BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 7 hits with Last Name = 'crich' and Initial = 'd'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Replicase polyprotein 1ab


(2019-nCoV)
BDBM31524
PNG
(5-amino-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]...)
Show SMILES C[C@@H](NC(=O)c1cc(N)ccc1C)c1cccc2ccccc12
Show InChI InChI=1S/C20H20N2O/c1-13-10-11-16(21)12-19(13)20(23)22-14(2)17-9-5-7-15-6-3-4-8-18(15)17/h3-12,14H,21H2,1-2H3,(H,22,23)/t14-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
GoogleScholar
Purchase

DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Similars

PubMed
n/an/a 2.40E+3n/an/an/an/an/an/a



University of Georgia



Assay Description
Emulating Ratia et al., who detailed the potency of these four compounds against SARS-CoV-1, we utilized the peptide-AMC substrate concentration of 5...


ACS Infect Dis 6: 2099-2109 (2020)


BindingDB Entry DOI: 10.7270/Q2474D7W
More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM31523
PNG
(Compound 6 | Naphthalene and Benzamide Derivative,...)
Show SMILES C[C@@H](NC(=O)c1cc(NC(C)=O)ccc1C)c1cccc2ccccc12
Show InChI InChI=1S/C22H22N2O2/c1-14-11-12-18(24-16(3)25)13-21(14)22(26)23-15(2)19-10-6-8-17-7-4-5-9-20(17)19/h4-13,15H,1-3H3,(H,23,26)(H,24,25)/t15-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
GoogleScholar
Purchase

PC cid
PC sid
PDB
UniChem

Similars

PubMed
n/an/a 5.00E+3n/an/an/an/an/an/a



University of Georgia



Assay Description
Emulating Ratia et al., who detailed the potency of these four compounds against SARS-CoV-1, we utilized the peptide-AMC substrate concentration of 5...


ACS Infect Dis 6: 2099-2109 (2020)


BindingDB Entry DOI: 10.7270/Q2474D7W
More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM420300
PNG
(7724772 | med.21724, Compound 157)
Show SMILES CC(NC(=O)c1ccccc1C)c1ccc2ccccc2c1
Show InChI InChI=1S/C20H19NO/c1-14-7-3-6-10-19(14)20(22)21-15(2)17-12-11-16-8-4-5-9-18(16)13-17/h3-13,15H,1-2H3,(H,21,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
GoogleScholar
UniChem
PubMed
n/an/a 2.35E+4n/an/an/an/an/an/a



University of Georgia



Assay Description
Emulating Ratia et al., who detailed the potency of these four compounds against SARS-CoV-1, we utilized the peptide-AMC substrate concentration of 5...


ACS Infect Dis 6: 2099-2109 (2020)


BindingDB Entry DOI: 10.7270/Q2474D7W
More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM420301
PNG
(6577871)
Show SMILES COc1ccc(CNC(=O)C2CCN(Cc3cccc4ccccc34)CC2)cc1
Show InChI InChI=1S/C25H28N2O2/c1-29-23-11-9-19(10-12-23)17-26-25(28)21-13-15-27(16-14-21)18-22-7-4-6-20-5-2-3-8-24(20)22/h2-12,21H,13-18H2,1H3,(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
GoogleScholar
UniChem
PubMed
n/an/a 1.01E+5n/an/an/an/an/an/a



University of Georgia



Assay Description
Emulating Ratia et al., who detailed the potency of these four compounds against SARS-CoV-1, we utilized the peptide-AMC substrate concentration of 5...


ACS Infect Dis 6: 2099-2109 (2020)


BindingDB Entry DOI: 10.7270/Q2474D7W
More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM420302
PNG
(9247873)
Show SMILES COc1cc(CNC(=O)C2CCN(Cc3ccccc3)CC2)cc(OC)c1OC
Show InChI InChI=1S/C23H30N2O4/c1-27-20-13-18(14-21(28-2)22(20)29-3)15-24-23(26)19-9-11-25(12-10-19)16-17-7-5-4-6-8-17/h4-8,13-14,19H,9-12,15-16H2,1-3H3,(H,24,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
GoogleScholar
UniChem
PubMed
n/an/a>2.00E+5n/an/an/an/an/an/a



University of Georgia



Assay Description
Emulating Ratia et al., who detailed the potency of these four compounds against SARS-CoV-1, we utilized the peptide-AMC substrate concentration of 5...


ACS Infect Dis 6: 2099-2109 (2020)


BindingDB Entry DOI: 10.7270/Q2474D7W
More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM31524
PNG
(5-amino-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]...)
Show SMILES C[C@@H](NC(=O)c1cc(N)ccc1C)c1cccc2ccccc12
Show InChI InChI=1S/C20H20N2O/c1-13-10-11-16(21)12-19(13)20(23)22-14(2)17-9-5-7-15-6-3-4-8-18(15)17/h3-12,14H,21H2,1-2H3,(H,22,23)/t14-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
GoogleScholar
Purchase

DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Similars

PubMed
n/an/an/an/a 2.76E+4n/an/an/an/a



University of Georgia



Assay Description
Emulating Ratia et al., who detailed the potency of these four compounds against SARS-CoV-1, we utilized the peptide-AMC substrate concentration of 5...


ACS Infect Dis 6: 2099-2109 (2020)


BindingDB Entry DOI: 10.7270/Q2474D7W
More data for this
Ligand-Target Pair
Replicase polyprotein 1ab


(2019-nCoV)
BDBM31523
PNG
(Compound 6 | Naphthalene and Benzamide Derivative,...)
Show SMILES C[C@@H](NC(=O)c1cc(NC(C)=O)ccc1C)c1cccc2ccccc12
Show InChI InChI=1S/C22H22N2O2/c1-14-11-12-18(24-16(3)25)13-21(14)22(26)23-15(2)19-10-6-8-17-7-4-5-9-20(17)19/h4-13,15H,1-3H3,(H,23,26)(H,24,25)/t15-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
GoogleScholar
Purchase

PC cid
PC sid
PDB
UniChem

Similars

PubMed
n/an/an/an/a 2.10E+4n/an/an/an/a



University of Georgia



Assay Description
Emulating Ratia et al., who detailed the potency of these four compounds against SARS-CoV-1, we utilized the peptide-AMC substrate concentration of 5...


ACS Infect Dis 6: 2099-2109 (2020)


BindingDB Entry DOI: 10.7270/Q2474D7W
More data for this
Ligand-Target Pair