BindingDB PrimarySearch

Found 12 of ic50 for monomerid = 25084

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM25084(3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]ph...)

IC50: 83nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM25084(3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]ph...)

IC50: 83nMpH: 7.4 T: 2°CAssay Description:The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM25084(3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]ph...)

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM25084(3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]ph...)

IC50: 235nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Targegen

BDBM25084(3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]ph...)

IC50: 235nMpH: 7.4 T: 2°CAssay Description:The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

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Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Targegen

BDBM25084(3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]ph...)

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

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Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Targegen

BDBM25084(3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]ph...)

IC50: 1.20E+3nMpH: 7.4 T: 2°CAssay Description:The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Targegen

BDBM25084(3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]ph...)

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM25084(3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]ph...)

IC50: 1.20E+3nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM25084(3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]ph...)

IC50: 1.30E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Targegen

BDBM25084(3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]ph...)

IC50: 1.30E+3nMpH: 7.4 T: 2°CAssay Description:The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

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Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Targegen

BDBM25084(3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]ph...)

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar

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Filter my 12 hits

Targets 7▿
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 3
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform 2
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform 2
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 2
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 1
Publications 3▿
- J Med Chem 50: 4279-94 (2007) 4
- Proc Natl Acad Sci U S A 103: 19866-71 (2006) 4
- Eur J Med Chem 163: 413-427 (2019) 4
Institutions 2▿
- Targegen 8
- China Pharmaceutical University 4
Affinity: 83 to 1.3E+3 nM▿
- IC50 12
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1