Affinity DataEC50: 5.00E+3nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR4a in ratMore data for this Ligand-Target Pair
Affinity DataEC50: 4.00E+3nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR2 in ratMore data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+4nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR5a in ratMore data for this Ligand-Target Pair
Affinity DataEC50: 9.00E+3nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR1a in ratMore data for this Ligand-Target Pair
Affinity DataEC50: 1.30E+4nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR1c in ratMore data for this Ligand-Target Pair
Affinity DataEC50: 5.60E+4nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR1b in ratMore data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+6nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR7 in ratMore data for this Ligand-Target Pair
Affinity DataEC50: 2.58E+3nMAssay Description:Agonist activity at human recombinant mGlu2 receptor E273D and L300Q mutant expressed in AV12 cells assessed as stimulation of Ca2+ mobilization afte...More data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+3nMAssay Description:Agonist activity at wild type human recombinant mGlu3 receptor expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by FLI...More data for this Ligand-Target Pair
Affinity DataEC50: 4.18E+3nMAssay Description:Agonist activity at human recombinant mGlu3 receptor D279E mutant expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by ...More data for this Ligand-Target Pair
Affinity DataEC50: 1.48E+3nMAssay Description:Agonist activity at human recombinant mGlu3 receptor Q306L mutant expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by ...More data for this Ligand-Target Pair
Affinity DataEC50: 5.12E+3nMAssay Description:Agonist activity at human recombinant mGlu3 receptor D279E and Q306L mutant expressed in AV12 cells assessed as stimulation of Ca2+ mobilization afte...More data for this Ligand-Target Pair
Affinity DataEC50: 1.83E+3nMAssay Description:Agonist activity at wild type human recombinant mGlu2 receptor expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by FLI...More data for this Ligand-Target Pair
Affinity DataEC50: 2.35E+3nMAssay Description:Agonist activity at human recombinant mGlu2 receptor E273D mutant expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by ...More data for this Ligand-Target Pair
Affinity DataEC50: 1.77E+3nMAssay Description:Agonist activity at human recombinant mGlu2 receptor L300Q mutant expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by ...More data for this Ligand-Target Pair
Affinity DataEC50: 1.25E+4nMAssay Description:Agonist activity at recombinant rat GluA1 receptor flip isoform expressed in Xenopus laevis oocytes by two-electrode voltage clamp assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.40E+3nMAssay Description:Agonist activity at recombinant rat GluA1 receptor flop isoform expressed in Xenopus laevis oocytes by two-electrode voltage clamp assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.47E+4nMAssay Description:Agonist activity at recombinant rat GluA2(Q) receptor flip isoform expressed in Xenopus laevis oocytes by two-electrode voltage clamp assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.12E+4nMAssay Description:Agonist activity at recombinant rat GluA3 receptor flip isoform expressed in Xenopus laevis oocytes by two-electrode voltage clamp assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.96E+4nMAssay Description:Agonist activity at recombinant rat GluA4 receptor flip isoform expressed in Xenopus laevis oocytes by two-electrode voltage clamp assayMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataEC50: 1.18E+3nMAssay Description:Agonist activity at human mGlu7 receptor expressed in HEK293 assessed as inhibition of forskolin stimulated cAMP productionMore data for this Ligand-Target Pair
Affinity DataEC50: 3.24E+3nMAssay Description:Agonist activity at rat mGlu4 receptor expressed in HEK293 cells assessed as inhibition of forskolin stimulated cAMP productionMore data for this Ligand-Target Pair
Affinity DataEC50: 3.20E+3nMAssay Description:Agonist activity at rat mGlu4 receptor expressed in HEK293 cells assessed as inhibition of forskolin stimulated cAMP productionMore data for this Ligand-Target Pair
Affinity DataEC50: 1.59E+3nMAssay Description:Agonist activity at rat mGlu1 receptor expressed in HEK293 cells by intracellular Ca2+ mobilization assayMore data for this Ligand-Target Pair
Affinity DataEC50: 4.70E+3nMAssay Description:Agonist activity at rat mGlu5 receptor expressed in HEK293 cells by intracellular Ca2+ mobilization assayMore data for this Ligand-Target Pair
Affinity DataEC50: 4.68E+3nMAssay Description:Agonist activity at rat mGlu5 receptor expressed in HEK293 cells by intracellular Ca2+ mobilization assayMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataEC50: 58nMAssay Description:Agonist activity at rat mGlu3 receptor expressed in HEK293 cells by [35S]GTP-gamma binding assayMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataEC50: 60nMAssay Description:Agonist activity at rat mGlu3 receptor expressed in HEK293 cells by [35S]GTP-gamma binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.82E+3nMAssay Description:Agonist activity at rat mGlu2 receptor expressed in HEK293 cells by [35S]GTP-gamma binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.80E+3nMAssay Description:Agonist activity at rat mGlu2 receptor expressed in HEK293 cells by [35S]GTP-gamma binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.60E+3nMAssay Description:Agonist activity at rat mGlu1 receptor expressed in HEK293 cells by intracellular Ca2+ mobilization assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.39E+4nMAssay Description:Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assayMore data for this Ligand-Target Pair
Affinity DataEC50: 8.99E+3nMAssay Description:Agonist activity at rat mGlu5 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.31E+4nMAssay Description:Agonist activity at rat mGlu2 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assayMore data for this Ligand-Target Pair
Affinity DataEC50: 9.49E+3nMAssay Description:Agonist activity at rat mGlu4 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assayMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataEC50: 6.51E+4nMAssay Description:Agonist activity at rat mGlu6 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assayMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 8(Rattus norvegicus (Rat))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataEC50: 1.40E+4nMAssay Description:Agonist activity at rat mGlu8 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.61E+4nMAssay Description:Agonist activity at rat mGlu2 receptor by FRET based mGlu sensor assayMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataEC50: 3.40E+3nMAssay Description:Agonist activity at rat mGlu3 receptor by FRET based mGlu sensor assayMore data for this Ligand-Target Pair
Affinity DataEC50: 6.40E+3nMAssay Description:Agonist activity at rat recombinant GluA1 receptor flop isoform expressed in Xenopus oocytesMore data for this Ligand-Target Pair
Affinity DataEC50: 1.30E+3nMAssay Description:Agonist activity at rat recombinant GluA3 receptor flop isoform expressed in Xenopus oocytesMore data for this Ligand-Target Pair
Affinity DataEC50: 2.20E+4nMAssay Description:Agonist activity at recombinant GluA1 receptor flop isoform expressed in Xenopus oocytesMore data for this Ligand-Target Pair
Affinity DataEC50: 6.20E+3nMAssay Description:Agonist activity at recombinant GluA2 receptor flop isoform expressed in Xenopus oocytesMore data for this Ligand-Target Pair
Affinity DataEC50: 3.50E+4nMAssay Description:Agonist activity at recombinant GluA3 receptor flop isoform expressed in Xenopus oocytesMore data for this Ligand-Target Pair
Affinity DataEC50: 2.26E+3nMAssay Description:Agonist activity at recombinant GluA1 receptor flip isoform expressed in Xenopus oocytes co-expressing gamma2-TARPMore data for this Ligand-Target Pair
Affinity DataEC50: 2.19E+3nMAssay Description:Agonist activity at recombinant GluA2 receptor flop isoform expressed in Xenopus oocytes co-expressing gamma2-TARPMore data for this Ligand-Target Pair
Affinity DataEC50: 3.66E+3nMAssay Description:Agonist activity at recombinant GluA3 receptor flop isoform expressed in Xenopus oocytes co-expressing gamma2-TARPMore data for this Ligand-Target Pair
Affinity DataEC50: 5.10E+4nMAssay Description:Agonist activity at rat recombinant GluA1 receptor flip isoform expressed in HEK293 cells assessed as effect on cyclothiazide-induced calcium flux by...More data for this Ligand-Target Pair
Affinity DataEC50: 1.90E+5nMAssay Description:Agonist activity at rat recombinant GluA2 receptor flip isoform expressed in HEK293 cells assessed as effect on cyclothiazide-induced calcium flux by...More data for this Ligand-Target Pair
Affinity DataEC50: 5.20E+4nMAssay Description:Agonist activity at rat recombinant GluA3 receptor flip isoform expressed in HEK293 cells assessed as effect on cyclothiazide-induced calcium flux by...More data for this Ligand-Target Pair