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Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosyl-DNA phosphodiesterase 1' and Ligand = 'BDBM50179183'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosyl-DNA phosphodiesterase 1


(Homo sapiens (Human))
BDBM50179183
PNG
(CHEMBL576840 | NSC-3198)
Show SMILES OC(=O)C(CSSCC(NC(=O)Cc1ccccc1)C(O)=O)NC(=O)Cc1ccccc1
Show InChI InChI=1S/C22H24N2O6S2/c25-19(11-15-7-3-1-4-8-15)23-17(21(27)28)13-31-32-14-18(22(29)30)24-20(26)12-16-9-5-2-6-10-16/h1-10,17-18H,11-14H2,(H,23,25)(H,24,26)(H,27,28)(H,29,30)
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Similars

Article
PubMed
n/an/a>1.11E+5n/an/an/an/an/an/a



Georgia State University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TDP1 using 5'-[32P]-labeled N14Y as substrate after 15 mins by PAGE method


Bioorg Med Chem Lett 26: 3232-3236 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.065
BindingDB Entry DOI: 10.7270/Q22809HF
More data for this
Ligand-Target Pair