Affinity DataIC50: 10nMAssay Description:Inhibitory concentration against alpha mitogen activated protein kinase p38 activityMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of p38 alpha MAPK in human whole blood assessed as phosphorylation of ATF-2 by immunosorbent non-radioactive enzyme assayMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
University Of Iowa
Curated by ChEMBL
University Of Iowa
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of human receptor-interacting serine-threonine kinase 2 (RIPK2) at 100 uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of mitogen-activated protein kinase p38 alpha 2More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Concentration required to inhibit human mitogen activated protein kinase p38 activity More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 expressed in E. coli.More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:In vitro inhibition of mitogen-activated protein kinase p38 alpha 2 derived from E. coliMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of p38alpha MAPK by non-radioactive immunosorbent assayMore data for this Ligand-Target Pair
Affinity DataIC50: 35nMpH: 7.5 T: 2°CAssay Description:Kinase assay using p38alpha MAP.More data for this Ligand-Target Pair
Affinity DataIC50: 37nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Antagonist activity at human glucagon receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Inhibition of MAP kinase p38alpha assessed as phosphorylation of ATF-2More data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Inhibition of Mitogen-activated protein kinase 14 (P38 alpha) at 100 uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...More data for this Ligand-Target Pair
Affinity DataIC50: 39nMAssay Description:Inhibition of Mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 39nMAssay Description:Inhibition of human p38-alpha kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 39nMAssay Description:Inhibition of p38 alpha activity by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of p38alpha by Cherenkov countingMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of p38alpha by immunosorbent based kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 44nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 45nMAssay Description:Inhibition of p38-alpha MAPKMore data for this Ligand-Target Pair
Affinity DataIC50: 48nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 0.17 mM ATP/[gamma-32P] ATP. 32P incorp...More data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inhibitory concentration against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inhibitory concentration against p38 alpha MAP kinase (Experimental value)More data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inhibition of p38alpha MAP kinase (unknown origin) in presence of 100 uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inhibition of human MAPK p38alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of p38alpha MAPK (unknown origin) by cell-free enzyme immunosorbent assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:Inhibition of human p38alpha by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 56nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair
Affinity DataIC50: 62nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 68nMAssay Description:Inhibition of p38 alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 72nMAssay Description:Inhibitory concentration against p38 alpha MAP kinase calculated by CoMFA model; FlexX score=-22.2kcal/mol More data for this Ligand-Target Pair
Affinity DataIC50: 75nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Merck Research Laboratory
Curated by ChEMBL
Merck Research Laboratory
Curated by ChEMBL
Affinity DataIC50: 78nMAssay Description:Inhibition of Mitogen-activated protein kinase p38 betaMore data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataIC50: 83nMAssay Description:Inhibition of LPS-induced p38-related TNF alpha release from human monocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of p38alpha kinaseMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase(Toxoplasma gondii)
Tulane University School Of Medicine
Curated by ChEMBL
Tulane University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of Toxoplasma gondii recombinant MAPK1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of CK1delta by Cherenkov counting in presence of 20 uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 124nMAssay Description:Inhibition of human casein kinase 1 delta at 100 uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 135nMAssay Description:Inhibition of human cyclin G associated kinase at 100 uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 273nMAssay Description:Inhibition of p38alpha MAP kinase (unknown origin) in presence of 300 uM ATPMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratory
Curated by ChEMBL
Merck Research Laboratory
Curated by ChEMBL
Affinity DataIC50: 280nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-beta 1More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Eberhard-Karls-University Of T£Bingen
Curated by ChEMBL
Eberhard-Karls-University Of T£Bingen
Curated by ChEMBL
Affinity DataIC50: 290nMAssay Description:Inhibition of JNK3 by nonradioactive JNK3 assayMore data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:Inhibition of Mitogen-activated protein kinase p38 (P38 MAPK)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratory
Curated by ChEMBL
Merck Research Laboratory
Curated by ChEMBL
Affinity DataIC50: 290nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 1More data for this Ligand-Target Pair