Found 16 Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase receptor Ret' and Ligand = 'BDBM2579'
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
National Cancer Institute-Bethesda
Curated by ChEMBL
National Cancer Institute-Bethesda
Curated by ChEMBL
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
National Cancer Institute-Bethesda
Curated by ChEMBL
National Cancer Institute-Bethesda
Curated by ChEMBL
Affinity DataIC50: 0.820nMAssay Description:Inhibition of recombinant human N-terminal GST-HIS6 fused RET V804L mutant C-terminal domain (H658 to S1114 residues) expressed in Sf9 insect cells u...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
National Cancer Institute-Bethesda
Curated by ChEMBL
National Cancer Institute-Bethesda
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant human N-terminal GST-HIS6 fused RET M918T mutant C-terminal domain (H658 to S1114 residues) expressed in Sf9 insect cells u...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
National Cancer Institute-Bethesda
Curated by ChEMBL
National Cancer Institute-Bethesda
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant human N-terminal GST-HIS6 fused RET V804M mutant C-terminal domain (H658 to S1114 residues) expressed in Sf9 insect cells u...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
National Cancer Institute-Bethesda
Curated by ChEMBL
National Cancer Institute-Bethesda
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of recombinant wild-type human N-terminal GST-HIS6 fused RET C-terminal domain (H658 to S1114 residues) expressed in Sf9 insect cells usin...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
National Cancer Institute-Bethesda
Curated by ChEMBL
National Cancer Institute-Bethesda
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
National Cancer Institute-Bethesda
Curated by ChEMBL
National Cancer Institute-Bethesda
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human RET using KKKVSRSGLYRSPSMPENLNRPR as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
National Cancer Institute-Bethesda
Curated by ChEMBL
National Cancer Institute-Bethesda
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human RET using KKKVSRSGLYRSPSMPENLNRPR as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
National Cancer Institute-Bethesda
Curated by ChEMBL
National Cancer Institute-Bethesda
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of RET (unknown origin) incubated for 1 hr by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
National Cancer Institute-Bethesda
Curated by ChEMBL
National Cancer Institute-Bethesda
Curated by ChEMBL
Affinity DataIC50: 4.70nMAssay Description:Inhibition of RET (unknown origin) by HTRF methodMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
National Cancer Institute-Bethesda
Curated by ChEMBL
National Cancer Institute-Bethesda
Curated by ChEMBL
Affinity DataKd: 28nMAssay Description:Binding constant for RET(M918T) kinase domainMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
National Cancer Institute-Bethesda
Curated by ChEMBL
National Cancer Institute-Bethesda
Curated by ChEMBL
Affinity DataKd: 15nMAssay Description:Binding constant for RET kinase domainMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
National Cancer Institute-Bethesda
Curated by ChEMBL
National Cancer Institute-Bethesda
Curated by ChEMBL
Affinity DataKd: 12nMAssay Description:Binding constant for RET(V804M) kinase domainMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
National Cancer Institute-Bethesda
Curated by ChEMBL
National Cancer Institute-Bethesda
Curated by ChEMBL
Affinity DataKd: 28nMAssay Description:Binding constant for RET(M918T) kinase domainMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
National Cancer Institute-Bethesda
Curated by ChEMBL
National Cancer Institute-Bethesda
Curated by ChEMBL
Affinity DataKd: 15nMAssay Description:Binding constant for RET kinase domainMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
National Cancer Institute-Bethesda
Curated by ChEMBL
National Cancer Institute-Bethesda
Curated by ChEMBL
Affinity DataKd: 15nMAssay Description:Binding constant for RET(V804L) kinase domainMore data for this Ligand-Target Pair