TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Chung-Ang University
Curated by ChEMBL
Chung-Ang University
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Antagonist activity at recombinant human N-terminal His6-tagged FMS (538 to end residues) expressed in baculovirus infected Sf21 insect cells using I...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Chung-Ang University
Curated by ChEMBL
Chung-Ang University
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of N-terminal GST-tagged CSF1R (unknown origin) (547 to 980 residues) expressed in baculovirus infected Sf9 cells using biotin-EAIYAPFAKKK...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Chung-Ang University
Curated by ChEMBL
Chung-Ang University
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant human GST-tagged CFMS kinase catalytic domain using biotin-EAIYAPFAKKK-NH2 as substrate after 40 mins by NXT scintillation ...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Chung-Ang University
Curated by ChEMBL
Chung-Ang University
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Chung-Ang University
Curated by ChEMBL
Chung-Ang University
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of cFMSChecked by AuthorMore data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Chung-Ang University
Curated by ChEMBL
Chung-Ang University
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of human CSF1R catalytic domain by ATP-based kinase assayMore data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Chung-Ang University
Curated by ChEMBL
Chung-Ang University
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Chung-Ang University
Curated by ChEMBL
Chung-Ang University
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of CSF1R in human monocytes assessed as inhibition of IL34-stimulated MCP releaseMore data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Chung-Ang University
Curated by ChEMBL
Chung-Ang University
Curated by ChEMBL
Affinity DataIC50: 148nMAssay Description:Inhibition of CSF1R in human monocytes assessed as inhibition of CSF1-stimulated MCP releaseMore data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
Chung-Ang University
Curated by ChEMBL
Chung-Ang University
Curated by ChEMBL
Affinity DataIC50: 392nMAssay Description:Inhibition of CSF1R in mouse MNFS-60 cells assessed as reduction in CSF-induced cell viability after 48 hrs by Ez-cytox reagent based assayMore data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Chung-Ang University
Curated by ChEMBL
Chung-Ang University
Curated by ChEMBL
Affinity DataIC50: 470nMAssay Description:Inhibition of CSF1R in human monocytesMore data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Chung-Ang University
Curated by ChEMBL
Chung-Ang University
Curated by ChEMBL
Affinity DataIC50: 470nMAssay Description:Binding affinity to CSF1R (unknown origin)More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
University Of Arkansas For Medical Sciences
Curated by ChEMBL
University Of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 880nMAssay Description:Inhibition of TRKA (unknown origin) by ATP site-dependent competition binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: >4.80E+3nMAssay Description:Inhibition of recombinant human His-tagged B-RAF after 60 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human GST-tagged ERK2 after 60 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human PDGFR-1bMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human His-tagged MK2 using K(biotin)KLNRTLSVA as substrate after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mouse LCKMore data for this Ligand-Target Pair
Affinity DataIC50: >1.30E+4nMAssay Description:Inhibition of human JAK2 catalytic domain after by scintillation countingMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: >1.30E+4nMAssay Description:Inhibition of human FLT3 catalytic domain after by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: >1.30E+4nMAssay Description:Inhibition of human PKCb1 catalytic domain after by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: >1.30E+4nMAssay Description:Inhibition of human PKCa catalytic domain after by scintillation countingMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: >1.30E+4nMAssay Description:Inhibition of human cKIT catalytic domain after by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibition of human SYKMore data for this Ligand-Target Pair
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibition of human JNK3More data for this Ligand-Target Pair
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibition of human ITKMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibition of human GST-tagged c-SRC autophosphorylation using biotin-(6-amino caproic acid)-AAAQQIYGQ-NH2 as substrate after 40 mins by homogenous t...More data for this Ligand-Target Pair
Affinity DataIC50: >1.90E+4nMAssay Description:Inhibition of recombinant human GST-tagged CDK4 catalytic domain after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human GST-tagged VEGFR2 catalytic domain using biotin-aminohexyl-EEEEYFELVAKKKK-NH2 as substrate after 40 mins by homogenous time-resol...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human GST-tagged Tie2 using biotin-(6-amino caproic acid)-LEARLVAYEGWVAGKKK-NH2 after 2 hrs by homogenous time-resolved fluorescence me...More data for this Ligand-Target Pair
Affinity DataIC50: >2.40E+4nMAssay Description:Inhibition of human His-tagged PKCz using biotin-(amino hexanoic acid)-FKLKRKGSFKKFA-CONH2 as substrate after 40 mins by scintillation proximity assa...More data for this Ligand-Target Pair
Affinity DataIC50: >2.40E+4nMAssay Description:Inhibition of human His-tagged EGFR using biotin-amino hexanoic acid-RAHEEIYHFFFAKKK-NH2 as substrate after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: >2.40E+4nMAssay Description:Inhibition of human His-tagged ERBB2 using biotin-amino hexanoic acid-RAHEEIYHFFFAKKK-NH2 as substrate after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: >2.40E+4nMAssay Description:Inhibition of human GST-tagged PLK1 using biotin-amino hexanoic acid-SFNDTLDFD-NH2 as substrate after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: >2.40E+4nMAssay Description:Inhibition of human His-tagged ERBB4 using biotin-amino hexanoic acid-RAHEEIYHFFFAKKK-NH2 as substrate after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: >2.80E+4nMAssay Description:Inhibition of human His-tagged PDHK4 using biotin-YHGHSMSDPGVSYRRR-amide as substrate after 20 mins by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: >3.20E+4nMAssay Description:Inhibition of human His-tagged GSK-3b using biotin-6-amino caproic acid-AAAKRREILSRRPS(PO3)YR-amide as substrate after 19 mins by NXT scintillation c...More data for this Ligand-Target Pair