Found 58 of ic50 for monomerid = 35229 
Affinity DataIC50: 0.25nMAssay Description:Compound was tested for its inhibitory activity against Alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Compound tested for its inhibitory activity against Histamine H1 receptorMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Medical And Pharmaceutical Industry Technology And Development Center
Curated by ChEMBL
Medical And Pharmaceutical Industry Technology And Development Center
Curated by ChEMBL
Affinity DataIC50: 0.930nMAssay Description:Displacement of [125I]RTI-55 from human NET expressed in MDCK cell membraneMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Medical And Pharmaceutical Industry Technology And Development Center
Curated by ChEMBL
Medical And Pharmaceutical Industry Technology And Development Center
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Displacement of [3H]Nisoxetine from human recombinant NET over-expressed in dog MDCK cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Compound was tested for its ability to inhibit the neurotransmitter serotonin-5-HT reuptake system using [3H]5-HT as radioligandMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Medical And Pharmaceutical Industry Technology And Development Center
Curated by ChEMBL
Medical And Pharmaceutical Industry Technology And Development Center
Curated by ChEMBL
Affinity DataIC50: 3.30nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Medical And Pharmaceutical Industry Technology And Development Center
Curated by ChEMBL
Medical And Pharmaceutical Industry Technology And Development Center
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Medical And Pharmaceutical Industry Technology And Development Center
Curated by ChEMBL
Medical And Pharmaceutical Industry Technology And Development Center
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Inhibition of norepinephrine reuptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Medical And Pharmaceutical Industry Technology And Development Center
Curated by ChEMBL
Medical And Pharmaceutical Industry Technology And Development Center
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Medical And Pharmaceutical Industry Technology And Development Center
Curated by ChEMBL
Medical And Pharmaceutical Industry Technology And Development Center
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human NET transfected in MDCK-Net6 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Medical And Pharmaceutical Industry Technology And Development Center
Curated by ChEMBL
Medical And Pharmaceutical Industry Technology And Development Center
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cells assessed as inhibition of norepinephrine uptakeMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Medical And Pharmaceutical Industry Technology And Development Center
Curated by ChEMBL
Medical And Pharmaceutical Industry Technology And Development Center
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Inhibition of [3H]norepinephrine uptake at human NET expressed in MDCK-Net6 cells by scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Medical And Pharmaceutical Industry Technology And Development Center
Curated by ChEMBL
Medical And Pharmaceutical Industry Technology And Development Center
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Medical And Pharmaceutical Industry Technology And Development Center
Curated by ChEMBL
Medical And Pharmaceutical Industry Technology And Development Center
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Inhibition of norepinephrine uptake at human norepinephrine transporter expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Medical And Pharmaceutical Industry Technology And Development Center
Curated by ChEMBL
Medical And Pharmaceutical Industry Technology And Development Center
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Medical And Pharmaceutical Industry Technology And Development Center
Curated by ChEMBL
Medical And Pharmaceutical Industry Technology And Development Center
Curated by ChEMBL
Affinity DataIC50: 3.90nMAssay Description:Inhibition of norepinephrine transporter (unknown origin)More data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Medical And Pharmaceutical Industry Technology And Development Center
Curated by ChEMBL
Medical And Pharmaceutical Industry Technology And Development Center
Curated by ChEMBL
Affinity DataIC50: 3.90nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in MDCK cellsMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Medical And Pharmaceutical Industry Technology And Development Center
Curated by ChEMBL
Medical And Pharmaceutical Industry Technology And Development Center
Curated by ChEMBL
Affinity DataIC50: 4.20nMAssay Description:Inhibition of [3H]norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Veterans Affairs Medical Center
Curated by ChEMBL
Veterans Affairs Medical Center
Curated by ChEMBL
Affinity DataIC50: 64nMAssay Description:Inhibition of [3H]5HT uptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:In vitro inhibition of accumulation of (-)-[3H]-Norepinephrine (NA) in mouse brain slicesMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Veterans Affairs Medical Center
Curated by ChEMBL
Veterans Affairs Medical Center
Curated by ChEMBL
Affinity DataIC50: 108nMAssay Description:Inhibition of [3H]serotonin uptake in human wild type SERT transfected HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of binding of [3H]imipramine to imipramine receptor in rat brainMore data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Veterans Affairs Medical Center
Curated by ChEMBL
Veterans Affairs Medical Center
Curated by ChEMBL
Affinity DataIC50: 560nMAssay Description:Inhibition of human SERT expressed in HEK293-MSR cells by 5-HT uptake assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by ChEMBL
F. Hoffmann-La Roche
Curated by ChEMBL
Affinity DataIC50: 1.38E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by ChEMBL
F. Hoffmann-La Roche
Curated by ChEMBL
Affinity DataIC50: 1.38E+3nMAssay Description:Inhibitory concentration against potassium channel HERGMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by ChEMBL
F. Hoffmann-La Roche
Curated by ChEMBL
Affinity DataIC50: 1.38E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by ChEMBL
F. Hoffmann-La Roche
Curated by ChEMBL
Affinity DataIC50: 1.39E+3nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by ChEMBL
F. Hoffmann-La Roche
Curated by ChEMBL
Affinity DataIC50: 1.39E+3nMAssay Description:Inhibition of hERG K channelMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by ChEMBL
F. Hoffmann-La Roche
Curated by ChEMBL
Affinity DataIC50: 1.51E+3nMAssay Description:Inhibition of human Potassium channel HERG expressed in mammalian cellsMore data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataIC50: 1.52E+3nMAssay Description:Inhibition of sodium current measured using whole-cell patch clamp experiments in HEK-293 cells stably transfected with hNaV1.5 cDNAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of noradrenaline transporter in NMRI albino mouse brain assessed as [3H]NA accumulation in hypothalamus after 5 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of neuronal uptake of Noradrenaline in rat brain homogenateMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Cavia porcellus)
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataIC50: 1.71E+3nMAssay Description:Inhibition of calcium current (ICaL) measured using whole-cell patch clamp experiments in isolated guinea pig ventricular myocytesMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Cavia porcellus)
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataIC50: 1.71E+3nMAssay Description:Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomesMore data for this Ligand-Target Pair
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Universidad De Valencia
Curated by ChEMBL
Universidad De Valencia
Curated by ChEMBL
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibitory activity against brain adenylate cyclase Histamine H2 receptorMore data for this Ligand-Target Pair
TargetSolute carrier family 22 member 1(Homo sapiens (Human))
University Of California
Curated by ChEMBL
University Of California
Curated by ChEMBL
Affinity DataIC50: 9.18E+3nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.30E+3nMAssay Description:Inhibition of 5-HT transporter in NMRI albino mouse brain assessed as [3H]5-HT accumulation in hypothalamus after 5 minsMore data for this Ligand-Target Pair
TargetSolute carrier family 22 member 2(RAT)
Institute Of Anatomy Of The Bayerische Julius-Maximilians-Universit£T
Curated by ChEMBL
Institute Of Anatomy Of The Bayerische Julius-Maximilians-Universit£T
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytesMore data for this Ligand-Target Pair
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of endogenous human CaV2.2 in human SH-SY5Y cells in presence of nifedipine by Calcium 4 dye based calcium influx fluorescence-imaging ass...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Jagiellonian University
Curated by ChEMBL
Jagiellonian University
Curated by ChEMBL
Affinity DataIC50: 1.17E+4nMAssay Description:Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMAssay Description:In vitro inhibition of accumulation of [14C]-5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by ChEMBL
F. Hoffmann-La Roche
Curated by ChEMBL
Affinity DataIC50: 1.30E+4nMAssay Description:HERG: The pre- and post-compound hERG current was evoked by a single voltage pulse consisting of a 20 s period holding at −70 mV, a 160 ms step...More data for this Ligand-Target Pair
TargetSolute carrier family 22 member 1(RAT)
Institute Of Anatomy Of The Bayerische Julius-Maximilians-Universit£T
Curated by ChEMBL
Institute Of Anatomy Of The Bayerische Julius-Maximilians-Universit£T
Curated by ChEMBL
Affinity DataIC50: 1.75E+4nMAssay Description:TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytesMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
New York University School Of Medicine
Curated by ChEMBL
New York University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 4.79E+4nMAssay Description:Inhibition of [3H]dopamine uptake in human wild type DAT transfected HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS methodMore data for this Ligand-Target Pair
TargetSolute carrier family 22 member 1(Homo sapiens (Human))
University Of California
Curated by ChEMBL
University Of California
Curated by ChEMBL
Affinity DataIC50: 5.68E+4nMAssay Description:Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopyMore data for this Ligand-Target Pair
TargetSolute carrier family 22 member 3(Rattus norvegicus)
Medical College Of Georgia
Curated by ChEMBL
Medical College Of Georgia
Curated by ChEMBL
Affinity DataIC50: 6.80E+4nMAssay Description:TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 1 uM) in OCT3-expressing HRPE cellsMore data for this Ligand-Target Pair
