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Compile Data Set for Download or QSAR

Found 1079 hits with Last Name = 'hunt' and Initial = 'kw'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 1 (aa 8-360)


(Homo sapiens (Human))
BDBM193676
PNG
(US9670208, Example 295 4-(3-(cyclopropylmethyl)-[1...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1ccn2c(CC3CC3)nnc2c1
Show InChI InChI=1S/C19H19N7/c1-25-17(5-8-21-25)22-16-11-14(4-7-20-16)15-6-9-26-18(10-13-2-3-13)23-24-19(26)12-15/h4-9,11-13H,2-3,10H2,1H3,(H,20,22)
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UniChem
US Patent
n/an/a 0.400n/an/an/an/a7.3n/a



Array BioPharma Inc

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360)


(Homo sapiens (Human))
BDBM193385
PNG
(US9670208, Example 57)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1ccn2c(Cc3cccc(Cl)c3Cl)nnc2c1
Show InChI InChI=1S/C21H16Cl2N8/c1-30-17(6-9-25-30)27-21-24-8-5-16(26-21)13-7-10-31-18(11-13)28-29-19(31)12-14-3-2-4-15(22)20(14)23/h2-11H,12H2,1H3,(H,24,26,27)
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n/an/a 0.5n/an/an/an/a7.3n/a



Array BioPharma Inc

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360)


(Homo sapiens (Human))
BDBM193773
PNG
(US9670208, Example 402 4-(3-(4-fluorobenzyl)-[1,2,...)
Show SMILES Fc1ccc(Cc2nnc3cc(ccn23)-c2ccnc(NC3CCOCC3)n2)cc1
Show InChI InChI=1S/C22H21FN6O/c23-17-3-1-15(2-4-17)13-20-27-28-21-14-16(6-10-29(20)21)19-5-9-24-22(26-19)25-18-7-11-30-12-8-18/h1-6,9-10,14,18H,7-8,11-13H2,(H,24,25,26)
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n/an/a 0.600n/an/an/an/a7.3n/a



Array BioPharma Inc

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(403-822)


(Homo sapiens (Human))
BDBM350052
PNG
(US10208024, Example 51 | US10766881, Example 51)
Show SMILES COCCN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1cc(C)c(=O)n(n1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C28H34N8O4/c1-18-11-24(33-36(28(18)37)21-12-22(39-3)14-23(13-21)40-4)26-27(29)30-16-25(32-26)19-15-31-35(17-19)20-5-7-34(8-6-20)9-10-38-2/h11-17,20H,5-10H2,1-4H3,(H2,29,30)
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n/an/a 0.600n/an/an/an/an/an/a



Array Biopharma Inc.

US Patent




US Patent US10766881 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350052
PNG
(US10208024, Example 51 | US10766881, Example 51)
Show SMILES COCCN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1cc(C)c(=O)n(n1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C28H34N8O4/c1-18-11-24(33-36(28(18)37)21-12-22(39-3)14-23(13-21)40-4)26-27(29)30-16-25(32-26)19-15-31-35(17-19)20-5-7-34(8-6-20)9-10-38-2/h11-17,20H,5-10H2,1-4H3,(H2,29,30)
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n/an/a 0.600n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GNW
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360)


(Homo sapiens (Human))
BDBM193675
PNG
(US9670208, Example 279 N-(1-methyl-1H-pyrazol-5-yl...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1ccn2c(CC(C)(C)C)nnc2c1
Show InChI InChI=1S/C20H23N7/c1-20(2,3)13-19-25-24-18-12-15(7-10-27(18)19)14-5-8-21-16(11-14)23-17-6-9-22-26(17)4/h5-12H,13H2,1-4H3,(H,21,23)
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n/an/a 0.600n/an/an/an/a7.3n/a



Array BioPharma Inc

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3 (FGFR3) (R397-T806)


(Homo sapiens (Human))
BDBM350059
PNG
(US10208024, Example 58 | US10766881, Example 58)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-n1nc(ccc1=O)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C25H25Cl2N7O3/c1-36-19-10-20(37-2)23(27)24(22(19)26)34-21(35)4-3-18(32-34)17-9-14(11-30-25(17)28)15-12-31-33(13-15)16-5-7-29-8-6-16/h3-4,9-13,16,29H,5-8H2,1-2H3,(H2,28,30)
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n/an/a 0.700n/an/an/an/an/an/a



Array Biopharma Inc.

US Patent




US Patent US10766881 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM350059
PNG
(US10208024, Example 58 | US10766881, Example 58)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-n1nc(ccc1=O)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C25H25Cl2N7O3/c1-36-19-10-20(37-2)23(27)24(22(19)26)34-21(35)4-3-18(32-34)17-9-14(11-30-25(17)28)15-12-31-33(13-15)16-5-7-29-8-6-16/h3-4,9-13,16,29H,5-8H2,1-2H3,(H2,28,30)
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Array BioPharma Inc

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GNW
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360)


(Homo sapiens (Human))
BDBM191370
PNG
(US9670208, Example 35)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1ccn2c(Cc3cc(ccn3)C3CC3)nnc2c1
Show InChI InChI=1S/C23H21N9/c1-31-20(6-10-26-31)28-23-25-9-5-19(27-23)17-7-11-32-21(13-17)29-30-22(32)14-18-12-16(4-8-24-18)15-2-3-15/h4-13,15H,2-3,14H2,1H3,(H,25,27,28)
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n/an/a 0.800n/an/an/an/a7.3n/a



Array BioPharma Inc

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360)


(Homo sapiens (Human))
BDBM193381
PNG
(US9670208, Example 49)
Show SMILES COc1ccc(Cc2nnc3cc(ccn23)-c2ccnc(Nc3ccnn3C)n2)cc1
Show InChI InChI=1S/C22H20N8O/c1-29-19(8-11-24-29)26-22-23-10-7-18(25-22)16-9-12-30-20(27-28-21(30)14-16)13-15-3-5-17(31-2)6-4-15/h3-12,14H,13H2,1-2H3,(H,23,25,26)
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n/an/a 0.800n/an/an/an/a7.3n/a



Array BioPharma Inc

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360)


(Homo sapiens (Human))
BDBM193672
PNG
(US9670208, Example 278 4-(3-(pyridin-2-ylmethyl)-[...)
Show SMILES C(c1nnc2cc(ccn12)-c1ccnc(NC2CCOCC2)n1)c1ccccn1
Show InChI InChI=1S/C21H21N7O/c1-2-8-22-17(3-1)14-20-27-26-19-13-15(5-10-28(19)20)18-4-9-23-21(25-18)24-16-6-11-29-12-7-16/h1-5,8-10,13,16H,6-7,11-12,14H2,(H,23,24,25)
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n/an/a 0.800n/an/an/an/a7.3n/a



Array BioPharma Inc

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(403-822)


(Homo sapiens (Human))
BDBM350042
PNG
(US10208024, Example 41 | US10766881, Example 41)
Show SMILES COc1cc(OC)c(F)c(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C24H25FN8O3/c1-35-16-9-19(22(25)20(10-16)36-2)33-21(34)4-3-17(31-33)23-24(26)28-12-18(30-23)14-11-29-32(13-14)15-5-7-27-8-6-15/h3-4,9-13,15,27H,5-8H2,1-2H3,(H2,26,28)
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n/an/a 0.800n/an/an/an/an/an/a



Array Biopharma Inc.

US Patent




US Patent US10766881 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350042
PNG
(US10208024, Example 41 | US10766881, Example 41)
Show SMILES COc1cc(OC)c(F)c(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C24H25FN8O3/c1-35-16-9-19(22(25)20(10-16)36-2)33-21(34)4-3-17(31-33)23-24(26)28-12-18(30-23)14-11-29-32(13-14)15-5-7-27-8-6-15/h3-4,9-13,15,27H,5-8H2,1-2H3,(H2,26,28)
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Array BioPharma Inc

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GNW
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360)


(Homo sapiens (Human))
BDBM193781
PNG
(US9670208, Example 493 4-(3-((6-ethoxypyridin-3-yl...)
Show SMILES CCOc1ccc(Cc2nnc3cc(ccn23)-c2ccnc(Nc3ccnn3C)n2)cn1
Show InChI InChI=1S/C22H21N9O/c1-3-32-21-5-4-15(14-24-21)12-19-28-29-20-13-16(8-11-31(19)20)17-6-9-23-22(26-17)27-18-7-10-25-30(18)2/h4-11,13-14H,3,12H2,1-2H3,(H,23,26,27)
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n/an/a 0.800n/an/an/an/a7.3n/a



Array BioPharma Inc

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350051
PNG
(US10208024, Example 50 | US10766881, Example 50)
Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C)c1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C25H28N8O3/c1-15-8-21(31-33(25(15)34)18-9-19(35-2)11-20(10-18)36-3)23-24(26)28-13-22(30-23)16-12-29-32(14-16)17-4-6-27-7-5-17/h8-14,17,27H,4-7H2,1-3H3,(H2,26,28)
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Array BioPharma Inc

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GNW
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(403-822)


(Homo sapiens (Human))
BDBM350051
PNG
(US10208024, Example 50 | US10766881, Example 50)
Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C)c1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C25H28N8O3/c1-15-8-21(31-33(25(15)34)18-9-19(35-2)11-20(10-18)36-3)23-24(26)28-13-22(30-23)16-12-29-32(14-16)17-4-6-27-7-5-17/h8-14,17,27H,4-7H2,1-3H3,(H2,26,28)
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n/an/a 0.900n/an/an/an/an/an/a



Array Biopharma Inc.

US Patent




US Patent US10766881 (2020)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360)


(Homo sapiens (Human))
BDBM193756
PNG
(US9670208, Example 317 4-(3-((4,4-difluorocyclohex...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1ccn2c(CC3CCC(F)(F)CC3)nnc2c1
Show InChI InChI=1S/C21H22F2N8/c1-30-17(5-10-25-30)27-20-24-9-4-16(26-20)15-6-11-31-18(28-29-19(31)13-15)12-14-2-7-21(22,23)8-3-14/h4-6,9-11,13-14H,2-3,7-8,12H2,1H3,(H,24,26,27)
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n/an/a 0.900n/an/an/an/a7.3n/a



Array BioPharma Inc

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360)


(Homo sapiens (Human))
BDBM193412
PNG
(US9670208, Example 276 N-(1-methyl-1H-pyrazol-5-yl...)
Show SMILES Cc1ccnc(Cc2nnc3cc(ccn23)-c2ccnc(Nc3ccnn3C)n2)c1
Show InChI InChI=1S/C21H19N9/c1-14-3-7-22-16(11-14)13-20-28-27-19-12-15(6-10-30(19)20)17-4-8-23-21(25-17)26-18-5-9-24-29(18)2/h3-12H,13H2,1-2H3,(H,23,25,26)
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n/an/a 0.900n/an/an/an/a7.3n/a



Array BioPharma Inc

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360)


(Homo sapiens (Human))
BDBM193396
PNG
(US9670208, Example 121)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1ccn2c(nnc2c1)[C@H](O)Cc1ccccc1
Show InChI InChI=1S/C23H21N7O/c1-29-21(8-11-25-29)26-20-14-17(7-10-24-20)18-9-12-30-22(15-18)27-28-23(30)19(31)13-16-5-3-2-4-6-16/h2-12,14-15,19,31H,13H2,1H3,(H,24,26)/t19-/m1/s1
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n/an/a 0.900n/an/an/an/a7.3n/a



Array BioPharma Inc

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360)


(Homo sapiens (Human))
BDBM193410
PNG
(US9670208, Example 272 4-(3-((6-methoxypyridin-3-y...)
Show SMILES COc1ccc(Cc2nnc3cc(ccn23)-c2ccnc(NC3CCOCC3)n2)cn1
Show InChI InChI=1S/C22H23N7O2/c1-30-21-3-2-15(14-24-21)12-19-27-28-20-13-16(5-9-29(19)20)18-4-8-23-22(26-18)25-17-6-10-31-11-7-17/h2-5,8-9,13-14,17H,6-7,10-12H2,1H3,(H,23,25,26)
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n/an/a 0.900n/an/an/an/a7.3n/a



Array BioPharma Inc

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360)


(Homo sapiens (Human))
BDBM193776
PNG
(US9670208, Example 403 4-(3-(3-fluoro-4-methoxyben...)
Show SMILES COc1ccc(Cc2nnc3cc(ccn23)-c2ccnc(NC3CCOCC3)n2)cc1F
Show InChI InChI=1S/C23H23FN6O2/c1-31-20-3-2-15(12-18(20)24)13-21-28-29-22-14-16(5-9-30(21)22)19-4-8-25-23(27-19)26-17-6-10-32-11-7-17/h2-5,8-9,12,14,17H,6-7,10-11,13H2,1H3,(H,25,26,27)
PDB

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n/an/a 0.900n/an/an/an/a7.3n/a



Array BioPharma Inc

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(403-822)


(Homo sapiens (Human))
BDBM350049
PNG
(6-(3-amino-6-(1-methyl- 1H-pyrazol-4-yl)pyrazin- 2...)
Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C2CC2)c1=O)-c1nc(cnc1N)-c1cnn(C)c1
Show InChI InChI=1S/C23H23N7O3/c1-29-12-14(10-26-29)20-11-25-22(24)21(27-20)19-9-18(13-4-5-13)23(31)30(28-19)15-6-16(32-2)8-17(7-15)33-3/h6-13H,4-5H2,1-3H3,(H2,24,25)
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Array Biopharma Inc.

US Patent




US Patent US10766881 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3 (FGFR3) (R397-T806)


(Homo sapiens (Human))
BDBM350052
PNG
(US10208024, Example 51 | US10766881, Example 51)
Show SMILES COCCN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1cc(C)c(=O)n(n1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C28H34N8O4/c1-18-11-24(33-36(28(18)37)21-12-22(39-3)14-23(13-21)40-4)26-27(29)30-16-25(32-26)19-15-31-35(17-19)20-5-7-34(8-6-20)9-10-38-2/h11-17,20H,5-10H2,1-4H3,(H2,29,30)
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Array Biopharma Inc.

US Patent




US Patent US10766881 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350049
PNG
(6-(3-amino-6-(1-methyl- 1H-pyrazol-4-yl)pyrazin- 2...)
Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C2CC2)c1=O)-c1nc(cnc1N)-c1cnn(C)c1
Show InChI InChI=1S/C23H23N7O3/c1-29-12-14(10-26-29)20-11-25-22(24)21(27-20)19-9-18(13-4-5-13)23(31)30(28-19)15-6-16(32-2)8-17(7-15)33-3/h6-13H,4-5H2,1-3H3,(H2,24,25)
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Array BioPharma Inc

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GNW
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM350052
PNG
(US10208024, Example 51 | US10766881, Example 51)
Show SMILES COCCN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1cc(C)c(=O)n(n1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C28H34N8O4/c1-18-11-24(33-36(28(18)37)21-12-22(39-3)14-23(13-21)40-4)26-27(29)30-16-25(32-26)19-15-31-35(17-19)20-5-7-34(8-6-20)9-10-38-2/h11-17,20H,5-10H2,1-4H3,(H2,29,30)
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Array BioPharma Inc

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GNW
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(403-822)


(Homo sapiens (Human))
BDBM350082
PNG
(US10208024, Example 81 | US10766881, Example 81)
Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C)c1=O)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C26H29N7O3/c1-16-8-24(31-33(26(16)34)20-10-21(35-2)12-22(11-20)36-3)23-9-17(13-29-25(23)27)18-14-30-32(15-18)19-4-6-28-7-5-19/h8-15,19,28H,4-7H2,1-3H3,(H2,27,29)
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Array Biopharma Inc.

US Patent




US Patent US10766881 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350082
PNG
(US10208024, Example 81 | US10766881, Example 81)
Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C)c1=O)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C26H29N7O3/c1-16-8-24(31-33(26(16)34)20-10-21(35-2)12-22(11-20)36-3)23-9-17(13-29-25(23)27)18-14-30-32(15-18)19-4-6-28-7-5-19/h8-15,19,28H,4-7H2,1-3H3,(H2,27,29)
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Array BioPharma Inc

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GNW
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(403-822)


(Homo sapiens (Human))
BDBM350033
PNG
(US10208024, Example 32 | US10766881, Example 32)
Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCN(C)CC1
Show InChI InChI=1S/C25H28N8O3/c1-31-8-6-17(7-9-31)32-15-16(13-28-32)22-14-27-25(26)24(29-22)21-4-5-23(34)33(30-21)18-10-19(35-2)12-20(11-18)36-3/h4-5,10-15,17H,6-9H2,1-3H3,(H2,26,27)
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n/an/a 1.30n/an/an/an/an/an/a



Array Biopharma Inc.

US Patent




US Patent US10766881 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350050
PNG
(6-(3-amino-6-(1-methyl- 1H-pyrazol-4-yl)pyrazin- 2...)
Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C2CCC2)c1=O)-c1nc(cnc1N)-c1cnn(C)c1
Show InChI InChI=1S/C24H25N7O3/c1-30-13-15(11-27-30)21-12-26-23(25)22(28-21)20-10-19(14-5-4-6-14)24(32)31(29-20)16-7-17(33-2)9-18(8-16)34-3/h7-14H,4-6H2,1-3H3,(H2,25,26)
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Array BioPharma Inc

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GNW
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(403-822)


(Homo sapiens (Human))
BDBM350050
PNG
(6-(3-amino-6-(1-methyl- 1H-pyrazol-4-yl)pyrazin- 2...)
Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C2CCC2)c1=O)-c1nc(cnc1N)-c1cnn(C)c1
Show InChI InChI=1S/C24H25N7O3/c1-30-13-15(11-27-30)21-12-26-23(25)22(28-21)20-10-19(14-5-4-6-14)24(32)31(29-20)16-7-17(33-2)9-18(8-16)34-3/h7-14H,4-6H2,1-3H3,(H2,25,26)
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Array Biopharma Inc.

US Patent




US Patent US10766881 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350033
PNG
(US10208024, Example 32 | US10766881, Example 32)
Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCN(C)CC1
Show InChI InChI=1S/C25H28N8O3/c1-31-8-6-17(7-9-31)32-15-16(13-28-32)22-14-27-25(26)24(29-22)21-4-5-23(34)33(30-21)18-10-19(35-2)12-20(11-18)36-3/h4-5,10-15,17H,6-9H2,1-3H3,(H2,26,27)
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Array BioPharma Inc

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GNW
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(403-822)


(Homo sapiens (Human))
BDBM350032
PNG
(US10208024, Example 31 | US10766881, Example 31)
Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C24H26N8O3/c1-34-18-9-17(10-19(11-18)35-2)32-22(33)4-3-20(30-32)23-24(25)27-13-21(29-23)15-12-28-31(14-15)16-5-7-26-8-6-16/h3-4,9-14,16,26H,5-8H2,1-2H3,(H2,25,27)
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Array Biopharma Inc.

US Patent




US Patent US10766881 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3 (FGFR3) (R397-T806)


(Homo sapiens (Human))
BDBM350049
PNG
(6-(3-amino-6-(1-methyl- 1H-pyrazol-4-yl)pyrazin- 2...)
Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C2CC2)c1=O)-c1nc(cnc1N)-c1cnn(C)c1
Show InChI InChI=1S/C23H23N7O3/c1-29-12-14(10-26-29)20-11-25-22(24)21(27-20)19-9-18(13-4-5-13)23(31)30(28-19)15-6-16(32-2)8-17(7-15)33-3/h6-13H,4-5H2,1-3H3,(H2,24,25)
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Array Biopharma Inc.

US Patent




US Patent US10766881 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350032
PNG
(US10208024, Example 31 | US10766881, Example 31)
Show SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C24H26N8O3/c1-34-18-9-17(10-19(11-18)35-2)32-22(33)4-3-20(30-32)23-24(25)27-13-21(29-23)15-12-28-31(14-15)16-5-7-26-8-6-16/h3-4,9-14,16,26H,5-8H2,1-2H3,(H2,25,27)
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Array BioPharma Inc

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GNW
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM350049
PNG
(6-(3-amino-6-(1-methyl- 1H-pyrazol-4-yl)pyrazin- 2...)
Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C2CC2)c1=O)-c1nc(cnc1N)-c1cnn(C)c1
Show InChI InChI=1S/C23H23N7O3/c1-29-12-14(10-26-29)20-11-25-22(24)21(27-20)19-9-18(13-4-5-13)23(31)30(28-19)15-6-16(32-2)8-17(7-15)33-3/h6-13H,4-5H2,1-3H3,(H2,24,25)
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Array BioPharma Inc

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GNW
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350045
PNG
(US10208024, Example 44 | US10766881, Example 44)
Show SMILES CCc1cc(nn(-c2cc(OC)cc(OC)c2)c1=O)-c1nc(cnc1N)-c1cnn(C)c1
Show InChI InChI=1S/C22H23N7O3/c1-5-13-6-18(20-21(23)24-11-19(26-20)14-10-25-28(2)12-14)27-29(22(13)30)15-7-16(31-3)9-17(8-15)32-4/h6-12H,5H2,1-4H3,(H2,23,24)
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Array BioPharma Inc

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GNW
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350043
PNG
(US10208024, Example 42 | US10766881, Example 42)
Show SMILES COCCN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1ccc(=O)n(n1)-c1cc(OC)cc(OC)c1F
Show InChI InChI=1S/C27H31FN8O4/c1-38-11-10-34-8-6-18(7-9-34)35-16-17(14-31-35)21-15-30-27(29)26(32-21)20-4-5-24(37)36(33-20)22-12-19(39-2)13-23(40-3)25(22)28/h4-5,12-16,18H,6-11H2,1-3H3,(H2,29,30)
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Array BioPharma Inc

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GNW
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(403-822)


(Homo sapiens (Human))
BDBM350045
PNG
(US10208024, Example 44 | US10766881, Example 44)
Show SMILES CCc1cc(nn(-c2cc(OC)cc(OC)c2)c1=O)-c1nc(cnc1N)-c1cnn(C)c1
Show InChI InChI=1S/C22H23N7O3/c1-5-13-6-18(20-21(23)24-11-19(26-20)14-10-25-28(2)12-14)27-29(22(13)30)15-7-16(31-3)9-17(8-15)32-4/h6-12H,5H2,1-4H3,(H2,23,24)
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Array Biopharma Inc.

US Patent




US Patent US10766881 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(403-822)


(Homo sapiens (Human))
BDBM350043
PNG
(US10208024, Example 42 | US10766881, Example 42)
Show SMILES COCCN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(n1)-c1ccc(=O)n(n1)-c1cc(OC)cc(OC)c1F
Show InChI InChI=1S/C27H31FN8O4/c1-38-11-10-34-8-6-18(7-9-34)35-16-17(14-31-35)21-15-30-27(29)26(32-21)20-4-5-24(37)36(33-20)22-12-19(39-2)13-23(40-3)25(22)28/h4-5,12-16,18H,6-11H2,1-3H3,(H2,29,30)
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Array Biopharma Inc.

US Patent




US Patent US10766881 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350061
PNG
(US10208024, Example 60)
Show SMILES COCCN1CCC(CC1)n1cc(cn1)-c1ccc(N)c(c1)-c1ccc(=O)n(n1)-c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C29H32Cl2N6O4/c1-39-13-12-35-10-8-20(9-11-35)36-17-19(16-33-36)18-4-5-22(32)21(14-18)23-6-7-26(38)37(34-23)29-27(30)24(40-2)15-25(41-3)28(29)31/h4-7,14-17,20H,8-13,32H2,1-3H3
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Array BioPharma Inc

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GNW
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360)


(Homo sapiens (Human))
BDBM193411
PNG
(US9670208, Example 275 N-(1-methyl-1H-pyrazol-5-yl...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1ccn2c(Cc3cccc(n3)-c3ccccc3)nnc2c1
Show InChI InChI=1S/C26H21N9/c1-34-23(11-14-28-34)31-26-27-13-10-22(30-26)19-12-15-35-24(16-19)32-33-25(35)17-20-8-5-9-21(29-20)18-6-3-2-4-7-18/h2-16H,17H2,1H3,(H,27,30,31)
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Array BioPharma Inc

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(403-822)


(Homo sapiens (Human))
BDBM462139
PNG
(US10766881, Example 60)
Show SMILES COCCN1CCC(CC1)n1cc(cn1)-c1cnc(N)c(c1)-c1ccc(=O)n(n1)-c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C28H31Cl2N7O4/c1-39-11-10-35-8-6-19(7-9-35)36-16-18(15-33-36)17-12-20(28(31)32-14-17)21-4-5-24(38)37(34-21)27-25(29)22(40-2)13-23(41-3)26(27)30/h4-5,12-16,19H,6-11H2,1-3H3,(H2,31,32)
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Array Biopharma Inc.

US Patent




US Patent US10766881 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM350048
PNG
(US10208024, Example 47 | US10766881, Example 47)
Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C(C)C)c1=O)-c1nc(cnc1N)-c1cnn(C)c1
Show InChI InChI=1S/C23H25N7O3/c1-13(2)18-9-19(21-22(24)25-11-20(27-21)14-10-26-29(3)12-14)28-30(23(18)31)15-6-16(32-4)8-17(7-15)33-5/h6-13H,1-5H3,(H2,24,25)
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Array BioPharma Inc

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GNW
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3 (FGFR3) (R397-T806)


(Homo sapiens (Human))
BDBM350048
PNG
(US10208024, Example 47 | US10766881, Example 47)
Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C(C)C)c1=O)-c1nc(cnc1N)-c1cnn(C)c1
Show InChI InChI=1S/C23H25N7O3/c1-13(2)18-9-19(21-22(24)25-11-20(27-21)14-10-26-29(3)12-14)28-30(23(18)31)15-6-16(32-4)8-17(7-15)33-5/h6-13H,1-5H3,(H2,24,25)
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Array Biopharma Inc.

US Patent




US Patent US10766881 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(403-822)


(Homo sapiens (Human))
BDBM350048
PNG
(US10208024, Example 47 | US10766881, Example 47)
Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C(C)C)c1=O)-c1nc(cnc1N)-c1cnn(C)c1
Show InChI InChI=1S/C23H25N7O3/c1-13(2)18-9-19(21-22(24)25-11-20(27-21)14-10-26-29(3)12-14)28-30(23(18)31)15-6-16(32-4)8-17(7-15)33-5/h6-13H,1-5H3,(H2,24,25)
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n/an/a 1.60n/an/an/an/an/an/a



Array Biopharma Inc.

US Patent




US Patent US10766881 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(403-822)


(Homo sapiens (Human))
BDBM350015
PNG
(6-(3-amino-6-(1- methyl-1H-pyrazol-4- yl)pyrazin-2...)
Show SMILES COc1cc(OC)c(Cl)c(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(C)c1
Show InChI InChI=1S/C20H18ClN7O3/c1-27-10-11(8-24-27)14-9-23-20(22)19(25-14)13-4-5-17(29)28(26-13)15-6-12(30-2)7-16(31-3)18(15)21/h4-10H,1-3H3,(H2,22,23)
PDB

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n/an/a 1.60n/an/an/an/an/an/a



Array Biopharma Inc.

US Patent




US Patent US10766881 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350044
PNG
(US10208024, Example 43 | US10766881, Example 43)
Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C)c1=O)-c1nc(cnc1N)-c1cnn(C)c1
Show InChI InChI=1S/C21H21N7O3/c1-12-5-17(19-20(22)23-10-18(25-19)13-9-24-27(2)11-13)26-28(21(12)29)14-6-15(30-3)8-16(7-14)31-4/h5-11H,1-4H3,(H2,22,23)
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Array BioPharma Inc

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GNW
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350048
PNG
(US10208024, Example 47 | US10766881, Example 47)
Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C(C)C)c1=O)-c1nc(cnc1N)-c1cnn(C)c1
Show InChI InChI=1S/C23H25N7O3/c1-13(2)18-9-19(21-22(24)25-11-20(27-21)14-10-26-29(3)12-14)28-30(23(18)31)15-6-16(32-4)8-17(7-15)33-5/h6-13H,1-5H3,(H2,24,25)
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Array BioPharma Inc

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GNW
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(403-822)


(Homo sapiens (Human))
BDBM350044
PNG
(US10208024, Example 43 | US10766881, Example 43)
Show SMILES COc1cc(OC)cc(c1)-n1nc(cc(C)c1=O)-c1nc(cnc1N)-c1cnn(C)c1
Show InChI InChI=1S/C21H21N7O3/c1-12-5-17(19-20(22)23-10-18(25-19)13-9-24-27(2)11-13)26-28(21(12)29)14-6-15(30-3)8-16(7-14)31-4/h5-11H,1-4H3,(H2,22,23)
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n/an/a 1.60n/an/an/an/an/an/a



Array Biopharma Inc.

US Patent




US Patent US10766881 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM350015
PNG
(6-(3-amino-6-(1- methyl-1H-pyrazol-4- yl)pyrazin-2...)
Show SMILES COc1cc(OC)c(Cl)c(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(C)c1
Show InChI InChI=1S/C20H18ClN7O3/c1-27-10-11(8-24-27)14-9-23-20(22)19(25-14)13-4-5-17(29)28(26-13)15-6-12(30-2)7-16(31-3)18(15)21/h4-10H,1-3H3,(H2,22,23)
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Array BioPharma Inc

US Patent


Assay Description
FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...


US Patent US10208024 (2019)


BindingDB Entry DOI: 10.7270/Q2CJ8GNW
More data for this
Ligand-Target Pair
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