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Found 3 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM377832'
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377832(1-[(3S)-1-acryloyl piperidin-3-yl]-5-amino-3-(4-ph...)
Affinity DataIC50:  1.30nMAssay Description:TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377832(1-[(3S)-1-acryloyl piperidin-3-yl]-5-amino-3-(4-ph...)
Affinity DataIC50:  1.30nMAssay Description:BTK: TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide p...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377832(1-[(3S)-1-acryloyl piperidin-3-yl]-5-amino-3-(4-ph...)
Affinity DataIC50: <100nMAssay Description:Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...More data for this Ligand-Target Pair
In DepthDetails US Patent