Found 30 Enz. Inhib. hit(s) with Target = 'RAF proto-oncogene serine/threonine-protein kinase' and Ligand = 'BDBM16673' 
Affinity DataIC50: 1nMpH: 7.8 T: 2°CAssay Description:To measure compound inhibitor effects on the ability of Raf enzymes to phosphorylate the Mek substrate, a capture ELISA utilizing streptavidin-coated...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of C-RAF kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of purified C-Raf (unknown origin) after 30 mins by homogeneous time-resolved fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant Raf-1 (305 to 648 residues) (unknown origin) expressed in baculovirus expression system using MEk1 as substrate after 25 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of human C-RAF measured after 40 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of RAF1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of C-Raf (unknown origin) using poly (Glu, Tyr) 4:1 substrate incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of C-Raf in presence of 5 uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 6.20nMAssay Description:Inhibition of cRAF (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6.20nMAssay Description:Inhibition of CRAF (unknown origin) using human His6-tagged MEK1 K97R mutant as substrate pretreated for 20 mins followed by [33P]-ATP addition measu...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of c-Raf (unknown origin) in presence of ATP by hotspot kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of RAF1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibitory activity against human Raf-1 kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of B-Raf1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of C-Raf (unknown origin) after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 24.3nMAssay Description:Inhibition of C-Raf kinase-mediated phosphorylation of Mek using [33P]gammaATP after 20 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of human cRAF using [gamma-33P-ATP] as a substrate by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 45nMpH: 7.5Assay Description:Inhibitor Concentration at 50% enzyme inhibition (IC50) values were calculated by quantifying the end-point ADP production from each kinase reaction ...More data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:1. Preparation of test compounds: according to the molecular weight of the compounds, an appropriate volume of DMSO was directly added to dissolve th...More data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:Inhibition of human CRAF using human His6-tagged MEK1 (K97R) as substrate preincubated for 20 mins followed by [33P-gamma]ATP addition and measured a...More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of CRAF (unknown origin) incubated for 10 mins using FAM-labeled peptide and ATP by mobility shift assayMore data for this Ligand-Target Pair
Affinity DataIC50: 370nMAssay Description:Inhibition of c-Raf in the presence of 100uM ATPMore data for this Ligand-Target Pair
Affinity DataKd: 230nMAssay Description:Binding constant for RAF1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 230nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 230nMAssay Description:Binding constant for RAF1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 230nMAssay Description:Binding affinity to RAF1More data for this Ligand-Target Pair
