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Compile Data Set for Download or QSAR

Found 6 hits of affinity data for UniProtKB/TrEMBL: Q9HD89   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Resistin


(Human)
BDBM486503
PNG
(US10947241, Example 46)
Show SMILES CNC1CCN(C1)c1nnc(-c2ccc(Cl)cc2)c2ccccc12
Show InChI InChI=1S/C19H19ClN4/c1-21-15-10-11-24(12-15)19-17-5-3-2-4-16(17)18(22-23-19)13-6-8-14(20)9-7-13/h2-9,15,21H,10-12H2,1H3
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Seoul National University Hospital

US Patent


Assay Description
Using THP-1 (human monocyte) cell line and ELISA system, the abilities to inhibit TNF-α secretion by hResistin (IC50) were evaluated for the com...


US Patent US10947241 (2021)

More data for this
Ligand-Target Pair
Resistin


(Human)
BDBM486516
PNG
(US10947241, Example 91)
Show SMILES CNC1CCN(C1)c1nnc(-c2ccc(Cl)cc2)c2cc(F)ccc12
Show InChI InChI=1S/C19H18ClFN4/c1-22-15-8-9-25(11-15)19-16-7-6-14(21)10-17(16)18(23-24-19)12-2-4-13(20)5-3-12/h2-7,10,15,22H,8-9,11H2,1H3
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 600n/an/an/an/an/an/a



Seoul National University Hospital

US Patent


Assay Description
Using THP-1 (human monocyte) cell line and ELISA system, the abilities to inhibit TNF-α secretion by hResistin (IC50) were evaluated for the com...


US Patent US10947241 (2021)

More data for this
Ligand-Target Pair
Resistin


(Human)
BDBM486504
PNG
(US10947241, Example 47)
Show SMILES CC(C)[C@H](N)C(=O)N1CCN(CC1)c1nnc(-c2ccc(Cl)cc2)c2ccccc12
Show InChI InChI=1S/C23H26ClN5O/c1-15(2)20(25)23(30)29-13-11-28(12-14-29)22-19-6-4-3-5-18(19)21(26-27-22)16-7-9-17(24)10-8-16/h3-10,15,20H,11-14,25H2,1-2H3/t20-/m0/s1
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 700n/an/an/an/an/an/a



Seoul National University Hospital

US Patent


Assay Description
Using THP-1 (human monocyte) cell line and ELISA system, the abilities to inhibit TNF-α secretion by hResistin (IC50) were evaluated for the com...


US Patent US10947241 (2021)

More data for this
Ligand-Target Pair
Resistin


(Human)
BDBM486505
PNG
(US10947241, Example 51)
Show SMILES Clc1ccc(cc1)-c1nnc(N2CCN(CC2)C(=O)[C@H]2CCCN2)c2ccccc12
Show InChI InChI=1S/C23H24ClN5O/c24-17-9-7-16(8-10-17)21-18-4-1-2-5-19(18)22(27-26-21)28-12-14-29(15-13-28)23(30)20-6-3-11-25-20/h1-2,4-5,7-10,20,25H,3,6,11-15H2/t20-/m1/s1
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 800n/an/an/an/an/an/a



Seoul National University Hospital

US Patent


Assay Description
Using THP-1 (human monocyte) cell line and ELISA system, the abilities to inhibit TNF-α secretion by hResistin (IC50) were evaluated for the com...


US Patent US10947241 (2021)

More data for this
Ligand-Target Pair
Resistin


(Human)
BDBM486515
PNG
(US10947241, Example 90)
Show SMILES CNC1CCN(C1)c1nnc(-c2ccc(Cl)cc2)c2cc(Cl)ccc12
Show InChI InChI=1S/C19H18Cl2N4/c1-22-15-8-9-25(11-15)19-16-7-6-14(21)10-17(16)18(23-24-19)12-2-4-13(20)5-3-12/h2-7,10,15,22H,8-9,11H2,1H3
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 900n/an/an/an/an/an/a



Seoul National University Hospital

US Patent


Assay Description
Using THP-1 (human monocyte) cell line and ELISA system, the abilities to inhibit TNF-α secretion by hResistin (IC50) were evaluated for the com...


US Patent US10947241 (2021)

More data for this
Ligand-Target Pair
Resistin


(Human)
BDBM486513
PNG
(US10947241, Example 88)
Show SMILES Clc1ccc(cc1)-c1nnc(N2CC3CCNC3C2)c2ccccc12
Show InChI InChI=1S/C20H19ClN4/c21-15-7-5-13(6-8-15)19-16-3-1-2-4-17(16)20(24-23-19)25-11-14-9-10-22-18(14)12-25/h1-8,14,18,22H,9-12H2
MMDB

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 900n/an/an/an/an/an/a



Seoul National University Hospital

US Patent


Assay Description
Using THP-1 (human monocyte) cell line and ELISA system, the abilities to inhibit TNF-α secretion by hResistin (IC50) were evaluated for the com...


US Patent US10947241 (2021)

More data for this
Ligand-Target Pair