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Found 7 Enz. Inhib. hit(s) with Target = 'Serine-protein kinase ATM' and Ligand = 'BDBM245474'
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245474(US9428503, 1)
Affinity DataIC50:  0.0400nMAssay Description:Inhibition of ATM (unknown origin) using p53 as substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs by HTRF as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245474(US9428503, 1)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of ATM in human A549 cells assessed as reduction in etoposide-stimulated KAP1 phosphorylation by In-Cell-Western assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245474(US9428503, 1)
Affinity DataIC50:  0.570nMAssay Description:Inhibition of ATM autophosphorylation at Ser1981 in human HT29 cells preincubated for 1 hr followed by X ray irradiation and measured after 1 hr by H...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245474(US9428503, 1)
Affinity DataIC50:  0.575nMT: 2°CAssay Description:Assay a) HT29 cells (ECACC #85061109) were seeded into 384 well assay plates (Costar #3712) at a density of 3500 cells/well in 40 μl EMEM medium c...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245474(US9428503, 1)
Affinity DataIC50:  0.580nMAssay Description:Competitive inhibition of ATM (unknown origin) measured by ATP-competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245474(US9428503, 1)
Affinity DataIC50:  0.580nMAssay Description:Inhibition of ATM (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM245474(US9428503, 1)
Affinity DataIC50: <1nMAssay Description:Inhibition of ATM (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed