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Found 1 hit Enz. Inhib. hit(s) with Target = 'Uridine-5'-diphosphoglucuronosyltransferase 1A4' and Ligand = 'BDBM10015'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Uridine-5'-diphosphoglucuronosyltransferase 1A4


(Homo sapiens (Human))
BDBM10015
PNG
(2-[3-(1-cyano-1-methylethyl)-5-(1H-1,2,4-triazol-1...)
Show SMILES CC(C)(C#N)c1cc(Cn2cncn2)cc(c1)C(C)(C)C#N
Show InChI InChI=1S/C17H19N5/c1-16(2,9-18)14-5-13(8-22-12-20-11-21-22)6-15(7-14)17(3,4)10-19/h5-7,11-12H,8H2,1-4H3
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Article
PubMed
n/an/a 4.72E+3n/an/an/an/an/an/a



University of Arkansas for Medical Sciences

Curated by ChEMBL


Assay Description
Drug metabolism assessed as hecogenin-mediated inhibition of human recombinant UGT1A4-catalyzed anastrozole glucuronidation after 90 mins


Drug Metab Dispos 41: 870-7 (2013)


Article DOI: 10.1124/dmd.112.048157
BindingDB Entry DOI: 10.7270/Q2HT2R29
More data for this
Ligand-Target Pair