Affinity DataKi: 0.0800nMAssay Description:Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.0823nMAssay Description:Binding affinity against human Melatonin receptor type 1A (MT1)More data for this Ligand-Target Pair
TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Takeda Chemical Industries
Curated by ChEMBL
Takeda Chemical Industries
Curated by ChEMBL
Affinity DataKi: 0.0823nMAssay Description:Ability to inhibit 2-[125I]iodomelatonin specific binding to human melatonin receptor type 1A (MT1) expressed in CHO cells.More data for this Ligand-Target Pair
Affinity DataKi: 0.0910nMAssay Description:Displacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectr...More data for this Ligand-Target Pair
Affinity DataKi: 0.0910nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Takeda Chemical Industries
Curated by ChEMBL
Takeda Chemical Industries
Curated by ChEMBL
Affinity DataKi: 0.0915nMAssay Description:Inhibition of Vascular endothelial growth factor receptor 2 (KDR)More data for this Ligand-Target Pair
Affinity DataKi: 0.120nMAssay Description:Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.120nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsMore data for this Ligand-Target Pair
Affinity DataKi: 0.120nMAssay Description:Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.120nMAssay Description:Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]-iodomelatonin as radioliga...More data for this Ligand-Target Pair
Affinity DataKi: 0.120nMAssay Description:Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.130nMAssay Description:Displacement of [125l]-lodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.130nMAssay Description:Binding affinity of the compound against human Melatonin receptor type 1A by displacement of [125I]-iodomelatonin stably expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.140nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.140nMAssay Description:Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]-iodomelatonin as ra...More data for this Ligand-Target Pair
TargetMelatonin receptor type 1A/1B(Homo sapiens (Human))
Takeda Chemical Industries
Curated by ChEMBL
Takeda Chemical Industries
Curated by ChEMBL
Affinity DataKi: 0.140nMAssay Description:Displacement of [125L]iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.140nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.141nMAssay Description:Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.150nMAssay Description:Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 minsMore data for this Ligand-Target Pair
Affinity DataKi: 0.150nMAssay Description:Displacement of 2-[125I]iodomelatonin from human recombinant MT2 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectr...More data for this Ligand-Target Pair
Affinity DataKi: 0.166nMAssay Description:Binding Affinity (pKi) towards human Melatonin receptor type 1AMore data for this Ligand-Target Pair
Affinity DataKi: 0.174nMAssay Description:Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radi...More data for this Ligand-Target Pair
Affinity DataKi: 0.176nMAssay Description:Effect of compound on Melatonin receptor in chicken brain in the presence of MnCl2More data for this Ligand-Target Pair
Affinity DataKi: 0.180nMAssay Description:Binding affinity to MT2 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 0.180nMAssay Description:Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.180nMAssay Description:Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 0.195nMAssay Description:Binding affinity against human Melatonin receptor type 1B (MT2)More data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Displacement of 2-[125I]-Iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Binding affinity for human melatonin receptor type 1A, expressed in HEK-293 cells (2-[125I]-Iodomelatonin is used as radioligand)More data for this Ligand-Target Pair
Affinity DataKi: 0.204nMAssay Description:Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation a...More data for this Ligand-Target Pair
Affinity DataKi: 0.204nMAssay Description:Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation an...More data for this Ligand-Target Pair
Affinity DataKi: 0.210nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.210nMAssay Description:Displacement of [125I]-2-iodomelatonin from human MT2 receptor expressed on CHO cells microscintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.210nMAssay Description:Displacement of 2-[125l]-lodomelatonin from human MT2 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.220nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.230nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsMore data for this Ligand-Target Pair
Affinity DataKi: 0.230nMAssay Description:Binding affinity of the compound against human Melatonin receptor type 1B by displacement of [125I]-iodomelatonin stably expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.240nMAssay Description:Displacement of 2-[125I]iodomelatonin from human cloned MT2 receptor expressed in rat NIH3T3 cellsMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(GUINEA PIG)
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Glaxo Wellcome Research And Development
Curated by PDSP Ki Database
Affinity DataKi: 0.240nMAssay Description:Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.240nMAssay Description:Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.240nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair