Compile Data Set for Download or QSAR
maximum 50k data
Found 12 of ic50 for monomerid = 135818
TargetLipopolysaccharide-induced tumor necrosis factor-alpha factor(Homo sapiens (Human))
Vtv Therapeutics

US Patent
LigandPNGBDBM135818(US10085990, Example 92 | US10568888, Example 92 | ...)
Affinity DataIC50:  2.40nMAssay Description:Samples were tested for TNF as per the manufacturer's instructions (TNF ELISA; R&D Systems, Cat #DY210). The samples were serially diluted with P...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
Vtv Therapeutics

US Patent
LigandPNGBDBM135818(US10085990, Example 92 | US10568888, Example 92 | ...)
Affinity DataIC50:  2.40nMT: 2°CAssay Description:Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at ro...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Vtv Therapeutics

US Patent
LigandPNGBDBM135818(US10085990, Example 92 | US10568888, Example 92 | ...)
Affinity DataIC50:  68nMAssay Description:The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)(Homo sapiens (Human))
Vtv Therapeutics

US Patent
LigandPNGBDBM135818(US10085990, Example 92 | US10568888, Example 92 | ...)
Affinity DataIC50:  68nMT: 2°CAssay Description:The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Vtv Therapeutics

US Patent
LigandPNGBDBM135818(US10085990, Example 92 | US10568888, Example 92 | ...)
Affinity DataIC50:  68nMT: 2°CAssay Description:The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIsoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2)(Homo sapiens (Human))
Vtv Therapeutics

US Patent
LigandPNGBDBM135818(US10085990, Example 92 | US10568888, Example 92 | ...)
Affinity DataIC50:  68nMAssay Description:A TR-FRET-based phosphodiesterase assay kit from Molecular Devices was used to test whether these compounds were indeed direct inhibitors of the PDE4...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Vtv Therapeutics

US Patent
LigandPNGBDBM135818(US10085990, Example 92 | US10568888, Example 92 | ...)
Affinity DataIC50:  68nMAssay Description:A TR-FRET-based phosphodiesterase assay kit from "Molecular Devices" was used to test whether these compounds were indeed direct inhibitors of the PD...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Vtv Therapeutics

US Patent
LigandPNGBDBM135818(US10085990, Example 92 | US10568888, Example 92 | ...)
Affinity DataIC50:  151nMT: 2°CAssay Description:The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Vtv Therapeutics

US Patent
LigandPNGBDBM135818(US10085990, Example 92 | US10568888, Example 92 | ...)
Affinity DataIC50:  151nMAssay Description:A TR-FRET-based phosphodiesterase assay kit from "Molecular Devices" was used to test whether these compounds were indeed direct inhibitors of the PD...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Vtv Therapeutics

US Patent
LigandPNGBDBM135818(US10085990, Example 92 | US10568888, Example 92 | ...)
Affinity DataIC50:  151nMAssay Description:A TR-FRET-based phosphodiesterase assay kit from Molecular Devices was used to test whether these compounds were indeed direct inhibitors of the PDE4...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Vtv Therapeutics

US Patent
LigandPNGBDBM135818(US10085990, Example 92 | US10568888, Example 92 | ...)
Affinity DataIC50:  151nMAssay Description:The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffer (DTT or Mn...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIsoform 10 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (10)(Homo sapiens (Human))
Vtv Therapeutics

US Patent
LigandPNGBDBM135818(US10085990, Example 92 | US10568888, Example 92 | ...)
Affinity DataIC50:  151nMT: 2°CAssay Description:The assay buffer was prepared by diluting 5× supplied Tween-based buffer in 1:5 in water to make 1× buffer. Add desired additive to buffe...More data for this Ligand-Target Pair
In DepthDetails US Patent