TargetIntegrin alpha-V/beta-1(Homo sapiens (Human))
University Of California San Francisco
Curated by ChEMBL
University Of California San Francisco
Curated by ChEMBL
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of integrin alphaVbeta1 (unknown origin)-mediated CHO cell adhesion to fibronectin preincubated for 15 to 30 mins followed by 60 min incub...More data for this Ligand-Target Pair
TargetIntegrin alpha-V/beta-1(Homo sapiens (Human))
University Of California San Francisco
Curated by ChEMBL
University Of California San Francisco
Curated by ChEMBL
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of integrin alphaVbeta1 (unknown origin)-mediated CHO cell adhesion to fibronectin preincubated for 15 to 30 mins followed by 60 min incub...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0200nMAssay Description:Displacement of [35S]-labeled ligand from VLA4 in human Jurkat cells washed with buffer containing non activating Ca2+ and Mg2+ by competitive bindin...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0220nMAssay Description:Inhibition of Integrin alpha-4-beta-1-mediated adhesion in human jurkat cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of VLA-4 receptor of Jurkat cells in BURJ assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0300nMAssay Description:Displacement of [35S]-labeled ligand from VLA4 in human Jurkat cells washed with buffer containing activating Mn2+ by competitive binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0300nMAssay Description:Displacement of [35S]-labeled ligand from VLA4 in human Jurkat cells washed with buffer containing non activating Ca2+ and Mg2+ by competitive bindin...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of [125I]VCAM-Ig binding to human integrin alpha4-beta1 (VLA-4) of Jurkat cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of VLA-4 to VCAM-1 bindingMore data for this Ligand-Target Pair
TargetIntegrin alpha-V/beta-1(Homo sapiens (Human))
University Of California San Francisco
Curated by ChEMBL
University Of California San Francisco
Curated by ChEMBL
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of integrin alphaVbeta1 (unknown origin)-mediated CHO cell adhesion to fibronectin preincubated for 15 to 30 mins followed by 60 min incub...More data for this Ligand-Target Pair
TargetIntegrin alpha-V/beta-1(Homo sapiens (Human))
University Of California San Francisco
Curated by ChEMBL
University Of California San Francisco
Curated by ChEMBL
Affinity DataIC50: 0.0631nMAssay Description:Inhibition of integrin alphaVbeta1 (unknown origin)-mediated CHO cell adhesion to fibronectin preincubated for 15 to 30 mins followed by 60 min incub...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0700nMAssay Description:Displacement of 125I-VCAM-Ig from VLA4 in human Jurkat cells incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0700nMAssay Description:Antagonistic activity against VLA-4 integrin of human jurkat cells using [125I]VCAM-Ig as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of [125I]VCAM-Ig binding to VLA-4 of Jurkat cells in the presence of Mn2+More data for this Ligand-Target Pair
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of Mn2+ activated state of very late antigen 4 (VLA-4)More data for this Ligand-Target Pair
Affinity DataIC50: 0.0700nMAssay Description:Binding affinity towards VLA-4 (alpha4 beta-1) receptor in human Jurkat cells using [125I]VCAM-Ig as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0700nMAssay Description:Antagonist activity at alpha4beta1 integrinMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of VLA4 in human whole bloodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of VLA-4 binding in Jurkat cells in the presence of Mg2+More data for this Ligand-Target Pair
Affinity DataIC50: 0.0800nMAssay Description:Displacement of 125I-VCAM-Ig from VLA4 in human Jurkat cells incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of [125I]VCAM-Ig binding to VLA-4 of Jurkat cells in the presence of Mn2+More data for this Ligand-Target Pair
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of [125I]VCAM-Ig binding to VLA-4 of Jurkat cells in the presence of Mn2+More data for this Ligand-Target Pair
Affinity DataIC50: 0.0800nMAssay Description:Antagonistic activity against VLA-4 integrin of human jurkat cells using [125I]VCAM-Ig as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of VLA-4 binding in Jurkat cells in the presence of Mg2+More data for this Ligand-Target Pair
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of [125I]VCAM-Ig binding to VLA-4 of Jurkat cells in the presence of [Ca2+]More data for this Ligand-Target Pair
Affinity DataIC50: 0.0800nMAssay Description:Antagonistic activity against VLA-4 integrin of human jurkat cells using [125I]VCAM-Ig as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of [125I]VCAM-Ig binding to VLA-4 of Jurkat cells in the presence of Mn2+More data for this Ligand-Target Pair
Affinity DataIC50: 0.0900nMAssay Description:Binding affinity towards VLA-4 (alpha4 beta-1) receptor in human Jurkat cells using [125I]VCAM-Ig as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0900nMAssay Description:Antagonistic activity against VLA-4 integrin of human jurkat cells using [125I]VCAM-Ig as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0900nMAssay Description:Antagonistic activity against VLA-4 integrin of human jurkat cells using [125I]VCAM-Ig as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of VLA-4 binding in Jurkat cells in the presence of Mg2+More data for this Ligand-Target Pair
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of [125I]VCAM-Ig binding to VLA-4 of Jurkat cells in the presence of Mn2+More data for this Ligand-Target Pair
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of [125I]VCAM-Ig binding to VLA-4 of Jurkat cells in the presence of Mn2+More data for this Ligand-Target Pair
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of VLA-4 binding in Jurkat cells in the presence of Mg2+More data for this Ligand-Target Pair
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of [125I]VCAM-Ig binding to VLA-4 of Jurkat cells in the presence of [Ca2+]More data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Displacement of 125I-VCAM-Ig from VLA4 in human Jurkat cells incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibitory binding concentration determined against VCAM/VLA-4 in ELISAMore data for this Ligand-Target Pair
TargetIntegrin alpha-V/beta-1(Homo sapiens (Human))
University Of California San Francisco
Curated by ChEMBL
University Of California San Francisco
Curated by ChEMBL
Affinity DataIC50: <0.100nMAssay Description:Inhibition of alphavbeta1 integrin (unknown origin) by solid phase binding assayMore data for this Ligand-Target Pair
TargetIntegrin alpha-V/beta-1(Homo sapiens (Human))
University Of California San Francisco
Curated by ChEMBL
University Of California San Francisco
Curated by ChEMBL
Affinity DataIC50: <0.100nMAssay Description:Inhibition of alphavbeta1 integrin (unknown origin) by solid phase binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Binding affinity towards VLA-4 (alpha4 beta-1) receptor in human Jurkat cells using [125I]VCAM-Ig as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Antagonistic activity against VLA-4 integrin of human jurkat cells using [125I]VCAM-Ig as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Antagonistic activity against VLA-4 integrin of human jurkat cells using [125I]VCAM-Ig as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibition of [125I]VCAM-Ig binding to VLA-4 of Jurkat cells in the presence of [Ca2+]More data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibition of [125I]VCAM-Ig binding to VLA-4 of Jurkat cells in the presence of [Ca2+]More data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibition of [125I]VCAM-Ig binding to VLA-4 of Jurkat cells in the presence of Mn2+More data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibition of [125I]VCAM-Ig binding to VLA-4 of Jurkat cells in the presence of Mn2+More data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibition of VLA-4 binding in Jurkat cells in the presence of Mg2+More data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibition of [125I]VCAM-Ig binding to VLA-4 of Jurkat cells in the presence of [Ca2+]More data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibition of VLA-4 binding in Jurkat cells in the presence of Mg2+More data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibition of CS-1 fragment binding to Very late antigen 4 expressed in Ramos cells in 10% fetal bovine serum(FBS)More data for this Ligand-Target Pair