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Compile Data Set for Download or QSAR

Found 367 hits of ic50 data for polymerid = 1570   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50428590
PNG
(CHEMBL2337969)
Show SMILES CCc1cc2c(ccc(OC)n2n1)C1=NN(CCCCOc2ccc(cc2)C2=NNC(=O)CC2C)C(=O)CC1
Show InChI InChI=1S/C29H34N6O4/c1-4-21-18-25-23(11-14-28(38-3)35(25)32-21)24-12-13-27(37)34(33-24)15-5-6-16-39-22-9-7-20(8-10-22)29-19(2)17-26(36)30-31-29/h7-11,14,18-19H,4-6,12-13,15-17H2,1-3H3,(H,30,36)
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n/an/a 0.270n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PDE3A (unknown origin) by radiochemical assay


Bioorg Med Chem Lett 23: 375-81 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.121
BindingDB Entry DOI: 10.7270/Q2B27WNB
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM86219
PNG
(CAS_5537 | NSC_5537 | Trequinsin)
Show SMILES COc1cc2CCn3c(cc(=Nc4c(C)cc(C)cc4C)n(C)c3=O)-c2cc1OC
Show InChI InChI=1S/C24H27N3O3/c1-14-9-15(2)23(16(3)10-14)25-22-13-19-18-12-21(30-6)20(29-5)11-17(18)7-8-27(19)24(28)26(22)4/h9-13H,7-8H2,1-6H3
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n/an/a 0.300n/an/an/an/a7.524



University of North Carolina



Assay Description
Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate.


J Biol Chem 287: 11788-97 (2012)


Article DOI: 10.1074/jbc.M111.326777
BindingDB Entry DOI: 10.7270/Q2K9364D
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50428577
PNG
(CHEMBL2337953)
Show SMILES CCc1cc2c(ccc(OC)n2n1)C1=NN(CCCCOc2ccc(cc2)C2=NNC(=O)CC2C)C(=O)CC1C
Show InChI InChI=1S/C30H36N6O4/c1-5-22-18-25-24(12-13-28(39-4)36(25)33-22)30-20(3)17-27(38)35(34-30)14-6-7-15-40-23-10-8-21(9-11-23)29-19(2)16-26(37)31-32-29/h8-13,18-20H,5-7,14-17H2,1-4H3,(H,31,37)
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n/an/a 1.20n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PDE3A (unknown origin) by radiochemical assay


Bioorg Med Chem Lett 23: 375-81 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.121
BindingDB Entry DOI: 10.7270/Q2B27WNB
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50496812
PNG
(CHEMBL3222276)
Show SMILES COc1ccc2nc(COc3ccc(cc3)-c3c(cnn3C)-c3ccncc3)ccc2c1
Show InChI InChI=1S/C26H22N4O2/c1-30-26(24(16-28-30)18-11-13-27-14-12-18)19-4-7-22(8-5-19)32-17-21-6-3-20-15-23(31-2)9-10-25(20)29-21/h3-16H,17H2,1-2H3
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n/an/a 1.5n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE3A assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...


Medchemcomm 4: 443-449 (2013)


Article DOI: 10.1039/c2md20239e
BindingDB Entry DOI: 10.7270/Q2N58QBF
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50428588
PNG
(CHEMBL2337971)
Show SMILES CCc1cc2c(ccc(OC)n2n1)C1=NN(CCCCOc2ccc(cc2)C2=NNC(=O)CC2C)C(=O)C1(C)C
Show InChI InChI=1S/C30H36N6O4/c1-6-21-18-24-23(13-14-26(39-5)36(24)33-21)28-30(3,4)29(38)35(34-28)15-7-8-16-40-22-11-9-20(10-12-22)27-19(2)17-25(37)31-32-27/h9-14,18-19H,6-8,15-17H2,1-5H3,(H,31,37)
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n/an/a 1.70n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PDE3A (unknown origin) by radiochemical assay


Bioorg Med Chem Lett 23: 375-81 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.121
BindingDB Entry DOI: 10.7270/Q2B27WNB
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50428589
PNG
(CHEMBL2337970)
Show SMILES CCc1cc2c(ccc(OC)n2n1)-c1ccc(=O)n(CCCCOc2ccc(cc2)C2=NNC(=O)CC2C)n1
Show InChI InChI=1S/C29H32N6O4/c1-4-21-18-25-23(11-14-28(38-3)35(25)32-21)24-12-13-27(37)34(33-24)15-5-6-16-39-22-9-7-20(8-10-22)29-19(2)17-26(36)30-31-29/h7-14,18-19H,4-6,15-17H2,1-3H3,(H,30,36)
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n/an/a 2.70n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PDE3A (unknown origin) by radiochemical assay


Bioorg Med Chem Lett 23: 375-81 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.121
BindingDB Entry DOI: 10.7270/Q2B27WNB
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50210628
PNG
(CHEMBL3946861)
Show SMILES CCSc1ncc(-c2cc([nH]c(=N)c2C#N)-c2ccc(Br)cc2)n1Cc1ccccc1
Show InChI InChI=1S/C24H20BrN5S/c1-2-31-24-28-14-22(30(24)15-16-6-4-3-5-7-16)19-12-21(29-23(27)20(19)13-26)17-8-10-18(25)11-9-17/h3-12,14H,2,15H2,1H3,(H2,27,29)
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n/an/a 3.80n/an/an/an/an/an/a



Hamdard University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3A using fluorescein-labelled cAMP as substrate measured after 60 mins by IMAP TR-FRET assay


Eur J Med Chem 125: 143-189 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.023
BindingDB Entry DOI: 10.7270/Q23T9K6Z
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50210628
PNG
(CHEMBL3946861)
Show SMILES CCSc1ncc(-c2cc([nH]c(=N)c2C#N)-c2ccc(Br)cc2)n1Cc1ccccc1
Show InChI InChI=1S/C24H20BrN5S/c1-2-31-24-28-14-22(30(24)15-16-6-4-3-5-7-16)19-12-21(29-23(27)20(19)13-26)17-8-10-18(25)11-9-17/h3-12,14H,2,15H2,1H3,(H2,27,29)
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n/an/a 3.80n/an/an/an/an/an/a



Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital

Curated by ChEMBL


Assay Description
Inhibition of recombinant N-terminal GST-tagged human PDE3A (484 to 1141 residues) expressed in Sf9 cells using cAMP as substrate after 60 mins by IM...


Eur J Med Chem 150: 742-756 (2018)


Article DOI: 10.1016/j.ejmech.2018.03.046
BindingDB Entry DOI: 10.7270/Q2JM2D83
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50428587
PNG
(CHEMBL2337972)
Show SMILES COc1ccc(C2=NN(CCCCOc3ccc(C4=NNC(=O)CC4)c(F)c3F)C(=O)C2(C)C)n2cc(nc12)C(F)(F)F
Show InChI InChI=1S/C28H27F5N6O4/c1-27(2)24(17-8-10-19(42-3)25-34-20(14-38(17)25)28(31,32)33)37-39(26(27)41)12-4-5-13-43-18-9-6-15(22(29)23(18)30)16-7-11-21(40)36-35-16/h6,8-10,14H,4-5,7,11-13H2,1-3H3,(H,36,40)
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n/an/a 5n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PDE3A (unknown origin) by radiochemical assay


Bioorg Med Chem Lett 23: 375-81 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.121
BindingDB Entry DOI: 10.7270/Q2B27WNB
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM15297
PNG
(CHEMBL34431 | Cilostamide | N-Cyclohexyl-N-methyl-...)
Show SMILES CN(C1CCCCC1)C(=O)CCCOc1ccc2[nH]c(=O)ccc2c1
Show InChI InChI=1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23)
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n/an/a 5n/an/an/an/a7.524



University of North Carolina



Assay Description
Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate.


J Biol Chem 287: 11788-97 (2012)


Article DOI: 10.1074/jbc.M111.326777
BindingDB Entry DOI: 10.7270/Q2K9364D
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50428591
PNG
(CHEMBL2337968)
Show SMILES COc1ccc(C2=NN(CCCCOc3ccc(C4=NNC(=O)CC4)c(F)c3F)C(=O)CC2C)c2cc(nn12)C(F)(F)F
Show InChI InChI=1S/C28H27F5N6O4/c1-15-13-23(41)38(37-27(15)17-6-10-24(42-2)39-19(17)14-21(36-39)28(31,32)33)11-3-4-12-43-20-8-5-16(25(29)26(20)30)18-7-9-22(40)35-34-18/h5-6,8,10,14-15H,3-4,7,9,11-13H2,1-2H3,(H,35,40)
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n/an/a 5.10n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PDE3A (unknown origin) by radiochemical assay


Bioorg Med Chem Lett 23: 375-81 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.121
BindingDB Entry DOI: 10.7270/Q2B27WNB
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50428586
PNG
(CHEMBL2337973)
Show SMILES COc1ccc(C2=NN(CCCCOc3ccc(C4=NNC(=O)CC4)c(F)c3F)C(=O)C2(C)C)c2sc(nc12)C(F)(F)F
Show InChI InChI=1S/C28H26F5N5O4S/c1-27(2)24(15-7-10-18(41-3)22-23(15)43-25(34-22)28(31,32)33)37-38(26(27)40)12-4-5-13-42-17-9-6-14(20(29)21(17)30)16-8-11-19(39)36-35-16/h6-7,9-10H,4-5,8,11-13H2,1-3H3,(H,36,39)
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n/an/a 6.90n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PDE3A (unknown origin) by radiochemical assay


Bioorg Med Chem Lett 23: 375-81 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.121
BindingDB Entry DOI: 10.7270/Q2B27WNB
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50350802
PNG
(CHEMBL1819121)
Show SMILES COc1cc2ncnc(N3CCCC(C3)c3ccccc3)c2cc1OC
Show InChI InChI=1S/C21H23N3O2/c1-25-19-11-17-18(12-20(19)26-2)22-14-23-21(17)24-10-6-9-16(13-24)15-7-4-3-5-8-15/h3-5,7-8,11-12,14,16H,6,9-10,13H2,1-2H3
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n/an/a 8.5n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of PDE3A


J Med Chem 54: 4536-47 (2011)


Article DOI: 10.1021/jm2001508
BindingDB Entry DOI: 10.7270/Q2PN961Q
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50428578
PNG
(CHEMBL2337954)
Show SMILES CCc1cc2c(ccc(OC)n2n1)C1=NN(CCCOc2ccc(cc2)C2=NNC(=O)CC2C)C(=O)CC1C
Show InChI InChI=1S/C29H34N6O4/c1-5-21-17-24-23(11-12-27(38-4)35(24)32-21)29-19(3)16-26(37)34(33-29)13-6-14-39-22-9-7-20(8-10-22)28-18(2)15-25(36)30-31-28/h7-12,17-19H,5-6,13-16H2,1-4H3,(H,30,36)
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n/an/a 11n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PDE3A (unknown origin) by radiochemical assay


Bioorg Med Chem Lett 23: 375-81 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.121
BindingDB Entry DOI: 10.7270/Q2B27WNB
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50338586
PNG
(CHEMBL1683806 | N'-(1-(3,3-dimethyl-2-oxoindolin-5...)
Show SMILES CC(=NNS(=O)(=O)c1ccc(C)cc1)c1ccc2NC(=O)C(C)(C)c2c1
Show InChI InChI=1S/C19H21N3O3S/c1-12-5-8-15(9-6-12)26(24,25)22-21-13(2)14-7-10-17-16(11-14)19(3,4)18(23)20-17/h5-11,22H,1-4H3,(H,20,23)
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n/an/a 14.8n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE3A


Bioorg Med Chem Lett 21: 1617-20 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.120
BindingDB Entry DOI: 10.7270/Q2WQ043X
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50428580
PNG
(CHEMBL2337958)
Show SMILES COc1ccc(C2=NN(CCCCOc3ccc(cc3)C3=NNC(=O)CC3C)C(=O)CC2C)c2cc(nn12)C(F)(F)F
Show InChI InChI=1S/C29H31F3N6O4/c1-17-14-24(39)33-34-27(17)19-6-8-20(9-7-19)42-13-5-4-12-37-25(40)15-18(2)28(36-37)21-10-11-26(41-3)38-22(21)16-23(35-38)29(30,31)32/h6-11,16-18H,4-5,12-15H2,1-3H3,(H,33,39)
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n/an/a 15n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PDE3A (unknown origin) by radiochemical assay


Bioorg Med Chem Lett 23: 375-81 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.121
BindingDB Entry DOI: 10.7270/Q2B27WNB
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50428592
PNG
(CHEMBL2337967)
Show SMILES COc1ccc(C2=NN(CCCCOc3ccc(C4=NNC(=O)C4(C)C)c(F)c3F)C(=O)CC2C)c2cc(nn12)C(F)(F)F
Show InChI InChI=1S/C29H29F5N6O4/c1-15-13-21(41)39(38-25(15)16-8-10-22(43-4)40-18(16)14-20(37-40)29(32,33)34)11-5-6-12-44-19-9-7-17(23(30)24(19)31)26-28(2,3)27(42)36-35-26/h7-10,14-15H,5-6,11-13H2,1-4H3,(H,36,42)
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n/an/a 15n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PDE3A (unknown origin) by radiochemical assay


Bioorg Med Chem Lett 23: 375-81 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.121
BindingDB Entry DOI: 10.7270/Q2B27WNB
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50042053
PNG
(CHEMBL3360172)
Show SMILES CCn1c(Nc2ccncc2F)nc2c(csc2c1=O)C1CCCN(C1)C(=O)C1(CC1)C#N
Show InChI InChI=1S/C23H23FN6O2S/c1-2-30-20(31)19-18(28-22(30)27-17-5-8-26-10-16(17)24)15(12-33-19)14-4-3-9-29(11-14)21(32)23(13-25)6-7-23/h5,8,10,12,14H,2-4,6-7,9,11H2,1H3,(H,26,27,28)
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n/an/a 17n/an/an/an/an/an/a



Kyoto 607-8042

Curated by ChEMBL


Assay Description
Inhibition of PDE3A (unknown origin)


Bioorg Med Chem Lett 25: 649-53 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.090
BindingDB Entry DOI: 10.7270/Q2542Q6P
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM15297
PNG
(CHEMBL34431 | Cilostamide | N-Cyclohexyl-N-methyl-...)
Show SMILES CN(C1CCCCC1)C(=O)CCCOc1ccc2[nH]c(=O)ccc2c1
Show InChI InChI=1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23)
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n/an/a 18.1n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE3A


Bioorg Med Chem Lett 21: 1617-20 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.120
BindingDB Entry DOI: 10.7270/Q2WQ043X
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50496801
PNG
(CHEMBL3222273)
Show SMILES COc1cc2ccccc2nc1COc1ccc(cc1)-c1c(cnn1C)-c1ccncc1
Show InChI InChI=1S/C26H22N4O2/c1-30-26(22(16-28-30)18-11-13-27-14-12-18)19-7-9-21(10-8-19)32-17-24-25(31-2)15-20-5-3-4-6-23(20)29-24/h3-16H,17H2,1-2H3
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n/an/a 19n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE3A assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...


Medchemcomm 4: 443-449 (2013)


Article DOI: 10.1039/c2md20239e
BindingDB Entry DOI: 10.7270/Q2N58QBF
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50496803
PNG
(CHEMBL3218037)
Show SMILES COc1cc(COc2ccc(cc2)-c2nn(C)cc2-c2ccncc2)nc2ccccc12
Show InChI InChI=1S/C26H22N4O2/c1-30-16-23(18-11-13-27-14-12-18)26(29-30)19-7-9-21(10-8-19)32-17-20-15-25(31-2)22-5-3-4-6-24(22)28-20/h3-16H,17H2,1-2H3
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n/an/a 28n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE3A assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...


Medchemcomm 4: 443-449 (2013)


Article DOI: 10.1039/c2md20239e
BindingDB Entry DOI: 10.7270/Q2N58QBF
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50496811
PNG
(CHEMBL3222274)
Show SMILES COc1cc(COc2ccc(cc2)-c2c(cnn2C)-c2ccncc2)nc2ccccc12
Show InChI InChI=1S/C26H22N4O2/c1-30-26(23(16-28-30)18-11-13-27-14-12-18)19-7-9-21(10-8-19)32-17-20-15-25(31-2)22-5-3-4-6-24(22)29-20/h3-16H,17H2,1-2H3
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n/an/a 29n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE3A assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...


Medchemcomm 4: 443-449 (2013)


Article DOI: 10.1039/c2md20239e
BindingDB Entry DOI: 10.7270/Q2N58QBF
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50042036
PNG
(CHEMBL3360170)
Show SMILES CCn1c(Nc2ccncc2F)nc2c(csc2c1=O)C1CCCN(C1)C(=O)OC
Show InChI InChI=1S/C20H22FN5O3S/c1-3-26-18(27)17-16(24-19(26)23-15-6-7-22-9-14(15)21)13(11-30-17)12-5-4-8-25(10-12)20(28)29-2/h6-7,9,11-12H,3-5,8,10H2,1-2H3,(H,22,23,24)
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n/an/a 29n/an/an/an/an/an/a



Kyoto 607-8042

Curated by ChEMBL


Assay Description
Inhibition of PDE3A (unknown origin)


Bioorg Med Chem Lett 25: 649-53 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.090
BindingDB Entry DOI: 10.7270/Q2542Q6P
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50042035
PNG
(CHEMBL3360171)
Show SMILES CCn1c(Nc2ccncc2F)nc2c(csc2c1=O)C1CCCN(C1)C(=O)C(C)(C)CO
Show InChI InChI=1S/C23H28FN5O3S/c1-4-29-20(31)19-18(27-22(29)26-17-7-8-25-10-16(17)24)15(12-33-19)14-6-5-9-28(11-14)21(32)23(2,3)13-30/h7-8,10,12,14,30H,4-6,9,11,13H2,1-3H3,(H,25,26,27)
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n/an/a 37n/an/an/an/an/an/a



Kyoto 607-8042

Curated by ChEMBL


Assay Description
Inhibition of PDE3A (unknown origin)


Bioorg Med Chem Lett 25: 649-53 (2015)


Article DOI: 10.1016/j.bmcl.2014.11.090
BindingDB Entry DOI: 10.7270/Q2542Q6P
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50428585
PNG
(CHEMBL2337974)
Show SMILES COc1ccc(C2=NN(CCCCOc3ccc(C4=NNC(=O)C4(C)C)c(F)c3F)C(=O)C2(C)C)n2cc(nc12)C(F)(F)F
Show InChI InChI=1S/C29H29F5N6O4/c1-27(2)22(36-37-25(27)41)15-8-10-17(21(31)20(15)30)44-13-7-6-12-40-26(42)28(3,4)23(38-40)16-9-11-18(43-5)24-35-19(14-39(16)24)29(32,33)34/h8-11,14H,6-7,12-13H2,1-5H3,(H,37,41)
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n/an/a 40n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PDE3A (unknown origin) by radiochemical assay


Bioorg Med Chem Lett 23: 375-81 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.121
BindingDB Entry DOI: 10.7270/Q2B27WNB
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50428593
PNG
(CHEMBL2337966)
Show SMILES COc1ccc(C2=NN(CCCCOc3ccc(C4=NNC(=O)C4(C)C)c(F)c3)C(=O)CC2C)c2cc(nn12)C(F)(F)F
Show InChI InChI=1S/C29H30F4N6O4/c1-16-13-23(40)38(37-25(16)19-9-10-24(42-4)39-21(19)15-22(36-39)29(31,32)33)11-5-6-12-43-17-7-8-18(20(30)14-17)26-28(2,3)27(41)35-34-26/h7-10,14-16H,5-6,11-13H2,1-4H3,(H,35,41)
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n/an/a 58n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PDE3A (unknown origin) by radiochemical assay


Bioorg Med Chem Lett 23: 375-81 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.121
BindingDB Entry DOI: 10.7270/Q2B27WNB
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50428584
PNG
(CHEMBL2337975)
Show SMILES COc1ccc(C2=NN(CCCCOc3ccc(C4=NNC(=O)C4(C)C)c(F)c3F)C(=O)C2(C)C)c2sc(nc12)C(F)(F)F
Show InChI InChI=1S/C29H28F5N5O4S/c1-27(2)22(36-37-24(27)40)14-8-10-16(19(31)18(14)30)43-13-7-6-12-39-26(41)28(3,4)23(38-39)15-9-11-17(42-5)20-21(15)44-25(35-20)29(32,33)34/h8-11H,6-7,12-13H2,1-5H3,(H,37,40)
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n/an/a 63n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PDE3A (unknown origin) by radiochemical assay


Bioorg Med Chem Lett 23: 375-81 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.121
BindingDB Entry DOI: 10.7270/Q2B27WNB
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM167515
PNG
(US9073917, 12- comparative)
Show SMILES CCOC(=O)c1[nH]cc2[C@@H](c3ccc(Sc4nc5ccccc5[nH]4)o3)C3=C(CCCC3=O)Nc12
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US Patent
n/an/a 68n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
The effect of the compounds of the invention on the activity of the enzyme PDE3 was evaluated by the company CEREP (Le bois I'Evêque, 86600 Celle...


US Patent US9073917 (2015)


BindingDB Entry DOI: 10.7270/Q2H993X4
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50428579
PNG
(CHEMBL2337976)
Show SMILES COc1ccc(C2=NN(CCCCCOc3ccc(cc3)C3=NNC(=O)CC3C)C(=O)CC2C)c2cc(nn12)C(F)(F)F
Show InChI InChI=1S/C30H33F3N6O4/c1-18-15-25(40)34-35-28(18)20-7-9-21(10-8-20)43-14-6-4-5-13-38-26(41)16-19(2)29(37-38)22-11-12-27(42-3)39-23(22)17-24(36-39)30(31,32)33/h7-12,17-19H,4-6,13-16H2,1-3H3,(H,34,40)
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n/an/a 72n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PDE3A (unknown origin) by radiochemical assay


Bioorg Med Chem Lett 23: 375-81 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.121
BindingDB Entry DOI: 10.7270/Q2B27WNB
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50496802
PNG
(CHEMBL3218039)
Show SMILES COc1ccc2nc(COc3ccc(cc3)-c3nn(C)cc3-c3ccncc3)ccc2c1
Show InChI InChI=1S/C26H22N4O2/c1-30-16-24(18-11-13-27-14-12-18)26(29-30)19-4-7-22(8-5-19)32-17-21-6-3-20-15-23(31-2)9-10-25(20)28-21/h3-16H,17H2,1-2H3
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n/an/a 78n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE3A assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...


Medchemcomm 4: 443-449 (2013)


Article DOI: 10.1039/c2md20239e
BindingDB Entry DOI: 10.7270/Q2N58QBF
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50350805
PNG
(CHEMBL1819122)
Show SMILES CCCOc1cc2c(ncnc2cc1OC)N1CCCC(C1)c1ccccc1
Show InChI InChI=1S/C23H27N3O2/c1-3-12-28-22-13-19-20(14-21(22)27-2)24-16-25-23(19)26-11-7-10-18(15-26)17-8-5-4-6-9-17/h4-6,8-9,13-14,16,18H,3,7,10-12,15H2,1-2H3
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n/an/a 98n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of PDE3A


J Med Chem 54: 4536-47 (2011)


Article DOI: 10.1021/jm2001508
BindingDB Entry DOI: 10.7270/Q2PN961Q
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50496800
PNG
(CHEMBL3218036)
Show SMILES COc1cc2ccccc2nc1COc1ccc(cc1)-c1nn(C)cc1-c1ccncc1
Show InChI InChI=1S/C26H22N4O2/c1-30-16-22(18-11-13-27-14-12-18)26(29-30)19-7-9-21(10-8-19)32-17-24-25(31-2)15-20-5-3-4-6-23(20)28-24/h3-16H,17H2,1-2H3
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n/an/a 123n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE3A assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...


Medchemcomm 4: 443-449 (2013)


Article DOI: 10.1039/c2md20239e
BindingDB Entry DOI: 10.7270/Q2N58QBF
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50428582
PNG
(CHEMBL2337956)
Show SMILES COc1ccc(C2=NN(CCOc3ccc(cc3)C3=NNC(=O)CC3C)C(=O)CC2C)c2cc(nn12)C(F)(F)F
Show InChI InChI=1S/C27H27F3N6O4/c1-15-12-22(37)31-32-25(15)17-4-6-18(7-5-17)40-11-10-35-23(38)13-16(2)26(34-35)19-8-9-24(39-3)36-20(19)14-21(33-36)27(28,29)30/h4-9,14-16H,10-13H2,1-3H3,(H,31,37)
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n/an/a 130n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PDE3A (unknown origin) by radiochemical assay


Bioorg Med Chem Lett 23: 375-81 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.121
BindingDB Entry DOI: 10.7270/Q2B27WNB
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50390617
PNG
(CHEMBL2069609)
Show SMILES COc1ccc(C2=NNC(=O)C2(C)C)n2cc(nc12)C(F)(F)F
Show InChI InChI=1S/C14H13F3N4O2/c1-13(2)10(19-20-12(13)22)7-4-5-8(23-3)11-18-9(6-21(7)11)14(15,16)17/h4-6H,1-3H3,(H,20,22)
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n/an/a 140n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE3A


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50428581
PNG
(CHEMBL2337957)
Show SMILES COc1ccc(C2=NN(CCCOc3ccc(cc3)C3=NNC(=O)CC3C)C(=O)CC2C)c2cc(nn12)C(F)(F)F
Show InChI InChI=1S/C28H29F3N6O4/c1-16-13-23(38)32-33-26(16)18-5-7-19(8-6-18)41-12-4-11-36-24(39)14-17(2)27(35-36)20-9-10-25(40-3)37-21(20)15-22(34-37)28(29,30)31/h5-10,15-17H,4,11-14H2,1-3H3,(H,32,38)
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n/an/a 140n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PDE3A (unknown origin) by radiochemical assay


Bioorg Med Chem Lett 23: 375-81 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.121
BindingDB Entry DOI: 10.7270/Q2B27WNB
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50363909
PNG
(CHEMBL1946933)
Show SMILES COc1ccc(C2=NNC(=O)CC2C)c2sc(nc12)C(F)(F)F
Show InChI InChI=1S/C14H12F3N3O2S/c1-6-5-9(21)19-20-10(6)7-3-4-8(22-2)11-12(7)23-13(18-11)14(15,16)17/h3-4,6H,5H2,1-2H3,(H,19,21)
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n/an/a 150n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human PDE3A catalytic domain


Bioorg Med Chem 20: 1644-58 (2012)


Article DOI: 10.1016/j.bmc.2012.01.033
BindingDB Entry DOI: 10.7270/Q2DB829P
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM98990
PNG
(US8497265, 446)
Show SMILES Nc1ncc2cc(ccc2n1)-c1nccnc1OC1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H19N7O/c25-24-28-12-17-11-16(5-7-20(17)30-24)22-23(27-10-9-26-22)32-18-13-31(14-18)21-8-6-15-3-1-2-4-19(15)29-21/h1-12,18H,13-14H2,(H2,25,28,30)
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n/an/a 208n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human PDE3A using FAM-cAMP substrate by TR-FRET progressive binding assay


Bioorg Med Chem 22: 6570-85 (2015)


Article DOI: 10.1016/j.bmc.2014.10.013
BindingDB Entry DOI: 10.7270/Q2RB766Q
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50117862
PNG
(CHEMBL3614035)
Show SMILES Fc1ccc(cc1)-c1csc(n1)-n1cc(cn1)-c1nnn[nH]1
Show InChI InChI=1S/C13H8FN7S/c14-10-3-1-8(2-4-10)11-7-22-13(16-11)21-6-9(5-15-21)12-17-19-20-18-12/h1-7H,(H,17,18,19,20)
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n/an/a 240n/an/an/an/an/an/a



DaQing Oil Field General Hospital

Curated by ChEMBL


Assay Description
Inhibition of human PDE3A using FAM-cAMP by fluorescence polarization assay


Bioorg Med Chem 23: 6111-7 (2015)


Article DOI: 10.1016/j.bmc.2015.08.002
BindingDB Entry DOI: 10.7270/Q2HT2R46
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50428573
PNG
(CHEMBL2337962)
Show SMILES COc1ccc(C2=NN(CCCCOc3ccc(cc3)C3=NNC(=O)C3(C)C)C(=O)CC2C)c2cc(nn12)C(F)(F)F
Show InChI InChI=1S/C29H31F3N6O4/c1-17-15-23(39)37(36-25(17)20-11-12-24(41-4)38-21(20)16-22(35-38)29(30,31)32)13-5-6-14-42-19-9-7-18(8-10-19)26-28(2,3)27(40)34-33-26/h7-12,16-17H,5-6,13-15H2,1-4H3,(H,34,40)
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n/an/a 270n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PDE3A (unknown origin) by radiochemical assay


Bioorg Med Chem Lett 23: 375-81 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.121
BindingDB Entry DOI: 10.7270/Q2B27WNB
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50151594
PNG
(4-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)
Show SMILES NC(=O)c1ccc(cc1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1
Show InChI InChI=1S/C20H20ClN3O2/c21-16-11-14(12-4-6-13(7-5-12)18(22)25)10-15-17(16)23-19(26)24-20(15)8-2-1-3-9-20/h4-7,10-11H,1-3,8-9H2,(H2,22,25)(H2,23,24,26)
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n/an/a 280n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
In vitro inhibition of human Phosphodiesterase 3A3 expressed in baculovirus infected Sf9 cells


Bioorg Med Chem Lett 14: 4623-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM14754
PNG
(1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoq...)
Show SMILES COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC
Show InChI InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3
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n/an/a 284n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of PDE3A


J Med Chem 55: 7299-331 (2012)


Article DOI: 10.1021/jm3004976
BindingDB Entry DOI: 10.7270/Q2C24XJK
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM14754
PNG
(1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoq...)
Show SMILES COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC
Show InChI InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3
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n/an/a 287n/an/an/an/an/an/a



Sun Yat-sen University

Curated by ChEMBL


Assay Description
Inhibition of PDE3A (unknown origin)


J Med Chem 62: 3707-3721 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00224
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM15296
PNG
(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N
Show InChI InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
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n/an/a 300n/an/an/an/a7.524



University of North Carolina



Assay Description
Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate.


J Biol Chem 287: 11788-97 (2012)


Article DOI: 10.1074/jbc.M111.326777
BindingDB Entry DOI: 10.7270/Q2K9364D
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50428575
PNG
(CHEMBL2337960)
Show SMILES COc1ccc(C2=NN(CCCCOc3ccc(cc3)C3=NNC(=O)CC3)C(=O)CC2C)c2cc(nn12)C(F)(F)F
Show InChI InChI=1S/C28H29F3N6O4/c1-17-15-25(39)36(13-3-4-14-41-19-7-5-18(6-8-19)21-10-11-24(38)33-32-21)35-27(17)20-9-12-26(40-2)37-22(20)16-23(34-37)28(29,30)31/h5-9,12,16-17H,3-4,10-11,13-15H2,1-2H3,(H,33,38)
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n/an/a 360n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PDE3A (unknown origin) by radiochemical assay


Bioorg Med Chem Lett 23: 375-81 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.121
BindingDB Entry DOI: 10.7270/Q2B27WNB
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50390629
PNG
(CHEMBL2069600)
Show SMILES COc1ccc(C2=NNC(=O)CC2C)c2cc(nn12)C(F)(F)F
Show InChI InChI=1S/C14H13F3N4O2/c1-7-5-11(22)18-19-13(7)8-3-4-12(23-2)21-9(8)6-10(20-21)14(15,16)17/h3-4,6-7H,5H2,1-2H3,(H,18,22)
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n/an/a 360n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE3A


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50390629
PNG
(CHEMBL2069600)
Show SMILES COc1ccc(C2=NNC(=O)CC2C)c2cc(nn12)C(F)(F)F
Show InChI InChI=1S/C14H13F3N4O2/c1-7-5-11(22)18-19-13(7)8-3-4-12(23-2)21-9(8)6-10(20-21)14(15,16)17/h3-4,6-7H,5H2,1-2H3,(H,18,22)
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n/an/a 360n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domains PDE3A (unknown origin)


Bioorg Med Chem Lett 23: 5311-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.07.069
BindingDB Entry DOI: 10.7270/Q20Z7663
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50428583
PNG
(CHEMBL2337955)
Show SMILES COc1ccc(C2=NNC(=O)C[C@@H]2C)c2cc(nn12)C(F)(F)F
Show InChI InChI=1S/C14H13F3N4O2/c1-7-5-11(22)18-19-13(7)8-3-4-12(23-2)21-9(8)6-10(20-21)14(15,16)17/h3-4,6-7H,5H2,1-2H3,(H,18,22)/t7-/m0/s1
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n/an/a 360n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PDE3A (unknown origin) by radiochemical assay


Bioorg Med Chem Lett 23: 375-81 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.121
BindingDB Entry DOI: 10.7270/Q2B27WNB
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50308952
PNG
(4-Methyl-6-({3-[(4-methylpiperidino)carbonyl]-benz...)
Show SMILES CC1CCN(CC1)C(=O)c1cccc(COc2ccc3[nH]c(=O)cc(C)c3c2)c1
Show InChI InChI=1S/C24H26N2O3/c1-16-8-10-26(11-9-16)24(28)19-5-3-4-18(13-19)15-29-20-6-7-22-21(14-20)17(2)12-23(27)25-22/h3-7,12-14,16H,8-11,15H2,1-2H3,(H,25,27)
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n/an/a 430n/an/an/an/an/an/a



Islamic Azad University

Curated by ChEMBL


Assay Description
Inhibition of human PDE3A by fluorescence microplate reader


Bioorg Med Chem 18: 855-62 (2010)


Article DOI: 10.1016/j.bmc.2009.11.044
BindingDB Entry DOI: 10.7270/Q2Q81F13
More data for this
Ligand-Target Pair
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50520683
PNG
(CHEMBL4476621)
Show SMILES Oc1ccccc1C(=O)NNC(=S)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H11Cl2N3O2S/c15-10-6-5-8(7-11(10)16)17-14(22)19-18-13(21)9-3-1-2-4-12(9)20/h1-7,20H,(H,18,21)(H2,17,19,22)
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n/an/a 490n/an/an/an/an/an/a



Universit£ Catholique de Louvain (UCLouvain)

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE3A using [3H]cAMP after 20 mins by scintillation counting analysis


Eur J Med Chem 159: 324-338 (2018)


Article DOI: 10.1016/j.ejmech.2018.09.067
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))
BDBM50357870
PNG
(CHEMBL1916130)
Show SMILES COc1cc(cc2c1nc(C)c1c(C)nc(-c3ccncc3C)n21)C(F)(F)F
Show InChI InChI=1S/C20H17F3N4O/c1-10-9-24-6-5-14(10)19-26-12(3)18-11(2)25-17-15(27(18)19)7-13(20(21,22)23)8-16(17)28-4/h5-9H,1-4H3
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n/an/a>500n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3A using [3H]cAMP after 1 hr by scintillation proximity assay


J Med Chem 54: 7621-38 (2011)


Article DOI: 10.1021/jm2009138
BindingDB Entry DOI: 10.7270/Q2125T2B
More data for this
Ligand-Target Pair
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