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PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Trifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
Wayne State University School Of Medicine

Curated by ChEMBL

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 30nMAssay Description:Inhibition of GARFTase in human KB cells assessed as inhibition of incorporation of [14C]glycine into [14C]formyl GAR after 30 mins in presence of az...More data for this Ligand-Target Pair

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Bifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 430nMAssay Description:DHFRs were assayed spectrophotometrically in the reaction buffer solution containing dihydrofolate. The reaction was initiated with an amount of enzy...More data for this Ligand-Target Pair

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Bifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

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Bifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 430nMAssay Description:Inhibition of Toxoplasma gondii DHFR by spectrophotometryMore data for this Ligand-Target Pair

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Bifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 430nMAssay Description:Inhibition of Toxoplasma gondii thymidylate synthaseMore data for this Ligand-Target Pair

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Bifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 460nMpH: 7.4Assay Description:Inhibition of Toxoplasma gondii DHFR at 30 degC under pH 7.4 by spectrophotometryMore data for this Ligand-Target Pair

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Bifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 460nMpH: 7.4 T: 2°CAssay Description:DHFRs were assayed spectrophotometrically in the reaction buffer solution containing dihydrofolate. The reaction was initiated with an amount of enzy...More data for this Ligand-Target Pair

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Bifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 460nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/TrEMBL
DrugBank GoogleScholar

Thymidylate synthase(Escherichia coli)
Duquesne University

Curated by ChEMBL

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 1.10E+3nMAssay Description:Inhibitory activity against Escherichia coli thymidylate synthaseMore data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Dihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 1.40E+3nMAssay Description:Inhibitory concentration against isolated Toxoplasma gondii DHFR (dihydrofolate reductase)More data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Dihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 1.40E+3nMAssay Description:Compound was evaluated as inhibitor of human Dihydrofolate reductaseMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Dihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 1.50E+3nMAssay Description:Inhibition of human dihydrofolate reductaseMore data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Dihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 1.50E+3nMpH: 7.4 T: 2°CAssay Description:DHFRs were assayed spectrophotometrically in the reaction buffer solution containing dihydrofolate. The reaction was initiated with an amount of enzy...More data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Dihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 2.30E+3nMAssay Description:Inhibitory activity against human dihydrofolate reductaseMore data for this Ligand-Target Pair

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MMDB NCI pathway Reactome pathway KEGG
UniProtKB/TrEMBL
B.MOAD GoogleScholar

Dihydrofolate reductase(Escherichia coli)
Duquesne University

Curated by ChEMBL

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 2.30E+3nMAssay Description:Inhibitory activity against recombinant Escherichia coli dihydrofolate reductaseMore data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Dihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 2.30E+3nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Dihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 2.30E+3nMAssay Description:Inhibitory concentration against isolated Lactobacillus casei Dihydrofolate reductaseMore data for this Ligand-Target Pair

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Bifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 2.30E+3nMAssay Description:Inhibitory activity against Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Dihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 2.30E+3nMpH: 7.4Assay Description:Inhibition of human dihydrofolate reductase at 37 degree C pH 7.4More data for this Ligand-Target Pair

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Bifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 2.80E+3nMAssay Description:Inhibition of Toxoplasma gondii TS assessed as oxidation of tetrahydrofolate to dihydrofolate after 2 to 12 mins by spectrophotometryMore data for this Ligand-Target Pair

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Bifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 2.80E+3nMAssay Description:Inhibition of Toxoplasma gondii thymidylate synthaseMore data for this Ligand-Target Pair

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Bifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 2.80E+3nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair

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Bifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

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Bifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 2.80E+3nMAssay Description:Inhibition of Toxoplasma gondii thymidylate synthaseMore data for this Ligand-Target Pair

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Bifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

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Bifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 2.80E+3nMpH: 7.4Assay Description:Inhibition of Toxoplasma gondii TS at 30 degC under pH 7.4 by spectrophotometryMore data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Thymidylate synthase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 5.70E+3nMAssay Description:Inhibitory activity against recombinant Pneumocystis carinii TSMore data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Thymidylate synthase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 5.70E+3nMAssay Description:Inhibitory activity against human thymidylate synthaseMore data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Dihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 6.60E+3nMAssay Description:Inhibitory concentration against isolated human Dihydrofolate reductaseMore data for this Ligand-Target Pair

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Dihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 6.60E+3nMAssay Description:Inhibition of human DHFR by spectrophotometryMore data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Dihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 6.60E+3nMAssay Description:DHFRs were assayed spectrophotometrically in the reaction buffer solution containing dihydrofolate. The reaction was initiated with an amount of enzy...More data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
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Dihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

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UniProtKB/SwissProt
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Dihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 6.60E+3nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Dihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 6.60E+3nMpH: 7.4Assay Description:Inhibition of human DHFR at 30 degC under pH 7.4 by spectrophotometryMore data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Dihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 6.60E+3nMAssay Description:Inhibition of human DHFRMore data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Thymidylate synthase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 9.50E+3nMAssay Description:Inhibition of human thymidylate synthase by spectrophotometric analysisMore data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Thymidylate synthase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 9.50E+3nMAssay Description:Inhibitory concentration against human thymidylate synthaseMore data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Thymidylate synthase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 9.50E+3nMAssay Description:Inhibition of human thymidylate synthaseMore data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Thymidylate synthase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 9.50E+3nMpH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Thymidylate synthase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 9.50E+3nMAssay Description:Inhibition of human thymidylate synthaseMore data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Thymidylate synthase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 9.50E+3nMAssay Description:Inhibition of human thymidylate synthaseMore data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Thymidylate synthase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Thymidylate synthase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 9.50E+3nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Thymidylate synthase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 9.50E+3nMpH: 7.4Assay Description:Inhibition of human thymidylate synthase at 30 degC under pH 7.4 by spectrophotometryMore data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Thymidylate synthase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 9.50E+3nMAssay Description:Inhibition of human TS assessed as oxidation of tetrahydrofolate to dihydrofolate after 2 to 12 mins by spectrophotometryMore data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
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Thymidylate synthase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 1.10E+4nMAssay Description:Compound was evaluated as inhibitor of human thymidylate synthaseMore data for this Ligand-Target Pair

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Bifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 1.40E+4nMAssay Description:Inhibition of Toxoplasma gondii thymidylate synthaseMore data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Thymidylate synthase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 1.90E+4nMAssay Description:Inhibition of human recombinant thymidylate synthaseMore data for this Ligand-Target Pair

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PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Thymidylate synthase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

BDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)

IC50: 1.90E+4nMpH: 7.4Assay Description:Inhibition of human thymidylate synthetase at 37 degree C pH 7.4More data for this Ligand-Target Pair

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