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Found 10 Enz. Inhib. hit(s) with Target = 'Replicase polyprotein 1ab' and Ligand = 'BDBM420297'
TargetReplicase polyprotein 1ab(2019-nCoV)
A*Star

LigandPNGBDBM420297(acs.jmedchem.1c00409_ST.30 | med.21724, Compound 6...)
Affinity DataIC50:  23nMAssay Description:SARS-CoV-2 3CLpro expression and purification is based on a published procedure and our modified protocol is found in the supplementary file. A highl...More data for this Ligand-Target Pair
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TargetReplicase polyprotein 1ab(2019-nCoV)
A*Star

LigandPNGBDBM420297(acs.jmedchem.1c00409_ST.30 | med.21724, Compound 6...)
Affinity DataIC50:  40nMAssay Description:This is a review article.More data for this Ligand-Target Pair
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TargetReplicase polyprotein 1ab(2019-nCoV)
A*Star

LigandPNGBDBM420297(acs.jmedchem.1c00409_ST.30 | med.21724, Compound 6...)
Affinity DataIC50:  40nMAssay Description:Recombinant SARS-CoV-2 Mpro was expressed and purified from Escherichia coli (E. coli) (18, 25). A fluorescently labeled substrate, MCA-AVLQ SGFR-Lys...More data for this Ligand-Target Pair
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TargetReplicase polyprotein 1ab(2019-nCoV)
A*Star

LigandPNGBDBM420297(acs.jmedchem.1c00409_ST.30 | med.21724, Compound 6...)
Affinity DataIC50:  40nMAssay Description:The assays are from references cited in this article.More data for this Ligand-Target Pair
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TargetReplicase polyprotein 1ab(2019-nCoV)
A*Star

LigandPNGBDBM420297(acs.jmedchem.1c00409_ST.30 | med.21724, Compound 6...)
Affinity DataIC50:  40nMAssay Description:Inhibition of N-terminal recombinant SARS CoV 2 3CL protease expressed in Escherichia coli BL21-DE3 cells using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as subs...More data for this Ligand-Target Pair
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TargetReplicase polyprotein 1ab(2019-nCoV)
A*Star

LigandPNGBDBM420297(acs.jmedchem.1c00409_ST.30 | med.21724, Compound 6...)
Affinity DataIC50:  40nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
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TargetReplicase polyprotein 1ab(2019-nCoV)
A*Star

LigandPNGBDBM420297(acs.jmedchem.1c00409_ST.30 | med.21724, Compound 6...)
Affinity DataIC50:  40nMAssay Description:Inhibition of SARS-CoV2 main proteaseMore data for this Ligand-Target Pair
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TargetReplicase polyprotein 1ab(2019-nCoV)
A*Star

LigandPNGBDBM420297(acs.jmedchem.1c00409_ST.30 | med.21724, Compound 6...)
Affinity DataIC50:  858nMAssay Description:Inhibition of SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) cells assessed as change in relative fluorescence unit using MCA-TSAVL...More data for this Ligand-Target Pair
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TargetReplicase polyprotein 1ab(2019-nCoV)
A*Star

LigandPNGBDBM420297(acs.jmedchem.1c00409_ST.30 | med.21724, Compound 6...)
Affinity DataEC50:  720nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
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TargetReplicase polyprotein 1ab(2019-nCoV)
A*Star

LigandPNGBDBM420297(acs.jmedchem.1c00409_ST.30 | med.21724, Compound 6...)
Affinity DataEC50:  330nMAssay Description:This is a review article.More data for this Ligand-Target Pair
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