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Found 2 Enz. Inhib. hit(s) with Target = 'Replicase polyprotein 1ab' and Ligand = 'BDBM448375'
TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM448375(Perampanel, 27)
Affinity DataIC50:  120nMAssay Description:Inhibition of proteolytic activity was tested using recombinant SARS-CoV-2Mpro, which was expressed and purified as previously described.8,12 For the...More data for this Ligand-Target Pair
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TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM448375(Perampanel, 27)
Affinity DataEC50:  1.10E+3nMAssay Description:The antiviral activity of compounds was examined by evaluating the cytopathic effect in Vero-E6 cells grown at 37°C in a 5% CO2 atmosphere for 72 h u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article