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Compile Data Set for Download or QSAR

Found 876 hits with Last Name = 'holm' and Initial = 'p'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50414563
PNG
(CHEMBL559873)
Show SMILES Clc1cccc(c1)N1CCN(CCN2CCCc3sccc3C2)C1=O
Show InChI InChI=1S/C19H22ClN3OS/c20-16-3-1-4-17(13-16)23-11-10-22(19(23)24)9-8-21-7-2-5-18-15(14-21)6-12-25-18/h1,3-4,6,12-13H,2,5,7-11,14H2
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0.631n/an/an/an/an/an/an/an/a



Cancer Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay


Bioorg Med Chem Lett 19: 4799-801 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.043
BindingDB Entry DOI: 10.7270/Q2154J9T
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50150685
PNG
(((S)-5-Phenyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-...)
Show SMILES CCCN(CCC)[C@H]1CCc2c(C1)cccc2-c1ccccc1
Show InChI InChI=1S/C22H29N/c1-3-15-23(16-4-2)20-13-14-22-19(17-20)11-8-12-21(22)18-9-6-5-7-10-18/h5-12,20H,3-4,13-17H2,1-2H3/t20-/m0/s1
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0.870n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-8-OH-DPAT binding to rat 5-hydroxytryptamine 1A receptor


J Med Chem 47: 3927-30 (2004)


Article DOI: 10.1021/jm0498102
BindingDB Entry DOI: 10.7270/Q2FQ9W2Z
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50150676
PNG
(((R)-8-Phenyl-chroman-3-yl)-dipropyl-amine | (R)-8...)
Show SMILES CCCN(CCC)[C@H]1COc2c(C1)cccc2-c1ccccc1
Show InChI InChI=1S/C21H27NO/c1-3-13-22(14-4-2)19-15-18-11-8-12-20(21(18)23-16-19)17-9-6-5-7-10-17/h5-12,19H,3-4,13-16H2,1-2H3/t19-/m1/s1
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1.23n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-8-OH-DPAT binding to rat 5-hydroxytryptamine 1A receptor


J Med Chem 47: 3927-30 (2004)


Article DOI: 10.1021/jm0498102
BindingDB Entry DOI: 10.7270/Q2FQ9W2Z
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50414574
PNG
(CHEMBL563580)
Show SMILES Clc1cccc(c1)N1CCN(CCN2[C@H]3CC[C@@H]2CCC3)C1=O
Show InChI InChI=1S/C18H24ClN3O/c19-14-3-1-6-17(13-14)22-12-10-20(18(22)23)9-11-21-15-4-2-5-16(21)8-7-15/h1,3,6,13,15-16H,2,4-5,7-12H2/t15-,16+
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1.26n/an/an/an/an/an/an/an/a



Cancer Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay


Bioorg Med Chem Lett 19: 4799-801 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.043
BindingDB Entry DOI: 10.7270/Q2154J9T
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50150678
PNG
(CHEMBL186758 | [(R)-8-(4-Methoxy-phenyl)-chroman-3...)
Show SMILES CCCN(CCC)[C@H]1COc2c(C1)cccc2-c1ccc(OC)cc1
Show InChI InChI=1S/C22H29NO2/c1-4-13-23(14-5-2)19-15-18-7-6-8-21(22(18)25-16-19)17-9-11-20(24-3)12-10-17/h6-12,19H,4-5,13-16H2,1-3H3/t19-/m1/s1
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1.31n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-8-OH-DPAT binding to rat 5-hydroxytryptamine 1A receptor


J Med Chem 47: 3927-30 (2004)


Article DOI: 10.1021/jm0498102
BindingDB Entry DOI: 10.7270/Q2FQ9W2Z
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50150677
PNG
(CHEMBL188176 | [(S)-5-(4-Methoxy-phenyl)-1,2,3,4-t...)
Show SMILES CCCN(CCC)[C@H]1CCc2c(C1)cccc2-c1ccc(OC)cc1
Show InChI InChI=1S/C23H31NO/c1-4-15-24(16-5-2)20-11-14-23-19(17-20)7-6-8-22(23)18-9-12-21(25-3)13-10-18/h6-10,12-13,20H,4-5,11,14-17H2,1-3H3/t20-/m0/s1
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1.49n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-8-OH-DPAT binding to rat 5-hydroxytryptamine 1A receptor


J Med Chem 47: 3927-30 (2004)


Article DOI: 10.1021/jm0498102
BindingDB Entry DOI: 10.7270/Q2FQ9W2Z
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50411402
PNG
(CHEMBL244946)
Show SMILES Cc1cc(-c2ccc3CCN(CCCSc4nnc(-c5cccc6nc(C)ccc56)n4C)CCc3c2)n(C)n1
Show InChI InChI=1S/C31H35N7S/c1-21-9-12-26-27(7-5-8-28(26)32-21)30-33-34-31(36(30)3)39-18-6-15-38-16-13-23-10-11-25(20-24(23)14-17-38)29-19-22(2)35-37(29)4/h5,7-12,19-20H,6,13-18H2,1-4H3
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1.58n/an/an/an/an/an/an/an/a



Cancer Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay


Bioorg Med Chem Lett 19: 4799-801 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.043
BindingDB Entry DOI: 10.7270/Q2154J9T
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50414578
PNG
(CHEMBL558058)
Show SMILES CN(CCN1CCN(C1=O)c1cccc(c1)C(F)(F)F)C[C@@]12CC[C@@H](CC1)C2(C)C
Show InChI InChI=1S/C23H32F3N3O/c1-21(2)17-7-9-22(21,10-8-17)16-27(3)11-12-28-13-14-29(20(28)30)19-6-4-5-18(15-19)23(24,25)26/h4-6,15,17H,7-14,16H2,1-3H3/t17-,22+
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1.58n/an/an/an/an/an/an/an/a



Cancer Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay


Bioorg Med Chem Lett 19: 4799-801 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.043
BindingDB Entry DOI: 10.7270/Q2154J9T
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50150680
PNG
(CHEMBL184535 | [(S)-5-(2-Methoxy-phenyl)-1,2,3,4-t...)
Show SMILES CCCN(CCC)[C@H]1CCc2c(C1)cccc2-c1ccccc1OC
Show InChI InChI=1S/C23H31NO/c1-4-15-24(16-5-2)19-13-14-20-18(17-19)9-8-11-21(20)22-10-6-7-12-23(22)25-3/h6-12,19H,4-5,13-17H2,1-3H3/t19-/m0/s1
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1.73n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor


J Med Chem 47: 3927-30 (2004)


Article DOI: 10.1021/jm0498102
BindingDB Entry DOI: 10.7270/Q2FQ9W2Z
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50130261
PNG
(6-(2-{2-[4-(4-Chloro-phenoxy)-piperidin-1-yl]-ethy...)
Show SMILES Clc1ccc(OC2CCN(CC[C@H]3CCCN3S(=O)(=O)c3ccc4cc[nH]c4c3)CC2)cc1
Show InChI InChI=1S/C25H30ClN3O3S/c26-20-4-6-22(7-5-20)32-23-11-16-28(17-12-23)15-10-21-2-1-14-29(21)33(30,31)24-8-3-19-9-13-27-25(19)18-24/h3-9,13,18,21,23,27H,1-2,10-12,14-17H2/t21-/m1/s1
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1.99n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]-5-HT radioligand


Bioorg Med Chem Lett 15: 747-50 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.013
BindingDB Entry DOI: 10.7270/Q2WD4027
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50150681
PNG
(4-(4-Chloro-phenoxy)-1-{2-[(R)-1-(3H-indene-5-sulf...)
Show SMILES Clc1ccc(OC2CCN(CC[C@H]3CCCN3S(=O)(=O)c3ccc4C=CCc4c3)CC2)cc1
Show InChI InChI=1S/C26H31ClN2O3S/c27-22-7-9-24(10-8-22)32-25-13-17-28(18-14-25)16-12-23-5-2-15-29(23)33(30,31)26-11-6-20-3-1-4-21(20)19-26/h1,3,6-11,19,23,25H,2,4-5,12-18H2/t23-/m1/s1
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1.99n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor


J Med Chem 47: 3927-30 (2004)


Article DOI: 10.1021/jm0498102
BindingDB Entry DOI: 10.7270/Q2FQ9W2Z
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50417494
PNG
(CHEMBL1288285)
Show SMILES CC(C)(C(=O)Nc1ccc(N2CCC3(CCN(CC4CC4)C3)CC2)c(Cl)c1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C29H35ClF3N3O/c1-27(2,21-4-3-5-22(16-21)29(31,32)33)26(37)34-23-8-9-25(24(30)17-23)36-14-11-28(12-15-36)10-13-35(19-28)18-20-6-7-20/h3-5,8-9,16-17,20H,6-7,10-15,18-19H2,1-2H3,(H,34,37)
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2n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human NPY Y2 receptor in KAN-TS cells by [35]GTPgammaS assay


Bioorg Med Chem Lett 20: 7341-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.065
BindingDB Entry DOI: 10.7270/Q2BV7HWV
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50125260
PNG
(2-{2-[4-(5-Fluoro-2-oxo-2,3-dihydro-benzoimidazol-...)
Show SMILES Fc1ccc2n(C3CCN(CCN4CCCc5ccccc5C4=O)CC3)c(=O)[nH]c2c1
Show InChI InChI=1S/C24H27FN4O2/c25-18-7-8-22-21(16-18)26-24(31)29(22)19-9-12-27(13-10-19)14-15-28-11-3-5-17-4-1-2-6-20(17)23(28)30/h1-2,4,6-8,16,19H,3,5,9-15H2,(H,26,31)
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2.24n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor


J Med Chem 47: 3927-30 (2004)


Article DOI: 10.1021/jm0498102
BindingDB Entry DOI: 10.7270/Q2FQ9W2Z
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50414403
PNG
(CHEMBL560177)
Show SMILES Clc1cccc(c1)N1CCN(CCN2Cc3ccccc3C2)C1=O
Show InChI InChI=1S/C19H20ClN3O/c20-17-6-3-7-18(12-17)23-11-10-22(19(23)24)9-8-21-13-15-4-1-2-5-16(15)14-21/h1-7,12H,8-11,13-14H2
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2.51n/an/an/an/an/an/an/an/a



Cancer Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay


Bioorg Med Chem Lett 19: 4799-801 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.043
BindingDB Entry DOI: 10.7270/Q2154J9T
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50414572
PNG
(CHEMBL563860)
Show SMILES Clc1cccc(c1)N1CCN(CCN2C[C@H]3CC[C@@H]2C3)C1=O
Show InChI InChI=1S/C17H22ClN3O/c18-14-2-1-3-16(11-14)21-9-8-19(17(21)22)6-7-20-12-13-4-5-15(20)10-13/h1-3,11,13,15H,4-10,12H2/t13-,15+/m0/s1
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2.51n/an/an/an/an/an/an/an/a



Cancer Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay


Bioorg Med Chem Lett 19: 4799-801 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.043
BindingDB Entry DOI: 10.7270/Q2154J9T
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50414557
PNG
(CHEMBL562464)
Show SMILES Clc1cccc(c1)N1CCN(CCN2C[C@@H]3CC[C@H]2Cc2ccccc2C3)C1=O
Show InChI InChI=1S/C24H28ClN3O/c25-21-6-3-7-23(16-21)28-13-12-26(24(28)29)10-11-27-17-18-8-9-22(27)15-20-5-2-1-4-19(20)14-18/h1-7,16,18,22H,8-15,17H2/t18-,22+/m1/s1
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2.51n/an/an/an/an/an/an/an/a



Cancer Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay


Bioorg Med Chem Lett 19: 4799-801 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.043
BindingDB Entry DOI: 10.7270/Q2154J9T
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50414570
PNG
(CHEMBL563635)
Show SMILES CCN(CC)CCN1CCN(C1=O)c1cccc(Cl)c1
Show InChI InChI=1S/C15H22ClN3O/c1-3-17(4-2)8-9-18-10-11-19(15(18)20)14-7-5-6-13(16)12-14/h5-7,12H,3-4,8-11H2,1-2H3
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2.51n/an/an/an/an/an/an/an/a



Cancer Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay


Bioorg Med Chem Lett 19: 4799-801 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.043
BindingDB Entry DOI: 10.7270/Q2154J9T
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50414466
PNG
(CHEMBL550583)
Show SMILES COc1ccccc1C(=O)N1CCN(CC1)c1ccc(NC(=O)C(C)(C)c2ccccc2)cc1Cl
Show InChI InChI=1S/C28H30ClN3O3/c1-28(2,20-9-5-4-6-10-20)27(34)30-21-13-14-24(23(29)19-21)31-15-17-32(18-16-31)26(33)22-11-7-8-12-25(22)35-3/h4-14,19H,15-18H2,1-3H3,(H,30,34)
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2.51n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human neuropeptide Y2 receptor in KAN-TS cells by [35]GTPgammaS assay


Bioorg Med Chem Lett 19: 4022-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.035
BindingDB Entry DOI: 10.7270/Q2B27VBW
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50150673
PNG
(CHEMBL363466 | [(S)-5-(2,6-Dimethoxy-phenyl)-1,2,3...)
Show SMILES COc1cccc(OC)c1-c1cccc2C[C@H](CCc12)N(C)C
Show InChI InChI=1S/C20H25NO2/c1-21(2)15-11-12-16-14(13-15)7-5-8-17(16)20-18(22-3)9-6-10-19(20)23-4/h5-10,15H,11-13H2,1-4H3/t15-/m0/s1
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2.55n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor


J Med Chem 47: 3927-30 (2004)


Article DOI: 10.1021/jm0498102
BindingDB Entry DOI: 10.7270/Q2FQ9W2Z
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50150673
PNG
(CHEMBL363466 | [(S)-5-(2,6-Dimethoxy-phenyl)-1,2,3...)
Show SMILES COc1cccc(OC)c1-c1cccc2C[C@H](CCc12)N(C)C
Show InChI InChI=1S/C20H25NO2/c1-21(2)15-11-12-16-14(13-15)7-5-8-17(16)20-18(22-3)9-6-10-19(20)23-4/h5-10,15H,11-13H2,1-4H3/t15-/m0/s1
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2.55n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-5-HT binding to rat 5-HT7 receptor


J Med Chem 47: 3927-30 (2004)


Article DOI: 10.1021/jm0498102
BindingDB Entry DOI: 10.7270/Q2FQ9W2Z
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50150679
PNG
(CHEMBL186316 | [(R)-8-(2-Methoxy-phenyl)-chroman-3...)
Show SMILES CCCN(CCC)[C@H]1COc2c(C1)cccc2-c1ccccc1OC
Show InChI InChI=1S/C22H29NO2/c1-4-13-23(14-5-2)18-15-17-9-8-11-20(22(17)25-16-18)19-10-6-7-12-21(19)24-3/h6-12,18H,4-5,13-16H2,1-3H3/t18-/m1/s1
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2.70n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor


J Med Chem 47: 3927-30 (2004)


Article DOI: 10.1021/jm0498102
BindingDB Entry DOI: 10.7270/Q2FQ9W2Z
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50150676
PNG
(((R)-8-Phenyl-chroman-3-yl)-dipropyl-amine | (R)-8...)
Show SMILES CCCN(CCC)[C@H]1COc2c(C1)cccc2-c1ccccc1
Show InChI InChI=1S/C21H27NO/c1-3-13-22(14-4-2)19-15-18-11-8-12-20(21(18)23-16-19)17-9-6-5-7-10-17/h5-12,19H,3-4,13-16H2,1-2H3/t19-/m1/s1
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2.92n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor


J Med Chem 47: 3927-30 (2004)


Article DOI: 10.1021/jm0498102
BindingDB Entry DOI: 10.7270/Q2FQ9W2Z
More data for this
Ligand-Target Pair
Androgen receptor (AR)


(Homo sapiens (Human))
BDBM309987
PNG
(N-((S)-1-(3-(3-chloro-4-cyano-2-methylphenyl)-1H-p...)
Show SMILES C[C@@H](Cn1ccc(n1)-c1ccc(C#N)c(Cl)c1C)NC(=O)c1csc(n1)C(C)O
Show InChI InChI=1S/C20H20ClN5O2S/c1-11(23-19(28)17-10-29-20(24-17)13(3)27)9-26-7-6-16(25-26)15-5-4-14(8-22)18(21)12(15)2/h4-7,10-11,13,27H,9H2,1-3H3,(H,23,28)/t11-,13?/m0/s1
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US Patent
3n/an/an/an/an/an/an/an/a



ORION CORPORATION

US Patent


Assay Description
Androgen receptor (AR) binding affinities of test compounds were studied in cytosolic lysates obtained from ventral prostates of castrated rats by co...


US Patent US9657003 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0X0M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50414563
PNG
(CHEMBL559873)
Show SMILES Clc1cccc(c1)N1CCN(CCN2CCCc3sccc3C2)C1=O
Show InChI InChI=1S/C19H22ClN3OS/c20-16-3-1-4-17(13-16)23-11-10-22(19(23)24)9-8-21-7-2-5-18-15(14-21)6-12-25-18/h1,3-4,6,12-13H,2,5,7-11,14H2
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3.16n/an/an/an/an/an/an/an/a



Cancer Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human D2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay


Bioorg Med Chem Lett 19: 4799-801 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.043
BindingDB Entry DOI: 10.7270/Q2154J9T
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50414555
PNG
(CHEMBL565075)
Show SMILES Clc1cccc(c1)N1CCN(CCN2C[C@H]3CC[C@H](CC3)C2)C1=O
Show InChI InChI=1S/C19H26ClN3O/c20-17-2-1-3-18(12-17)23-11-10-22(19(23)24)9-8-21-13-15-4-5-16(14-21)7-6-15/h1-3,12,15-16H,4-11,13-14H2/t15-,16+
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3.16n/an/an/an/an/an/an/an/a



Cancer Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay


Bioorg Med Chem Lett 19: 4799-801 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.043
BindingDB Entry DOI: 10.7270/Q2154J9T
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50150685
PNG
(((S)-5-Phenyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-...)
Show SMILES CCCN(CCC)[C@H]1CCc2c(C1)cccc2-c1ccccc1
Show InChI InChI=1S/C22H29N/c1-3-15-23(16-4-2)20-13-14-22-19(17-20)11-8-12-21(22)18-9-6-5-7-10-18/h5-12,20H,3-4,13-17H2,1-2H3/t20-/m0/s1
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3.38n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor


J Med Chem 47: 3927-30 (2004)


Article DOI: 10.1021/jm0498102
BindingDB Entry DOI: 10.7270/Q2FQ9W2Z
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50098549
PNG
((6aR,aR)-3-Methyl-2-(6-methyl-5,6,6a,7-tetrahydro-...)
Show SMILES CN1CCc2cccc-3c2[C@H]1Cc1cccc(-c2c(C)cccc2C#N)c-31
Show InChI InChI=1S/C25H22N2/c1-16-6-3-9-19(15-26)23(16)20-10-5-8-18-14-22-25-17(12-13-27(22)2)7-4-11-21(25)24(18)20/h3-11,22H,12-14H2,1-2H3/t22-/m1/s1
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3.79n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor


J Med Chem 47: 3927-30 (2004)


Article DOI: 10.1021/jm0498102
BindingDB Entry DOI: 10.7270/Q2FQ9W2Z
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50370572
PNG
(CHEMBL85606 | SB-277011)
Show SMILES O=C(N[C@H]1CC[C@H](CCN2CCc3cc(ccc3C2)C#N)CC1)c1ccnc2ccccc12
Show InChI InChI=1S/C28H30N4O/c29-18-21-5-8-23-19-32(16-13-22(23)17-21)15-12-20-6-9-24(10-7-20)31-28(33)26-11-14-30-27-4-2-1-3-25(26)27/h1-5,8,11,14,17,20,24H,6-7,9-10,12-13,15-16,19H2,(H,31,33)/t20-,24-
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3.98n/an/an/an/an/an/an/an/a



Cancer Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay


Bioorg Med Chem Lett 19: 4799-801 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.043
BindingDB Entry DOI: 10.7270/Q2154J9T
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50414572
PNG
(CHEMBL563860)
Show SMILES Clc1cccc(c1)N1CCN(CCN2C[C@H]3CC[C@@H]2C3)C1=O
Show InChI InChI=1S/C17H22ClN3O/c18-14-2-1-3-16(11-14)21-9-8-19(17(21)22)6-7-20-12-13-4-5-15(20)10-13/h1-3,11,13,15H,4-10,12H2/t13-,15+/m0/s1
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3.98n/an/an/an/an/an/an/an/a



Cancer Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human D2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay


Bioorg Med Chem Lett 19: 4799-801 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.043
BindingDB Entry DOI: 10.7270/Q2154J9T
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50414465
PNG
(CHEMBL550559)
Show SMILES CC(C)(C(=O)Nc1ccc(N2CCN(CC2)C(=O)c2ccccc2C(F)(F)F)c(Cl)c1)c1ccccc1
Show InChI InChI=1S/C28H27ClF3N3O2/c1-27(2,19-8-4-3-5-9-19)26(37)33-20-12-13-24(23(29)18-20)34-14-16-35(17-15-34)25(36)21-10-6-7-11-22(21)28(30,31)32/h3-13,18H,14-17H2,1-2H3,(H,33,37)
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3.98n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human neuropeptide Y2 receptor in KAN-TS cells by [35]GTPgammaS assay


Bioorg Med Chem Lett 19: 4022-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.035
BindingDB Entry DOI: 10.7270/Q2B27VBW
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50414566
PNG
(CHEMBL563435)
Show SMILES COc1cccc(c1)N1CCN(CCN(C)C[C@@]23CC[C@@H](CC2)C3(C)C)C1=O
Show InChI InChI=1S/C23H35N3O2/c1-22(2)18-8-10-23(22,11-9-18)17-24(3)12-13-25-14-15-26(21(25)27)19-6-5-7-20(16-19)28-4/h5-7,16,18H,8-15,17H2,1-4H3/t18-,23+
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5.01n/an/an/an/an/an/an/an/a



Cancer Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay


Bioorg Med Chem Lett 19: 4799-801 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.043
BindingDB Entry DOI: 10.7270/Q2154J9T
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50414470
PNG
(CHEMBL551311)
Show SMILES Cc1cccc(c1)C(C)(C)C(=O)Nc1ccc(N2CCN(CC2)C(=O)c2ccccc2)c(Cl)c1
Show InChI InChI=1S/C28H30ClN3O2/c1-20-8-7-11-22(18-20)28(2,3)27(34)30-23-12-13-25(24(29)19-23)31-14-16-32(17-15-31)26(33)21-9-5-4-6-10-21/h4-13,18-19H,14-17H2,1-3H3,(H,30,34)
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5.01n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human neuropeptide Y2 receptor in KAN-TS cells by [35]GTPgammaS assay


Bioorg Med Chem Lett 19: 4022-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.035
BindingDB Entry DOI: 10.7270/Q2B27VBW
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50414574
PNG
(CHEMBL563580)
Show SMILES Clc1cccc(c1)N1CCN(CCN2[C@H]3CC[C@@H]2CCC3)C1=O
Show InChI InChI=1S/C18H24ClN3O/c19-14-3-1-6-17(13-14)22-12-10-20(18(22)23)9-11-21-15-4-2-5-16(21)8-7-15/h1,3,6,13,15-16H,2,4-5,7-12H2/t15-,16+
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5.01n/an/an/an/an/an/an/an/a



Cancer Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human D2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay


Bioorg Med Chem Lett 19: 4799-801 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.043
BindingDB Entry DOI: 10.7270/Q2154J9T
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50150684
PNG
((R)-8-(2,6-dimethoxyphenyl)-N,N-dimethylchroman-3-...)
Show SMILES COc1cccc(OC)c1-c1cccc2C[C@H](COc12)N(C)C
Show InChI InChI=1S/C19H23NO3/c1-20(2)14-11-13-7-5-8-15(19(13)23-12-14)18-16(21-3)9-6-10-17(18)22-4/h5-10,14H,11-12H2,1-4H3/t14-/m1/s1
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5.29n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor


J Med Chem 47: 3927-30 (2004)


Article DOI: 10.1021/jm0498102
BindingDB Entry DOI: 10.7270/Q2FQ9W2Z
More data for this
Ligand-Target Pair
Androgen receptor (AR)


(Homo sapiens (Human))
BDBM309973
PNG
((S)-N-(1-(3-(4-cyano-3-methylphenyl)-1H-pyrazol-1-...)
Show SMILES C[C@@H](Cn1ccc(n1)-c1ccc(C#N)c(C)c1)NC(=O)c1cc(n[nH]1)-c1ccco1
Show InChI InChI=1S/C22H20N6O2/c1-14-10-16(5-6-17(14)12-23)18-7-8-28(27-18)13-15(2)24-22(29)20-11-19(25-26-20)21-4-3-9-30-21/h3-11,15H,13H2,1-2H3,(H,24,29)(H,25,26)/t15-/m0/s1
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US Patent
6n/an/an/an/an/an/an/an/a



ORION CORPORATION

US Patent


Assay Description
Androgen receptor (AR) binding affinities of test compounds were studied in cytosolic lysates obtained from ventral prostates of castrated rats by co...


US Patent US9657003 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0X0M
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50414565
PNG
(CHEMBL563274)
Show SMILES CN(CCN1CCN(C1=O)c1cccc(Cl)c1)C[C@@]12CC[C@@H](CC1)C2(C)C
Show InChI InChI=1S/C22H32ClN3O/c1-21(2)17-7-9-22(21,10-8-17)16-24(3)11-12-25-13-14-26(20(25)27)19-6-4-5-18(23)15-19/h4-6,15,17H,7-14,16H2,1-3H3/t17-,22+
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6.31n/an/an/an/an/an/an/an/a



Cancer Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay


Bioorg Med Chem Lett 19: 4799-801 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.043
BindingDB Entry DOI: 10.7270/Q2154J9T
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50414458
PNG
(CHEMBL562725)
Show SMILES Clc1cc(NC(=O)C(c2ccccc2)c2ccccc2)ccc1N1CCN(CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C31H28ClN3O2/c32-27-22-26(33-30(36)29(23-10-4-1-5-11-23)24-12-6-2-7-13-24)16-17-28(27)34-18-20-35(21-19-34)31(37)25-14-8-3-9-15-25/h1-17,22,29H,18-21H2,(H,33,36)
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6.31n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human neuropeptide Y2 receptor in KAN-TS cells by [35]GTPgammaS assay


Bioorg Med Chem Lett 19: 4022-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.035
BindingDB Entry DOI: 10.7270/Q2B27VBW
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50150686
PNG
(CHEMBL182792 | [(R)-8-(2,6-Dimethoxy-phenyl)-chrom...)
Show SMILES CCCN(CCC)[C@H]1COc2c(C1)cccc2-c1c(OC)cccc1OC
Show InChI InChI=1S/C23H31NO3/c1-5-13-24(14-6-2)18-15-17-9-7-10-19(23(17)27-16-18)22-20(25-3)11-8-12-21(22)26-4/h7-12,18H,5-6,13-16H2,1-4H3/t18-/m1/s1
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6.44n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor


J Med Chem 47: 3927-30 (2004)


Article DOI: 10.1021/jm0498102
BindingDB Entry DOI: 10.7270/Q2FQ9W2Z
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50150686
PNG
(CHEMBL182792 | [(R)-8-(2,6-Dimethoxy-phenyl)-chrom...)
Show SMILES CCCN(CCC)[C@H]1COc2c(C1)cccc2-c1c(OC)cccc1OC
Show InChI InChI=1S/C23H31NO3/c1-5-13-24(14-6-2)18-15-17-9-7-10-19(23(17)27-16-18)22-20(25-3)11-8-12-21(22)26-4/h7-12,18H,5-6,13-16H2,1-4H3/t18-/m1/s1
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6.44n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]-5-HT radioligand


Bioorg Med Chem Lett 15: 747-50 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.013
BindingDB Entry DOI: 10.7270/Q2WD4027
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50150682
PNG
(2a-[4-(6,7-Dihydro-4H-thieno[3,2-c]pyridin-5-yl)-b...)
Show SMILES O=C1Nc2cccc3CCCC1(CCCCN1CCc4sccc4C1)c23
Show InChI InChI=1S/C22H26N2OS/c25-21-22(11-4-6-16-5-3-7-18(23-21)20(16)22)10-1-2-12-24-13-8-19-17(15-24)9-14-26-19/h3,5,7,9,14H,1-2,4,6,8,10-13,15H2,(H,23,25)
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6.46n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor


J Med Chem 47: 3927-30 (2004)


Article DOI: 10.1021/jm0498102
BindingDB Entry DOI: 10.7270/Q2FQ9W2Z
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50150674
PNG
(CHEMBL361875 | [(S)-5-(2,6-Dimethoxy-phenyl)-1,2,3...)
Show SMILES CCCN(CCC)[C@H]1CCc2c(C1)cccc2-c1c(OC)cccc1OC
Show InChI InChI=1S/C24H33NO2/c1-5-15-25(16-6-2)19-13-14-20-18(17-19)9-7-10-21(20)24-22(26-3)11-8-12-23(24)27-4/h7-12,19H,5-6,13-17H2,1-4H3/t19-/m0/s1
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7.90n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor


J Med Chem 47: 3927-30 (2004)


Article DOI: 10.1021/jm0498102
BindingDB Entry DOI: 10.7270/Q2FQ9W2Z
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50150674
PNG
(CHEMBL361875 | [(S)-5-(2,6-Dimethoxy-phenyl)-1,2,3...)
Show SMILES CCCN(CCC)[C@H]1CCc2c(C1)cccc2-c1c(OC)cccc1OC
Show InChI InChI=1S/C24H33NO2/c1-5-15-25(16-6-2)19-13-14-20-18(17-19)9-7-10-21(20)24-22(26-3)11-8-12-23(24)27-4/h7-12,19H,5-6,13-17H2,1-4H3/t19-/m0/s1
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7.90n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-5-HT binding to rat 5-HT7 receptor


J Med Chem 47: 3927-30 (2004)


Article DOI: 10.1021/jm0498102
BindingDB Entry DOI: 10.7270/Q2FQ9W2Z
More data for this
Ligand-Target Pair
Androgen receptor (AR)


(Homo sapiens (Human))
BDBM309982
PNG
((S)-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-...)
Show SMILES C[C@@H](Cn1ccc(n1)-c1ccc(C#N)c(Cl)c1)NC(=O)c1cc([nH]n1)-c1csc(C)n1
Show InChI InChI=1S/C21H18ClN7OS/c1-12(24-21(30)19-8-18(26-27-19)20-11-31-13(2)25-20)10-29-6-5-17(28-29)14-3-4-15(9-23)16(22)7-14/h3-8,11-12H,10H2,1-2H3,(H,24,30)(H,26,27)/t12-/m0/s1
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US Patent
8n/an/an/an/an/an/an/an/a



ORION CORPORATION

US Patent


Assay Description
Androgen receptor (AR) binding affinities of test compounds were studied in cytosolic lysates obtained from ventral prostates of castrated rats by co...


US Patent US9657003 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0X0M
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50414567
PNG
(CHEMBL562948)
Show SMILES CN(CCN1CCN(C1=O)c1ccccc1)C[C@@]12CC[C@@H](CC1)C2(C)C
Show InChI InChI=1S/C22H33N3O/c1-21(2)18-9-11-22(21,12-10-18)17-23(3)13-14-24-15-16-25(20(24)26)19-7-5-4-6-8-19/h4-8,18H,9-17H2,1-3H3/t18-,22+
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10n/an/an/an/an/an/an/an/a



Cancer Therapeutics

Curated by ChEMBL


Assay Description
Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay


Bioorg Med Chem Lett 19: 4799-801 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.043
BindingDB Entry DOI: 10.7270/Q2154J9T
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50414459
PNG
(CHEMBL549771)
Show SMILES CC(C)(C(=O)Nc1ccc(N2CCN(CC2)C(=O)c2ccccc2)c(Cl)c1)c1ccccc1
Show InChI InChI=1S/C27H28ClN3O2/c1-27(2,21-11-7-4-8-12-21)26(33)29-22-13-14-24(23(28)19-22)30-15-17-31(18-16-30)25(32)20-9-5-3-6-10-20/h3-14,19H,15-18H2,1-2H3,(H,29,33)
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10n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human neuropeptide Y2 receptor in KAN-TS cells by [35]GTPgammaS assay


Bioorg Med Chem Lett 19: 4022-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.035
BindingDB Entry DOI: 10.7270/Q2B27VBW
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50150679
PNG
(CHEMBL186316 | [(R)-8-(2-Methoxy-phenyl)-chroman-3...)
Show SMILES CCCN(CCC)[C@H]1COc2c(C1)cccc2-c1ccccc1OC
Show InChI InChI=1S/C22H29NO2/c1-4-13-23(14-5-2)18-15-17-9-8-11-20(22(17)25-16-18)19-10-6-7-12-21(19)24-3/h6-12,18H,4-5,13-16H2,1-3H3/t18-/m1/s1
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10.3n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-8-OH-DPAT binding to rat 5-hydroxytryptamine 1A receptor


J Med Chem 47: 3927-30 (2004)


Article DOI: 10.1021/jm0498102
BindingDB Entry DOI: 10.7270/Q2FQ9W2Z
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))
BDBM50150680
PNG
(CHEMBL184535 | [(S)-5-(2-Methoxy-phenyl)-1,2,3,4-t...)
Show SMILES CCCN(CCC)[C@H]1CCc2c(C1)cccc2-c1ccccc1OC
Show InChI InChI=1S/C23H31NO/c1-4-15-24(16-5-2)19-13-14-20-18(17-19)9-8-11-21(20)22-10-6-7-12-23(22)25-3/h6-12,19H,4-5,13-17H2,1-3H3/t19-/m0/s1
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11.7n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-8-OH-DPAT binding to rat 5-hydroxytryptamine 1A receptor


J Med Chem 47: 3927-30 (2004)


Article DOI: 10.1021/jm0498102
BindingDB Entry DOI: 10.7270/Q2FQ9W2Z
More data for this
Ligand-Target Pair
Androgen receptor (AR)


(Homo sapiens (Human))
BDBM309988
PNG
((S)-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-...)
Show SMILES C[C@@H](Cn1ccc(n1)-c1ccc(C#N)c(Cl)c1)NC(=O)c1csc(n1)-c1cn[nH]c1
Show InChI InChI=1S/C20H16ClN7OS/c1-12(25-19(29)18-11-30-20(26-18)15-8-23-24-9-15)10-28-5-4-17(27-28)13-2-3-14(7-22)16(21)6-13/h2-6,8-9,11-12H,10H2,1H3,(H,23,24)(H,25,29)/t12-/m0/s1
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12n/an/an/an/an/an/an/an/a



ORION CORPORATION

US Patent


Assay Description
Androgen receptor (AR) binding affinities of test compounds were studied in cytosolic lysates obtained from ventral prostates of castrated rats by co...


US Patent US9657003 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0X0M
More data for this
Ligand-Target Pair
Androgen receptor (AR)


(Homo sapiens (Human))
BDBM309990
PNG
((R)-N-(2-(3-(4-cyano-3,5-difluorophenyl)-1H-pyrazo...)
Show SMILES C[C@H](CNC(=O)c1csc(CC#N)n1)n1ccc(n1)-c1cc(F)c(C#N)c(F)c1
Show InChI InChI=1S/C19H14F2N6OS/c1-11(9-24-19(28)17-10-29-18(25-17)2-4-22)27-5-3-16(26-27)12-6-14(20)13(8-23)15(21)7-12/h3,5-7,10-11H,2,9H2,1H3,(H,24,28)/t11-/m1/s1
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12n/an/an/an/an/an/an/an/a



ORION CORPORATION

US Patent


Assay Description
Androgen receptor (AR) binding affinities of test compounds were studied in cytosolic lysates obtained from ventral prostates of castrated rats by co...


US Patent US9657003 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0X0M
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50150677
PNG
(CHEMBL188176 | [(S)-5-(4-Methoxy-phenyl)-1,2,3,4-t...)
Show SMILES CCCN(CCC)[C@H]1CCc2c(C1)cccc2-c1ccc(OC)cc1
Show InChI InChI=1S/C23H31NO/c1-4-15-24(16-5-2)20-11-14-23-19(17-20)7-6-8-22(23)18-9-12-21(25-3)13-10-18/h6-10,12-13,20H,4-5,11,14-17H2,1-3H3/t20-/m0/s1
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12.4n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor


J Med Chem 47: 3927-30 (2004)


Article DOI: 10.1021/jm0498102
BindingDB Entry DOI: 10.7270/Q2FQ9W2Z
More data for this
Ligand-Target Pair
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