Affinity DataIC50: 372nM EC50: 70nMAssay Description:CAII assays were performed at CEREP (paris). All other kinase assays were performed at Upstate (Dundee, UK).More data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of human BCR-ABL T315I mutant expressed in mouse BAF3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assayMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 90nMAssay Description:Antiproliferative activity against K562 cells expressing Bcr-AblMore data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Bonn
University Of Bonn
Affinity DataEC50: 9.82E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataEC50: 100nMAssay Description:Inhibition of c-Kit by cellular assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Affinity DataEC50: 1.77E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 34nMAssay Description:Inhibition of human wild type BCR-ABL expressed in mouse BAF3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assayMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataEC50: 90nMAssay Description:Inhibition of PDGFRalpha by cellular assayMore data for this Ligand-Target Pair