl-2-(2-hyd...)
Affinity DataIC50:  7.15nMAssay Description:PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM486484(7-((1-acetylpiperidin-4-yl)amino)-4-ethyl-2-(2-hyd...)
Affinity DataIC50:  4.99E+3nMAssay Description:PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM486484(7-((1-acetylpiperidin-4-yl)amino)-4-ethyl-2-(2-hyd...)
Affinity DataEC50:  682nMAssay Description:The PRMT5 TE assay is a biomarker assay for identifying compounds that inhibit symmetric dimethylation of arginine (SDMA) of PRMT5 substrates. This a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent