Compile Data Set for Download or QSAR
maximum 50k data
Found 17 of ec50 for monomerid = 19459
TargetEstrogen receptor beta(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM19459(5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataIC50:  61nM EC50:  73nMAssay Description:Ligand binding was determined using a scintillation proximity assay with streptavidin-coated SPA beads (Amersham) and biotinylated receptor. Receptor...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM19459(5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataIC50:  200nM EC50:  4.10nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM19459(5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataIC50:  1.97E+3nM EC50:  956nMAssay Description:Ligand binding was determined using a scintillation proximity assay with streptavidin-coated SPA beads (Amersham) and biotinylated receptor. Receptor...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM19459(5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataIC50:  3.92E+3nM EC50:  48nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM19459(5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataEC50:  1.42E+4nMAssay Description:Potentiation of wild-type CFTR (unknown origin) expressed in FRT cells assessed as chloride transport by measuring membrane potential in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM19459(5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataEC50:  28nMAssay Description:Agonist activity at human ERbeta expressed in yeast AH109 by yeast two hybrid assayMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM19459(5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataEC50:  200nMAssay Description:Ability to activate estrogen receptor 2-mediated transcription.More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM19459(5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataEC50:  2.40nMAssay Description:Estrogenic activity at ERbeta (unknown origin) expressed in human MDA-MB-231/beta41 cells after 18 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM19459(5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataEC50:  240nMAssay Description:Estrogenic activity at ERalpha in human Ishikawa cells assessed as induction of alkaline phosphatase activity using p-nitrophenol as substrate treate...More data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM19459(5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataEC50:  8.20E+3nMAssay Description:Potentiation of CFTR F508del mutant (unknown origin) expressed in CHO cells assessed as chloride transport by measuring membrane potential preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM19459(5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataEC50:  8.48E+3nMAssay Description:Potentiation of CFTR F508del mutant (unknown origin) expressed in CHO cells assessed as chloride transport by measuring membrane potential incubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM19459(5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataEC50:  6.17E+3nMAssay Description:Potentiation of CFTR F508del mutant (unknown origin) expressed in FRT cells assessed as chloride transport by measuring membrane potential in presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM19459(5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataEC50:  950nMAssay Description:Ability to activate estrogen receptor 1-mediated transcription.More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM19459(5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataEC50:  20nMAssay Description:Transcriptional potency (EC50) at Human estrogen receptor alphaMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM19459(5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataEC50:  6nMAssay Description:Transcriptional potency (EC50) at Human estrogen receptor BetaMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM19459(5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataEC50: >3.00E+5nMAssay Description:Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetEstrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM19459(5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataEC50:  810nMAssay Description:Agonist activity at human ERalpha expressed in yeast AH109 by yeast two hybrid assayMore data for this Ligand-Target Pair