Found 161 of ec50 for monomerid = 10755 
Affinity DataKi: 1.05E+3nM ΔG°: -8.15kcal/mole EC50: 12nMpH: 7.4 T: 2°CAssay Description:Radioligand binding studies were performed in buffer contains test compound, [3H]-GR113808, and receptor C6 glial cell membrane preparation. Nonspeci...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataEC50: 8.5nMAssay Description:Compound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptor in guinea pig substantia nigraMore data for this Ligand-Target Pair
Affinity DataEC50: 5nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity as increased response to electrical stimulation in guinea pig ileumMore data for this Ligand-Target Pair
Affinity DataEC50: 17nMAssay Description:In vitro relaxation of carbachol pre-contracted rat oesophageal TMM.More data for this Ligand-Target Pair
Affinity DataEC50: 30nMAssay Description:Inhibition of Forskolin-stimulated adenylate cyclase activity against 5-hydroxytryptamine 1A receptor of guinea pig hippocampusMore data for this Ligand-Target Pair
Affinity DataEC50: 16nMAssay Description:Inhibition of Forskolin-stimulated adenylate cyclase activity against 5-hydroxytryptamine 1D receptor of guinea pig substantia nigraMore data for this Ligand-Target Pair
Affinity DataEC50: 1.5nMAssay Description:Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometricimaging plate readerMore data for this Ligand-Target Pair
Affinity DataEC50: 1.70nMAssay Description:Functional activity against human 5-hydroxytryptamine 2C receptor expressed in CHO cells using fluorometricimaging plate readerMore data for this Ligand-Target Pair
Affinity DataEC50: 5.20nMAssay Description:Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 5nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus an...More data for this Ligand-Target Pair
Affinity DataEC50: 4.82nMAssay Description:Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 4.70nMAssay Description:The intrinsic activity of the compound was evaluated for its ability to inhibit forskolin-stimulated c-AMP formation mediated by cloned 5-hydroxytryp...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Columbia University College Of Physicians And Surgeons
Curated by ChEMBL
Columbia University College Of Physicians And Surgeons
Curated by ChEMBL
Affinity DataEC50: 1nMAssay Description:Agonistic activity at human 5HT1A in CHO cells by the inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Columbia University College Of Physicians And Surgeons
Curated by ChEMBL
Columbia University College Of Physicians And Surgeons
Curated by ChEMBL
Affinity DataEC50: 3nMAssay Description:Agonist activity at 5HT1A receptor (unknown origin) after 20 mins by [35S]GTP-gammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 11nMAssay Description:Functional activity against human 5-hydroxytryptamine 2A receptor expressed in CHO cells using fluorometricimaging plate readerMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Universidad Complutense De Madrid
Curated by ChEMBL
Universidad Complutense De Madrid
Curated by ChEMBL
Affinity DataEC50: 17nMAssay Description:Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.5nMAssay Description:Binding to human 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 11nMAssay Description:Binding to human 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 1.70nMAssay Description:Binding to human 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.920nMAssay Description:Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.210nMAssay Description:Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.90nMAssay Description:Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Columbia University College Of Physicians And Surgeons
Curated by ChEMBL
Columbia University College Of Physicians And Surgeons
Curated by ChEMBL
Affinity DataEC50: 0.700nMAssay Description:Agonist activity assessed by stimulation of [35S]GTPgammaS binding to human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Columbia University College Of Physicians And Surgeons
Curated by ChEMBL
Columbia University College Of Physicians And Surgeons
Curated by ChEMBL
Affinity DataEC50: 1nMAssay Description:Agonistic activity at human 5HT1A in CHO cells by the inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
Affinity DataEC50: 58nMAssay Description:Activity against 5HT2A mediated intracellular calcium mobilization by FLIPR in rat vascular smooth muscle cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 2.80nMAssay Description:Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 3.5nMAssay Description:Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Columbia University College Of Physicians And Surgeons
Curated by ChEMBL
Columbia University College Of Physicians And Surgeons
Curated by ChEMBL
Affinity DataEC50: 28nMAssay Description:Agonist activity at human 5-HT1A receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 15 mins by EL...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Columbia University College Of Physicians And Surgeons
Curated by ChEMBL
Columbia University College Of Physicians And Surgeons
Curated by ChEMBL
Affinity DataEC50: 170nMAssay Description:Agonist activity at human 5-HT1A receptor expressed in CHO cells after 90 mins by beta-arrestin-2 recruitment assayMore data for this Ligand-Target Pair
Affinity DataEC50: 302nMT: 2°CAssay Description:Partial agonist activity at human 5-HT2A receptor expressed in HEK293 cells preincubated for 1 hr at 37 degC followed by incubated for 15 mins at roo...More data for this Ligand-Target Pair
Affinity DataEC50: 191nMT: 2°CAssay Description:Partial agonist activity at human 5-HT2C receptor expressed in HEK293 cells preincubated for 1 hr at 37 degC followed by incubated for 15 mins at roo...More data for this Ligand-Target Pair
Affinity DataEC50: 323nMAssay Description:Agonist activity at 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus assessed as increase in [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0900nMAssay Description:Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.5nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 5.80nMAssay Description:Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Universidad Complutense De Madrid
Curated by ChEMBL
Universidad Complutense De Madrid
Curated by ChEMBL
Affinity DataEC50: 15nMAssay Description:Agonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Columbia University College Of Physicians And Surgeons
Curated by ChEMBL
Columbia University College Of Physicians And Surgeons
Curated by ChEMBL
Affinity DataEC50: 43nMAssay Description:Compound was tested for the inhibition of forskolin-stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptor in guinea pigMore data for this Ligand-Target Pair
Affinity DataEC50: 25nMAssay Description:Agonist activity at human recombinant 5HT2C receptor expressed in CHO K1 cells assessed as induction of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 11nMAssay Description:Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 141nMAssay Description:Partial agonist activity at human 5HT3A receptor expressed in HEK293 cells assessed as decrease in 10 uM 5-chloroindole-induced increase in intracell...More data for this Ligand-Target Pair
Affinity DataEC50: 178nMAssay Description:Partial agonist activity at human 5HT3A receptor expressed in HEK293 cells assessed as effect on serotonin-induced responseMore data for this Ligand-Target Pair
Affinity DataEC50: 1.20E+4nMAssay Description:Response at rat 5-hydroxytryptamine 3a receptor expressed in xenopus oocytesMore data for this Ligand-Target Pair
Affinity DataEC50: 7.90nMAssay Description:In vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 55.8nMAssay Description:The receptor (5-hydroxytryptamine 2A ) mediated mobilization of intracellular calcium [Ca2+] was studied in rat smooth muscle cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 351nMAssay Description:In vitro relative agonist activity against 5-hydroxytryptamine 2A using PI assay in rat vascular smooth muscle cellsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Columbia University College Of Physicians And Surgeons
Curated by ChEMBL
Columbia University College Of Physicians And Surgeons
Curated by ChEMBL
Affinity DataEC50: 3.70nMAssay Description:Tested for functional response on CHO cells expressing cloned human 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 523nMAssay Description:Basal binding towards Dopamine receptor D3 was evaluated using [35S]- GTP-gamma S radioligandMore data for this Ligand-Target Pair
Affinity DataEC50: 47nMAssay Description:Agonist activity at 5-HT2A receptor (unknown origin) expressed in CHOK1 cells co-expressing G-alpha 15 by Fluo-4 dye based FLIPR assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Columbia University College Of Physicians And Surgeons
Curated by ChEMBL
Columbia University College Of Physicians And Surgeons
Curated by ChEMBL
Affinity DataEC50: 15nMAssay Description:Agonist activity at 5-HT1A receptor (unknown origin) expressed in CHOK1 cells co-expressing G-alpha 15 by Fluo-4 dye based FLIPR assayMore data for this Ligand-Target Pair
