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Found 22 Enz. Inhib. hit(s) with Target = 'Retinol-binding protein 4' and Ligand = 'BDBM249474'
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York

US Patent
LigandPNGBDBM249474(US10072016, Compound 77 | US10407433, Compound 77 ...)
Affinity DataIC50:  1.62nMAssay Description:Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR interaction resulting in the decreased FRET signal (FIG. 7 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York

US Patent
LigandPNGBDBM249474(US10072016, Compound 77 | US10407433, Compound 77 ...)
Affinity DataIC50:  2.88nMAssay Description:The analogs of Compounds 63-162 described herein analogously bind to RBP4 and antagonize retinol-dependent RBP4-TTR interaction. Additional piperidin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York

US Patent
LigandPNGBDBM249474(US10072016, Compound 77 | US10407433, Compound 77 ...)
Affinity DataIC50:  2.88nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York

US Patent
LigandPNGBDBM249474(US10072016, Compound 77 | US10407433, Compound 77 ...)
Affinity DataIC50:  2.88nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York

US Patent
LigandPNGBDBM249474(US10072016, Compound 77 | US10407433, Compound 77 ...)
Affinity DataIC50:  2.88nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York

US Patent
LigandPNGBDBM249474(US10072016, Compound 77 | US10407433, Compound 77 ...)
Affinity DataIC50:  2.88nMpH: 7.5Assay Description:Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR interaction resulting in the decreased FRET signal (FIG. 7)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York

US Patent
LigandPNGBDBM249474(US10072016, Compound 77 | US10407433, Compound 77 ...)
Affinity DataIC50:  7.96nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York

US Patent
LigandPNGBDBM249474(US10072016, Compound 77 | US10407433, Compound 77 ...)
Affinity DataIC50:  7.96nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York

US Patent
LigandPNGBDBM249474(US10072016, Compound 77 | US10407433, Compound 77 ...)
Affinity DataIC50:  7.96nMAssay Description:The analogs of Compounds 63-162 described herein analogously bind to RBP4 and antagonize retinol-dependent RBP4-TTR interaction. Additional piperidin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York

US Patent
LigandPNGBDBM249474(US10072016, Compound 77 | US10407433, Compound 77 ...)
Affinity DataIC50:  7.96nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York

US Patent
LigandPNGBDBM249474(US10072016, Compound 77 | US10407433, Compound 77 ...)
Affinity DataIC50:  7.96nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York

US Patent
LigandPNGBDBM249474(US10072016, Compound 77 | US10407433, Compound 77 ...)
Affinity DataIC50:  7.96nMpH: 7.5Assay Description:Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR interaction resulting in the decreased FRET signal (FIG. 7)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York

US Patent
LigandPNGBDBM249474(US10072016, Compound 77 | US10407433, Compound 77 ...)
Affinity DataIC50:  8.5nMAssay Description:The analogs of Compounds 63-162 described herein analogously bind to RBP4 and antagonize retinol-dependent RBP4-TTR interaction. Additional piperidin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York

US Patent
LigandPNGBDBM249474(US10072016, Compound 77 | US10407433, Compound 77 ...)
Affinity DataIC50:  8.5nMpH: 7.5Assay Description:Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR interaction resulting in the decreased FRET signal (FIG. 7)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York

US Patent
LigandPNGBDBM249474(US10072016, Compound 77 | US10407433, Compound 77 ...)
Affinity DataIC50:  8.5nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York

US Patent
LigandPNGBDBM249474(US10072016, Compound 77 | US10407433, Compound 77 ...)
Affinity DataIC50:  8.5nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York

US Patent
LigandPNGBDBM249474(US10072016, Compound 77 | US10407433, Compound 77 ...)
Affinity DataIC50:  8.5nMAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York

US Patent
LigandPNGBDBM249474(US10072016, Compound 77 | US10407433, Compound 77 ...)
Affinity DataIC50:  8.50nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York

US Patent
LigandPNGBDBM249474(US10072016, Compound 77 | US10407433, Compound 77 ...)
Affinity DataIC50:  10.6nMpH: 7.5 T: 2°CAssay Description:TR-FRET assay for retinol-induced RBP4-TTR interaction Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR inte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York

US Patent
LigandPNGBDBM249474(US10072016, Compound 77 | US10407433, Compound 77 ...)
Affinity DataIC50:  10.6nMAssay Description:Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR interaction resulting in the decreased FRET signal (FIG. 7 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York

US Patent
LigandPNGBDBM249474(US10072016, Compound 77 | US10407433, Compound 77 ...)
Affinity DataIC50:  30.6nMpH: 7.5 T: 2°CAssay Description:TR-FRET assay for retinol-induced RBP4-TTR interaction Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR inte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRetinol-binding protein 4(Homo sapiens (Human))
The Trustees Of Columbia University In The City Of New York

US Patent
LigandPNGBDBM249474(US10072016, Compound 77 | US10407433, Compound 77 ...)
Affinity DataIC50:  30.6nMAssay Description:Binding of a desired RBP4 antagonist displaces retinol and induces hindrance for RBP4-TTR interaction resulting in the decreased FRET signal (FIG. 7 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent