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Found 12 of ic50 for monomerid = 50034043
TargetAlpha-2A adrenergic receptor [16-465](Rattus norvegicus (rat))
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)
Affinity DataIC50:  0.400nMAssay Description:Binding affinity against Alpha-1 adrenergic receptor was determined using [3H]WB-4101 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(BOVINE)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)
Affinity DataIC50:  9nMAssay Description:Binding affinity against 5-hydroxytryptamine 2 receptor was determined using [ [3H]spiperone radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)
Affinity DataIC50:  64nMAssay Description:Binding affinity against sigma receptor using [3H]-( +)-SKF10,047 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)
Affinity DataIC50:  110nMAssay Description:Affinity for dopamine receptor D2 binding sites by its ability to displace [3H]spiperone from rat striatum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)
Affinity DataIC50:  110nMAssay Description:Binding affinity against Dopamine receptor D2 was determined using [ [3H]-spiperone radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1A(Mus musculus (Mouse))
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)
Affinity DataIC50:  210nMAssay Description:Binding affinity against 5-hydroxytryptamine 1A receptor was determined using [3H]-8-OH-DPAT radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Mus musculus (Mouse))
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)
Affinity DataIC50:  750nMAssay Description:Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(RAT)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)
Affinity DataIC50: >1.00E+3nMAssay Description:Binding affinity against Muscarinic acetylcholine receptor using [3H]quinuclidinyl benzilateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)
Affinity DataIC50:  2.34E+4nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed