Found 137 of ic50 for monomerid = 50000541 TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant 5-LOX assessed as reduction in leukotriene B4 synthesis using arachidonic acid substrate by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of 5-Lipoxygenase of rat basophilic leukemia cellsMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of human 5-Lipoxygenase using H2DCFDA as substrate preincubated for 5 mins and measured by Spectrophotometric assayMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of human 5-lipoxygenase using arachidonic acid as substrate pretreated for 10 mins followed by substrate and ATP addition and measured aft...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 180nMpH: 7.4 T: 2°CAssay Description:5-LOX enzyme assay was carried out with some modifications of ferric oxidation of xylenol orange (FOX) assay, which is based on the complex formation...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Sookmyung Women'S University
Curated by ChEMBL
Sookmyung Women'S University
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of 5-LO in mouse BMM cells assessed as formation of LTC4 after 30 mins by enzyme immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Compound was tested for its inhibitory activity against 5-lipoxygenase in rat.More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of 5-LOX (unknown origin) using arachidonic acid as substrate after 5 mins by EIAMore data for this Ligand-Target Pair
Affinity DataIC50: 320nMAssay Description:The compound was tested for its inhibitory activity against arachidonic acid in rat 5-lipoxygenaseMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 320nMAssay Description:Inhibition of calcium ionophore (A-23187)-stimulated LTB4 formation in human neutrophil assayMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 350nMAssay Description:Inhibition of human recombinant 5-LOX assessed as reduction in leukotriene B4 production pre-incubated for 10 mins before arachidonic acid addition a...More data for this Ligand-Target Pair
Affinity DataIC50: 370nMAssay Description:In vitro inhibition of 5-lipoxygenase (5-HETE) derived from the 9000xg supernatant of RBL broken cell assayMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:Inhibition of human recombinant 5-LO expressed in Escherichia coli by cell-free assayMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Universidad De Chile
Curated by ChEMBL
Universidad De Chile
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:Binding affinity towards human peroxisome proliferator activated receptor gamma (PPAR gamma) was determined by HTRF assayMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 410nMAssay Description:Inhibition of 5-LOX (unknown origin)-mediated leukotriene (LT)B4 biosynthesisMore data for this Ligand-Target Pair
Affinity DataIC50: 420nMAssay Description:In vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophilsMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibitory activity against 5-lipoxygenase catalysis (5-LO) in sonicated rat basophilic leukemia cell lysateMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibitory activity against 5-lipoxygenase obtained from rat basophilic leukemia cellsMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of 5-lipoxygenaseMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:The compound was tested for inhibitory activity against 5-Lipoxygenase in rat RBL-1More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE productionMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of 5-LOX in stimulated leukocytesMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of 5-lipooxygenase in cell free S100 freshly isolated human PMNL cells assessed as inhibition of A23187-stimulated 5-LO product formation ...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of 5-lipooxygenase in human polynuclear leukocytes assessed as inhibition of A23187-stimulated 5-LO product formation preincubated for 15 ...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of recombinant human 5-lipoxygenase expressed in Escherichia coli BL21 (DE3) cells using arachidonic acid as substrate preincubated for 10...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of recombinant human 5-lipoxygenase expressed in Escherichia coli BL21 (DE3) cells using arachidonic acid as substrate preincubated for 10...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 518nMAssay Description:Inhibitory concentration against human 5-lipoxygenaseMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 521nMAssay Description:Inhibition of 5-LO in human PMNL cells assessed as reduction in LTB4, 5-H(P)ETE, 12-HETE and 15-HETE products formation using arachidonic acid as sub...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 540nMAssay Description:Inhibition of 5-LOX in human neutrophils assessed as reduction in LTB4 and 5-H(P)ETE) formation pre-incubated for 15 mins before A23187 and arachidon...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 560nMAssay Description:Inhibition of human recombinant 5-LO expressed in Escherichia coli BL21 using arachidonic acid as substrate after 10 minsMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 560nMAssay Description:Inhibition of 5-LO (unknown origin)More data for this Ligand-Target Pair
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Gazi University
Curated by ChEMBL
Gazi University
Curated by ChEMBL
Affinity DataIC50: 580nMAssay Description:Inhibition of FLAP in Ca+2 ionophore A23187 stimulated human neutrophils assessed as 5-LO product formation preincubated for 15 mins measured after 1...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 590nMAssay Description:Inhibition of human 5-LOX using arachidonic acid as substrate measured after 10 mins by ELISAMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 590nMAssay Description:Inhibition of human 5-LOX using arachidonic acid as substrate measured after 10 mins by ELISAMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 590nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 incubated for 10 mins in presence of arachidonic acid by RP-HPLC based cell-...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Goethe-University Frankfurt
Curated by ChEMBL
Goethe-University Frankfurt
Curated by ChEMBL
Affinity DataIC50: 591nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase expressed in Escherichia coli using 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methylester-2-o...More data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:In vitro inhibition of 5-lipoxygenase (5-lo) from the 20000 g supernatant of RBI-1 cellsMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of human recombinant 5-LO assessed as product formation by cell-free assay relative to controlMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of human recombinant 5-LO expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 5 to 10 mins by HPLC ana...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of human recombinant 5-lipoxygenase expressed in Escherichia coli BL21 using arachidonic acid as substrate incubated 5 to 10 mins prior to...More data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of mPGES-1 isolated from microsomes of interleukin-1 beta-stimulated human A549 cells using PGH2 as substrate preincubated for 15 mins fol...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of 5-Lipoxygenase (unknown origin)More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 630nMAssay Description:Inhibition of recombinant human 5LOX expressed in baculovirus infected Sf insect cells using linoleic acid as substrate preincubated for 5 mins follo...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 660nMAssay Description:Inhibition of human recombinant 5-LOX assessed as reduction in LTB4 level using 800 uM arachidonic acid as substrate preincubated with enzyme for 10 ...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:Inhibition of 5-LO in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production from arachidonic acid preincubated for 15 mins by ...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:Inhibition of 5-lipoxygenase in human whole bloodMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:Inhibition of 5-lipoxygenase in human whole blood assessed as inhibition of LTB4 production by HPLC methodMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 740nMAssay Description:Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Czech Academy Of Sciences
Curated by ChEMBL
Czech Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 740nMAssay Description:5-lipoxygenase Inhibitory activity was measured by enzyme immunoassay using human whole blood stimulated with calcium ionophore (A23187) and LTB4 (le...More data for this Ligand-Target Pair
